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Family Amaranthaceae

Beta vulgaris Linn.

Jun de cai

Scientific names Common names
Beta alba DC. Beet (Engl.)
Beta altissima Steud. Common beet (Engl.)
Beta atriplicifolia Rouy Garden beet (Engl.)
Beta bemngalensis Roxb. Red beet (Engl.)
Beta carnulosa Gren. Red beetroot (Engl.)
Beta cicla (L.) L.  
Beta crispa Tratt.  
Beta decumbens Moench  
Beta esculenta Salisb.  
Beta hortensis Mill.  
Beta hybrida Andrz.  
Beta incarnata Steud.  
Beta lutea Steud.  
Beta marina Crantz  
Beta maritima L.  
Beta noeana Bunge ex Boiss.  
Beta orientalis Roth  
Beta purpurea Steud.  
Beta rapa Dumort.  
Beta rapacea LinnHegetschew.  
Beta rosea Steud.  
Beta sativa Bernh.  
Beta stricta K.Koch  
Beta sulcata Gasp.  
Beta triflora Salisb.  
Beta vulgaris Linn.  
Beta vulgaris L. is an accepted name. The Plant List

Other vernacular names
CHINESE: Hong niu pi cai, Tian cai, Zi luo bo, Hong cai tou, Zhu na cai, Hai bai cai.
CZECH: Flepa Obecná.
DANISH: Bederoe, Rødbede.
DUTCH: Biet, Kroot, Kroten, Rode Biet.
ESTONIAN: Harilik, Punapeet.
FINNISH: Punajuurikas.
FRENCH: Betterave Potagère, Betterave Rouge Potagère.
GERMAN: Rübe, Rote Beete, Rote Bete, Rote Rübe, Rote Rüben, Runkelrübe.
HEBREW: Selek Adom.
INDIA: Chukandar, Ullam gadda.
IRAQ: Salk.
ITALIAN: Barba, Barbabietola, Barbabietola da insalata, Barbabietola rossa, Barbabietole da orto, Bietola a radice rossa, Bietola comune, Bietola rossa, Bietola rossa e gialla.
JAPANESE: Aka Kabu, Biito, Biitsu, Kaensai, Shokuyou Biito
NEPALESE: Cukandar, Guliyo Muulaa
POLISH: Burak Zwyczajny.
PORTUGUESE: Beterraba, Beterraba de salada, Beterraba-vermelha, Patarrábia, Terraba
RUSSIAN: Svëkla Obyknovennaia, Svëkla Stolóvaia.
SLOVENIAN: Navadna Pesa, Rdezhe Pesa.
SPANISH: Remolacha, Remolacha colorada, Remolacha de mesa, Remolacha roja, Betarraga.
SWEDISH: Beta, rödbeta.
THAI: Phakkat Daeng, Phakkat Farang.

Gen info
- Beta vulgaris is economically the most important crop of the large order Caryophyllales.
- It has several cultivar groups: (1) Sugar beet, which produces table sugar; (2) root vegetable known as beet root or garden beet; (3) leaf vegetable known as chard or spinach beet; and (4)
mangelwurzel, the fodder crop. (30)
- The wild ancestor of the cultivated beets is the sea beet, Beta vulgaris subsp. maritima, (30)

Beet is a succulent, smooth herb. Erect stem is 30 to 90 centimeters long. Lower or root leaves are ovate or oblong-obtuse, often trowel-shaped, up to 25 centimeters long. Upper leaves are rhombic-ovate, oblong-ovate or lanceolate. Flowers are greenish, stalkless, solitary or 2- to 3-adnate, in axillary spikes or corymbose clusters. Spikes are slender, 15 to 45 centimeters long. Utricle is adnate to the disk and base of the perianth. Seed is horizontal with thin testa, floury albumen and annular embryo.

- Grown in many places in the Philippines, especially Baguio.
- Native to the Mediterranean.
- Widely cultivated in America, Europe, and throughout India.

• Herb contains saponin, betaine phytosterine, ash, calcium, iron, vitamins A, B and C.
• Root contain saponin, isoleucin, leucine, tyrosine, betaine, lysin, arginine, histidine, phenylalanine, urease and tyrosinase.
• Root has yielded flavonoids, carbohydrates, betain, neobetain and anthocyanin pigments.
• Root yields betanins, used industrially as a red food colorants.
• Phytochemical screening has yielded flavonoids, carbohydrates, pentose, amino acids, saponins, tannins and steroids.

• Proximate composition of beetroot showed average values of proteins 1. 35 ± .2%; fats 0.3 ± 0.1%; carbohydrates 7.59 ± 0.4%; dietary fiber 1.9 ±0.2%; moisture 87.4 ± 0.3%; ash 1.4 ±0.2%. Mineral composition with average value (mg/100g) yielded iron 0.75 ±1.20; potassium 30.12 ± 0.29; calcium 12.20 ±1.20; manganese 0.79 ± 1.98; copper 0.09 ± 0.47. (34)
• Study of aerial parts for essential oil yielded 25 components, accounting for 98.1% of the total oil, characterized by a high proportion of oxygenated sesquiterpenes (39.2%), followed by sesquiterpene hydrocarbons (30.3%) and one apocarotenoid (26.3%). Main compounds were gamma-irone (26.3%). a-cadinol (12.1%), T-cadinol (10.6%), bicyclogermacrene (10.4%) and delta-cardinene (6.0%). (see study below) (36)
• Study evaluated the roots of three cultivars for triterpene saponins. Results showed the roots of all three cultivars contained 11 saponins consisting of oleanolic acid or hederagenin aglycone and varying numbers of sugars, with the dominant triglycoside derivative of oleanolic acid. (49)

• Roots traditionally used as expectorant, diuretic, and cure for mental and hepatic diseases.
• Leaves considered tonic, diuretic, anti-inflammatory.

Parts utilized
Roots and leaves.

Edibility / Culinary
• Highly prized for their large, red, edible roots.
• Succulent fleshy roots are cooked and eaten in salads and as vegetables.
• Leaves are also boiled and eaten as a vegetable; used as substitute for spinach.
• A traditional food for Jewish Rosh Hashana (New Year.)
• A good source of calcium and iron.
• Red beet used as an emmenagogue.
• White beet is used as laxative and diuretic.
• Decoction, with a little vinegar added, used for itching, cleans scurf and dandruff. Also used for all ulcerous and running sores.
• Seeds have cooling and diaphoretic properties.
• Fresh leaves applied to burns and bruises.
• Hippocrates suggested the use of beet leaves as binding for wounds.
• In Roman times, used as aphrodisiac.
• In Turkey, used for diabetes.
• In Iraq, used for folk treatment of liver and kidney diseases, for stimulation of the immune and hematopoietic systems, and in special diets in the treatment of cancer. (35)
• In the Aravali regions of Rajasthan, India, rhizome juice drunk to cure kidney stones. (45)
Colorant: Betanins from the roots used industrially as red food colorant, e.g., to intensify the color of tomato paste, desserts, jams, jellies, etc.

Hepatoprotective / CCl4-Induced Hepatotoxicity: Ethanolic extract of Beta vulgaris roots exhibited significant dose-dependent hepatoprotective activity against carbon tetrachloride-induced hepatotoxicity in rats. (1)
Antidiabetic: Chard (B vulgaris L var. cicla) is used as a hypoglycemic agent in diabetic patients in Turkey. The study showed the plant extract when administered by gavage may reduce blood sugar by regeneration of beta cells. (2)
Anti-Adhesion Activity: Study showed B vulgaris (beet) root has the potential of interfering with adhesion of bacteria to host epithelial surfaces. (3)
Cytotoxicity Reduction: A crude extract of leaves of Indian spinach (B vulgaris L var. benghalensis) was observed to modify significantly the cytotoxic effects of a known carcinogen, lead subacetate, in mice in vivo (4).

Antioxidant / Duodenal Protecting Effect: Study concludes table beet can protect the entire body from oxidative damage caused by ischemia-reperfusion of the liver but the effects on gut mucosa needs further investigation. (5)
Anti-Inflammatory: Study of aqueous extract showed anti-inflammatory activity in the carrageenan-induced rat paw edema, closely resembling indomethacin. (6)
Betanine / Natural Red Dye: Beetroot is the main source for the natural red dye. (FDA approved E162) The main component of the extracted "beetroot red" is betanine. Studies have shown betanines have antioxidant, antimicrobial, and antiviral activities. The study is on the development of a statistical method for optimizing extraction conditions. (9)
Cytotoxicity / Anti-Cancer: Study evaluated the cytotoxic effect of red beetroot extract with anticancer drug, doxorubicin (adriamycin) in human prostate cancer cells and human breast cancer cells. Results showed betanin, the major betacyanin constituent, may play a role in the cytotoxicity exhibited by the red beetroot extract. (10)
Hepatoprotective / Ethanol-Medicated Hepatotoxicity: Study showed an n-butanol fraction of Beta vulgaris to possess potent hepatoprotective effect against ethanol-induced hepatic toxicity, with a potential role in the management of alcoholic liver disease. Silymarin was the reference drug. (11)
Peroxidase Source / Production: Peroxidase is an enzyme that plays a crucial role in scavenging free radicals within the plant system. Commercially they are components in chemical diagnostics and laboratory experiments. Study showed the red beet hairy root system is a promising source for the production of this expensive enzyme. (12)
Hematopoietic Benefits / Anemia Remedy: Study in experimental rat models showed a methanolic root extract produced dose-dependent increase in packed cell volume, hemoglobin concentration, RBC counts, and total lymphocyte counts. (13) Study evaluated the anti-anemic effect of beetroot on male wistar rats with anemia induced by phenylhydrazine. All the red cell indices increased in the beet group compared to control. (58)
Phenolics Content: Total phenolic contents in roots parts were found to decrease in the order peel, crown, flesh. Cold storage produced significant differences. (14)
Pharmaceutical Excipient / Disintegrating Agent:` Study showed Beta vulgaris pulp powder is a good pharmaceutical adjuvant, specifically as a disintegrating agent. (15)
Radiotherapy and Benefits of Beta vulgaris Supplementation: Study showed supplementation of Beta vulgaris in irradiated patients did not worsen survival time. There was reduction of acute radiation reactions, and level markers of oxidative stress/DNA damage were not influenced. Results suggest supplementation of Beta vulgaris in irradiated patients is safe. (16)
Anti-Inflammatory / Roots: An ethanolic extract of B. vulgaris roots showed good anti-inflammatory activity on carrageenan-induced rat paw edema method. (17)
Hepatoprotective in Diabetes: Study evaluated chard extracts on its effect on the liver of diabetic rats. In the diabetic group given chard, serum enzymes, total lipid level, sialic and uric acid levels, blood glucose and liver LPO and NEG levels decreased. Results conclude the extract has a protective effect on liver in diabetes mellitus. (18)
Chemical Composition of Leaves during Developmental Stages: Study showed beetroot leaves are an excellent source of omega-3, in addition to having significant antioxidant activity and total phenolic compounds and minerals. Chemical constituents changed during developmental stages, with the 100-day leaves showing the greatest amount of omega 3 and 6 and TPC. Results the food uses and nutritional value of in natura and dehydrated beetroot leaves. (19)
Antiproliferative / Immunomodulatory: Study evaluated the various concentrations of methanolic extracts of roots for in vitro anti-proliferative and in-vivo immunomodulatory activity of Beta vulgaris against MCF7 breast cancer cell line. Results showed in vitro inhibition of tumor cell growth. It showed immunomodulatory effects in-vivo via assessment of humoral antibody response and delayed-type hypersensitivity response. (20)
Hypolipidemic Effects: In the study of STZ-induced diabetic rats, the augmented triglyceride and cholesterol due to diabetes were significantly decreased by the Beta vulgaris plant extract. (21)
• Review / Benefit of Supplementation in Health and Disease: Review discusses beetroot's biological activity and evaluates evidence from studies that specifically investigated the effect of supplementation on inflammation, oxidative stress, cognition and endothelial function. (23)
• Nephroprotective / Amelioration of Gentamicin-Induced Nephrotoxicity: Study evaluated the protective effect of beetroot ethanolic extract on gentamicin-induced nephrotoxicity. Results suggest beetroot extract treatment attenuates renal dysfunction and structural damage through reduction of oxidative stress, inflammation, and apoptosis in the kidney. (24)
• Chemical Compositional Study of Leaves in Various Developmental Stages: Study evaluated beetroot leaves in natura and dehydrated form in terms of fatty acid composition, proximate composition, minerals, total phenolic compounds and antioxidant activity. Results showed significant levels of protein and lipids in all developmental stages. All proximate composition nutrients decreased during the maturation stages. Antioxidant activity and chemical constituents, mainly the ω-3fatty acid, increased during the stages of development. Results suggest that in natura and dehydrated leaves can be used in the preparation of broths, meals, or added to other foods. Dehydrated leaves showed the greatest nutritional value. (25)
• Study for Use as Natural Coloring Agent for Foods and Cosmetics: Study evaluated beet as coloring agent in food and cosmetic. The juice showed good antioxidant and antimicrobial qualities. The juice augmented Henna color, with the best results obtained with 50:50 mixture. When added to homemade cakes, it was acceptable to many volunteers in color and taste questionnaires. Study suggests further study of plants in the formulation of natural plant pigments. (26)
• Antimicrobial / Roots: Study of an ethanolic root extract of B. vulgaris showed antimicrobial activity against gram negative and gram positive bacteria. Streptomycin was used as reference control. (27)
• Effect on Oxidative Injury in Aorta and Heart of Streptozotocin-Diabetic Rats: Study evaluated the effect of feed chard (B. vulgaris var. cicla) on diabetes-induced free radical-mediated injury in rat aorta and heart tissues of female Swiss albino rats. Results showed treatment reversed the effects of diabetes on blood glucose and tissue lipid peroxidation and glutathione levels. (28)
• Prevention of High Blood Pressure: Study evaluated the efficacy of natural sources vs medications in the prevention of high blood pressure. Results suggest natural sources, especially a combination of garlic and beet roots, gave good results. (29)
• Improvement of Scopolamine Induced Spatial Memory Disorder / Antioxidant / Leaves: Study evaluated the effect of beet root leaf extract on scopolamine-induced spatial memory impairment in male Wistar rats. Morris water maze task was used to assess spatial memory. The extract significant increased antioxidant capacity and decreased serum MDA level in scopolamine-treated rats (p<0.05). Results suggest the leaf extract can ameliorate memory impairments and provide protective effects against scopolamine induced oxidation. (31)
• Effect on Liver Enzymes . Non-Alcoholic Fatty Liver Disease / Clinical Trial: A double-blind parallel group, randomized clinical trial evaluated the efficacy of Beta vulgaris extract in the treatment of NAFLD. Integration of B. vulgaris extract in the standard treatment of NAFLD significantly improved AST, ALP, FBS. LDL and HDL. The effect on ALT increased over time. (32)
• Antibacterial / Aerial Parts: Study evaluated the ethanol extracts from aerial parts of four plants, including Beta vulgaris, Amaranthus graecizans, Rumex obtusifolius and Polygonum patulum for antibacterial activity against some gram positive and gram negative bacteria i.e., P. aeruginosa, L. monocytogenes, S. epidermis, S. aureus, K. pneumonia, S. typhi, B. cereus, B. anthracis, E. coli and S. pyogenes. The majority of extracts showed inhibitory effects at different concentrations. E. coli was the most resistant. Beta vulgaris showed second highest inhibitory zone with 20 mm against Staphylococcus epidermis. (33)
• Dermatological Use / Acne and Psoriasis / Leaves: Study evaluate aqueous and methanolic extracts of fresh and dried leaves for phytochemical contents and the effects in the treatment of acne and psoriasis using 360 patients. Phytochemical screening showed rich flavonoids content, specially quercetin and kaempferol. Results showed significant healing effect in the treatment of acne, with more predominant results with fresh leaves. The solution form showed better results than the ointment formulation in the treatment of acne. Same results were seen for psoriasis,except for the ointment formulation showing better results. (35)
• Essential Oil / Antioxidant / Cytotoxicity / Aerial Parts: Study evaluated the chemical composition, antioxidant, cytotoxic, anticholinesterase and anti-tyrosinase activities of essential oil of aerial parts. Study of aerial parts for essential oil yielded 25 components. The EO exhibited high antioxidant activity (IC50 0.055± 0.006 mg/ml) with catalase value of 524.447 ±2.58 units/mg protein. It also exhibited significant cytotoxic eff3ct against A549 cell line, with IC50 of 42.44 ± 1.40 µg/ml. Results suggest potential application in the food and pharmaceutical industries. (see constituents above) (36)
• Antihypertensive / Raw Beet Juice and Cooked Beet: Study evaluated the effect of raw beet juice (RBJ) and cooked beet (CB) on blood pressure of 24 hypertensive patients. aged 25-68. Although both forms of beetroot were effective in improving BP, endothelial function and systemic inflammation, the raw beetroot juice had greater antihypertensive effects. along with more improvement in endothelial function and systemic inflammation compared with CB. (37)
• Antiacetylcholinesterase / Antioxidant: Study showed that chard (Beta vulgaris) may provide a natural source of antioxidant and antiacetylcholinesterase and proline content. (38)
|• Antibacterial / Antioxidant / Beetroot: Study evaluated the total phenolic content (TPC), antioxidant and antibacterial activities of methanolic extract of Marigold flower (MF) and beet root (BR). BR total phenolic compound was 38,4 mg/g GAE compared to MF 42.5 mg/g GAE. Both extracts showed significant activities against both type of Gram negative (E. coli, S. dysenteriae) and Gram-positive (B. subtilis, S. aureus) bacterial strains. (39)
|• Antiviral / Antiherpetic: Study in Colombia evaluated extracts from nine species of plants traditionally used for treatment of various diseases for potential antitumor (cytotoxicity) and antiherpetic activity.
Beta vulgaris did not show cytotoxic activity. The aqueous extract of Beta vulgaris, showed some antiherpetic activity with acceptable therapeutic indexes (the ratio of CC50 to EC50). (40)
|• Hematological Effects in Female Volunteers / Red Beetroot: Study evaluated the effect of taking 8 g of beetroot for 30 days on the blood hematological parameters of female volunteers. Results showed mild increase in hemoglobin levels, decrease in total iron binding capacity (TIBC), increase in serum ferritin and decrease in transferrin, along with a mild increase in serum iron levels after taking beetroot. MCV increased in four volunteers. Further studies were suggested to identify mechanisms of action and optimum dosing patterns. (41)
Hypocholesterolemic: Study evaluated the lyophilized aqueous extract of B. vulgaris (beet root) for possible antihypercholesterolemic and antioxidant potential in cholesterol rich diet-induced hypercholesterolemia in Wistar albino rats. Beet root extract treatment significantly reduced MDA level and significantly replenished the reduced NP-SH content in both liver and heart tissue. BVE at doses of 250 and 500 mg/kbw for 70 consecutive days showed a significant decrease in total cholesterol and triglycerides and significant increase in HDL-C. Acute toxicity testing showed no mortality of morbidity in rats. Results suggest significant antihyperchlesterolemic and antioxidant potential and/or free radical scavenging/ properties. (42)
Mitigation of the Effects of Food Preservatives and Colorants: Study evaluated the the biochemical influence of broccoli and beet extracts on selected individual additives NaNo2 or sunset yellow treated rats, in addition to gene expression of some antioxidant enzymes. Results showed rats co-administered with beet or broccoli extracts had a significant decrease in serum AST, AL, ALP, urea, total lipids, and triglycerides, and a significant increase in reduced glutathione (GSH), glutathione peroxidase (GSH-px) and SOD enzyme activities. Study suggests broccoli and beet extracts have a protective effect against NaNO2 or sunset yellow in rat treated groups. (43)
Hypoglycemic / Betavulgarosides / Root: Study of roots isolated betavulgarosides I, II, III, and IV, oleanic acid oligoglycosides, along with betavulgarosides VI, VII and VIII. Betavulgarosides II, III, and IV exhibited hypoglycemic activity in an oral glucose tolerance test in rats. (44)
Nutritional and Functional Potential / Cicla and Rubra / Root: Swiss chard (Beta vulgaris cicla, BVc) and beetroot (Beta vulgaris rubra BVr) are vegetables with a long history of use in folk medicine. BVc has shown antihypertensive, hypoglycemic, and antiioxidant activity. It contains apigenin, flavonoids (vitexin, vitexin-2-O-rhamnoside and vitexin-2-O-xyloside), which has shown antiproliferative activity on cancer cell lines. BVr contains secondary metabolites, called betalains, used as natural dyes in food and show anticancer activity. Both can be considered functional food, with potential for purification of chemopreventive molecules for use in functional foods and nutraceutical products. (46)
Anxiolytic/ Antidepressant / Antioxidant / Leaves: Study evaluated the protective effect of Beta vulgaris ethanolic extract of leaves against acute restraint stress (ARS)-induced anxiety= and depressive-like behavior and oxidative stress in mice using open field test (OFT), elevated plus maze (EPM), forced swim test (FST) and tail suspension test (TST). Results showed anxiolytic and antidepressant activity in stressed mice along with good antioxidant property suggesting therapeutic potential in the treatment of stress-related psychiatric disorders. (47)
Anxiolytic/ Antidepressant / Antioxidant / Leaves: Exposure to organophosphorus insecticides causes problems to humans and animals. Study evaluated the potential of red beet root (RBR) extract to prevent chlorpyrifos (CPF)-induced liver injury, with emphasis on oxidative stress, inflammation and apoptosis. RBR prevented CPF-induced biological alterations, and ameliorated liver function LPO, NO, iNOS and pro-inflammatory cytokines. RBR enhanced antioxidant defenses, suggesting potential use for therapeutic intervention to minimize CPF hepatotoxicity. (48)
Anticoagulant / Antioxidant / Genotoxicity / Juice: Study evaluated Beta vulgaris juice and methanol extract for anticoagulant properties and genotoxicity. The ME and juice showed surprising anticoagulant and antioxidant activities. The ME showed highest phenolic and flavonoid contents with values of 39.75 mg GAE/g bad 20.73 mg CE/g extract, respectively. They were devoid of any genotoxicity or cytotoxic effects. Results suggest potential, especially for the juice, as source of bioactive molecules for therapeutic use possible in the treatment of cardiovascular diseases. (49)
Peroxidase Enzyme / Phenolic Antioxidants / Leaves: Peroxidases are heme containing enzymes that are produced by a number of organisms. Study reports on the purification of a plant peroxidase from the leaves of chard (B. vulgaris subsp. cicla). Phenolic and flavonoid contents in chard that connected with antioxidant properties were 17.5 µg GA/mg extract and 11.7 µg/ QE/mg extract, respectively.. Results suggest a novel rich source of phenolic antioxidants and high peroxidase activity. (50)
• Synergism with DMSA against Lead-Induced Neurotoxicity: Lead (Pb) is one of the most prevalent causes of human neurotoxicity. Study evaluated the protective role of Beta vulgaris juice (BVJ) alone and with DMAA (dimercaptosuccinic acid) on rat neurotoxicity induced by Pb Results showed that BVJ contains considerable amounts of polyphenols, triterpenoids, and betalains which play an important role as antioxidant and anti-inflammatory, The BVJ exhibited a protective effect against neurotoxicity by reduction of Pb levels in the blood and brain. It decreased oxidative stress, inflammation and cell death induced by Pb, and regulated activities of acetylcholine esterase and monoamine oxidase. BVJ and DMSA together displayed a synergistic antineurotoxicity effect. (51)
• Amelioration of Cyclosporine A-Induced Hepatotoxicity: Cyclosporine hepatotoxicity is one of its major side effects. Study evaluated the protective effects of beet root extract and silymarin against hepatotoxicity induced by cyclosporine-A in male albino rats. Co=administration of beet root extract of beet root extract or silymarin + CsA ameliorated liver enzyme and MDA changes and histopathological liver changes induced by CsA, Protective effect was attributed to decreased oxidative stress, inflammation, DNA damage, apoptosis and repairing of histopathological changes. (52)
• Sugar Beet as New Natural Emulsifier: Study evaluated the interfacial and emulsion-forming properties of sugar beet extract (Beta vulgaris L) and compared to a Quillaja extract that is widely used within the food industry. The sugar beet extract showed high surface activity. The formation of small emulsion droplets was successful; however, the droplets were bigger than those from the Quillaja extract. Results indicate sugar beet is an effective natural emulsifier and may be utilized for a variety of food and beverage applications. (53)
• Protection from Radiation Damage / Acceleration of Hematopoiesis / Beetroot : Study evaluated the radioprotective effects of beetroot in hematopoietic stem cells (HSCs) and progenitor cells in C47BL/6 mice. Beetroot extract was administered at day 10 after gamma-irradiation. Beetroot not only stimulated cell proliferation, but also minimized DNA damage of splenocytes. Beetroot also repopulated S-phase cells and increased Ki-67 or c-Kit positive cells in bone marrow. Results suggest beetroot has the potency to preserve bone marrow integrity and stimulate the differentiation of HSCs against ionizing radiation. (54)
• Antihyperglycemic Mechanisms: Study evaluated the possible mechanisms of antihyperglycemic activity pf an aqueous fraction of B. vulgaris extract. Results clearly proved the role of acetylcholine and GLP-1 on the insulin secreting activity of B. vulgaris. Increased glucose uptake in the skeletal muscle and subsequent glycogen synthesis may also play a part in the anti-hyperglycemic activity of B. vulgaris. (55)
• Toxicity Study: Study evaluated the safety of beetroot as a health promoting and disease preventing functional food. Freeze-dried beetroot was extracted with water. Doses of 10-1000 mg/kbw and 1600-5000 mg/kbw were administered orally as a single dose. Doses of 200-3000 mg/kbw for 28 days were administered orally. There was a significant decrease in serum blood glucose levels at 500 and 1000 mg/kbw of extract. Platelets and lymphocytes were significantly (p<0.05) decreased. at lower doses, while WBC, monocyte and granulocytes dose-dependently increased. LD50 was greater than 5000 mg/kg body weight. Results suggest extract consumption is safe, and possesses hypoglycemic properties. (56)
• Neuroprotective in Parkinson's Disease: Study evaluated the neuroprotective role of Beta vulgaris in Parkinson's disease (PD). PD was induced by reserpine i.p. for 5 consecutive days. Symptoms of PD such as tremors, akinesia, rigidity, catalepsy and vacuous chewing movements were evaluated. Combination of L-dopa and carbidopa were used as standard. Pretreatment with MEBV (200 and 400 mg/kg) significantly reduced the intensity of muscular rigidity, duration of catalepsy, akinesia and number of tremors, vacuous chewing movements, and increased fighting behavior. Results indicated a protective role against PD, which may be due to augmentation of cellular antioxidants. (57)
• Hepatoprotective / Lipopolysaccharide and Alcohol Induced Toxicity: Study evaluated the protective effects of beetroot in LPS and alcohol induced liver damage. Beta vulgaris showed good antioxidant activity in contents of polyphenol and flavonoid compounds, and electron-donating ability and ABTS radical scavenging activity. As for anti-inflammatory effect in RAW 264.7 cells, inhibition rate of NO production was increased in a dose-dependent manner. In hepatotoxicity induced by LPS and alcohol in rat, the extract significantly decreased AST, ALT, and GGTP concentrations in a dose dependent manner. (59)
• Copper Oxide Nanoparticles / Antibacterial / Anticancer: Study reports on the green synthesis of copper oxide nanoparticles using an aqueous extract of B. vulgaris. The CuONPs induced apoptosis in A549 cell line with IC50 of 25µg/mL. There was also cell cycle arrest in G2/M phase in A549 cells, The NP showed antibacterial activity against tested pathogens. (60)



Updated May 2021 / April 2017 / November 2014

Photo © Godofredo Stuart / StuartXchange
IMAGE SOURCE / Beta maritima / Walter Hood Fitch / Illustrations of the British Flora (1924) / GFDL by Kurt Stueber. Source: www.biolib.de / alterVISTA

Additional Sources and Suggested Readings
Hepatoprotective activity of Beta vulgaris against CCl4-induced hepatic injury in rats / M Agarwal et al / Fitoterapia, Feb 2006; Volume 77, Issue 2: pp 91-93 / doi:10.1016/j.fitote.2005.11.004
Effects of chard (Beta vulgaris L. var. cicla) extract on pancreatic B cells in streptozotocin-diabetic rats: a morphological and biochemical study / S Bolkent, R Yanarda et al / Journal of Ethnopharmacology,
Volume 73, Issues 1-2, November 2000, Pages 251-259 / doi:10.1016/S0378-8741(00)00328-7

Dietary supplementation with leaf extract of Beta vulgaris L. var. benghalensis Hort. in modifying cytotoxicity of lead subacetate in mouse in vivo / Phalguni Nandi et al / Phytotherapy Research, Vol 11 Issue 4, Pages 273 - 276 / DOI 10.1002/(SICI)1099-1573(199706)11:4<273::AID-PTR73>3.0.CO;2-5
Duodenum protecting effects of table beet (Beta vulgaris L. ssp. esculenta var. rubra) during hepatic ischaemia-reperfusion / L Vali et al / Acta Alimentaria, Vol 35, Number 4/December 2006 / DOI 10.1556/AAlim.35.2006.4.8
Anti-Inflammatory Activity of Aqueous Extract of Beta Vulgaris L. / Swati Jain, Vipin Kumar Garg and Pramod Kumar Sharma / Journal of Basic and Clinical Pharmacy
Beta vulgaris L. (accepted name) / Chinese names / Catalogue of Life, China
Beta vulgaris (Beet) / Common names / Zipcodezoo
Cytotoxic effect of the red beetroot (Beta vulgaris L.) extract compared to doxorubicin (Adriamycin) in the human prostate (PC-3) and breast (MCF-7) cancer cell lines. / Kapadia GJ, Azuine MA, Rao GS, Arai T, Iida A, Tokuda H. / Anticancer Agents Med Chem. 2011 Mar; 11(3): pp 280-284 / DOI: 10.2174/187152011795347504
Peroxidase production from hairy root cultures of red beet (Beta vulgaris) / Thimmaraju Rudrappa and Bhagyalakshmi Neelwarne* / Electronic Journal of Biotechnology ISSN: 0717-3458 Vol. 8 No. 2, Issue of August 15, 2005
Phenolics and Betacyanins in Red Beetroot (Beta vulgaris) Root: Distribution and Effect of Cold Storage on the Content of Total Phenolics and Three Individual Compounds / Tytti S. Kujala ,* Jyrki M. Loponen , Karel D. Klika , and Kalevi Pihlaja / J. Agric. Food Chem., 2000, 48 (11), pp 5338–5342 / DOI: 10.1021/jf000523q
Preparation and characterization of Beta vulgaris pulp powder as a pharmaceutical excipient / Pharmacognosy Journal, 2010; 2(11):395–399
Influence of Beta Vulgaris Supplementation on the Level of Oxidative DNA Damage/Oxidative Stress in Head and Neck Cancer Patients Undergoing Radiotherapy / Krzysztof Roszkowski* / J Nucl Med Radiat Ther 2012, 3:4 / http://dx.doi.org/10.4172/2155-9619.100013
ANTIOXIDANT AND ANTI-INFLAMMATORY ACTIVITY OF ETHANOLIC EXTRACT OF BETA VULGARIS LINN. ROOTS / Rita Chakole, Shubhangi Zade, Manoj Charde / International Journal of Biomedical and Advance Research, Vol 2, No 4 (2011)
Effects of chard (Beta vulgaris L. var cicla) on the liver of the diabetic rats: a morphological and biochemical study. / Ozsoy-Sacan O1, Karabulut-Bulan O, Bolkent S, Yanardag R, Ozgey Y. / Biosci Biotechnol Biochem. 2004 Aug;68(8): pp 1640-1648 / DOI: 10.1271/bbb.68.1640 / PMID: 15322346
Evaluation of beetroot (Beta vulgaris L.) leaves during its developmental stages: a chemical composition study / Polyana Batoqui França BiondoI; Joana Schuelter BoeingI; Érica Oliveira BarizãoI; Nilson Evelazio de SouzaII; Makoto MatsushitaI; Claudio Celestino de OliveiraI; Marcela BoroskiI,III; Jesuí Vergílio VisentainerI* / Food Sci. Technol (Campinas) vol.34 no.1 Campinas Jan./Mar. 2014 Epub Mar 11, 2014 / http://dx.doi.org/10.1590/S0101-20612014005000007
Effect of Beta vulgaris extract on triglyceride and cholesterol in diabetic male rats / M Khalili; MR Vaez Mahdavi / Iranian Journal of Pharmaceutical Research (2004): Supplement 2: 55-55
Beta vulgaris / Synonyms / The Plant List
The Potential Benefits of Red Beetroot Supplementation in Health and Disease / Tom Clifford, Glyn Howatson, Daniel J. West, and Emma J. Stevenson* / Nutrients. 2015 Apr; 7(4): 2801–2822. / doi: 10.3390/nu7042801
Beetroot (Beta vulgaris L.) Extract Ameliorates Gentamicin-Induced Nephrotoxicity Associated Oxidative Stress, Inflammation, and Apoptosis in Rodent Model / Ali A. El Gamal, Mansour S. AlSaid, Mohammad Raish, Mohammed Al-Sohaibani, Shaza M. Al-Massarani, Ajaz Ahmad, Mohamed Hefnawy, Mohammed Al-Yahya, Omer A. Basoudan, and Syed Rafatullah / Mediators of Inflammation, Volume 2014 (2014) /
Evaluation of beetroot (Beta vulgaris L.) leaves during its developmental stages: a chemical composition study / Polyana Batoqui França Biondo; Joana Schuelter Boeing; Érica Oliveira Barizão; Nilson Evelazio de Souza; Makoto Matsushita; Claudio Celestino de Oliveira; Marcela Boroski; Jesuí Vergílio Visentainer* / Food Sci. Technol (Campinas) vol.34 no.1 Campinas Jan./Mar. 2014 Epub Mar 11, 2014 / http://dx.doi.org/10.1590/S0101-20612014005000007
Use of Beta vulgaris as natural coloring agent for foods and cosmetics in Libya / Marwa M. Dlim , Sami G. Alsabri , Sofian S. Mohamed , Abdulmottaleb E. Zetrini / Journal of Chemical and Pharmaceutical Research, 2013, 5(11): pp 340-345 / ISSN: 0975-7384
ANTIMICROBIAL ACTIVITY OF ETHANOLIC ROOT EXTRACT OF BETA VULGARIS / Krishnaraj R*, Murugan R, Premlal KR / Journal of Science, Vol 6, Issue 1, 2016, pp 39-40
Effects of Chard (Beta vulgaris L. var. cicla) Extract on Oxidative Injury in the Aorta and Heart of Streptozotocin-Diabetic Rats / G. Sener, Ö. Saçan, R. Yanardağ, and G. Ayanoğlu-Dülger. / Journal of Medicinal Food. July 2004, 5(1): pp 37-42. / doi:10.1089/109662002753723205.
Prevention of High Blood Pressure by the Beeta Vulgaris Root Solution and Allium Sativum Bulbs Solution by the Survey Study / Lavanya Rentikota / Health Science Journal
Beta vulgaris / Wikipedia
The antioxidant activity of Beta vulgaris leaf extract in improving scopolamine-induced spatial memory disorders in rats / Shadieh Hajihosseini, Mahbubeh Setorki, Zahra Hooshmandi / Vicenna Journal of Phytomedicine, Sept-Oct 2017; 7(5): pp 417-425 / PMID: 29062803
Effect of Beta vulgaris Extract on Liver Enzymes in Patients with Non-Alcoholic Fatty Liver Disease: A Randomized Clinical Trial / Nikta Afzali, Seyed Shayan Ebadi, Hasan Afzali, Habibollah Rhamini et al / Hepatitis MonthlyL International Monthly Journal in the Field of Hepatology
Antibacterial activity: Amarathus graecizans; Beta vulgaris; Polyconum patulum; Rumex obtusifolius: Ethanolic extract / Haniyeh Koochak, Seyyed Mansour Seyyednejad, Hussein Motamedi / Asian Paciific Journal of Tropical Medicine, March 2010; 3(3): pp 180-184 / DOI: https://doi.org/10.1016/S1995-7645(10)60004-1
Studies on evaluation of physical and chemical composition of beetroot (Beta vulgaris L.) / Kale RG, Sawate A R, Kshirsagar R B, Patil B M, and Mane R P / International Journal of Chemical Studies, 2018; 6(2): pp 2977-2979 / pISSN: 2349-8528 eISSN: 2321-4902
Phytochemical study of the Iraqi Beta vulgaris leaves and itw clinical applications for the treatment of different dermatological diseases / Nidhal K Maraie, Thukaa Z Abdul-Jalil, Anas T Alhamdany, and Hassan A Janabi / World Journal of Pharmacy and Pharmaceutical Sciences, 2014; 3(8): pp 5-19 / ISSN: 2278-4357
Chemical Composition and Biological Studies of the Essential Oil from Aerial Parts of Beta vulgaris subsp. maritima (L.) Arcang. Growing in Tunisia / Afifa Zardi-Bergaoui et al / Chemistry & Biodiversity, Oct 2017; 14(10): e1700234 / DOI: https://doi.org/10.1002/cbdv.201700234
Improvement of hypertension, endothelial function and systemic inflammation following short-term supplementation with red beet (Beta vulgaris L.) juice: a randomized crossover pilot study / S Asgaru, M R Afshani, N Sarrafzadegan et al / Journal of Human Hyperytension, 2016; 30: pp 627-632 /
DOI: https://doi.org/10.1038/jhh.2016.34
Antioxidant and antiacetylcholinesterase activities of chard (Beta vulgaris L. var. cicla) / Ozlem Sacan, Refiye Yanardag / Food and Chemical Toxicology, May 2010; 48(5): pp 1275-1280 /
DOI: https://doi.org/10.1016/j.fct.2010.02.022
Evaluation of pigments from methanol extract of Tagetes erecta and Beta vulgaris as antioxidant and antibacterial agent / Mariya Sanni, Reena Lawrence, and Kapil Lawrence / Natural Products Research, 2018; 32(10) / DOI: https://doiorg/10.1080/14786419.2017.1326037
Antitumor and Antiviral Activity of Columbian Medicinal Plant Extracts / L A Betancur-Galvis, J Saez, H Granados, A Salazar, J E Ossa / Memorias do Instituto Oswaldo Cruz, July 1999; 94(4): pp 531-535 /
DOI: https://doi.org/10..1590/S0074-02761999000400019
Effect of red beetroot (Beta vulgaris L.) intake on the level of some hematological tests in a group of female volunteers / Nora M Al-aboud / ISABB Journal of Food and Agriculture Science, Feb 2018; 8(2): pp 10-17 / ISSN: 1937-3244 / DOI: 10.5897/ISABB-JFAS2017.0070
Effect of Beta vulgaris L. on cholesterol rich diet0induced hypercholesterolemia in rats / Mohammed Al-Dosari, Saleh Alqasoumi, Majid Ahmad, Mohammed Al-Yahya, M Nazam Ansari =, Syed Rafatullah / Farmacia, 2011; 59(5) pp 559-679
Biochemical and molecular studies on the possible influence of the Brassica oleracea and Beta vulgaris extracts to mitigate the effect of food preservatives and food chemical coloorants on albino rats / Mohammed A A Sarhan, Ali A Shati. fahmy G Elsaid / Saudi Journal of Biological Sciences, Sept 2014; 21(4): pp 342-354 / DOI: https://doi.org/10.1016/j.sjbs.2013.11.004
Medicinal Foodstuffs. III. Sugar Beet (1): Hypoglycemic Oleanolic Acid Oligoglycosides, Betavulgarosides I, II, III, and IV from the Roots of Beta vulgaris (Chenopodiaceae) / Masuki Yoshikawa, Toshiyuki Murakami, Nobutoshi Murakami et al / Chemical and Pharmaceutical Bulletin. 1966; 44(6): pp 1212-1217 /
DOI: https://doi.org/10.1248/cpb.44.1212
Study of medicinal plants in Aravali regions of Rajasthan for treatment of kidney stoone and urinary tract troubles / Neha Sharma, Babeet Singh Tanwer and Rekha Vijayvergia / International Journal of PharmTech Research, Jan-Mar 2011; 3(1): pp 110-113 / ISSN: 0974-4304
Nutritional and functional potential of Beta vulgars cicla and rubra / Paolino Ninfali, Donato Angelino et al / Fitoterapia, Sept 2013; Col 89: pp 188-199 / DOI: https://doi.org/10.1016/j.fitote.2013.06.004
Effect of Beta vulgaris Linn. Leaves Extract on Anxiety- and Depressive-like Behavior and Odixative Stress in Mice After Acute Restraint Stress / Kunjbihari Sulakhiya, Vikas Kumar Patel, Rahul Saxena, Jagrati Dashore, Amit Kumar Srivastava and Manoj Rathore / Pharmacognosy Research, Jan-Mar 2016; 8(1): pp 1-7 / PMID: 26941529 / DOI: https://doi.org/10.4103/0974-8490.171100
Ameliorative Effect of Beta vulgaris Root Extract on Chlorpyrifos-Induced Oxidative Stress, Infammation and Liver Injury in Rats / Gadah Albasher, Rafa Ameer, Ayman M Mahmoud et / Biomolecules, 9(7) /
DOI: 10.3390/biom9070261
Triterpene Saponin Content in the Roots of Red Beet (Beta vulgaris L.) Cultivars / Agnieszka Meoxzek, Ireneusz Kapusta, Bogdan Janda,, Wirginia Janiszowska / Journal of Agricultural and Food Chemistry, 2012; 60(50): pp 12397-12402
Kinetic Properties of Peroxidase Enzymes from Chard (Beta vulgaris Subspecies cicla) Leaves / Ercan Bursal / International Journal of Food Properties, 2014; 16(6) /
DOI: https://doi.org/10.1080/10942912.2011.585729
Synergistic protective effect of Beta vulgaris with meso-2,3-dimercaptosuccinic acid against lead-induced neurotoxicity inn male rats / Nadia Z Shaban, Sara E Abd E;-Lader, Noha H Habashy et al / Scientific Reports, 2021; 11, Art No: 252 / DOI: https://doi.org/10.1038/s41598-020-80669-4
Prophylactic Impact of Beta vulgaris L in Ameliorating Cyclosporine A-Induced Hepatotoxicity in Rats / Wafa I Albalawi, Nadin A Abdul Majid, Iman A Sharaf / International Journal of Pharmaceutical Research & Alied Sciences, 2019; 8(2): pp 22-34 / ISSN: 2277-3657
Sugar Beet Extract (Beta vulgaris L.) as a New Natural Emulsifier: Emulsion Formulation / Theo Ralla, Hanna Salminen, Jochen Weiss et al / Journal of Agricultural and Food Chemistry, 2017; 65(20): pp 4153-4160 DOI: https://doi.org/10.1021/acs.jafc.7b00441
Beetroot (Beta vulgaris) rescues mice from y-ray irradiation by accelerating hematopoiesis and curtainling immunosuppression / Jinhee Cho, So Jin Biing, Areum Kim, Nam Ho Lee, Sang-Hee Byeon / Pharmaceutical Biology, 2017l 55(1) / DOI: https://doi.org/10.1080/13880209.2016.1237976
Aqueous Fraction of Beta vulgaris Ameliorates Hypoglycemia in Diabetic mice due to Enhanced Glucose Stimulated Insulin Secretion, Mediated by Acetylcholine and GLP-1, and Elevated Glucose Uptake via Increased Membrane Bound GLUT4 Transporters / Ashraf Ul Kabiir, Mehdi Bin Samad, J M A Hannan et
al / PLOS ONE, Feb 2015 / DOI: https://doi.org/10.1371/journal.pone.0116546
Toxicity Study of Beetroot (Beeta vulgaris) Extract in Normal Sprague Dawley Rats / Fidelis E Olumese, Henrietta A Oboh / NISEB Journal, 2017; 17(3)
Neuroprotective potential of Beta vulgaris L. in Parkinson's disease / Vandana S Nade, Laxman A Kawale, Shankar S Zambre, Amit B Kapure / IIndian Journal of Pharmacology, Jul-Aug 2015; 47(4): pp 403-408 / PMID: 26288473 / DOI: 10.4103/0253-7613.161263
The Ethanolic Extract of Beetroot (Beta vulgaris) Ameliorates Some Red Cell Parameters in Phenylhydrazine-Induced Anaemic Rats / Favour, Nyoh Beshel, Justin Atiang Beshel and Ekamma Edet Ante / IOSR Journal of Nursing and Health Science, Jul-Aug 2018; 7(4) Ver X: pp 27-30 /
DOI: 10.9790/1959-0704102730
Beet root (Beta vulgaris) protects lipopolysaccharide and alcohol-induced liver damage in rat / Bae-Hwan Kim, Se-Hoon Jung, Suryun Jung / Toxicological Research, 2020; 36: pp 275-282 /
DOI: https://doi.org/10.1007/s43188-019-00030-4
Phytosynthesis and Characterization of Copper Oxide Nanoparticles using the Aqueous Extract of Beta vulgaris L. and Evaluation of their Antibacterial and Anticancer Activities / Rajkuberan Chandrasekaran, Sangilimuthu Alagar Yadav and Sivaramakrishnan Sivaperumal / Journal of Cluster Science, 2020; 31: pp 221-230 / DOI: https://doi.org/10.1007/s10876-019-01640-6

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