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Family Malvaceae
Babara
Malvastrum coromandelianum (L.) Garcke

FALSE MALLOW
Sai kui

Scientific names  Common names
Malva coromandeliana Linn. Babara (Ilk.) 
Malva coromandelica Panz. Gagabuten (Ilk.) 
Malva domingensis Spreng. ex DC. Kinaylumpang (Tag.) 
Malva havanensis Sessé & Moc. Salsaluyut (Ilk.)
Malva lindheimeriana Scheele Sinaguri-babai (Sul.)
Malva subhastata Cav. Takkimbaka (Ilk.)
Malvastrum coromandelianum (Linn.) Garcke Tachin-kabayo (Iv.)
Malvastrum lindheimerianum (Scheele) Walp. Broom weed (Engl.)
Malvastrum ruderale Hance ex Walp. Clock plant (Engl.)
Malvastrum tricuspidatum A. Gray. Common false mallow (Engl.)
Malveopsis coromandeliana (L.) Morong False mallow (Engl.)
Sida fauriei H. Lév Prickly malvastrum (Engl.)
Sida oahuensis H. Lév Spiked malvastrum (Engl.)
Malvastrum coromandelianum (L.) Garcke is an accepted name. The Plant List

Other vernacular names
CHINESE: Sai kui, Huang huo jin, Huang huo cao.
HINDI: Kharenti.
KANNADA: Sannabindige.
MARATHI: Chandiri.
PAKISTAN: Dhamnii bhooti.
THAI: Dai kat.

Botany
Babara is an erect, somewhat hairy, branched, half-woody perennial, about 1 meter high. Leaves are oblong to ovate-lanceolate, 2 to 5 centimeters long, with blunt tip, rounded base and irregularly toothed margins. Flowers are axillary and terminal. Calyx is green, about 7 millimeters long, with lanceolate and pointed lobes. Petals are yellow, about 8 millimeters long. Fruit has 8 to 12 reniform, compressed, hirsute carpels, 2 to 3 millimeters long, each carpel having 3 short, straight projections.

Distribution
- A common weed in and about towns throughout the Philippines.
- Probably of American origin.
- Now pantropic.

Constituents
- Studies on whole plant have yielded bioactive compounds such as stigmasterol, lutein, phenylethylamine, indole alkaloids, fatty acids (palmitic, oleic, linoleic, and sterulic), etc.
- Seed oil of MC contained palmitic acid (22.7%), palmitoleic acid (2.4%), stearic acid (2.7%), oleic acid (14.6%), linoleic acid (37%), malvalic acid (10.5%) and sterculic acid (10.1%).

- Phytochemical screening of leaves yielded alkaloids, tannins, amino acid proteins, and carbohydrates, with appreciable amounts of phenolic and flavonoid contents. Petroleum ether extract yielded ß-sitosterol. (16)
- Study of leaves showed appreciable amounts of phenolic and flavonoid content, while HPTLC analysis showed the presence of ß-sitosterol in petroleum ether extract. (24)
- Study of aerial parts for essential oil yielded 50 compounds representing 98.5% of the oil. Major constituents were palmitic acid (19.2%), hexahydrofarnesyl acetone (5.2%), linoleic acid (4.8%), ß-caryophyllene (3.5%), and cedren-8-en-15-ol (3.1%). (see study below) (25)

Properties
- Studies have shown anti-inflammatory, antipyretic, analgesic, antibacterial, hypoglycemic, hypolipidemic, antiulcer, antimycobacterial antioxidant, wound healing, immunomodulatory, antifungal, antidiarrheal, anthelmintic properties.

Parts utilized
Leaves.

Uses
Folkloric
- Leaves used for carbuncles.
- In Mexico, decoction of leaves used to clean wounds; also used for dysentery.
- In Tanzania, used for wounds and sores; also used as diaphoretic.
- In the West Indies, plant is considered resolvent and emollient.
- In India, flowers used in cough and lung diseases. Leaves used for jaundice.
- Irulas of Tamil Nadu use the leaves and roots together with leaves of Sida acuta, ground into a paste and applied externally to blisters. (22)
- In Thailand, used for diabetes.
- In Pakistan, decoction of dried rhizomes are used as tonic and for relief of muscular pain. Powdered rhizome used to for fever and diarrhea. (12)
- In Jamaica, used for stomach pains. (17)
- In Western Ghats, Tamil Nadu, India, decoction of flowers and leaves used for dysentery and sores and as antidote. (32)
Others
- Crafts: Plant is used in making brooms.

Studies
Antinociceptive / Aerial Parts: Aerial parts of Malvastrum coramandelianum showed antinociceptive activity in acid-induced writhing test in mice. Effects are comparable with acetylsalicylic acid. (1) Study evaluated the antinociceptive property of hydroalcoholic extract of M. coromandelianum by tail-flick, hot-plate, and acetic acid induced writhing method in a rat model. The HEMC showed central analgesic action probably via inhibition of central pain receptors and peripheral analgesic effect probably mediated by prostaglandin inhibition. (20)
Anti-Inflammatory / Analgesic: Study showed M coromandelianum water extract inhibited hind-paw edema induced by carrageenan and exhibited analgesic activity in the formalin test. (2)
Anti-Staphylococcal / Aerial Parts: Study evaluated crude water extract of MC aerial parts for anti-Staphylococcus aureus activity against S. aureus ATCC 25923, SA ATCC29213 and clinical ioslat3s of MSSA and MRSA. Results suggest potential benefits as alternative remedy for Methicillin resistant Staphylococcus aureus. Although it did not show bactericidal activity to all tested strains of MSRA, the crude water extract showed inhibitory effect at considerable low concentration against most of the tested MSRA. (3)
Antioxidant / Leaves: Various extracts of the leaf of three plants, M. coromandelianum, T. purpurea, and Clitorea ternatea, were tested for antioxidant potential. Screening suggested flavonoids. Leaves of all three plants exhibited antioxidant properties and can serve as free radical inhibitors or scavengers. M. coromandelianum was not as potent as the other two plants. (5)
Antidiabetic / Antihyperlipidemic / Leaves: Study evaluated aqueous extracts of leaves of Malvastrum coromandelianum on alloxan-induced diabetic rats. Results showed antidiabetic activity with significant reduction in fasting blood glucose levels and antihyperlipidemic activity with normalization of lipid profile. (7)
Chronic Toxicity Study: A chronic toxicity study of a water extract in Wistar rats at doses of 0.2 to 20 g/kbw per day for 60 days did not produce toxicity in the test animals. (8)
Wound Healing / Ointment Formulation : Study evaluated the effects of topical administration of an ethanolic extract of Malvastrum tricuspidatum ointment on two types of wound models in wistar rats. Results showed wound healing properties with faster epithelization and higher wound contraction in the incision model, and increase tensile strength in the incision model. (9)
Antibacterial / Antifungal / Irritant: Study evaluated various extracts of Malva parviflora and Malvastrum coromandelianum for antibacterial, antifungal, and irritant activities. Results showed similar patterns of antibacterial activities against E. coli, and slight variations against Proteus vulgaris, Bacillus subtils, and Staphylococcus aureus, and the same activities against Aspergillus niger and A. oryzae. Application of hexane, chloroform and aqueous extracts on the inner surface of ear of male albino rabbits caused an irritant response. (10)
Immunomodulatory: Study evaluated an ethanolic extract of whole plant in experimental models of immunity in Swiss albino mice. Results showed the extract to possess potential for augmenting immune activity by cellular and humoral mediated mechanisms.
(11)
Hypoglycemic: Study evaluated extracts and fractions of dried powder of M. coromandelianum for hypoglycemic activity in normal and alloxan-induced diabetic rats. At doses of 4 g/kbw, an MC-1 extract showed significant hypoglycemic activity in alloxan-induced diabetic rats. Other fractions failed to show hypoglycemic activity. (13)
Antipyretic / Analgesic / Anti-Inflammatory: Study of an aqueous extract of whole plant and root of M. coromandelianum showed lowering of rabbit fever in fever induced by typhoid-paratyphoid vaccine, decreased mice writhing, inhibition of ear edema and decrease in permeability of blood capillary in abdominal cavity of mice. Results suggest antipyretic, analgesic, and anti-inflammatory effects. (14)
Study of Glucose-Lowering Effect / No Efficacy / Clinical Trial: A double blind, randomized controlled trial evaluated the glucose-lowering efficacy of a water extract of M. coromandelianum in type 2 Diabetes patients. In this study, MC in dosage of 1,200 mg/day dose showed no glucose lowering efficacy in type 2 diabetes. (18)
Antidiarrheal / Leaves: Study evaluated the in vivo antidiarrheal effect of ethanolic extract of leaves of M. tricuspidatum in rats, evaluated by castor oil, magnesium sulfate and charcoal. Results showed significant (p<0.05) activity against castor oil-induced diarrhea. It also inhibited magnesium sulfate induced enteropooling and significant reduction in gastrointestinal motility in charcoal meal test. (19)
• Anthelmintic / Leaves: Study evaluated a methanolic leaf extract for anthelmintic activity against Indian earthworm Pheretima posthuma and compared with standard drug Albendazole. Results showed significant anthelmintic effect with higher activity at higher concentrations. (21)
• Antibacterial / Cytotoxicity / Antioxidant / Essential Oil of Aerial Parts: Study evaluated the chemical composition, antibacterial, cytotoxic, and antioxidant activities of essential oil from aerial parts. GC/FID and GC/MS analysis identified 50 compounds, representing 98.5% of the oil. The essential oil exhibited significant antibacterial activity against S. aureus, B. subtilis, and E. coli with MICs of 0.156 mg/mL, 0.156 mg/mL, and 0.078 mg/mL, respectively. MTT assay showed moderate cytotoxic effect against HepG2 and MCF-7 cell lines with IC50s of 116.40 µg/mL and 120.27 µg/mL. The EO showed weak antioxidant effects by DPPH, ABTS, and FRAP assays. (see constituents above) (25)
• Arabinoxylan / Antioxidant / Leaves: Study isolated an alkali-soluble polysaccharide (MAP) from the leaves of M. coromandelianum. The MAP was found to be an arabinoxylan which also exhibited ferric ion reducing activity, with a reducing power of 0.914 ± 0.01 at 1 mg/mL concentration which showed dose dependent behavior. Results suggest the MAP may be utilized as a potential antioxidant. (26)
• Quercetrin and Trans-Tiliroside / Antioxidant: Study of methanol extract isolated two compounds characterized as tiliroside and quercetrin. The invitro IC50 values against DPPH for tiliroside, quercetrin, and extract were 60.40 ± 0.24, 68.05 — 0.36, and 71.98 ± 0.29 µg/mL, respectively.. Results suggest significant antioxidant activity. (27)
• Antimycobacterial / Anti-Inflammatory: Study of crude leaf extracts isolated bioactive secondary metabolites. The ethyl acetate fraction showed the highest anti-mycobacterial and anti-inflammatory activities. Fractionation yielded apigenin-7-O-β-6″(p-coumaroyl)-glucopyranoside (1) and apigenin-8-C-glucopyranoside, vitexin (2). Both compounds showed interesting antimycobacterial activity against at least one Mycobacterium strain with MIC range of 0.03-0.25 mg/ml. Compounds showed anti-inflammatory activity with IC50s of 6.67 and 8.02 µg/ml, respectively. Results suggest possible lead compounds for antimycobacterial and anti-inflammatory products. (28)
• Antiulcer: Study investigated the antiulcer effect of various extracts of whole plant of Malvastrum tricuspidatum on ethanol-, aspirin-, cold-restraint stress-, and pylorus-ligation-induced gastric ulcer models in rats. The ethanol extract showed better ulcer protection in ethanol-induced ulcer model. The EE also showed concomittant attenuation of gastric secretory volume, free acidity, total acidity, and peptic activity in ulcerated rat. (29)
• Formulation of Film-Coated Tablets: Study reports on the preparation of film-coated tablets of high dose MCS by direct compression and pan coating techniques, with varying amounts of lactose cellulose, sodium starch glycolate, and fixed amounts of lubricants with 300 mg of MCS. The tablets had good appearance and met the requirement of compendia. (31)

Availability
- Cultivated.

- Dried whole plants in the cybermarket.


Updated January 2020 / August 2017 / May 2016

IMAGE SOURCE: PHOTO / Malvastrum coromandelianum subsp. coromandelianum / Flower and leaves at Kahana, Maui / Credit: Forest and Kim Starr - Plants of Hawaii - Image licensed under a Creative Commons Attribution 3.0 License, permitting sharing and adaptation with attribution / click on image to go to source page / Luirig alterVISTA
OTHER IMAGE SOURCE: ILLUSTRATION / File:Malvastrum coromandelianum Blanco2.251-original.png / Flora de Filipinas / 1880 - 1883 / Francisco Manuel Blanco (O.S.A) / Public Domain / Wikimedia Commons

Additional Sources and Suggested Readings
(1)
Antinociceptive activity of Malvastrum coromandelinum / Y S R Reddy et al / Fitoterapia
Volume 72, Issue 3, March 2001, Pages 278-280 / doi:10.1016/S0367-326X(00)00308-7
(2)
Anti-inflammatory and Analgesic Activities of Water Extract of Malvastrum coromandelianum (L.) Garcke / Parirat Khonsung et al / Thai J Pharmacol., 2006; Vol 28, No 3
(3)
Antibacterial Activity of Malvastrum coromandelianum Garcke Against Methicillin-Sensitive and Methicillin-Resistant Strains of Staphylococcus aureus / Chaiyasit Sittiwet et al / Current Res. Bacteriol., 1: 42-45. / DOI: 10.3923/crb.2008.42.45
(4)
A moderate source of cyclopropenoid fatty acids in Malvastrum coromandelianum seed oil and its possible medicinal importance / Hosamani K M et al / Journal of Medicinal and Aromatic Plant Sciences
(5)
Flavonoids - its antioxidant potential – A comparative study / C. Shreedhara, S. Dhirendra, S. Vijayakumar, K. Srinivasan
(6)
Malvastrum coromandelianum (L.) Gürcke (accepted name) / Chinese names / Catalogue of Life, China
(7)
Antidiabetic and Antihyperlipidemic Activities of Malvastrum coromandelianum Linn leaves in Alloxan induced Diabetic Rats / Amol Bhalchandra Deore, Preetam Nivrutti Chavan, Vinayak Dnyandev Sapakal, Nilofar S. Naikwade / Int.J.PharmTech Res., 2012,4(1): pp 351-357
(8)
Chronic Toxicity Study of Malvastrum coromandelianum (L.) Garcke / Aimmanas Attawish, Pranee Chavalittumrong, Anchalee Chuthaputti, Jaree Bansiddhi, Pranee Chuntapet, Somkial Panyamung / Bulletin of the Department of Medical Sciences, July-Sept 1998.; Vol 40, No 3
(9)
Investigation of wound healing activity of Malvastrum tricuspidatum syn Malvastrum coromandelianum on experimental animals / N. K. Gangrade*, R.V. Sheorey, H. Rawal and S. Chouhan / Int. J. of Pharm. & Life Sci. (IJPLS), December 2012; Vol. 3, Issue 12(Suppl.): pp 2259-2264
(10)
Antimicrobial and Irritant Activities of the Extracts of M. parviflora, Malvastrum coromandelianum and Amaranthus viridis - A Preliminary Investigation / Islam et al / Pak. J. Pharm, 20-23 (1 & 2) 3-6, 2007-2010
(11)
Immunopotentiating properties of ethanolic extract of Malvastrum tricuspidatum A. Gray whole plant / Neelam Balekar, Santosh Ghule, Pankaj Dixit, Dinesh Kumar Jain and Varun Tandan / Indian Journal of Natural Products and Resources, Vol 4(1), March 2013, pp 54-60.
(12)
FOLK RECIPES OF SOME MEDICINAL PLANTS USED BY THE INHABITANTS OF SOON VALLEY KHUSHAB (PAKISTAN) / ABDUL GHANI AND MADIHA BATOOL / International Journal of Current Pharmaceutical Research, Vol 4, Issue 1, 2012
(13)
Hypoglycemic activity of daikhad (Malvastrum coromandelianum (L.) Garcke) in rats / Sadudee Rattanajarasroj, Amporn Kun-Anake, Bunjong / Bulletin of The Department of Medical Sciences (Jul-Sep 2005)
(14)

Antipyretic, Analgesic and Anti-inflammatory Effects of Coromadel Coast Falsemallow (Malvastrum coromandelianum) / Lou Moulun, Zhong Wen, Huang Shiying, et al / CHINESE TRADITIONAL AND HERBAL DRUGS, 1999-06
(15)
Malvastrum coromandelianum / Synonyms / The Plant List
(16)
Pharmacognostic and phytochemical investigation of the leaves of Malvastrum coromandelianum (L.) Garcke / Dhirendra B. Sanghai, S. Vijaya Kumar, K. K. Srinivasan, H. N. Aswatharam, and C. S. Shreedhara / Anc Sci Life, 2013 Jul-Sep; 33(1): pp 39–44. / doi: 10.4103/0257-7941.134596
(17)
MEDlCINAL PLANTS OF JAMAICA. PARTS 1 & 11. / G. F. Asprey, M.Sc., Ph.D. (B'ham.) and Phyllis Thornton, B.Sc. / West Indian Medical Journal. Vol. 2 No. 4. Vol. 3 No. 1.
(18)
Glucose-Lowering Efficacy of Water Extract of Malvastrum coromandelianum in Type 2 Diabetes Subjects: A Double Blind, Randomized Controlled Trial / Thipaporn Tharavanij, Kammal Kumar Pawa, Puritat Maungboon, Pitvara Panpitpat, Suthon Porntisan, Wirote Thangcharoende, Adis Tasanarong, Garnpimol C Ritthidej, Sukanya Jesadanont / Journal of the Medical Association of Thailand, Chotmaihet Thangphaet 2015, 98 Suppl 3: S75-80
(19)
Antidiarrheal potential of ethanolic leaf extract of Malvastrum tricuspidatum in albino rats / Neelam Balekar*, Gaurav Parihar, Dinesh Kumar Jain, Shreya Gupta /
J. Adv. Pharm. Edu. & Res., Apr-Jun 2014, Vol 4, Issue 2.
(20)
ANALGESIC ACTIVITY OF HYDROALCOHOLIC EXTRACT OF AERIAL PARTS OF MALVASTRUM COROMANDELIANUM / Bhupesh Chander Semwal, Kalyani D, Rohit B / Asian Journal of Pharmaceutical and Clinical Research, Sept 2016; Vol 9, Issue 5 / DOI  https://doi.org/10.22159/ajpcr.2016.v9i5.12822
(21)
Evaluation of Phytochemical Screening and In vitro Anthelmintic Activity of Malvastrum coromandalianum / Suresh Kasala, Suhas Ganga, Prabhudas. P, Chandrababu. K, Himabindhu. J / Int. J. Pharm. Sci. Rev. Res., March -April 2017; 43(2); Article No. 41: pp 228-230
(22)
FOLK MEDICINE OF THE IRULAS OF COIMBATORE FORESTS / P.BALASUBRAMANIAN, A. RAJASEKARAN and S.N PRASAD / Ancient Science of Life, Vol XV13, January 1997
(23)
Shaving cream containing malvastrum coromandelianum medicinal material / CN 103690438 B

(24)
Pharmacognostic and phytochemical investigation of the leaves of Malvastrum coromandelianum (L.) Garcke / Dhirendra B Sanghai, S Vijaya Kumar, K K Srinivasan et al / DOI: 10.4103/0257-7941.134596
(25)
Chemical Composition, Antibacterial, Cytotoxic and Antioxidant Activities of the Essential Oil of Malvastrum coromandelianumAerial Parts / Yuanji Liu, Xiaodan Su, Yingxin Xiang, Xueting Wang, and Pengxiang Lai / Journal of Essential Oil Bearing Plants, 2019; 22(4) / https://doi.org/10.1080/0972060X.2019.1651224
(26)
Structural analysis and antioxidant activity of an arabinoxylan from Malvastrum coromandelianum L. (Garcke) / Shanti Devi, Ajeet K Lakhera, Vineet Kumar / RSC Advances, 2019; Issue 42
(27)
Comprehensive structural analysis of cis- and trans-tiliroside and quercetrin from Malvastrum coromandelianum and their antioxidant activities / Shanti Devi, Vineet Kumar / Arabian Journal of Chemistry, Jan 2020; 13(1): pp 1720-1730 / https://doi.org/10.1016/j.arabjc.2018.01.009
(28)
Bioactive constituents from Malvastrum coromandelianum (L.) Garcke leaf extracts / Aderogba M A, Madikizela B, McGaw L J / South African Journal of Botany, 2018; Vol 126: pp 371-376 /https://dx.doi.org/10.1016/j.sajb.2019.06.008
(29)
Evaluation of Antiulcer Activity of Whole Plant Extract of Malvastrum tricuspidatum in Experimental Animals / Neelam Balekar, Dinesh Kumar Jain, Pankaj V Dixit, Sandeep Singh Bhadoriya / IJPT: Iranian Journal of Pharmacology & Therapeutics, July 2012; 11(2): pp 53-59
(30)
Clinical Trial Phases I and II of Malvastrum Coromandelianum as Adjunctive Treatment in Type 2 Diabetes / Pattaraporn Tungsukruthai, Tipaporn Taravanich, Chayaninee Patthapong et al / TMJ, 2007; 7(4)
(31)
Formulation development of film coated tablets of Malvastrum coromandelianum (Linn.) Garcke spray-dried extract / P Prasertwaree, S Jesadanont, S Pongsamart, GC Ritthidej  / Planta Med, 2008; 74 - PC131 / DOI: 10.1055/s-0028-1084649
(32)
ETHNOMEDICINAL APPROACHES FOR TREATING VARIOUS DISEASE BY IRULAS TRIBALS, KONBANUR VILLAGE, ANAIKATTI HILLS,THE WESTERN GHATS, COIMBATORE DISTRICT / Ganesan, C.M. and G. Kumaresan / Kong. Res. J., 2017; 4(2): pp 1-8

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