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Family Lamiaceae
Salvia officinalis

Scientific names Common names
Oboskon cretica (L.) Raf. Common sage
Salvia chromatica Hoffmanns. Culinary sage
Salvia clusii Vilm. Garden sage
Salvia cretica Linn. True sage
Salvia crispa Ten. Scarlet sage
Salvia digna Stokes Meadow sage
Salvia grandiflora Ten.                    [Illegitimate]  
Salvia hispanica Garsault               [Invalid]  
Salvia minor Garsault                     [Invalid]  
Salvia officinalis Linn.  
Salvia papillosa Hoffmanns.  
Salvia tricolor Vilm.  
Salvia officinalis L. is an accepted name. The Plant List

Other vernacular names
ARABIC: Maramia (Palestine).
TURKEY: Adacayi.

Sage is a herbaceous perennial shrub with wiry and squared stems. Leaves are opposite. grayish green, softly hairy or velvety, long stalked with round-toothed margins. Flowers are axillary, in whorls of 4 to 8, tubular, purple, blue or white.

- Recently introduced.
- Cultivated in the Bagiuo area.

- Some important volatile constituents are a-thujone, b-thujone, 1,8-cineole and b-caryophyllene.
- Contains terpene, camphor and salvene.

- Phytochemical screening of leaves yielded flavonoid, saponin, hydrolysable and condensed tannin groups. (See study below) (9)
- Essential oil study yielded main compounds of 1,8-cineole (39.5–50.3%) and camphor (8.8–25.0%). (See study below) (10)
- Nutrition analysis per 100 g of dried, ground Salvia officinalis yield: (Proximates) water 7.96 g, energy 315 Kcal, carbohydrate 60.73 g, protein 10.63 g, total fat 12.75 g, cholesterol 0 mg, dietary fiber 40.3 g; total sugars 1.71 g, (Vitamins) folate 274 µg, niacin 5.720 mg, pyridoxine 2.690 mg, riboflavin 0.336 mg, thiamin 0.754 mg, vitamin A 5900 mg, vitamin C 32.4 mg, vitamin E 7.48 mg, vitamin K 1714.5 µg; (Electrolytes) sodium 11 mg, potassium 1070 mg; (Minerals) calcium 1652 mg, copper 0.757 mg, iron 28.12 mg, magnesium 428 mg, manganese 3.133 mg, zinc 4.70 mg; (Phytonutrients) ß-carotene 3485 µg, crypto-xanthin-ß 109 µg, lutein-zeaxanthin 1895 µg; (Lipids) total saturated fatty acids 7.030 g, total monosaturated fatty acids 1.870 g, total polyunsaturated fatty acids 1.760 g. (USDA) (32)
- Constituent composition yields: essential oil (up to 3%), hydroxycinnamic acid derivatives (3.54%), phenolic diterpenes, triterpenes, flavonoids, phenolic glycosides, polysaccharides, phytosterols and benzoic acid derivatives. (34)
- Essential oil constituents (up to 3%) consist of monoterpenoids (a-thujone 10-60%, ß-thujone 4-36%, camphor 5-20%, 1,8-cineole 1-15%) and sesquiterpenes (a-humulene, ß-caryophyllene, viridiflorol). (34)
- Study have yielded flavonoids (apigenin, cirsimaritin, ellagic acid, genkwanin, hispidulin, luteolin, quercetin, rosmarinic acid, and rutin) and terpenes and terpenoids (borneol, camphor, carnosol, ursolic acid, cineole, oleanolic acid, limonene, linalool and a-thujone). (38)

- Considered anhidrotic, antiseptic, astringent, antispasmodic, antiviral, antiplaque, antibacterial, antifungal, carminative, tonic, stimulant.
- Oils are antiseptic, antibacterial, astringent and irritant.

- Studies have suggested antimicrobial, antidiabetic, antifungal, anti-inflammatory, cholinesterase inhibiting, antidiabetic, renoprotective, diuretic, antioxidant properties

Parts utilized

- Lemony and pleasantly bitter.
- Young leaves eaten fresh in salads.
- Used for omelets, soups and poultry stuffing.
- An enhancing condiment for lamb, fish, duck, goose, artichoke. cheese, beans.
- No known folkloric medicinal use in the Philippines.
- Because of it antiseptic and astringent properties, used for sore throats, mouth irritations, cuts and bruises.
- Used for snake bites.
- Used for drying up perspiration.
- Used to lower blood sugars in diabetics.
- Used to treat amenorrhea and dysmenorrhea. Used as cicatrizant.
- Green leaves rubbed on teeth and gums to fortify them.
- In Germany, various preparations used for treatment of dyspeptic complaints (heartburn, bloating), minor skin inflammation, excessive sweating, symptomatic inflammation of the mouth or throat. (34)
- Cosmetics: infusions used to color the hair silver or gray.
- Used as an after-shave astringent.
- Used in perfumery.
- Mouthwash for halitosis: Used as mouthwash for halitosis because of its antibacterial properties. Infusion prepared with a spoonful of dried plant per cup of water. (36)
- Decorative: Used for making culinary wreaths.
- German Commission E: GCE approved the internal use of sage for dyspeptic symptoms and excessive perspiration, and the external use for inflammation of mucous membranes of the mouth and throat. (34)

• Studies have shown sage slows down the release of enzymes that break down the neurotransmitter, acetylcholine; and inhibition of this enzyme can improve mood with maintaining optimal levels of acetylcholine. A study using 300 to 600 mg of sage leaf extract showed some benefit in alertness and calmness. An alternative to the capsules, a decoction of tsp dried sage in 1 cup of water (Do not use if pregnant).
Alzheimer's Disease / Improved Cognition / Clinical Study: In a double-blind, randomized, and placebo-controlled trial in patients with mild to moderate Alzheimer's disease, a Salvia officinalis extract showed significant benefits in cognition possibly through cholinesterase inhibition. Mild agitation side effects were noted in the placebo group. S. officinalis may well reduce agitation and may be an additional advantage for use in patients with Alzheimer's disease. (1)
Antibacterial: Study of Salvia officinalis essential oil and its fractions showed significant antibacterial effect against S aureus and B subtilis. (3)
Acute Pharyngitis / Spray Formulation: Randomized, double-blind, parallel group phase II/III study of spray (containing S. officinalis fluid extract) vs placebo showed a 15% sage spray to be a safe and convenient treatment for patients with acute pharyngitis, with a relief superior to placebo. (4)
Cholinesterase Inhibiting Property: Study confirms the cholinesterase inhibiting property of S officinalis and improved mood and cognitive performance following single-dose use in healthy young participants. (5)
Antioxidant: Tunisian study of oils produced from the aerial parts of SO showed it to possess strong antioxidant properties.
Liver antioxidant: An in vivo study of a traditional sage water infusion in mice and rats showed bioactivities and improvement in liver antioxidant potential. (6)
Antimutagenic: Study demonstrated the antimutagenic activity of volatile sage terpenes, suggesting further antimutagenesis and anticarcinogenesis studies. (7)
Metformin-like effect: Study effects on fasting glucose and its metformin-like effects on rat hepatocytes suggest sage may be a useful food supplement for T2D. (8)
Antibacterial / Leaves: Study evaluated chloroform and hydroalcoholic extracts of S. officinalis leaves against four strains of gram negative (E. coli, P. aeruginosa, K. pneumonia, and Proteus spp.) and two strains of gram positive bacteria (S. aureus and Bacillus cereus). Chloroform extract was active against Staphylococcus aureus and Proteus spp. (9) Essential oil and its fractions showed significant antibacterial effect against S. aureus and B. subtilis.(11) Study of ethanol extracts of sage showed antibacterial effect on multi-drug resistant bacteria. Results suggest a potential use of herbs as alternative to antibiotics. (24)
Essential Oil / Antifungal and Anti-Inflammatory: The main compounds of S. officinalis oils were 1,8-cineole (39.5–50.3%) and camphor (8.8–25.0%). The oils exhibited antifungal activity against dermatophyte strains and significantly inhibited NO production stimulated by LPS in macrophages, without affecting cell viability. (10)
Hepatic Effects / Herb Toxicant Effect / Induction of CYP2E1: Sage tea drinking did not protect against carbon tetrachloride induced toxicity in mice. Instead, sage tea potentiated the toxicity of CCl4 in mice. Herb-toxicant effect may be, in part, due to significant induction of CYP 2E1 protein by sage tea. However, the dose used in the study was much higher than that usually taken by humans. Nevertheless, it suggests possible herb-drug interactions between sage and drugs metabolized by the liver. (12)
• Herb-Drug Interactions: Moderate herb-drug interaction concerns: (1) Sage may decrease blood sugar and caution advised when taken with diabetic medications. (2) Seizure medications may interact with sage. Sage may decrease the effectiveness of medications being taken for seizures. (3) Sage may cause sleepiness and drowsiness and caution advised for patients taking sedatives. Possible interaction with drugs metabolized by the liver through induction of CYP 2E1 protein. Also, sage tea lowers fasting glucose in mice and has a diuretic effect. (33)
Antidiabetic Effects: Sage tea was found to lower fasting plasma glucose in mice indicating effects on gluconeogenesis. Sage tea drinking also increased glucose uptake capacity and increased hepatocyte sensitivity to insulin and inhibited gluconeogenesis. (12)
Diuretic / Leaves: Study evaluated the diuretic effects of a methanol leaf extract in normal rats. Results showed significant increase in urine volume with increase excretion of sodium and a potassium conserving effect. Diuretic effect was comparable to reference drug hydrochlorothiazide (HCTZ). (13)
Cytotoxic / Apoptosis Induction / Human Lymphoma and Leukemia Cells: Study evaluated the in vitro cytotoxic activities of crude methanolic extracts on lymphoma and leukemia cell lines. Results showed dose- and time-dependent inhibition of proliferation of lymphoma and leukemic cells possibly via an apoptosis-dependent pathway. (14)
Antidiarrheal / Antispasmodic: Crude extract of S. officinalis exhibited antidiarrheal and antispasmodic activities probably mediated through the dominant activation of voltage-dependent K+ channels. (16)
Disinfectant / Essential Oils: S. officinalis essential oils showed a potent vapor activity against a panel of bacterial, yeast, and fungi. Results suggest a potential for a natural eco-friendly disinfectant to manage airborne microbes. (17)
Cytotoxic / α-humulene and Transcaryo-phyllene / Animal and Human Tumor Cells: Study showed α-humulene and trans-caryophyllene extracted from S. officinalis essential oil inhibit tumor cell growth. (18)
Antiangiogenic / Anti-Tumor / Essential Oils: Study evaluated the anti-angiogenic effect of SO extract on chicken chorioallantoic membrane (CAM) neovascularization model. Results showed dose-dependent inhibitory activity and suggests a promise as anti-angiogenic treatment. (19)
Antigenotoxicity / Anti-Oxidative Stress: Study investigated the antioxidative possible genotoxic, and antigenotoxic potency of SO extract against cyclophosphamide (CYP)-induced oxidative stress and genotoxicity in Wistar albino rats. Results showed a protective against CYP-induced oxidative stress and genotoxicity through its antioxidant property. (20)
Antioxidant / STZ-induced Stress: Study evaluated the protective effects of SO against oxidative stress induced by intracerebroventricular injection of streptozotocin in male rats. Results showed antioxidant effects could prevent STZ-induced oxidative stress. (21)
Hepatoprotective / Antioxidant: Study evaluated a hydroalcoholic extract of S. officinalis for antioxidant and hepatoprotective effects in male rats with INH induced necrosis. Results showed anti-oxidative and hepatoprotective effects in rats co-administered with S. officinalis extract and INH. (22)
Antiulcerogenic: Study evaluated a crude ethanolic extract of S. officinalis in a gastric lesion induction model in male Wistar rats. Results showed potential use of S. officinalis for effective treatment of injuries caused by absolute alcohol. (23)
Menopausal Hot Flushes / Estrogenic Flavonoids: A recent study showed a SO tincture to reduce hot flushes frequency and intensity. Study investigating possible mechanisms suggest the involvement of ubiquitous estrogenic flavonoids in the in vitro anti-hot flush effect of S. officinalis, and suggests a safe herbal alternative product for menopausal hot flushes. (25)
Antiprotease and Antimetastatic Activity of Ursolic Acid:Natural products were evaluated in the in vitro antiprotease assay on serine proteases (trypsin, thrombin and urokinase) and on the cysteine protease cathepsin B. Results showed ursolic acid isolated from Salvia officinalis significantly inhibited all tested proteases in vitro in the micromolar range. Ursolic acid showed the strongest inhibition activity to urokinase and cathepsin B as proteases included in tumor invasion and metastasis. suggesting possible anticancer effectivity. (26)
Safety Profile / Kidney and Liver: Study evaluated an aqueous leaf extract of S. officinalis on kidney and liver of male Sprague Dawley rats. Histopath assessment suggests SO has not deleterious effects on kidney and liver of rats. (27)
Renoprotective / Gentamicin-Induced Nephrotoxicity: Sage exhibited nephroprotective effect in gentamicin induced renal damage probably through its antioxidant activity. (28)
Lozenge Tablet Formulation: Study evaluated evaluating a lozenge tablet formulation of S. officinalis clearly indicated that it can be a good alternative for traditional forms of sage. Palatability and taste were found desirable by human subjects. (29)
• Antioxidant / Antibacterial / Leaves and Essential Oil: Study evaluated in vitro antioxidant potential and antibacterial activities of essential oils and methanolic leaf extracts of S. officinalis. Results showed high polyphenol content in the leaf extracts which exhibited strong antioxidant activities compared to vitamin C and BHT (butylated hydroxyl toluene) with IC50 of 37.29 µg/ml by DPPH assay. The essential oil only showed weak antioxidant activity. Study also showed significant antibacterial activity for the methanolic extracts and essential oils. (35)
• Use in Dentistry: Review highlighted the various uses of S. officinalis in the dental field along with its medical applications. The thujone in the volatile oil has antiseptic and antibiotic action, and as mouthwash helps with throat infections, dental abscesses, infected gums and mouth ulcers. Phenolic acids are especially helpful against S. aureus. The high tannin contents provides astringent action. (36)
• Anti-Inflammatory / Essential Oil: Study evaluated the anti-inflammatory response of hydroalcoholic extract and sage essential oil using an experimental model of acute inflammation and a leukocyte migration assay. The SE exhibited a topical anti-inflammatory effect by significant inhibition of croton oil-induced ear edema. All SO doses significantly inhibited leukocytes migration to spermatic fascia after inflammatory stimulus. SO constituents were monoterpene ketones, characterized as
α-thujone (90%) and ß-thujone (6%). Thujone reduces the production of pro-inflammatory cytokines (TNF-α, IL-ß, IL-6, GMC-stimulating factor). The anti-inflammatory activity of the oil could be due to its constituents. (38)
• Bronchodilator Activity / Inhibition of Phosphodiesterase Enzyme and K+ Channels: Study evaluated an aqueous methanolic extract of aerial parts of SO for use in asthma using an in vivo bronchodilatory assay and isolated tracheal preparations. Results showed bronchodilatory activity mediated predominantly via activation of voltage-dependent K+ channels and inhibition of phosphodiesterase enzyme. (39)
• Anti-Diabetic / Improved Insulin Sensitivity / Anti-Obesity: Study evaluated the anti-diabetic, anti-inflammatory and anti-obesity effects of sage methanol extract in a mouse nutritional model of obesity, inflammation, and insulin resistance, and its effects of lipolysis and lipogenesis. Sage ME at low dose showed effects similar to rosiglitazone. It improved insulin sensitivity, inhibited lipogenesis in adipocytes and reduced inflammation as evidenced by increase anti-inflammatory cytokines IL-2, IL-4, and IL-10 and decreased pro-inflammatory cytokines IL-12 THF-
α, and KC/GRO. (40)
• Effect on Thyroid Hormone Level in Hypothyroid Rat: Study evaluated the effects on SO extract on thyroid hormones and TSH in hypothyroid rats. Results showed SOE had a stimulatory effect on thyroid gland function and raised plasma T3 and T4 levels. (41)
• Benefits in Diabetic Patients / Double-Blind Clinical Trial: A double-blind clinical trial evaluated the hypoglycemic effect of Salvia officinalis on blood glucose, HbA1c, lipid profile, liver and renal function tests. Results showed S. officinalis may be beneficial in diabetic patients, with reduction of 2hr PPBS and cholesterol levels. Higher doses might be needed to decrease fasting sugars and glycosylated hemoglobin. (15)
• Wound Healing / Leaves: Study evaluated in vivo wound healing activity of hydroethanolic extract of S. officinalis leaves in excision and incision wound models in Wistar rats. The leaf extract showed high total flavonoid, phenolic content and antioxidant capacity. Topical application of the extract, especially at higher dose, significantly (p<0.05) increased the percentage of wound contraction, period of re-epithelialization, breaking strength ration and upregulated hydroxyproline content. There was also significant (p<0.05) increase in new vessel formation and fibroblast distribution. (41)
• Add-On to Statin Therapy / Improvement of Diabetic and Lipid Profile / Clinical Trial: Randomized clinical trial evaluated the efficacy and safety of S. officinalis combined with statin therapy in dyslipidemic patients. The extract showed antioxidant activity which may be beneficial for the prevention of cardiovascular complications in type-2 diabetes patients. Results showed that sage combined with glyburide, metformin, and atorvastatin further lowered fasting blood sugar, 2-hour postprandial blood sugar, HbA1c, total cholesterol, triglycerides, LDL-C and increased HDL-C in T2DM patients. Sage as add-on therapy is safe and further improved the lipid profile. (42)
• Effect on Ovarian Angiogenesis: Study evaluated the effect of S. officinalis on ovarian angiogenesis at the preimplantation time in mice. Results suggest increased ovarian angiogenesis after exposure to S. officinalis may induce vascular permeability and contribute to a variety of disorders including clinical signs similar to the ovarian hyperstimulation syndrome. (43)
• Effect on Estradiol Hormone / Postmenopausal Hot Flushes and Night Sweats: A double-blind randomized clinical trial evaluated the effect of salvia tablets on 100 qualified postmenopausal women with hot flushes. Results showed the level of estradiol hormone increase in the sage group. Sage tablets were effective in the treatment of hot flushes, night sweats, and other symptoms in postmenopausal women. It presents as an alternative therapy for individuals not able to take hormone replacement therapy. (45)
• Cytotoxic / Cytogenetic on Tumor Cell Lines: Study evaluated the cytotoxicity of Salvia officinalis extracts on two tumor cell lines, Rhabdomyosarcoma (RD) and Murine mammary adenocarcinoma (AMN3) and a normal cell line, Murine fibroblast (L20B). The aqueous extracts showed antiproliferative effects o both RD and AMN3 cell lines. Cytotoxic activity was more efficacious than Cisplatin. Cytogenetic effect was less than that of cyclophosphamide. (46)

- Wild-crafted.
- Capsules, dried leaves in the cybermarket.

© Godofredo U. Stuart Jr., M.D.

Updated May 2018 / December 2016

Photos © Godofredo Stuart / StuartXchange
OTHER IMAGE SOURCE: Illustration: Salvia officinalis L. / Public Domain / Franz Eugen Köhler, Köhler's Medizinal-Pflanzen / Wikipedia

Additional Sources and Suggested Readings
Salvia officinalis extract in the treatment of patients with mild to moderate Alzheimer's disease: a double blind, randomized and placebo-controlled trial / Akhondzadeh S, Noroozian M, Mohammadi M, Ohadinia S, Jamshidi AH, Khani M. / Journal of Clinical Pharmacy and Therapeutics (2003) 28, 53-59 / https://doi.org/10.1046/j.1365-2710.2003.00463.x
Sage Eases Anxiety, Boosts Alertness. Sara Altshul. Prevention. Oct 2006
Comparative study on the antibacterial activity of volatiles from sage (Salvia officinalis L.) / Arch. Biol. Sci., Belgrade, 57 (3), 173-178, 2005.
Efficacy and tolerability of a spray with Salvia officinalis in the treatment of acute pharyngitis - a randomised, double-blind, placebo-controlled study with adaptive design and interim analysis. / Eur J Med Res. 2006 Jan 31;11(1):20-6.
Effects of Cholinesterase Inhibiting Sage (Salvia officinalis) on Mood, Anxiety and Performance on a Psychological Stressor Battery / Kennedy DO1, Pace S, Haskell C, Okello EJ, Milne A, Scholey AB./ Neuropsychopharmacology. 2006 Apr;31(4):845-52.
The drinking of a Salvia officinalis infusion improves liver antioxidant status in mice and rats / Journal of Ethnopharmacology
Volume 97, Issue 2 , 28 February 2005, Pages 383-389
Metformin-like effect of Salvia officinalis (common sage): is it useful in diabetes prevention? / British Journal of Nutrition (2006), 96, 326–333 DOI: 10.1079/BJN20061832
Antibacterial and Phytochemical Study of Iraqi Salvia officinalis Leave Extracts / Lana Y. Muttalib* and Alaadin M. Naqishbandi* / Iraqi J Pharm Sci, Vol.21(1) 2012
Essential Oil of Common Sage (Salvia officinalis L.) from Jordan: Assessment of Safety in Mammalian Cells and Its Antifungal and Anti-Inflammatory Potential / M. S. Abu-Darwish, C. Cabral, I. V. Ferreira, M. J. Gonçalves, C. Cavaleiro, M. T. Cruz, T. H. Al-bdour, and L. Salgueiro / BioMed Research International Volume 2013 (2013) / http://dx.doi.org/10.1155/2013/538940
Comparative study on the antibaCterial aCtivity of volatiles from sage (Salvia officinaliS l.) / DRAGANA MITIĆ-ĆULAFIĆ, BRANKA VUKOVIĆ-GAČIĆ, JELENA KNEŽEVIĆ-VUKČEVIĆ, S. STANKOVIĆ and DRAGA SIMIC / Arch. Biol. Sci., Belgrade, 57 (3), 173-178, 2005.
Effects of Salvia officinalis in the liver: Relevance of glutathione levels / Cristóvão Fernando Macedo Lima / Tese de Doutoramento—Ciências Biológicas / Nov 2006
Inhibitory and Cytotoxic Activities of Salvia Officinalis L. Extract on Human Lymphoma and Leukemia Cells by Induction of Apoptosis / Fatemeh Zare Shahneh, Samira Valiyari, Behzad Baradaran*, Jalal Abdolalizadeh, Ali Bandehagh, Abbas Azadmehr, Reza Hajiaghaee / Advanced Pharmaceutical Bulletin, 2013, 3(1), 51-55 / doi:http://dx.doi.org/10.5681/apb.2013.009
Effect of Salvia officinalis on diabetic patients / Saeed Behradmanesh, Fatemeh Derees, Mahmoud Rafieian-kopaei* / J Ren Inj Prev. 2013; 2(2): 51-54. /
DOI: 10.12861/jrip.2013.18
Antidiarrheal and antispasmodic activities of Salvia officinalis are mediated through activation of K+ channels / Aslam Khan, Najeeb-ur- Rehman, Khalid M. AlKharfy, Anwarul-Hassan Gilani / Bangladesh Journal of Pharmacology, Vol 6, No 2 (2011)
Disinfectant properties of essential oils from Salvia officinalis L. cultivated in Tunisia / Mohamed Bouaziz, Thabèt Yangui, Sami Sayadi, Abdelhafidh Dhouib * / Food and Chemical Toxicology 47 (2009) 2755–2760
Cytotoxic activity of α-humulene and transcaryo- phyllene from Salvia officinalis in animal and human tumor cells / Adil el Hadri*, María Ángeles Gómez del Río, Jesús Sanz, Azucena González Coloma, Mohamed Idaomar, Bartolomé Ribas Ozonas, Juana Benedí González, María Isabel Sánchez Reus / An. R. Acad. Nac. Farm., 2010, 76 (3): 343-356
Anti Tumor Activity of Salvia officinalis is Due to Its Anti-Angiogenic, Anti-Migratory and Anti-Proliferative Effects / Maryam Keshavarz, M.Sc, Ali Bidmeshkipour. Ph.D*, Ali Mostafaie, Ph.D., Kamran Mansouri, M.Sc., Hamid-Reza Mohammadi-Motlagh, M.Sc. / CELL JOURNAL(Yakhteh), Vol 12, No 4, Winter 2011
Protective effects of Salvia officinalis extract against cyclophosphamide-induced genotoxicity and oxidative stress in rats / Fulya ÜSTÜN ALKAN*, Feraye ESEN GÜRSEL, Atila ATEŞ, Mustafa ÖZYÜREK, Kubilay GÜÇLÜ, Mehmet ALTUN / Turk. J. Vet. Anim. Sci. 2012; 36(6): 646-654 © / doi:10.3906/vet-1105-36
Effect of hydroalcoholic extract of Salvia officinalis L. on the activity of catalase and superoxide dismutase in an oxidative stress model created by intracerebroventricular STZ injection in male rats / Shahram Shahmohamadi, Akbar Hajizadeh moghaddam *, Maryam Khosravi / Physiol Pharmacol. 2013; 17 (2) :176-184
Hepatoprotective and Antioxidant Effects of Salvia officinalis L. hydroalcoholic Extract in Male Rats / Khakpour Shahrzad, Najari Mahya, Tokazabani Belasei Fatemeh, Khosravi Maryam, Farhadi Belasei , Mohammadreza, Mahsa Hadipour Jahromy* / Chinese Medicine, Vol.5 No.2(2014) / DOI:10.4236/cm.2014.52016
Antiulcerogenic potential of Salvia officinalis L. extract in rats / Taís Regina Fiorentin*, Michela Bianchi De Mello, Aline Maria Krube Aquino, Bruna Alexsandra Rigo, Carla Giane Loss, Melissa Schwanz, Arno Ernesto Hofmann Junior, Sandra Manoela Dias Macedo / Journal of Applied Pharmaceutical Science Vol. 3 (08), pp. 032-035, August, 2013 / DOI: 10.7324/JAPS.2013.3806
In-Vitro Antibacterial Properties of Sage (Salvia officinalis) Ethanol Extract against Multidrug Resistant Staphylococcus aureus, Escherichia coli, Pseudomonas aeruginosa and Klebsiella pneumoniae / Elham Mosafa,* Sima Yahyaabadi, Monir Doudi / Zahedan J Res Med Sci 2014 Oct; 16(10): 42-46
Salvia officinalis for menopausal hot flushes: Towards determination of mechanism of activity and active principles / S Rahte, R Evans, PJ Eugster, L Marcourt, JL Wolfender, A Kortenkamp, D Tasdemir / Planta Med 2013; 79 - PN108 / DOI: 10.1055/s-0033-1352450
Antiprotease and Antimetastatic Activity of Ursolic Acid Isolated from Salvia officinalis / Andrej Jedinák*, Marta Mucˇkova, Daniela Kosˇt'a ́lova, Tibor Maliar, and Irena Masˇterova / Z. Naturforsch. 61c, 777Ð782 (2006)
The histopathological effects of salvia officinalis on the kidney and liver of rats / A. D. Adekomi, T.D. Adeniyi, A.M. Afodun, K.K. Quadri / Scientific Journal of Medical Science, Vol 2, No 3 (2013)
Protective effects of Salvia Officinalis extract against gentamicin-induced nephrotoxicity in rat / Saeed Changizi Ashtiani*, Mostafa Jafari, Houshang Najafi, Mahboubeh Ahmadi / Journal of Kermanshah University of Medical Sciences. 2013; 17(4): 212-220
Formulation and Physicochemical Evaluation of Lozenge Tablets Containing Salvia Officinalis / Elmira Bajelan*, Mohammad Kamali-nejad, Seyed Mohsen Foroutan, Hiam Albasha / Journal of Young Pharmacists, 2014; 6(1):34-38 / doi:10.5530/jyp.2014.1.6
Salvia officinalis / Common names / Wikipedia
Salvia officinalis / Synonyms / The Plant List
Sage Herb Nutrition Facts / Nutrition-and-You
Sage Interactions / WebMD

Phytochemical Study and Biological Activity of Sage (Salvia officinalis L.) / Mekhaldi Abdelkader, Bouznad Ahcen, Djibaoui Rachid, Hamoum Hakim / International Journal of Biological, Biomolecular, Agricultural, Food and Biotechnological Engineering Vol:8, No:11, 2014
Salvia officinalis in dentistry / Nikhita Narayanan, Lakshmi Thangavelu /
Chemistry, Pharmacology, and Medicinal Property of Sage (Salvia) to Prevent and Cure Illnesses such as Obesity, Diabetes, Depression, Dementia, Lupus, Autism, Heart Disease, and Cancer / Mohsen Hamidpour, Rafie Hamidpour, Soheila Hamidpour, and Mina Shahlari / J Tradit Complement Med, Apri-Jun 2014; 4(2): 82-88 / doi:  10.4103/2225-4110.130373
Anti-Inflammatory activity of Salvia officinalis L. / Gessilda Alcantara Nogueira de Melo, Jefferson Pitelli Fonseca, Thiago Oliveira Farinha, Rilson José do Pinho, Márcio José Damião, Renata Grespan, Expedito Leite da Silva, Ciomar A. Bersani-Amado and Roberto Kenji Nakamura Cuman / Journal of Medicinal Plants Research Vol. 6(35): pp 4934-4939, 12 September 2012 / DOI: 10.5897//JJMPR12.251
Studies on Bronchodilator Activity of Salvia officinalis (Sage): Possible Involvement of K+ Channel Activation and Phosphodiesterase Inhibition / Anwarul-Hassan Gilani, Najeeb-Ur Rehman, Aslam Khan, Khalid M Alkarfy / Phytotherapy Research, Vol 29, Issue 9; Sept 2015 / https://doi.org/10.1002/ptr.5384
Preventive effects of Salvia officinalisleaf extract on insulin resistance and inflammation in a model of high fat diet-induced obesity in mice that responds to rosiglitazone / Ben Khedher MR, Hammami M, Arch JRS, Hislop DC, Eze D, Wargent ET, Kępczyńska MA, Zaibi MS / PeerJ 6:e4166 /
Topical application of Salvia officinalis hydroethanolic leaf extract improves wound healing process / Sirvan Karimzadeh & Mohammad Reza Farahpour* / Indian Journal of Experimental Biology Vol. 55, February 2017, pp. 98-106
Salvia officinalis (Sage) Leaf Extract as Add-on to Statin Therapy in Hypercholesterolemic Type 2 Diabetic Patients: a Randomized Clinical Trial / Saeed Kianbakht∗, Farzaneh Nabati, Behrooz Abasi / IJMCM, Summer 2016, Vol 5, No 3
Effect of the Ethanolic Extract of Salvia officinalis on Ovarian Angiogenesis in Mice at Preimplantation: A Morphological and Molecular Analysis / Beigi Boroujeni N, Gholami M R. / Jundishapur J Helath Res. 2017 ;8(1): e44386 / doi: 10.5812/jjhr.44386.
Effects of Salvia officinalis L. (sage) leaves Extracts in Normal and Alloxan - Induced Diabetes in White Rats / Kareem T.. Khashan, Karar Abbas Al-khefaji / International Journal of Scientific & Engineering Research, Vol 6, Issue 1; January 2015
The effect of salvia officinalis tablet on hot flashes, night sweating, and estradiol hormone in postmenopausal women / Sima Kianirad , Sedighe Forouhari *, Alamtaj Samsami Dehaghani, Homeira Vafaei, Mehrad Sayadi and Maryam Asadi / International Journal of Medical Research & Health Sciences, 2016, 5, 8: pp 257-263
Cytotoxic and cytogenetic effects of Salvia officinalis on different tumor cell lines / Reshna K Al-Barazanjy, Kawa Dizaye, Assad A Al-Asadye / Middle East Journal of Internal Medicine, Vol 6, Issue 4, July 2013

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