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Family Menispermaceae
Arcangelisia flava (L.) Merr.

Fu shan long

Scientific names  Common names
Anamirta flavescens (Lam.) Miq. Abustra (Ilk.) 
Anamirta florewscens Müll.Berol Abutra (S. L. Bis.)
Anamirta lactuosa Miers Albotra (P. Bis.)
Anamirta lemniscata Miers  Alibodra (P. Bis.) 
Arcangelisia flava (L.) Merr. Buti (Tag.) 
Arcangelesia lemniscata Miers Lagtal (S.L.Bis.) 
Arcangelesia loureiri (Pierre) Diels Lagtan, (P. Bis.) 
Arcangelesia inclyta Becc. Lagtang (Tag., Bik., Sul.)
Arcangelesia lemniscata (Miers.) Becc. Suma (Tag., Pamp.) 
Arcangelesia loureiroi (Pierre) Diels Taua (Bag.) 
Menispermum flavum Linn. Uplig (Ilk.)
  Yellow-fruit moonseed (Engl.)
  Yellow root (Engl.)
Lagtang is a local common name shared by (1) Anamirta cocculus, indian cockle, levant nut, and (2) Arcangelisia flava, abutra
Arcangelisia flava (L.) Merr. is an accepted name. The Plant List

Other vernacular names
CHINESE: Fu shan long.
INDONESIA: Areuy ki koneng, sirawan, daun bulan, Akar kuning.
MALAYSIA: Mengkunyit.
THAILAND: Khamin khruea, kamphaeng jedchunum.
THAILAND: Khaminkhruea.
VIETNAM: V[ar]y d[aws]ng.

Abutra is a woody, perennial, climbing plant with a very long stem growing from the ground level to the canopy of trees. Old stems are about 5 centimeters thick, with a gray bark and yellow wood. Leaves are leathery, smooth, broadly ovate, 16 centimeters wide and 16 centimeters long, the tip abruptly pointed, the base obtusely round or subtruncate, with 5 veins radiating from the base, with one or two lateral nerves arising from the midvein above the middle. Inflorescence is axillary, pendulous and spicately panicled, usually clustered along the stems. Flowers are fragrant, yellowish, crowded and stalkless. Exterior perianth segments are 3, and small; interior ones are 6, oblong, much longer, and spreading. Fruit is nearly spherical, about 2 centimeters in diameter, green or yellowish green.

- Scattered in thickets and forests at low and medium altitudes from the Batan Islands to Palawan and Mindanao.
- Widely distributed from China, Indo-China, Malaysia, Borneo, the Moluccas to New Guinea.

- Stems yield a yellow dye, berberine, the active principle in barberry.
- Study showed the stems contain approximately 4.8 percent pure alkaloid.
- The plant yields several alkaloids: berberine, the principal alkaloid, with jatrorhizine, columbamine and shobakunine.
- A single plant has been reported to yield one kilo of berberine.
- Roots yielded a furanoditerpenoid, fibaruretin B.
- Study yielded 11 secondary metabolites including 2-dehydroarcangelisinol, 6-
hydroxyarcangelisin, fibleucin, fibraurin, 6-
hydroxyfibleucin, 6-hydroxyfibraurin,
berberine, columbamine, jatrorrhizine,
palmatine, and tinophyllol. (see study below) (23)
- Phytochemical screening yielded alkaloid, flavonoid, saponin, and terpenoid compounds, with the absence of tannin. (see study below) (24)
- Study isolated two furanoditerpenes, 2
α,3α-epoxy-2,3,7,8α-tetrahydropenianthic acid methyl ester (1) and 2α,3α-epoxy-2,3-dihydropenianthic acid methyl ester (2) from the roots of A. flava. NMR and EI-MS studies also isolated fibraurin (3), fibleucin (4) 2ß, 3α-dihydroxy-2,3,7, 8α-tetrahydropenianthic acid-2.17-lactone (5), along with p-hydroxybenzaldehyde and vanillin. (see study below) (33)

Considered antimalarial, germicidal, tonic, stomachic, febrifuge, emmenagogue, abortive, antiperiodic, diaphoretic (much of these due to the berberine).
- Studies have suggest anti-inflammatory, antioxidant, antibacterial, antifungal, antimalarial, andcancer, hepatoprotective, antibabesial, antidiarrheal, antidiabetic, neuraminidase inhibitory,
hypocholesterolemic properties.

Parts used
Bark, roots, and stems.

• Decoction of wood used for cleansing wounds; used as a cure for itches and tropical ulcers.
• Decoction or infusion of plant used as stomachic and febrifuge.
• Decoction of roots and stem used as febrifuge, tonic and emmenagogue. Also used as abortive.
• In Zambales used as expectorant in bronchial affections.
• In Malaya, decoction taken internally for jaundice, indigestion and as vermifuge.
• Smoke used as inhalant for mucous membrane affections of the nose and mouth.
• In Indo-China used as antidiabetic drug.
• In East Asian traditional medicine, used as bitter tonic and for jaundice, infectious diarrheal disease and skin abscess.
• Used for treatment of malaria and dysentery and as a tonic.
• Sap from cut stems drunk as treatment for fever and sprue. (16)
- Dye: Stems used for its yellow dye (berberine), a single plant yielding as much as one kilo of berberine.
- Germicide: Popular in the Philippines as a germicide.

Antioxidant / Cytotoxic / Anti-Breast Cancer:
Study evaluated the antioxidant and cytotoxic activities of A. flava, C. blumeanum and F. tinctoria: A. flava showed antioxidant activity and pronounced cytotoxic activity against human cancer cell line MCF-7 (breast adenocarcinoma). Berberine, palmatine and jatrorrhizine were isolated from A. flava. (1)
Antimalarial / Cytotoxic:
Study evaluated 49 plants and 228 extracts from plants traditionally use to treat malaria in south Vietnam for in-vitro activity against Plasmodium falcifarum and antitoxicity against human cancer cell lines HeLa and the embryonic lung MRC5 cell line. At concentration of 10 µg/ml
, 82 extracts showed antiplasmodial activity. Six plants, including A. flava, showed antiplasmodial activity with IC50 ranging from 0.4 to 8.6 µg/ml with good selectivity. (2)
Phytochemical / New Furanoditerpenes:
Study yielded four new furanoditerpenes plus fibraurin, fibleucin, and 6-hydroxyfibraurin. (3)
Antibabesial Activity / Protoberberine Alkaloids:
Study isolated palmatine, berberine, jatrorrhizine, dihydroberberine and 20-hydroxyecdysone. Four compounds caused significant inhibition of Babesia gibsoni, an intraerythrocytic parasite that causes hemolytic anemia in wild and domesticated dogs. The mechanism was possibly through prevention of parasite invasion of erythrocytes and inhibition of growth. (4)
In a study of 138 medicinal plant preparations used in the Philippines were studied for genotoxicity. 12, including A. flava exhibited detectable genotoxicity.
Furanoditerpenoids / Fibaruretin: Furanoditerpenoids are secondary metabolites found in Menispermaceae plants, found to possess anti-inflammatory and antimalarial activities. Study of the roots of A. flava isolated a furanoditerpenoids compound, fibaruretin. (6)
Protoberberine Alkaloids / Anti-Babesial:Stems yielded palmatine, berberine, jatrorrhizine, dihydroberberine and 20-hydroxyecdysone. Compounds 1-4 showed growth inhibiting effects on Babesia gibsoni in culture. (B. gibsoni is an emerging pathogen in dogs.) (7)
Berberine: A. flava yields the plant alkaloid berberine. Review lists its physiological effects: anti-diarrheal, anti-malarial, anti-tumor, stimulates cardiac contractility and anti-arrhythmic, anti-inflammatory and antihepatotoxic.
Anti-Babesial: Study evaluated the inhibitory effects of 45 selected plant extracts from Central Kalimantan, Indonesia in invitro and its acute toxicity to mice. Arcangelisia flava showed to have appreciable antibabesial activity without toxicity to mice. (9)
Hepatoprotective: In vivo studies of secondary metabolites of abutra (akar kuning) saponin extracts without alkaloids showed hepatoprotective activity in paracetamol induced liver damage in Sprague Dawley rats. (10)
Anti-Malarial / Anti-Telomerase: Berberine, extracted from Arcangelisia flava dose-dependently inhibited telomerase activity in erythrocytic cycle of Plasmodium flaciparum suggested P. falcifarum telomerase may be a potential target for future malarial chemotherapy. (12)
Antihypertensive / Anti-Cancer: A study of twenty-two medicinal plants showed the pepsin hydrosylates of Arcangelisia flava bark to have antihypertensive (ACE inhibitory) and anticancer (≥50 % inhibition of human cancer cell lines) activities. (13)
• Natural Food Additive / Antimicrobial / Acidity-Stabilizing Effects in Palm Sugar: Study investigated the antimicrobial and acidity-stabilizing effects of yellow root extract. A water extract showed antimicrobial activity against Salmonella typhi, Staphylococcus aureus, and Trichophyton rubrum. The extract showed ability to stabilize the acidity of fresh palm sap due to fermentation mechanism. Toxicity testing using Brine shrimp lethality assay showed A. flava to be a natural product without toxicity. Results suggest A. flava can be used as a safe natural food additive, especially in the production of palm sugar. (15)
• Safety Study on Hepatotoxicity: Study sought to determine if A. flava is hepatotoxic to rats. A freeze-dried preparation was administered intraperitoneally to rats. Only an isolated case of SGPT elevation was noted; the majority were within normal range. (1
• Pharmacologic Effects / Berberine: Study was done to determine whether the pharmacologic effects of A. flava extracts are attributable to the berberine content, the principal alkaloid content of the plant. The study did not settle the issue, but concluded the following: (1) IV doses of the extract to a dog caused hypotension, bradycardia, and increased myocardial contraction. (2) In isolated turtle heart, the extract caused a decreased in heart rate. (3) IV to dogs, the extract caused an initial stimulation of respiratory rate followed by depression without changes in tidal air. (4) Increase in ileal amplitude and tone. (5) Intraarterially, produced paralysis of the gastrocnemius-soleus contractions of the dog. (18)
• EGFR Inhibition / Potential Benefit in HER2-Positive Breast Cancer / Berberine: Cancer cell over-proliferation can be caused by abnormalities of EGFRs, a group of receptors that play a role in initiation of cell proliferation. EGFRs inhibition could inhibit cancer cell proliferation process. Study evaluated the potent secondary metabolites of akar kuning as EGFRs inhibitors. Over-expression activity of EGFR-2 often occurs in breast cancer. Study predicted that berberine has EGFR inhibitory activity, especially EGFR-2 and has potential for HER2-positive breast cancer therapy. (19)
• Selective Cytotoxicity Against Breast and Colon Cancer Cell Lines / Leaves: Study of an ethanolic extract of A. flava leaves is cytotoxic and selective against breast and colon cancer. Results suggest it has potential to be developed as a cancer co-chemotherapeutic agent especially for breast and colon cancer. (20)
• Antidepressant: Study evaluated the antidepressant activity of A. flava on immobility time of white male mice strain Balb-c by forced swim test method. Amitryptiline was used as positive control. Results showed best antidepressant effect at 312 mg/kbw, with minimum immobility time. (21)
• Potential for α-Glucosidase Inhibition / Antidiabetic / Bark: Study evaluated the bark extract of yellow root plant for α-glucosidase enzyme. Results showed very weak inhibitory activity towards α-glucosidase enzyme. The supposed antidiabetic mechanism of yellow root-stem is via inhibition of α-glucosidase enzyme and stimulation of pancreatic ß-cells, thereby increasing insulin production or secretion. (22)
• Neuraminidase Inhibition / Fibleucin: Study evaluated the relationship between secondary metabolites of akar kuning and neuraminidase (NA) with molecular docking study and to determine the most potent NA inhibitor from metabolites from akar kuning. Study isolated a total of 11 secondary metabolites, including fibleucin. In silico molecular molecular docking and pharmacophore optimization indicated fibleucin could be considered as NA inhibitor, with a potential as anti-influenza particularly to H5N1 with oseltamivir resistance, (see constituents above) (23)
• Antibacterial Against Aeromonas hydrophila: Study evaluated the antibacterial activity of A. flava against Aeromonas hydrophila. The chloroform solvent exhibited the widest preventive zone (17.25 mm) on A. hydrophila. (24)
• Antibacterial / Molecular Docking Study / Berberine: Molecular docking study was done on several secondary metabolites of akar kuning against active site of several antibacterial receptors known for many antibiotics including cell wall protein, nucleic acid, synthesis inhibitors and antimetabolites. Findings showed that among 11 metabolites studied, 6-hydroxyfibraurin, berberine, and fibleucin showed lowest free energy of binding between 11 antibacterial receptors compared with natural substrates or inhibitors from each receptor. Results showed the for the selected secondary metabolites of akar kuning, the main mechanism of action was inhibition of protein synthesis which was shown by berberine. (25)
• Antidiabetic / Antioxidant / Leaves: Study evaluated the in-vitro antioxidant and antidiabetic activity of hexane, ethyl acetate, and methanol extract of Kaya kuning leaves. The methanol extract showed highest scavenging activity on superoxide and hydroxyl radical, while the ethyl acetate extract showed highest scavenging activity on DPPH radical. Compared to standard acarbose, the hexane and EA extracts showed potent potent antidiabtic activity, with the EA extract showing highest potency. Antidiabetic activity was evaluated using α-amylase and α-glucosidase assays. (26)
• Hypocholesterolemic / Stem / Root: A previous study showed a methanol extract of A. flava leaves reduced TC and LDL cholesterol, and reduced the atherogenic index value and number of foam cells. The antihyperlipidemic effect was attributed to berberine and flavonoid in the extract. In this study in hyperlipidemic rats, the stem extract reduced TG, TC, and LDL cholesterol levels. The hypo-cholesterolemic effect could also be attributed to berberine and flavonoid. (27) Study evaluated the anti-hypercholesterolemic extract of A. flava root extract in male mice induced by high fat diet of quail egg yolks. The A. flava extract at 9.5 mg, 10 mg, 38 mg / 20gBB decreased total cholesterol by 10%, 13%, and 17%, respectively. The effect was still different from simvastatin 10 mg. (40)
• Berberine and Jatrorrhizine / Src Inhibitor in Cancer Therapy: Proto-oncogene tyrosine protein kinase (Src) protein is one of the targets in various cancer therapies such as leukemia. Study evaluated the potential secondary metabolites of akar kuning as Src inhibitors Molecular docking was done using quercetin and dasatinib as reference ligands. Docking results showed berberine to have the highest affinity. Results showed the combination of berberine and and jatrorrhizine is predicted to be optimally used as an Src inhibitor to cancer therapy. (28)
• Antioxidant / Stems: Study evaluated the antioxidant activity of akar kuning stem extract using DPPH method. The ethanol extract from yellow root plant stem showed moderate antioxidant activity with IC50 values of 136.81 ppm. (29)
• Growth Inhibition of Candida albicans and Trichophyton mentagrophytes / Stems: Study evaluated the antifungal activity of stem extract of A. flava against C. albicans and T. mentagrophytes using agar diffusion and microdilution methods. The extract contained 1.55 ± 0.12& w/ alkaloid calculated as Berberine chloride. Inhibition zones were 16.65 ± 4.52 and 6.55 ± 0.05 mm for CA and TM, respectively. The MIC for both fungi was 10 mg/mL, and MBC was 40 mg/mL for Ca and 50 mg/mL for Tm. (30)
• Antibacterial against Pseudomonas fluorescens / Leaves: Study evaluated the antibacterial activity of A. flava leaf on Pseudomonas fluorescens infection in water culture. Phytochemical screening yielded secondary metabolites such as alkaloid, phenol, flavonoid, and saponin. Highest inhibitory activity was seen at concentration of 1.5% with mean inhibition zone of 7.18 mm. (31)
• Hepatoprotective / Modulation of Caspase-3 Expression in Acetaminophen Toxicity: Study evaluated the effect of A. flava extract on modulation of caspase-3 in acetaminophen-induced hepatotoxicity in Wistar male rats. A higher dose of A. flava extract showed hepatoprotective activity as evidenced by prevention of elevation of serum transaminase and transferase levels. Findings suggest modulation of expression of caspase-3 protein in a dose-dependent manner. (32)
Furanoditerpenes / Antifungal / Roots: Study isolated two furanoditerpenes, 2a,3a-epoxy-2,3,7,8a-tetrahydropenianthic acid methyl ester (1) and 2a,3a-epoxy-2,3-dihydropenianthic acid methyl ester (2)from the roots of A. flava. NMR and EI-MS studies also isolated fibraurin (3), fibleucin (4) 2ß, 3a-dihydroxy-2,3,7, 8a-tetrahydropenianthic acid-2.17-lactone (5), along with p-hydroxybenzaldehyde and vanillin. Compound 5 showed the highest antifungal activity of the five isolated furanoditerpenes against white-rot fungus (Rametes versicolor) and a brown-rot fungus (Fomitopsis palustris. (33)
Immunostimulant on Edwardsiella tarda Infection / Roots: Study evaluated the immunomodulator activity of yellow root in non-specific resistance of catfish Pangasionodon hypophthalmus infected with bacterium E. tarda. Results showed the yellow root extract at highest doses, 0.7 g/L was the most effective dose as immunostimulant in P. hypopthalmus. raising total leucocyte, hematocrit level, phagocytic activity, and survival rate that are beneficial for overcoming E. tarda infection. (34)
Comparative Effects of Water and Brackish Water on Kidneys and Uterus of Rats: Study evaluated the effects of yellow root decoctions on biochemical and histopathological profile of kidney and uterus in Wistar rats after subchronic treatment of yellow root water decoctions and brackish water decoctions at doses of 1.25, 2.5, and 5 g/kbw of dried yellow root/ The groups[s treated with brackish water decoctions revealed no significant changes except at highest doses. With water decoction, results showed significant differences with the control group. Histopathological features in all doses of the water decoction group revealed organ damage manifested as hemorrhage, degeneration and necrosis of the kidneys, as well as epithelial damage and inflammatory infiltration of the uterus. (35)
Anti-Inflammatory / Expression of COX-2 Enzyme in Induced Complete Freund's Adjuvant / Stem Bark: Study evaluated the anti-inflammatory effect of katola (A. flava) on cyclooxygenase-2 enzyme expression in Wistar rats inflamed with CFA induction. Results showed the infusa of katola stem bark, which contained Berberine Hcl 5.69 ± 0.18 at dose of 450 mg/kbw significantly decreased the expression of COX-2 by 95% (p<0.05).
Suppression of Cancer Cell Lines / Non-Apoptotic Pathway / Leaves: Study evaluated an ethanolic leaf extract for mechanism of cytotoxicity. The EEAFL obtained from 16.1 g/100g of dried leaves yielded 16.1%. The EEAFL tends to trigger necrosis rather than apoptosis on HeLa, MCF-7 and WiDr. The higher the concentration, the more cells to undergo necrosis, except on HeLa cell line. (37)
Antimalarial / Inhibition of Heme Polymerization: An earlier investigation showed A. flava can inhibit P. falcifarum growth. Study evaluated the antimalarial activity and IC50 based on inhibition of heme polymerization. Results showed the water extract had an IC50 pf 601 ppm, and FTIR and GA-MS study identified the chemical constituent, stigmastan. (39)
Anti-Inflammatory / Phytoconstituents against Nitric Oxide Synthase / Molecular Docking: Study sought to discover inducible nitric oxide synthase (iNOS) inhibitors from Morus sp. and A. flava for anti-inflammatory drug candidates. Molecular docking of phytoconstituents yielded 10 phytoconstituents in A. flava and eight compounds in Morus sp. interacting with Glu377, an important amino acid residue in the iNOS binding pocket. The phytoconstituents fit the pharmacophore features generated from AT2 or SEITU complex with iNOS with potential as iNOS inhibitors. (41)
Effect on Estrous Cycle / Bark: Study evaluated the effects of A. flava bark decoction on the estrous cycle of female albino mice with bark decoction administered orally for one month. Results showed a decrease in the number of estrous cycles in the treated groups. The proestrus stages of the group that received 3 mL of decoction showed prolonged mean duration. (42)
EGFR Inhibitors / Breast Cancer Therapy: Akar kuning (A. flava) is known for anticancer activities. Several secondary metabolites have shown antiproliferative activity towards cancer cells. Study aimed to determine the most potent secondary metabolites of akar kuning as several EGFRs inhibitors. Molecular docking results showed berberine provided the most negative free energy of binding and lowest inhibition constant towards all EGFRs. Berberine showed activity as EGFR inhibitor, especially EGFR-2, with potential for development as HER2-positive breast cancer therapy. (44)
Toxicity Against Head Louse: Head lice infestation caused by Pediculus humanus capitis is one of the most important public health problem in children worldwide. Study kuning

- Wild-crafted. 
- Capsules, supplements, tea bags in the hypermarket.

Updated June 2021 / December 2017 / July 2014

IMAGE SOURCE: Photo / Arcangelisia flava (L.) Merr. / by VanLap Hoang / Creative Commons / click on photo to go to source page / Useful Tropical Plants
IMAGE SOURCE: Illustration / Arcangelisia flava (L.) Merr. [as Anamirta loureiroi Pierre] Pierre, L., Flore forestiere de la Cochinchine, vol. 2: t. 110 (1839) / PlantIllustrations.org
IMAGE SOURCE: / Arcangelisia flava / Line drawing from <http://proseanet.org/prosea/_newsletters/newsletter_16_april1996_new.htm>

Additional Sources and Suggested Readings
Antioxidant and cytotoxic activities of A. flava, C. blumeanum and F. tinctoria / Niwat Keawpradub et al / Songklanakarin J. Sci. Technol., 2005, 27(Suppl. 2) : 455-467
Antimalarial and cytotoxic activities of ethnopharmacologically selected medicinal plants from South Vietnam / Julie Nguyen-Pouplin et al / Journal of Ethnopharmacology. Feb 2007; Vol 109, Issue 3: pp 417-427 / doi:10.1016/j.jep.2006.08.011
Indonesian Medicinal Plants. I. New Furanoditerpenes from Arcangelisia flava MERR./ Chemical & pharmaceutical bulletin / 33(2) pp.479-487 19850225
Antibabesial Activity of Protoberberine Alkaloids and 20-Hydroxyecdysome from Arcangelisia flava against Babesia gibsoni in Culture / Subeki, Matsuura H, Takahashi K et al / J. Vet. Med. Sci., 2005; 67(2): pp 223-227 / DOI: https://doi.org/10.1292/jvms.67.223
Mutagenic and Antimutagenic Activities in Philippine Medicinal and Food Plants / Clara Y Lim-Sylianco and W Tomas Shier / Summary Toxin Reviews / 1985, Vol. 4, No. 1, Pages 71-105 / DOI 10.3109/15569548509014414
Absolute configuration of fibaruretin B / H.-K. Fun, A. W. Salae, I. A. Razak, M. Khairuddean and S. Chantrapromma / Acta Cryst. (2011) 1246-o1247 / doi:10.1107/S1600536811014887
Antibabesial activity of protoberberine alkaloids and 20-hydroxyecdysone from Arcangelisia flava against Babesia gibsoni in culture. / Subeki, Matsuura H, Takahashi K, Yamasaki M, Yamato O, Maede Y, Katakura K, Suzuki M, Trimurningsih, Chairul, Yoshihara T. / J Vet Med Sci. 2005 Feb;67(2):223-7.
Physiological Effects of Berberine / Review Article / Jaruwan Wongbutdee / Thai Pharm Health Sci J 2008;4(1):78-83
Effects of Central Kalimantan plant extracts on intraerythrocytic Babesia gibsoni in culture. / Subeki, Matsuura H, Yamasaki M, Yamato O, Maede Y, Katakura K, Suzuki M, Trimurningsih, Chairul, Yoshihara T. / J Vet Med Sci. 2004 Jul;66(7):871-4.
Uji In Vivo Saponin Tanaman Akar Kuning (Arcangelisia flava (L.) Merr) Sebagai Hepatoprotektor / Achmadi, Suminar Setiati; Sulistiyani; Batubara, Irmanida; Kayun, Saraswati P. / IPB Bogor Agricultural University Scientific Repository
Arcangelisia flava / Vernacular names / GLOBinMED
Stage specificity of Plasmodium falciparum telomerase and its inhibition by berberine / Sriwilaijareon N, Petmitr S, Mutirangura A, Ponglikitmongkol M, Wilairat P. / Parasitol Int. 2002 Mar;51(1):99-103.
SCREENING OF ANTIHYPERTENSIVE AND ANTICANCER PEPTIDES FROM ENZYMATIC HYDROLYSATES OF SOME MEDICINAL PLANTS / Thakorn Sornwatana, Sittiruk Roytrakul, Nuanchawee Wetprasit, and Sunanta Ratanapo / Poster 080 / Abstracts for the 2nd Biochemistry and Molecular Biology Conference, 7-8 May 2009, Khon Kaen University
Arcangelisia flava (L.) Merr. / Synonyms / The Plant List
Study of Yellow Root (Arcangelisia FlavaMerr) as a Natural Food Additive with Antimicrobial and Acidity-stabilizing Effects in the Production Process of Palm Sugar / Hesty Heryani, Agung Nugroho / Procedia Environmental Sciences, Vol 23 (2015); pp 346-350 / https://doi.org/10.1016/j.proenv.2015.01.050
Arcangelisia flava / Useful Tropical Plants
An experimental study on the hepatotoxicity of Arcangelisia flava (albutra) in rats / Mendoza SM, Abola LE, Guevara MC, Alcon JH / UERMMMC Journal of Health Sciences 2000;3(1):9-14.
Some pharmacologic effects of Arcangelisia flava (Linn.) Merr. extract. / Horacio R. Estrada, Gerardo V. de Leon, Pilar T Lim, Quintin L Kintanar / Acta Medica Philippina, Vol 19, Issue 3, Jan-Mar 1963
Akar Kuning (Arcangelisia Flava) Sebagai Inhibitor EGFR : Kajian in Silico / Akar Kuning (Arcangelisia Flava) As EGFR Inhibitor: In Silico Study / Mohammad Rizki Fadhil Pratama / Jurnal Farmagazine, Vol. 3, No. 1 (February 2016)
Ethanolic Extract of Arcangelisia flava Leaves is Cytotoxic and Selective against Breast and Colon Cancer Cell Lines / Endah Puspitasari, Dian Agung Pangaribowo, Ika Yanuar Isparnaning, Yora Utami / Proceeding of The 1st University of Muhammadiyah Purwokerto - Pharmacy International Conference 5-6 June 2015
The Antidepressant Effects of (Arcangelisia flava (l.) Merr) Water-Soluble Extract in Balb-C Mice Reviewed from Immobility Time by Forced / Tiara A., Arief R.H. and Sudarsono / Biology, Medicine, & Natural Product Chemistry, 2014; Vol 3, No 2: pp 65-67 / DOI: 10.14421/biomedich.2014.32.65-67
The Potential of Ethanol Extract o f The Yellow Root ( Arcangelisia Flava L ) As The Inhibitor o f Enzyme Α - Glucosidase / Raudhatul Fadhilah, and Dedeh Kurniasih / IOSR Journal of Pharmacy and Biological Sciences, Vol 12, Issue 4, Ver VI, July-August 2017 / DOI: 10.9790/3008-1204066972
Akar Kuning (Arcangelisia Flava) As Neuraminidase Inhibitor: Molecular Docking And Pharmacophore Optimization Approach/ Mohammad Rizki Fadhil Pratama / Advances in Health Science Research, Vol 6, 2nd Sari Mulia International Conference on Health and Sciences (SMICHS 2017) / ISSN: 2468-5739 /
DOI: https://doi.org/10.2991/smichs-17.2017.63
/ The Phytochemistry and The Anti-Bacterial Activity of Yellow Root (Arcangelisia flava Merr.) against Aeromonas hydrophila / Maryani; Marsoedi; Nursyam, Happy; Maftuch / Journal of Biology & Life Science (JBLS); Aug 2013, Vol 4, Issue 2
Antibacterial Activity of Akar Kuning (Arcangekusua fkava) Secondary Metabolites: Molecular Docking Approach / Mohammad Rizki Fadhil Pratama, Suratno Suratno, Evi Mulyani / Asian Journal of Pharmaceutical and Clinical Research, 2018; 11(11)
Potential Antioxidant and Antidiabetic Activities of Kayu Kuning (Arcangelisia flava) / Lilik Diwi Wahyudi, Tri Agus Siswoyo et al / Agriculture and Agricultural Science Procedia, 2016; Vol 9: pp 396-402 /
DOI: https://doi.org/10.1016/j.aaspro.2016.02.155
Antihypercholesterolemic effect of Arcangelisia flava stem extract in hyperlipidemic rats / Evi Umayah Ulfa, Ema Rachmawati / Proceeding ICMHS 2016, ISBN: 978-602-60569-3-1
Molecular Docking Study of Akar Kuning (Arcangelisia flava) Secondary Metabolites as Src Inhibitor / MohMMs Rizki Fadhil Pratama, Evi Mulyani, Suratno Suratno / Indonesian Journal of Cancer Chemoprevention, 2019; 10(3)
In-Vitro Study of Antioxidant Activities from Ethanol Extracts of Akar Kuning (Arcangelisia flava) / Suratno Suratno, Muhammad Ikhwan Rizki, Mohammad Rizki Fadhil Pratama / Jurnal Surya Medika (JSM), 2019; 4(2)
The Effect of Water-Soluble Stem Extract "Kayu Kuning" (Arcangelisia flava) on the Growth Inhibition of Candida albicans ATCC 10231 and Trichophyton mentagrophytes In-Vitro / Rini Setyowati, Sudarsono Sudarsono, Setyowati E P / Biology, Medicine & Natural Product Chemistry, 2014; 3(1)
In vitro test of natural antibacterial activity of yellow-fruit moonseed Arcangelisia flava Merr. leaf on bacterium Pseudomonas fluorescens under different doses / Rosita Maryani, Sinta Monalisa, Mohamad Rozik / AACL Bioflux, 2018: 11(1)
Modulation of Caspase-3 Expression by Arcangelisia flava Post-Acetaminophen-Induced Hepatotoxicity in Rat's Liver / Sheffi Liem, Tina Rostinawati, Ronny Lesmana, Sri Adi Sumiwi, Tiana Milanda, Mutakin Mutakin, Irma Melyani Puspitasari, Jutti Levita / The Indonesian Biomedical Journal, 2018; 10(2)
Furanoditerpenes from Ancangelisia flava (L.) Merr. and their antifungal activity / Toshisada Sizuki, Tamiko Kiyotani, Mami Maeda, Kateshi Katayama, Kaori Tomita-Yokotani, Wasrub Stafii, Sipon Muladi / Phytochemistry Letters, Sept 2011; 4(3): pp 333-336 / DOI: https://doi.org/10.1016/j.phytol.2011.07.002
Immunostimulant activities of yellow root (Arcangelisia flava Merr.) extract on Edwardsiella tarda infection / Maryani, Ida Ratnasari, Subhan Alhidayat, Tutwuri Handayani, Nursiah, Yusintha Tanduh / AACL Bioflux, 2020, 13(3)
Comparative Effects of Yellow Root (Arcangelisia flava (L.) Merr.) Water and Brackish Water on Kidneys and Uterus in Wistar Rats / Suwijiyo Pramono, Risqika Y T Paramidhita, Marini Marini, Moch. Saiful Bachri / Majalah Obat Tradisional, 2020; 25(2) / ISSN: 2406-9086 / DOI: https://doi.org/10.22146/mot.55178
Anti-inflammatory activity extract of katola (Arcangelisia flava (L.) Merr.) on the expression of cyclooxygenase -2 enzyme in Wistar rats induced complete freund's adkivamt (CFA) / Hasnaeni Hasnaeni / International Medicinal Journal, 25(5): pp 2513-2516 / ISSN: 1341-2051
Arcangelisia flava leaves ethanol extract suppresses cancer cell lines via non apoptotic pathway / Endah Puspitasari et al / Proceeding ICMHS 2016 / ISBN 978-602-60569-3-1
Extract of Yellow Root (Arcangelisia flava L. Merr) from Several Regions in Kalimantan: Alkaloid Content and Cytotoxicity towards WiDr Colorectal Cancer Cells / R Mutiah, F O Kirana, R Annisa et al / Indonesian Journal of Cancer Chemoprevention, 2020; 11(2)
Chemical Constituent and Antimalarial Activity Based on Inhibition of Heme Polymerization from Water Extract of Yellow Root (Arcagelisia flava L. Merr) / Yatri Hapsari, Partomuan Simanjuntak, Wien Kusharyoto, Sumi Hudiyono / Chimica et Natura Acta, 2019; 7(3) / https://doi.org/10.24198/xn.v7n3.26264
Effect of Methanol Extract of Arcangelisia flava (L.) in High-Fat Diet-Induced Hyperlipidemic Mice / Elly Purwati, Wheni Eka Ristanti, Cikra Ikhda Nur Hamidah Safitri / IOSR Journal of Dental and Medical Sciences, May 2018; 17(5): pp 55-59 / eISSN: 2279-0853 / pISSN: 2279-0861 / DOI: 10.9790/0853-1705085559
Pharmacophore modeling and molecular docking of phytoconstituents in Morus sp. and Arcangelisia flava against nitric oxide synthase for anti-inflammatory discovery / Jutti Levita, Recky Patala, Jennifer Kolina, Tiana Milanda, Mutakin Mutakin, Irma Melyani Puspitasari, Nyi Mekar Saptarini, Sri Adi Sumiwi / JAPS: Journalof Applied Pharmaceutical Science, Dec 2018; 8(12) / https://doi.org/10.7 324/JAPS.2018.81207
Effects of oral administration of Arcangelisia flava (abiutra) bark decoction on the estrous cycle of female albino mice / Claren Lyn Q Jakosalem / 1997 / ANIMO REPOSITORY
Flowcytometric analysis of the effect of Berberine on the expression of glucocorticoid receptors in human hepatoima HepG2 cells / Chin-Wen Chi, Tsung-Yun Liu et al / Life Sciences, 1994; 54(26): pp 2099-2107 / DOI: https://doi.org/10.1016/0024-3205(94)00719-5
Akar Kuning (Arcangelisia flava) as EGFR Inhibitor: In Silico Study / Mohammad Rizki Fadhil Pratama / Jurnal Farmagazine, Feb 2016; 3(1)

DOI: It is not uncommon for links on studies/sources to change. Copying and pasting the information on the search window or using the DOI (if available) will often redirect to the new link page. (Citing and Using a (DOI) Digital Object Identifier)

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