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Family Simaroubaceae
Balaniog
Brucea javanica (L.) Merr.
JAVA BRUCEA

Ya dan zi

Scientific names Common names
Ailanthus gracilis Salisb. Balaniog (Chab.)
Brucea amarissima Desv. ex Gomes Bago-bago (P. Bis., C. Bis.)
Brucea glabrata Decne. Magkapayos (S. L. Bis.)
Brucea gracilis (Salisb.) DC. Manongao-bobi (C. Bis.)
Brucea javanica (L.) Merr. Selte (Yak.)
Brucea sumatrana Roxb. Java brucea (Engl.)
Brucea sumatrensis Spreng.  
Gonus amarissimus Lour.  
Rhus javanica Linn.  
Brucea javanica (L.) Merr. is an accepted name The Plant List

Other vernacular names
CHINESE: Ya dan zi, Ku shen zu, Lao ya dan, Ya tan tzu.
CAMBODIAN: Damil thnang, Pramat monus.
INDONESIAN: Kuwalot, Malur, Tambar marica.
LAOTIAN: Ich kone, Kom roi, Phla fan.
MALAYSIAN: Embalau padang, Kusum, Lada pahit.
THAI: Ratchadat, Ka chaplak, Dee khon.
VIETNAMESE: C[aa]y su[oos]t, C9uws]t chu[ooj]t, S[aaf]u d[aa]u.

Botany
Balaniog is a somewhat hairy shrub, 1 to 3 meters high. Leaves are alternate, compound-pinnate, about 30 centimeters or more in length. Leaflets are 5 to 11, 4 to 10 centimeters in length, 2 to 4 centimeters wide, pointed at the apex and rounded or pointed at the base, with prominently toothed margins. Flowers are small, reddish, occurring in axillary inflorescences. Fruit is oval, black when ripe, smooth, reticulated, about 0.5 centimeter long. Seeds are dark brown, compressed and rugose.

Distribution
- In thickets at low altitudes in Pangasinan Province in Luzon; in Leyte; Palawan: Negros; and Surigao, Bukidnon, Cotobato, Misamis Provinces in Mindanao, and in Basilan.
- Also reported in India to southern China through Malaya to Australia.

Constituents
- Studies yielded tannin 1.5%, and a small amount of hydrolytic enzymes.
- Bark yielded an amorphous bitter principle, volatile acids and protein.

- Phytochemical screening yielded flavonoids, tannins, triterpenes, steroids, anthraquinones, anthrones, flavonoids glycosides, coumarins.
- Contains quassinoid triterpenes, including bruceatin, bruceantinol, bruceantinoside a, bruceins A-G and Q, bruceolide, bruceosides, dihydrobrucein A.
- Seeds yielded quassinoid glucosides, javanicosides I, J, K and L, along with two known quassinoids, bruceins D and E, and seven known quassinoid glucosides, yadanziosides B, C, E, I and K, bruceoside B and yadanzigan. (14)
- Leaves yielded a new secoiridoid glucoside, 6'-O-trans p-coumaroyloleuropein, together with two known ones, ligustroside and oleuropein. (17)
- Fruit yielded an alkaloid (4-ethoxycarbonyl-2-quinolone) and a quassinoid (bruceine I) along with three well known compounds viz., vanillic acid, quercetin-3-O-beta-D-galactoside, and luteolin-7-O-beta-D-glucoside. (19)

Properties
- Seeds are may be toxic in single full doses, especially the powdered form, and can produce nausea, vomiting, abdominal pain and purging.
- No toxic signs or symptoms were observed when the seeds were administered in divided doses.
- Toxic components are no in oil of the seed, but in the bitter portion of the nonoleated fraction of the seed.
- On examination of a small amount of stool with living dysentery amoeba mixed with 2% cold infusion of powdered seed (free oil), the amoeba became round and died instantly.
- Expressed oil has no amebicidal action although the ethereal extract has.
- In some parts of Asia, considered anti-malarial, antipyretic, and homeostatic.
- Studies have shown antitumorla, antimalarial, anti-inflammatory properties.

Parts used
Seed, fruit.

Uses

Folkloric
- Fresh fruit used for stomachache.
- In the East Indies, all parts of the plant are used as stomachic tonic; also used for diarrhea, intermittent fever and worms.
- Seed has been reportedly used as remedy for most types of pernicious dysentery.
- Seeds used for malaria, with effects comparable to quinine.
- In China, used to treat malaria, amebic dysentery, chronic dysentery, hemorrhoids; also, used as insecticide. Seeds used for dysentery, malaria and cancer. Fruit used to treat cancer, malaria and amoebic dysentery; also used as insecticide.
- In Indonesia, fruit used for fever and as anti-malarial.
- Elsewhere, poultice used on boils, ringworn, scurf, centipede bites, hemorrhoids, enlarged spleens. Seed and seed oil used on warts and corns.
- Seeds used for diabetes.


Studies
Indole Alkaloid / Cytotoxicity:
Study has yielded an indole alkaloid canthin-6-one. The compound and its hydroxylated and methoxylated derivatives have demonstrated marked cytotoxic activities against malaria, leukemia, carcinoma, keratinocytes of guinea-pig ear, and bacteria (Anderson et al, 1983.) (2)
Antioxidant: In a study of the crude methanol extracts of four Philippine medicinal plants for their antioxidant activity, B amarissima showed to be the most potent. Phytochemical screening yielded flavonoids, tannins, triterpenes, steroids, anthraquinones, anthrones, flavanoid glycosides and coumarins.
(3)
Quassinoid: Study isolated javanacin, a novel quassinoid from the seeds of B. javanica.
(4)
Hypoglycemic / Bruceines: Study of B. javanica seeds isolated bruceines E and D which were administered to STZ-induced diabetic rats. Results showed reduction of blood glucose concentration by both bruceines comparable to glibenclamide probably by acting as an insulin secretagogue. (5)
Anti-Malarial: Study showed of extracts of B. javanica fruit showed anti-malarial activity that was attributed to its quassinoid constituents. Nine of the quassinoids showed activity against chloroquine-resistant Plasmodium falciparum. (6)
Bioactive Seed Constituents: Study Study isolated a new quassinoid, yadanziolide S, from the seeds of B. javanica, along with 10 known compounds, flazin, bruceine D, yadanziolide B, bruceoside A, yadanziolide S, yadanzigan, glycerol 1,3-bisoleate, azelaic acid, (±)-8-hydroxyhexadecanoic acid, and vanillin. The isolates were evaluated for potential to induce human promyelocytic leukemia (HL-60) cell differentiation and to inhibit COX-1, COX-2, and DMBA-induced lesions in a mouse mammary culture model. (7)
NF-kB Inhibitors: Study identified nuclear factor kappaB (NF-xB) inhibitors exhibiting reactive oxygen species (ROS) intracellular amplification. Bruceajavanone B, bruceantin, bruceine A, (-)-hydnocarpin, and chrysoeriol exhibited cytotoxic potential and NF-kB p65 inhibition. Chrysoeriol exhibited selective cytotoxicity against leukemia cells and potentiates the amplification of ROS levels, and can serve as a potential chemotherapeutic modifier for leukemia chemotherapy. (8)
Oral Candida Inhibition: Study evaluated the growth inhibitory effect of a crude aqueous leaf extract of B. amarissima. At higher concentration (6mg/mL), the extract exhibited significant growth reduction and also reduced the µ-values of all Candida strains by more than 90%. Results showed fungistatic (<6mg/mL) and fungicidal (>6mg/mL) activities, presenting as a promising candidate as a natural antifungal. (11)
Acute Toxicity Study / Leaves: Study evaluated the oral acute toxicity of leaves extract on male and female DDY-mice. Single oral doses of leaves extract up to 4500 mg/kbw did not induce acute toxic effects. However, there were 26 deaths during the experimental period. Data suggests mild toxicity. Considering the dose, the body effects/damage were minor and not permanent. (12)
Hyphal Wall Protein (HPW1) Suppression / Non-Candida albicans Species: Study evaluated expression of HWP1 following treatment with Piper betle and Brucea javanica aqueous extracts. The expression levels were reduced with higher concentration of B. javanica extract. B. javanica and P. betle have potential to be developed as oral health products. (13)
Antiprotozoal / Cytotoxic / Seeds: Study evaluated the in vitro antiprotozoal and cytotoxic activity of extracts and fractions of B. sumatrana seeds against twos Trypanosoma species (T. cruzi and T. brucei brucei), Leishmania infantum and P. falcifarum and MRC-5 cell lines. Results showed the 80% methanolic extract with cytotoxic effect against MRC-5 cell lines. Extracts showed moderate to pronounced antiprotozoal activities. (15)
Hypoglycemic Bioactives / Seeds: Study evaluated seed extracts for diabetes treatment. Fractionation of extracts yielded bruceines D and E which exhibited hypoglycemic activity in STZ-induced diabetic rats. (16)
Antiproliferative and Apoptosis-Inducing Activity / Human Carcinoma Cells: Study reports on the potential anticancer activity of water extract of B. javanica against four cancer cell lines, including A549 non-small cell lung cancer, Hep3B hepatocellular carcinoma, MDA-MB231 breast cancer, and SLMT-1 esophageal squamous cell carcinoma. Results suggest BJE-induced cancer cell death proceeds through a mitochondrial dependent pathway associated with caspase 3 activation. (20)
Induction of Apoptotic Death of Acute Myeloid Leukemia Cells / Seed Oil: Study investigated the antileukemic potential of BJO in human myeloid leukemia cell lines (AML) U937 and HL-60 in vitro in mouse U937 tumor model. Results showed BJO induced AML cell apoptosis through activation of caspase-8 and modulation of apoptosis-related proteins. (21)
Antidiabetic / Antioxidant / Seeds: Study evaluated an ethanol extract of BJ seed for antioxidant and antidiabetic activities. An ethyl acetate fraction (EAF), rich in tannin, showed the strongest antioxidant activities to DPPH, FRAP, and NORSA. Along with GPα inhibitory activity, EAF effectively improved glucose tolerance. Rats treated with EAF showed a 39.91% decrease (p<0.05) in blood glucose at 30 minutes with a continuous fall at 60 and 90 minutes. (22)
Anticoccidial / Antioxidant / Seeds: Study investigated the prophylactic and therapeutic effects of ethanol extract of B. javanica on coccidiosis induced by Eimeria tenella in broiler chickens. Results showed considerable anticoccidial effects and a promising potential in controlling avian coccidiosis. (23)

Availability
Wild-crafted.
Extracts in the cybermarket.

Godofredo U. Stuart Jr., M.D.

Last Update May 2016

© Godofredo Stuart / StuartXchange
IMAGE SOURCE: / Illustration / Brucea javanica (L.) Merr. [as Brucea sumatrana Roxb.] / [8359-160807-161847] / Indian medicinal plants, vol. 2: t. 206 () / PlantIllustrations.org
OTHER IMAGE SOURCE: / Photo / Simaroubaceae : Brucea javanica / Leaf / Copyright © 2011 by Leonardo L. Co (contact: benctan@berkeley.edu) [ref. DOL26209] / Non-Commercial Use / Phytoimages.siu.edu

Additional Sources and Suggested Readings
(1)
Fructus brucea / WHO Monographs on Selected Medicinal Plants - Volume 1 (1999; 295 pages) /
(2)
Improved production of the indole alkaloid canthin-6-one from cell suspension culture of Brucea javanica (L.) Merr. / ME Wagih, G Alam et al / Indian Journal of Science and Technology, Volk 1, No 7, Dec 2008
(3)
Antioxidant and cytotoxic activities and phytochemical screening of four Philippine medicinal plants
/ Nonita Peteros and Mylene Uy / Journal of Medicinal Plants Research Vol. 4(5), pp. 407-414, 4 March, 2010
(4)
A quassinoid from Brucea javanica / L Z Lin, G A Cordell et al / Phytochemistry (1990), Volume: 29, Issue: 8, Pages: 2720-2722
(5)
Hypoglycemic effect of quassinoids from Brucea javanica (L.) Merr (Simaroubaceae) seeds / Ajmi NoorShahida, Tin Wui Wong, Chee Yan Choo / Journal of Ethnopharmacology, Vol 124, No 3, 30 July 2009, Pages 586-591 / doi:10.1016/j.jep.2009.04.058
(6)
Plants as Sources of Antimalarial Drugs, Part 4: Activity of Brucea javanica Fruits Against Chloroquine-Resistant Plasmodium falciparum in vitro and Against Plasmodium berghei in vivo / Melanie J. O'Neill, Dorothy H. Bray, Peter Boardman, Kit L. Chan et al / J. Nat. Prod., 1987, 50 (1), pp 41–48 / DOI: 10.1021/np50049a007
(7)
Bioactive Constituents of the Seeds of Brucea javanica / Bao-Ning Su, Leng Chee Chang, Eun Jung Park et al / Planta Med 2002; 68(8): 730-733 / DOI: 10.1055/s-2002-33798
(8)
NF-κB Inhibitors from Brucea javanica Exhibiting Intracellular Effects on Reactive Oxygen Species
/ JEONG-AH KIM, EDWARD K. LAU et al / ANTICANCER RESEARCH 30: 3295-3300 (2010)
(9)
Brucea javanica (L.) Merr. (accepted name) / Chinese names / Catalogue of Life, China
(10)
Brucea javanica (L.) Merrill / Vernacular namesc/ GLOBinMED
(11)
Inhibitory Effect of Crude Aqueous Brucea amarissima Extract on the Growth Profile of Oral Candida / W Wan Harun, M Nordin, F Abdul Razak / Planta Med 2011; 77 - PF83 / DOI: 10.1055/s-0031-1282471
(12)
Acute Toxicity of Brucea javanica Merril Leaves Extract on Mice / Marissa Angelina*, Indah D. Dewijanti, Banjarnahor S.D.S., Megawati,Tri Yuliani / THE JOURNAL OF TROPICAL LIFE SCIENCE, VOL. 2, NO. 2, pp. 29 – 31, May, 2012
(13)
Effect of Piper betle and Brucea javanica on the Differential Expression of Hyphal Wall Protein (HWP1) in Non-Candida albicans Candida (NCAC) Species / Wan Himratul Aznita Wan Harun, Nur Alyaa Jamil, Nor Hazwani Jamaludin, and Mohd-Al-Faisal Nordin / Evidence-Based Complementary and Alternative Medicine
Volume 2013 (2013), Article ID 397268, 6 pages / http://dx.doi.org/10.1155/2013/397268
(14)
Quassinoid glucosides from seeds of Brucea amarissima / Ik Hwi Kim, Yukio Hitotsuyanagi, Koichi Takeya / Phytochemistry, 01/2005; 65(23):3167-73. / DOI:10.1016/j.phytochem.2004.08.029
(15)
In Vitro Antiprotzoal and Cytotoxic Activity of the Aqueous Extract, the 80% Methanol Extract and Its Fractions from the Seeds of Brucea sumatrana Roxb. (Simaroubaceae) Growing in Democratic Republic of Congo
/
Michel Tshodi Ehata, Adelard Mbenza Phuati, Stanislas Nsaka Lumpu, Cyprien Kikweta Munduki, Donatien Bakana Phongi, Gaston Tona Lutete, Oscar Kambu Kabangu, Richard Cimanga Kanyanga, Ann Matheeussen, Paul Cos, Sandra Apers, Luc Pieters, Louis Maes, Arnold J. Vlietinck / CM, Vol.3 No.1, March 2012 / http://dx.doi.org/10.4236/cm.2012.31011
(16)
Hypoglycemic Bioactives from a Traditional Herb / C. Y. Choo*, A. NoorShahida, T. W. Wong / ACS Symposium Series, Vol. 1093 / Emerging Trends in Dietary Components for Preventing and Combating Disease, Chapter 14, pp 263–274 / Chapter DOI: 10.1021/bk-2012-1093.ch014
(17)
A New Secoiridoid Glucoside from Brucea amarissima / Misono Yuka, Ishibashi Masami et al /
(18)
Brucea jananica / Synonyms / The Plant List
(19)
Studies on the chemical constituents of Brucea javanica (L.) Merr. / Yu YN1, Li X / Yao Xue Xue Bao. 1990;25(5):382-6.
(20)
Antiproliferative and apoptosis-inducing activity of Brucea javanica extract on human carcinoma cells. /
Lau FY, Chui CH, Gambari R, Kok SH, Kan KL, Cheng GY, Wong RS, Teo IT, Cheng CH, Wan TS, Chan AS, Tang JC. / Int J Mol Med. 2005 Dec;16(6):1157-62.
(21)
Seed Oil of Brucea javanica Induces Apoptotic Death of Acute Myeloid Leukemia Cells via Both the Death Receptors and the Mitochondrial-Related Pathways / Hong Zhang, Jing Yu Yang, Fan Zhou, Li Hui Wang, Wen Zhang, Sha Sha, and Chun Fu Wu / Evidence-Based Complementary and Alternative Medicine
Volume 2011 (2011) / http://dx.doi.org/10.1155/2011/965016
(22)
Evaluation of Antidiabetic and Antioxidant Properties of Brucea javanica Seed / Abdulwali Ablat, Jamaludin Mohamad, Khalijah Awang, Jamil A. Shilpi, and Aditya Arya / The Scientific World Journal
Volume 2014 (2014) / http://dx.doi.org/10.1155/2014/786130
(23)
Anticoccidial evaluation of a traditional chinese medicine—Brucea javanica—in broilers / L. Lan, B. Zuo, H. Ding, Y. Huang, X. Chen and A. Du / Poultry Science (April 2016) 95 (4): 811-818. / doi: 10.3382/ps/pev441

It is not uncommon for links on studies/sources to change. Copying and pasting the information on the search window or using the DOI (if available) will often redirect to the new link page.

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