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Family Lamiaceae
Premna odorata Blanco

Mao yu xiu mu

Scientific names  Common names
Gumira leucostoma (Miq.) Kuntze  Abgau (P. Bis.)
Gumira odorata (Blanco) Kuntze  Adgau (P. Bis., Bik.)
Gumira vestita (Schauer) Kuntze  Adiyo (Tag.)
Premna cumingiana var. pierreana (Dop) P.H.Ho Aggau (C. Bis.)
Premna curaranii H.J. Lam   Alagao (Tag.)
Premna depauperata Merr. Alagau (Tag., Ilk.)
Premna depauperata var. oswaldiana Moldenke Alagaw (Tag.)
Premna depauperata var. serrulata Moldenke Alagaw-bagin (Tag.)
Premna flavescens var. rubens C.B.Clarke Alagbaguin (Tag.)
Premna goeringii Turcz.  Anobran (Ilk.)
Premna inaeuilateralis Beer & H.J.Lam  Argau (P. Bis.)
Premna latifolia var. cuneata C.B.Clarke Asedaong (Ilongot)
Premna latifolia var. major Moldenke Atiñgi (Gad.)
Premna leucostoma Miq. Duragau (Sub.)
Premna maclurei Merr. Guachal (Ig.) 
Premna oblongata var. puberula H.J.Lam Karimog (Maranao)
Premna odorata Blanco Lagau (Mag.) 
Premna odorata var. detergibilis (C.B.Clarke) Moldenke Lassi (Ibn.) 
Premna odorata var. pierreana (Dop) Moldenke Pumuhat tangli (Pang.) 
Premna peekelii H.J.Lam Siargaw (Tag.)
Premna rubens (C.B.Clarke) Ridl. Saliargao (C. Bis.)
Premna rufidula Miq. Saliargaw (Bis.)
Premna ruttenii H.J.Lam Tibangñgen (Bon.) 
Premna subscandens Merr. Uradgao (Bis.)
Premna subscandens var. minutiflora Moldenke Fragrant premna (Engl.) 
Premna tomentosa var, detergibilis C.B.Clarke   
Premna tomentosa var, pierreana Dop  
Premna vestita Schauer   
Alagau is a shared common name for: (1) Magilik, alagau (P. Bis.), Premna cumingiana (2) Alagau-gubat, Premna nauseosa and (3) Alagau, Premna odorata.
Quisumbing's compilation lists Premna integrifolia Blanco as a separate specie from Premna serratifolia L. Other compilations list them as synonymous species. Some compilations list Premna serratifolia Linn. as separate species from P. serratifolia Blanco.
Premna odorata Blanco is an accepted species.  KEW: Plants of the World Onine

Other vernacular names
CHINESE: Mao yu xiu mu.
INDONESIA: Sengkel, Waits-kedi, Somoko, Kleob katoe.

Gen info
- Premna is a genus of flowering plants in the mint family, Lamiaceae.
- Premna odorata
is a species of flowering plant in the Lamiaceae family.

- The island of Siargao in the Philippines is named after P. odorata, known as siargaw or saliargaw in local languages. (39)
- Etymology: The genus  name Premna derives from Greek 'premon', which means tree stump. referring to the twisted and short trunks of P. serratifolia, which was the first discovered species of the genus. The specific epithet odorata means fragrant or perfumed.

Alagau is a small hairy tree, 3 to 8 meters high. Leaves are ovate to broadly ovate, 10 to 20 centimeters long, with broad, rounded, or somewhat heart-shaped base, and pointed tips. Under surface of the blade is usually covered with short hairs, aromatic when crushed. Flowers are greenish-white or nearly white, 4 to 5 millimeters long and borne on terminal inflorescences (cymes) 8 to 20 centimeters in diameter. Fruit is fleshy, dark purple, rounded, about 5 millimeters in diameter.

- Native to the Philippines.
- Common In thickets and secondary forests at low altitudes from the Batan Islands and northern Luzon to Mindanao, in most islands and provinces.
- Also
native to Assam, Bangladesh, Bismarck Archipelago, Borneo, Cambodia, Christmas Is., Hainan, India, Jawa, Laos, Lesser Sunda Is., Malaya, Maluku, Myanmar, New Guinea, Northern Territory, Philippines, Queensland, Sri Lanka, Sulawesi, Sumatera, Taiwan, Thailand, Vietnam. (13)

- Leaves do not contain alkaloid, tannin, saponin or cyanogenetic substance.
- Leaves yield 0.02 percent yellowish-green essential oil with a characteristic scent.
- Study isolated two iridoid glycosides: 2″- and 3″-caffeoyl-6-α-l-rhamnopyranosylcatalpol respectively.
- Study isolated ten 10-O-acylated derivatives of catalpol and asystasioside E from a 1-butanol-soluble fraction of a methanol extract of leaves.
- Study isolated acyclic monoterpenediol diesters, premnaodorosides A, B, and C, together with phenethyl alcohol glycosid4es, verbscoside, isoacteoside, bioside (decaffeoylverbascoside) and cistanoside F. (10)
- Leaves yielded
premnethanosides A and B, premnaodorosides A,B, and C, premnosides A-D, 2''-caffeoyl-6-α-L-rhamnopyranosylcatalpol, and 3''-Caffeoyl-6-α-L-rhamnopyranosylcatalpol. (17)
- Crude leaf extract yielded steroids, terpenoids, flavonoids and hydrolysable tannins. (see study below) (19)
- GC-MS analysis of P. odorata lipoidal extract yielded 25 compounds representing 72.15% of total identified compounds consisting mainly of fatty acids in free and ester forms (%). Linoleic acid and its ester form were the main compounds representing 18.58% and 19.00% of total compounds, respectively. (see study below) (21)
- GC-MS analysis showed the volatile oil consisted of monoterpenes, sesquiterpenes, diterpenes, and higher alkanes; monoterpens and sesquiterpenes were the major oil fractions. Trans-caryophyllene (29.403% and 14.638%) and ß-phellandrene (22.390 and 11.701%) were major compounds in leaves and young stem oils, respectively. (see study below) (24)
- GC-MS and GC-FID study of leaf essential oil yielded 97 constituents accounting for 94.19%, 92.27%, 91.95% and 92.63% for POS (spring), POM (summer), POA (autumn) and POW (winter) whole essential oils. β-Caryophyllene was the main metabolite in the oil in the different seasons. (see study below) (30)

- Sudorific, pectoral, carminative.
- Studies have suggested antimicrobial, antiviral, cardiotonic, anticoagulant, hepatoprotective, antitubercular, antitumor, antimutagenic, anti-parasitic, antioxidant properties.

Parts utilized
Leave, shoots, fruits, and flowering tops, fresh or dried.

Young leaves used in the cooking of "paksiw" and "bopis."
· In the Philippines, sugared decoction of leaves with a little "calamansi" as tea helps loosen up phlegm and effective for coughs.
- The Ayta community of Dinalupihan, Bataan, Philippines apply decoction of leaves and shoots directly to wounds to facilitate healing. (2
- Ati negrito use external application of boiled leaves for postpartum bleeding. (27)
- The Ilongot-Egongot community of Aurora, Philippines apply leaves and stem-bark to wounds. (28)
· Decoction of fresh leaves used for vaginal irrigation.
· Decoction of leaves for fever and colds, cough and bronchitis, fever blisters of the lips and stomachaches.
· "Kochoi," a local patent preparation, is claimed to benefit tuberculosis.
· Decoction of leaves used for flatulence (gas pains) in adults; in children, crushed leaves mixed with a little coconut or sesame oil are applied to the abdomen.
· Crushed leaves applied to forehead and temples for headaches.
· Leaf decoction has been used for tuberculosis.
· Roots are chewed and the saliva swallowed for cardiac troubles.
· Infusion of leaves is carminative.
· Decoction of roots, leaves, flowers, and fruits used as sudorific, pectoral, and carminative.
· Decoction of shoots used as parasiticide.
· Decoction of leaves used for bathing infants; also used as treatment for beriberi.
· Extract of leaves for cleaning wounds and for ticks and fleas.
· Leaves applied over the bladder facilitates urination.
Pito-pito: Leaves are one of the seven ingredients of the popular herbal Filipino tea blend – alagaw, banaba, bayabas, pandan, manga, anis and cilantro. (See: Pito-Pito)

Ethno-Veterinary / Fumigation: Dried leaves and bark used for fumigation of poultry houses, reportedly effective for getting rid of lice and ticks. (11)
• Decoction of leaves and flowering tops used as vaginal wash or douche; antiseptic properties make it useful for cleansing and incorporation with bath-care products.

• Collagen Network / Acetoside:
Study of methanol extract of leaves of Premna odorata exhibited a promotion of collagen network formation by M cells and isolated acetoside, an phenylethanoid with a variety of biological activities. Acetoside may contribute to wound healing. (1)
• Anti-Viral Activity: Study of 61 medicinal plants in Malaysia showed P odorata was 1 of 11 plants to show selective activity against vesicular stomatitis (VSV) viruses. (2)
• In-vitro Photo-Cytotoxic Activity: A study of 155 extracts from 93 species of plants in Malaysia screened for in vitro photo-cytotoxic activity using a human leukemia cell line, P odorata was one of 29 plants that was able to reduce in vitro cell viability by more than 50% when exposed to broad spectrum light. (3)
• Hepatoprotective / Cytotoxic Activity: Study showed the alcoholic extract with significant hepatoprotective activity evidenced by decrease of serum enzymes, bilirubin and lipid peroxidation, comparable to drug silymarin. It also exhibited significant in-vitro cytotoxic activity. Results showed the alcoholic extract not only as an effective hepatoprotective agent, but with also significant antitumor activity. (4)
• Antiparasitic Activity:
In a study of 18 medicinal plants in New Caledonia evaluated in vitro against several parasites, Scaevola balansae and Premna serratifolia were the most active against Leishmania donovani. (5)
Study evaluated the anti-parasitic activity of three invasive verbena species (Premna odorata, Lantana camara, and Duranta erecta) against earthworm Lumbricus terrestris and roundworm Ascaris lumbricoides. All three plant extracts were active against earthworm and roundworms. For the alagao extract death time ranged from 0.30 to o.45 minutes for earthworms and 32.52 to 47.48 minutes for roundworms. (22)
• E. Coli Inhibitory Activity / Bark: Various extracts were tested against E. Coli. A 100% ethanol bark extract showed activity against E. coli, while aqueous extract concentrations were inactive against E. coli. However, the inhibitory activity could not compete with ciprofloxacin. (7)
• Diosmetin / Acacetin: Study of leaves isolated diosmetin and acacetin. Diometin has been commercially available as the glycoside diosmin, used as a vasotonic agent for the treatment of varicose veins, hemorrhoids and other venous diseases.
• Flavones / Antimicrobial / Anti-Inflammatory / Chemopreventive: Partitioning and fractionation of crude ethanolic extract of leaves yielded two amorphous powders identified as flavone aglycones — acacetin and the non-widespread diosmetin. Earlier studies reported antimicrobial, anti-inflammatory, and chemopreventive activities. (8)
• Antitubercular Constituents / Leaves: Study evaluated the antitubercular property of crude extract and sub-extracts of leaves and isolated the bioactive principles from active fractions. Crude methanolic extract and sub-extracts showed poor inhibitory activity against MTb H37Rv. However, increased inhibitory potency was seen from fractions eluted from the DCM extract. Purification of the most active fraction yielded 1-heneicosyl formate (1), 4:1 mixture of β-sitosterol (2), stigmasterol (3) and diosmetin (4). Compound 1 had an MIC of 8 µg/mL. (14)
• Cytotoxicity Against Selected Human Cancer Cell Lines / Bark and Leaves: Study evaluated the cytotoxic activities of P. odorata leaves and bark, A. camansi and G. sepium against selected human cancer cell lines. Results showed the leaves and bark hexane fractions of P. odorata and A. camansi leaves to be highly cytotoxic against the cancer cell lines. The PO bark hexane extract showed highest selectivity index for HCT116, MCF-7 and A549 cancer cell lines. (15)
• Antibacterial / Leaves: Study evaluated the antibacterial activity of leaves extract against selected human pathogens viz. Bacillus subtilis, E. coli, S. aureus. Results showed antibacterial activity with dose dependent inhibition. (16)
• Phlebotonic Diosmetin / Leaves: Study isolated phlebotonic diosmetin from the leaves of Premna odorata. On brine shrimp lethality assay, the LC50 of the crude ethanolic extract was 564 µg/ml while a decoction was 685 µg/ml. Among the partitioned fractions, the hexane-soluble fraction (HSF) had the highest bioactivity at 81.2% lethality. The diosmetin from the dichlormethane fraction (DMF) showed 76.9% lethality, which suggested no observable synergistic effects on diosmetin's bioactivity by other principles present in the crude ethanolic extract. Results justify the isolation and use of pure diosmetin as medicinal. (18)
• Antinociceptive / Anti-Inflammatory / Leaves: Study investigated the antinociceptive and anti-inflammatory activities of Premna odorata crude leaf extract in in-vivo and in-vitro methods. No toxicity was seen at dose of 2000 mg/kbw. In-vivo testing showed antinociceptive and anti-inflammatory activities. At 1000 mg/kbw, there was significant inhibition of hind paw edema with suppression of early phase of inflammation. The crude leaf extract showed significant inhibition of 5-lipoxygenase (41.38%) and selective inhibition of cycloxygenase-2 (54.51%) enzymes, suppressing the release of inflammatory mediators. (19)
• Antimutagenic / Leaves: Study investigated selected Philippine plants for their ability to inhibit chromosomal damage induced by tetracycline in an in-vivo micronucleus test (MT). Study established the antimutagenic activity of C. ovatum, C. religiosa, P. campechiana and Premna odorata.     (20)
• Anti-Inflammatory / Composition / Lipoidal Extract: Study evaluated a lipoidal extract for chemical constituents and anti-inflammatory activity. The n-hexane extract showed anti-inflammatory activity which interferes with COX-II and IL-6 roles during progression of inflammatory disease. (see constituents above) (21)
• Acylated Iridoids and Rhamnopyranoses / Transcription Factor Receptor Inhibitor for Control of Breast Cancer: Study yielded three new acylated iridoid glycosides (1-3) and two new acylated rhamnopyranoses (9 and 10) along with ten known compounds. Results showed the acylated rhamno-pyranoses are potential novel c-Met inhibitors to control c-Met-dependent breast malignancies. (23)
• Antitubercular (Anti-TB Activity) / Volatile Oil: Study evaluated the volatile oil isolated from different plant organs (leaves, young stems, and flowers) for anti-tuberculosis activity. Results showed the VO exhibited anti-TB activity would could be related to the presence of cyclic terpenes (major) and acyclic oxygenated terpenes (minor) compounds. (see constituents above) (24)
• Antimicrobial and Antioxidant / Natural Preservative in Ointment Formulation: Preservatives are substances added to food and pharmaceutical to extend shelf-life. Synthetic preservatives have been reported to cause adverse effects. Study evaluated the preservative efficacy of five plants ie., Psidium guajava, Premna odorata, Mimosa pudica, Allium sativum and Zingiber officinale. Ethanolic extract of all the studied plants yielded sapogenins and glycosides. AAS analysis showed the extracts are safe. Among the five plants, P. guajava and P. odorata exhibited highest antioxidant activity in DPPH assay at 0.25-0.50 mg/ml and 1-5 mg/mL, respectively. P. guajava showed highest preservative capability. (26)
• Antifungal: Fungal organisms are opportunistic pathogens commonly found in the oral cavity and vagina. Study evaluated the antifungal activity of P. odorata extracts against two clinical fungal isolates. ChMa extracts demonstrated significant antifungal activity against Candida albicans, Monilinia spp., higher than a water extract. DES2 reported the highest phenolic contents (3.58 mg GAE/100 g DW) and total flavonoid content (0.028 mg RE/100g DW). Results suggest a friendly green alternative with low toxicity with potential application in antifungal therapy. (29)
• Anti-Ageing Potential / Leaf Essential Oil: Study showed that different compounds in essential oil of P. odorata leaves exhibited binding to active sites with variable degrees suggest anti-ageing potential. Palmitic acid displayed the highest fitting for both collagenase and elastase active centers in both pH-based and rule-based ionization methods. In vitro assays showed considerable anti-elastase and anti-hyaluronidase potential as evidenced by IC50s of 49.3 and 37.7 µg/mL, respectively. The EO displayed mild anti-collagenase potential. Results suggest anti-ageing potential for a naturally occurring deg that can be incorporated in anti-ageing and anti-skin wrinkling cosmetics.  (30
• Neuroprotective / Aluminum Toxicity: Study the neuroprotective effect of P. odorata extracts in rats with aluminum-induced toxicity. Aluminum toxicity resulted in decline of GSH, elevation of MDA and AChE activity. Except for decreased GABA, there was marked increased in amino acid and monoamine neurotransmitters, and increase in mRNA expressions of TNF-α and COX-2. Results showed the P. odorata extract reduced oxidative stress and counteracted the augmentations in AChE, along with marked improvements in most measured neurotransmitters with downregulation of pro-inflammatory gene expression, and restoration of altered histopathology induced by AlCl3. (31)
• Hepato-Nephroprotective / Aluminum Toxicity: Study evaluated the effect of P. odorata on hepatic and nephrotoxicity induced by aluminum chloride (AlCl3) in Wistar rats. AlCl3 significantly increased the activities of liver enzymes and increased total cholesterol, triglyceride, urea, and creatinine concentrations, and significantly reduced glutathione content and increased catalase activity, malondialdehyde, and TNF-α in the liver and kidney tissues. Co-treatment of extract with AlCl3 alleviated its harmful effects on biochemical parameters and reduced histopathological alterations induced by AlCl3. Study suggests the potent protective effect against oxidative stress induced by Al toxicity may be via downregulation of MMP9 and TGF-ß gene expression. (32)
• Immunomodulatory in Mycobacterium tuberculosis / Volatile Oils from Leaves, Flowers, and Stems: Study evaluated the in vivo anti-TB efficacy of volatile oils of P. odorata from different parts of P. odorata in mice. TB-infected mice showed significant increase in serum levels of TNF-α, IFN-γ, IL-1ß and mRNA expression levels of TLR-4 & NF-kB and decrease in IL-10 and total antioxidant capacity. Treatment with VOs from leaves, flowers, young stems, and combination of the three oils reversed these effects. Study suggests the immunomodulatory effects of VOs against TB infection involve the TLR-4/NF-kkB signaling pathway and antioxidant effects. (33)
• Hepatoprotective / Anti-Inflammatory / Antioxidant / Leaves: Study evaluated crude extract of leaves for scavenger activity on HepG2 human liver cancer cell line and hepatoprotective effect in alcohol-inflamed liver in female Wistar albino rats. Treatment with defatted crude and n-hexane extract of leaves significantly improved liver damage evidenced by reduction of elevated biochemical parameters. Reduced levels of GSH and TAC were normalized and histological collagen fiber distribution returned to its normal pattern. The anti-inflammatory and antioxidant effects may be partly due to combined effects of phytochemicals and synergistic interactions. (34)
• Silver Nanoparticles / Leaves: Study reports on the eco-friendly and cost-effective biosynthesis of silver nanoparticles using the Alagaw plant as reducing agent. (35)
• Antidiabetic / Aerial Parts: Study evaluated in vitro α-amylase, α-glucosidase, and glucose diffusion inhibition activities of aerial parts of P. odorata. DCM bark  and fruit/flower extracts showed significant
-amylase and α-glucosidase inhibitory activities. The bark extract and flower/fruit extracts also promoted increase (89% and 97%) in glucose uptake in yeast cell and significant glucose diffusion inhibition (73% and 69%) across dialysis membrane, respectively. Results suggest antidiabetic effects and a potential source of novel compounds for treatment of diabetes. (36)
• Triple-Negative Breast Cancer Suppressive Activity / Antioxidant / Stems: Study of young stems yielded four new acylated rhamnopyranoses 1-4, along with 14 known compounds 5-19. Isolated compounds were evaluated for cell proliferation and migration inhibition activities against invasive human triple-negative breast cancer cells MDA-MB-231 and MCF-7. and normal cell line MCF-10A. Compound 1 was the most active as antiproliferative agent, showing high to moderate antiproliferative effect with IC50s of 4.95 and 17.7 µM against MCF-7 and MDA-MB-231, respectively. Compounds 1-10 suppressed MDA-MB-231 cell migration in the wound healing assay at 10 µM concentration. Compounds 1-5 exhibited highest DPPH radical scavenging activities with IC50s range of 17.5-200.43 µg/mL. Acylated rhamnopyranoses can be considered good scaffolds for developing new anti-breast cancer and antioxidant compounds. (37)
• Antimicrobial / Icetexane Diterpenoids / Roots: Study of ethyl acetate extract of roots isolated two icetexane diterpenoids, PPA-1 and PPA-2. PPA-1 showed medium activity against Bacillus pumilus and weak activities against B. subtilis, Staphylococcus aureus, Candida albicans, and E. coli. PPA-2 showed medium activities against B. pumilus, C. albicans and weak activity against E. coli. (38)


Updated March 2023 / July 2019 / November 2016

Photos © Godofredo Stuart / StuartXchange

Additional Sources and Suggested Readings
A Collagen Network Formation Effector from Leaves of Premna subscandens / September 1999 / Hirokazu SUDO, Kaori KIJIMA et al / Chem. Pharm. Bull. 47(9) 1341—1343 (1999)

Antiviral and Cytotoxic Activities of Som.e Plants Used in Malaysian Indigenous Medicine / Ali, Abdul Manaf and Mackeen et al / Pertanika J. Trop. Agric. Sci., 19 (2/3). pp. 129-136.
Systematic analysis of in vitro photo-cytotoxic activity in extracts from terrestrial plants in Peninsula Malaysia for photodynamic therapy / Cheng Yi Ong et al / Journal of Photochemistry and Photobiology B: Biology • Volume 96, Issue 3, 4 September 2009, Pages 216-222 / doi:10.1016/j.jphotobiol.2009.06.009
Evaluation of Hepatoprotective and In-vitro Cytotoxic Activity of Leaves of Premna serratifolia Linn / R Vadivu et al / J. Sci. Res. 1 (1), 145-152 (2009)
Antiparasitic activity of some New Caledonian medicinal plants / Julie Desrivot et al / Journal of Ethnopharmacology • Volume 112, Issue 1, 30 May 2007, Pages 7-12 / doi:10.1016/j.jep.2007.01.02
Two iridoid glycoside caffeoyl esters from Premna odorata / Hideaki Otsuka, Naoko Kubo, Kazuo Yamasaki, William G. Padolina / Phytochemistry, 1989; Volume 28, Issue 2: pp 513–515
Inhibitory Effect of Alagaw (Premna Odorata) Bark Aqueous and Ethanol Extracts Against Escherichia coli In - Vitro / FAITH L. MALECDAN DAN JOHNSON E. MALIONES HESTER ORVEN K. MAYAPIT AISAREL JOY A. MENDOZA GEORGE D. MARRERO /
Isolation and characterization of antimicrobial, anti-inflammatory and chemopreventive flavones from Premna odorata Blanco / Lunesa C. Pinzon, Mylene M. Uy, Kung Hong Sze, Mingfu Wang and Ivan Keung Chu / Journal of Medicinal Plants Research, 4 July 2011; 5(13): pp. 2729-2735 / ISSN: 1996-0875
10-O-acylated iridoid glucosides from leaves of Premna subscandens / Hirokazu Sudo, Toshinori Ide et al / Phytochemistry, Volume 46, Issue 7, December 1997, Pages 1231–1236
Premnaodorosides A, B and C, iridoid glucoside diesters of an acyclic monoterpenediol from leaves of Premna odorata / Hideaki Otsuka, Naozumi Kashima, Tomoki Hayashi, Naoko Kubo, Kazuo Yamasaki, William G. Padolina / Phytochemistry, 1992; Volume 31, Issue 9: pp 3129–3133
Ethno-Veterinary Practices for Control of Ectoparasites / Jan 07, 2014 / Copyright © SAPPLPP 2013
Biosynthesis of silver nanoparticles from Premna serratifolia L.leaf and its anticancer activity in CCl4 -induced hepato-cancerousSwiss albino mice / JJ. Arockia John Paul•, B. Karunai Selvi•, N. Karmegam / Appl Nanosci / DOI 10.1007/s13204-014-0397-z
Premna odorata / KEW: Plants of the World Online
Antitubercular constituents from Premna odorata Blanco. / Lirio SB, Macabeo AP, Paragas EM, Knorn M, Kohls P, Franzblau SG, Wang Y, Aguinaldo MA / J Ethnopharmacol., 11 June 2014;154(2): pp 471-474 / DOI: 10.1016/j.jep.2014.04.015
Cytotoxic activity of crude extracts and fractions from Premna odorata (Blanco), Artocarpus camansi (Blanco) and Gliricidia sepium (Jacq.) against selected human cancer cell lines / Ourlad Alzeus G. Tantengco, Sonia D. Jacinto / Asian Pacific Journal of Tropical Biomedicine, December 2015; Volume 5, Issue 12: pp 1037–1041 / https://doi.org/10.1016/j.apjtb.2015.09.011
ANTIBACTERIAL ACTIVITY OF Premna odorata Blanco (ALAGAW) LEAF EXTRACT ON Bacillus subtilis, Escherichia coli, AND Staphylococcus aureus / ANGELITA B. PANGILINAN / Philippine Science High School Central Luzon Campus / MARCH 2013
A Phytochemistry of the Genus Premna: A Review / K. Rekha, Pandey Richa, K. Suresh Babu and J. Madhusudana Rao* / INTERNATIONAL JOURNAL OF PHARMACEUTICAL AND CHEMICAL SCIENCES, Vol 4 (3) Jul-Sep 2015
Bioactivity studies on the extracts and the phlebotonic diosmetin isolated from Premna odorata Blanco (Lamiaceae) / Lunesa Pinzon, Mylene Uy / Bulletin of Environment, Pharmacology and Life Sciences, February 2016; 5(3): pp 01-04 / eISSN: 2277-1808
The antinociceptive and anti-inflammatory activities of the methanolic extract of the leaves of Premna odorata blanco (Verbenaceae) / Irene Jane M. Montoya / Thesis, March 2012 / Philippine Council for Health Research and Development Library / Herdin Record #: PCHRD13020609414737
Antimutagenic potential and phytochemical analysis of selected Philippine plants / Christine L Chichioco-Hernandez, Noemi D Paguigan / Pharmacognosy Magazine, 2009; Volume 5, Issue 20: pp 388-393
ANTI-PARASITIC ACTIVITY OF THREE INVASIVE VERBENA SPECIES (Premna odorata B., Lantana camara L. and Duranta erecta L.) AGAINST Lumbricus terrestris (EARTHWORMS) AND Ascaris lumbricoides (ROUNDWORMS) / MIKAILA DENISE H. LOANZON SHAYNE C. DE CASTRO MICAH ANGELA C. PELISMINO / Cavite National High School, Sept 2016
Acylated Iridoids and Rhamnopyranoses from Premna odorata (Lamiaceae) as Novel Mesenchymal– Epithelial Transition Factor Receptor Inhibitors for the Control of Breast Cancer / Abeer H Elmaidomy, Mohamed M Mohyeldin, Mostafa M Ibrahim, Hossam M Hassan, Elham Amin, Mostafa E Rateb, Mona H Hetta, Khalid A El-Sayed / Phytotherapy Research, 2017; 31(10) / https://doi.org/10.1002/ptr.5882
Premna odorata Volatile Oil as a New Mycobacterium tuberculosis Growth Inhibitor for the Control of Tuberculosis Disease / Abeer H. Elmaidomy, Hossam M. Hassan, Elham Amin, Waleed Mohamed
and Mona H. Hetta / European Journal of Medicinal Plants, 2017; 21(4): pp 1-11 / Article no.EJMP.38375
Ethnobotanical Survey of Medicinal Plants used by Ayta Communities in Dinalupihan, Bataan, Philippines / Ourlad Alzeus G. Tantengco, Marlon Lian C. Condes, Hanna Hasmini T. Estadilla, Elena M. Ragragio / Pharmacogn J., 2018; 10(5): pp 859-870 / DOI: 10.5530/pj.2018.5.145
COMPARATIVE ANALYSIS OF THE ANTIMICROBIAL AND ANTIOXIDANT PROPERTIES OF SELECTED PLANT EXTRACTS AS NATURAL PRESERVATIVES IN OINTMENT FORMULATION / Erna C. Arollado, Leslie P. Bucog, Richelle Ann M. Manalo / European Journal of Pharmaceutical and Medical Research, 2015; 2(4): pp 757-768
Ati Negrito medicinal plants and phytotherapies for female reproductive healthcare / Hindawi ecam journal
Ethnomedicinal Plants Utilized by the Ilongot-Eǵongot Community of Bayanihan, Maria Aurora, Aurora, Philippines / Balberona, A. N., Noveno, J. J., Angeles, M. G. B., Santos R. I., Cachin, E. J. D. J. and Cruz, K. G. J. / International Journal of Agricultural Technology, 2018; 14(2): pp 145-159 / eISSN: 2630-0192
Evaluation of anti-fungal activity derivative from Premna odorata Blanco extract by deep eutectic solvents
/ Ahmad Kamis Abdullah, Ali Sami Dheyab, Raed Obaid Saleh / Plant Science Today, 2021; 8(4) /
DOI: 10.14719/pst.2021.8.4.1381
Premna odorata: Seasonal Metabolic Variation in the Essential Oil Composition of Its Leaf and Verification of Its Anti-Ageing Potential via In Vitro Assays and Molecular Modelling / Ahmed E Altyar, Mohamed L Ashour, Fadia S Youssef / Biomolecules, 10(6) / DOI: 10.3390/biom10060879
Premna odorata extract as a protective agent on neurotoxic effect of aluminum: neurochemical, molecular, and histopathological alterations / Walaa M S Ahmed, Nermeen A Helmy, Marwa A Ibrahim, Hossam M Hassan, Amr R Zaki / Environmental Science and Pollution Research, 2021; 28: pp 2146-2157 /
DOI: 10.1007/s11356-020-10659-6
Amelioration of aluminum-induced hepatic and nephrotoxicity by Premna odorata extract is mediated by lowering MMP9 and TGF-β gene alterations in Wistar rat / Walaa M S Ahmed, Marwa A Ibrahim, Nermeen A Helmy, Akram M Elkashlan, Abeer H Elmaidomy, Amr R Zakii /  Environmental Science and Pollution Research, 2022; 29: pp 72827-72838 / DOI: 10.1007/s11356-020-20735-8
Immunomodulatory effect of Premna odorata volatile oils in Mycobacterium tuberculosis by inhibiting TLR4/NF-κB pathway / Waleed A Mohammad, Samah S Abbas, Mona F Schaalan et al /  JHP: Journal of Herbmed Pharmacology, 2019; 8: pp 1-7 / DOI: 10.1517/jhp.2019.01 / eISSN: 2345-5004
Anti-Inflammatory and Antioxidant Activities of Terpene- and Polyphenol-Rich Premna odorata Leaves on Alcohol-Inflamed Female Wistar Albino Rat Liver / Abeer H Elmaidomy, Hani A Alhadrami, Elham Amin, Hanan F Aly et al / Molecules, 25(14) / DOI: 10.3390/molecules25143116
Green Synthesis of Silver Nanoparticles Using Alagaw (Premna odorata) Leaf Extract / Peter Jay Corros, Jeremie Germina, Kimberlyn Ferrer /  Science Open Preprints
In vitro antidiabetic activity of Premna odorata Blanco (Fam. Lamiaceae) / Deanne Marizthel J Madrio, Paola Georgia P Awatin, Aaron Dell A Cobeng, Oliver Shane R Dumaoa, Omar A Villalobos / Asia Pacific Journal of Allied Health Sciences, 2020; 3(1): pp 7-14 / ISSN: 2704-3568
Triple-negative breast cancer suppressive activities, antioxidants and pharmacophore model of new acylated rhamnopyranoses from Premna odorata / Abeer H Elmaidomy, Rabab Mhammed,  Hossam M Hassan et al / RSC Adv., 2020; 10: oo 10584-10598 / DOI: 10.1039/D0RA01697G
ICETEXANE DITERPENOIDS ISOLATED FROM THE ROOTS OF PREMNA ODORATA BLANCO / Pa Pa Aung, Hnin Yu Win, Myint Myint Sein / 2nd Myanmar Korea Conference Research Journal
Premna odorata / Wikipedia

DOI: It is not uncommon for links on studies/sources to change. Copying and pasting the information on the search window or using the DOI (if available) will often redirect to the new link page. (Citing and Using a (DOI) Digital Object Identifier)

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