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Family Annonaceae
Amuyon
Goniothalamus amuyon (Blanco) Merr.
TAIWAN GONIOTHALAMUS

Tai wan ge na xiang

Scientific names Common names
Goniothalamus amuyon (Blanco) Merr. Amuyon (C. Bis.)
Goniothalamus amuyon var. ramosii Ban Amuyong (Tag.)
Polyalthia sasakii Yamam. Bantana (Buk.)
Uvaria amuyon Blanco Sagiat (Ilk.)
  Taiwan goniothalamus (Engl.)
Goniothalamus amuyon (Blanco) Merr. is an accepted name The Plant List

Other vernacular names
CHINESE: Tai wan ge na xiang.
SPANISH: Grano del paraiso.

Botany
Amuyon is a small tree. Leaves are smooth, oblong, 15 to 25 centimeters long and about 5 centimeters wide, and pointed at both ends. Flowers are yellowish green, borne on the sides or at the axils of the leaves, nodding, upon 1-centimeter-long pedicels. Sepals are smooth and pointed. Outer petals are lanceolate, 3 to 5 centimeters long; the inner one are scarcely half as long. Fruit is smooth, cylindrically elongated or sausage-like, about 3 centimeters long, containing one to three seeds.

Distribution
- Found in forests at low and medium altitudes in Abra, Ilocos Norte, Ilocos Sur, Pangasinan, Batangas, Rizal, and Quezon Provinces in Luzon; in Negros, Bohol and Mindanao.
- Also reported in Taiwan.

Constituents
- Phytochemical screening yielded five isoquinoline alkaloids.
- Study of stems yielded two new compounds, goniothalesacetate (1) and goniothalesdiol A (2) together with goniodiol-7-monoacetate, goniodiol-8-monoacetate, leiocarpin C, liriodenine, griffithazanone A, 4-methyl-2,9,10-(2H)-1-azaanthracencetrione, velutinam and aristolactam BII. (3)

Properties
- Stomachic, antitumor, anti-scabies.

Parts used
Seeds, fruit.

Uses

Folkloric
- Seeds, cooked with oil, used as liniment for rheumatic complaints.
- Decoction of seeds used for tympanites.
- Fruit used as stomachic.
- In Taiwan, extracts of seeds used for treatment of edema and rheumatism. Seeds also used for treatment of scabies.
Others
Rope: Bark of the plant yields an apricot-buff colored bast fiber which is used for making rope.


Studies
Cytotoxicity / Anti-tumor:
Study isolated styrylpyrone, goniodiol-7-monoacetate, which showed potent cytotoxicities against KB, P-388, RPMI and TE671 tumor cells. (1)
Cytotoxic Styrylpyrones: Study of leaves and stems yielded two new styrylpyrones, (6R,7R,8R)-8-methoxygoniodiol and (6R,7R,8R)-8-chlorogoniodiol, together with seven known styrylpyrones and eight other known compounds. Compound 2 showed significant selective cytotoxicity toward the HONE-1 cancer cell line. (2)
Three New Styryllactones / Cytotoxicity: Study of aerial parts yielded three new styrylpyrone analogues, digoniodiol (2), deoxygoniopypyrone A (3), and goniofupyrone A (4), along with ten known styryllactones. Goniothalamin, goniothalamin epoxide, and 8-chlorogoniodiol showed significant cytotoxicity against the HepG2 cancer cell line and moderate toxicity toward Hep3B, MDA-MB-231, and MCF-7 cancer cell lines. (8)
Goniothalamin: Goniothalamin (GTN) is a natural compound that has shown to be cytotoxic to a variety of tumor cell lines including breast, blood, ovary, lung, kidney, prostate, hepatoblast and colon. (1) Study isolated goniothalamin (GTN) from G. amuyon. Results showed goniothalamin induced apoptosis in HCC (hepatocellular carcinoma) derived cells through distinct signaling pathways. (4)
Anti-Lung Cancer:
Study investigated the anticancer activities of GTN against human lung cancer using non-small cell lung cancer cell line. GTN exhibited significant inhibition of cellular proliferation. The DNA-damaging effect of GTN against lung cancer cells leads to growth inhibition and depression in migration ability. Results suggest GTN has potential as a chemotherapeutic agent against lung cancer.
Goniothalamin / Noxa-mediated Apoptosis / Anti-Hepatocellular Cancer: Study showed GTN triggered phorbol-12-myristate-13-acetate-induced protein 1 (PMAIP1, also known as NOXA)-mediated apoptosis via TP53-dependent and -independent pathways. GTN might represent a novel anticancer drug that induces apoptosis in HCC-derived cells through PMA1P1 transactivation. (9)

Availability
Wild-crafted.

Godofredo U. Stuart Jr., M.D.

Last Update May 2016

IMAGE SOURCE: Photograph / Goniothalamus amuyon (Blanco) Merr. / © subject.forest.gov.tw/species/twtrees/book1/67.htm
OTHER IMAGE SOURCE: / Photo / Annonaceae : Goniothalamus amuyon det. Michael Calaramo 13-Jul-15 /Twig / Copyright © 2015 by P.B. Pelser & J.F. Barcelona (contact: pieter.pelser@canterbury.ac.nz) [ref. DOL101065] / Non-Commercial Use / click on image to go to source page / Phytoimages.siu.edu
IMAGE SOURCE: 1. Goniothalamus amuyon (Blanco) Merr. In Philip. J. Sci. Bot. 10: 264. 1915; Li in Fl. Taiwan 2: 395. pl. 348. 1976. Pl. 194, Photo 159 / click on image to go to source page / Flora of Taiwan

Additional Sources and Suggested Readings
(1)
The Crystal Structure and Cytotoxicity of Gonodiol-7-Monoacetate from Goniothalamus amuyon / Yang-Chang Wu, Chang-Yih Duh et al / Journal of Natural Products, Vol 54, No 4, Pp 1077-1081, Jul-Aug 1991
(2)
Cytotoxic Styrylpyrones from Goniothalamus amuyon
/ Yu-Hsuan Lan, Fang-Rong Chang et al / J. Nat. Prod., 2003, 66 (4), pp 487–490 / DOI: 10.1021/np020441r
(3)
New Constituents from Stems of Goniothalamus amuyon / Yu-Hsuan Lan, Fang-Rong Chang et al / CHEMICAL & PHARMACEUTICAL BULLETIN / Vol. 54 (2006) , No. 7 1040
(4)
Goniothalamin induces TP53-dependent and -independent apoptosis in hepatocellular carcinoma derived cells / Cheng-Hui Tsai / Thesis, 2007
(5)
Goniothalamus Species: A Source of Drugs for the Treatment of Cancers and Bacterial Infections?
/ Review / Christophe Wiart /
(6)
Goniothalamin Inhibits Growth of Human Lung Cancer Cells through DNA Damage, Apoptosis, and Reduced Migration Ability / Chien-Chih Chiu, Po-Len Liu, Kuang-Jing Huang et al / J. Agric. Food Chem., 2011, 59 (8), pp 4288–4293 / DOI: 10.1021/jf200566a
(7)
Sorting Goniothalamus names / MULTILINGUAL MULTISCRIPT PLANT NAME DATABASE
(8)
Digoniodiol, deoxygoniopypyrone A, and goniofupyrone A: three new styryllactones from Goniothalamus amuyon / Yu-Hsuan Lan, Fang-Rong Chang, Chih-Chuang Liaw, Chin-Chung Wu, Michael-Y Chiang, Yang-Chang Wu / Planta Med. 2005 Feb ;71 (2):153-9 15729624 Cit:4
(9)
Involvement of phorbol-12-myristate-13-acetate-induced protein 1 in goniothalamin-induced TP53-dependent and -independent apoptosis in hepatocellular carcinoma-derived cells
/ Kung-Kai Kuo, Yi-Ling Chen, Lih-Ren Chen, Chien-Feng Li, Yu-Hsuan Lan, Fang-Rong Chang, Yang-Chang Wu, Yow-Ling Shiue / Toxicology and Applied Pharmacology 256 (2011) 8–23
(10)
Goniothalamus amuyon (Blanco) Merr. (accepted name) / Chinese name / Catalogue of Life, China
(11)
Goniothalamus amuyon / Synonyms / The Plant List

It is not uncommon for links on studies/sources to change. Copying and pasting the information on the search window or using the DOI (if available) will often redirect to the new link page.

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