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Family Acanthaceae
Acanthus ilicifolius L.
Lao shu le

Scientific names  Common names
Acanthus doloariu Blanco  Daguari (Tag.) 
Acanthus ilicifolius L. Daluari (Tag.)
Acanthus ilicifolius subsp. orientalis Bremek. Diliwario (Tag.)
Acanthus ilicifolius subsp. subinteger Nees Diluariu (Tag.)
Acanthus neoguineensis Engl. Doloariu (Tag.)
Dilivaria ilicifolia Nees Duduaria (Tag.)
  Dulauari (Pamp.)  
  Duluarin (Tag.)  
  Duluariu (Tag.) 
  Galura (Tag)  
  Kasumba (Ilk.) 
  Lagiu-lagiu (Tag.) 
  Lagiuriu (P. Bis.)
  Laguiriu (P. Bis.)
  Santing (Sul.)
  Takis-lakis (Tag.)
  Tindoi (Tag.)
  Tinlui (Tag.)
  Tinglui (Tag.)
  Tinglog (Tag.)
  Titio (Bis.)
  Sea holly (Engl.)
  Holly-leaved Acanthus (Engl.)
Diluariu is a common name shared by: (1) Diluario, Acanthus ilicifolius, and (2) Kachumba, Argemone mexicana
Acanthus ilicifolius L. is an accepted name. The Plant List

Other vernacular names
CHINESE: Lao shu le.
GERMAN: Stechpalmenblättrige Bärenklau.
INDIA: Karimkurunji, Krishnasaireyaka.
JAPANESE: Akansasu irikiforiusu.
TURKISH: Çobanpüskülü yaprakli ayi pençesi.

Diluariu is an erect or ascending, slightly branched, smooth shrub, 0.5 to 1.5 meters high. Stems are cylindrical and greenish, with a pair of short, sharp spines at the base of each petiole. Leaves are rigid, coriaceous, green and shining, oblong to oblong-lanceolate, 9 to 14 centimeters long, sinuate-toothed in the margins with spinous teeth. Leaf stalks are 1 centimeter long or less. Flowers are about 4 centimeters long, each subtended by an ovate, green, closely appressed bracts 7 to 8 millimeters long, and by two similar but smaller bracteoles, borne in terminal, solitary, dense, or interrupted spikes. Calyx is green, 10 to 12 millimeters long. Corolla tube is 1 centimeter long, the lower lip, pale-blue, spreading or recurved, about 3 centimeters long, 2.5 cm wide, and pubescent within. Capsule is brown, shining, and 2 to 2.5 centimeters long. Seeds are 6 to 10 millimeters long, with white testa.

- In low wet lands near the sea, subject to the influence of salt water, throughout the Philippines along tidal streams, swamps, mangrove, etc.

- Also occurs in tropical Asia, from South India to Sri Lanka to Indo-China, Indonesia and northern Australia.

• Powdered leaves yield soft resins and a fatty matters colored with chlorophyll.
• Yields a bitter alkaloid which assumes a reddish-brown color with sulphuric acid
• Study yielded: acancifoliuside, a new coumaric acid derivative, acancifoliuside, and six known compounds: acteoside, isoacteoside, acanthaminoside, (+)-lyoniresinol 3a-O-ß-glucopyranoside, (-)-lyoniresino, and a-amyrin.
• Study of aerial parts yielded two lignan glucosides, (+)-lyoniresinol 3a-[2-(3,5-dimethoxy-4-hydroxy)-benzoyl]-O- -glucopyranoside, and dihydroxymethyl-bis(3,5-dimethoxy-4-hydroxyphenyl) tetrahydrofuran-9(or 90)-O--glucopyranoside have been isolated, together with eight known compounds. (25)
• Study isolated a new compound, 5,11-epoxymegastigmane glucoside, along with one known compound, megastigmane glucosides, (6S, 9S)-roseoside.
• Study yielded five compounds: luteolin 7-O-beta-D-glucuronide, apigenin-7-O-beta-D-glucuronide, methylapigenin-7-O-beta-D-glucuronate, uridine, and uracil.
- Phytochemical screening of leaves yielded flavanoids, phenols, terpenoids, and glycosides, with absence of saponin, alkaloids, steroids, tannins and reducing sugar. (29ee
- Study of aerial parts yielded two benzoxazinoid glucosides, 7-chloro-(2R)-2-O-ß-D-glucopyranosyl-2H-1,4-benzoxazin-3(4H)-one and (2R)-2-O-ß-D-glucopyranosyl-5-hydroxy-2H-1,4-benzoxazin-3(4H), together with six known compounds.
- Study yielded six organic compounds consisting of three lignins and three indole alkaloids, with structures identified as: (+)-lyoniresinol 3α-O-β-D-glucopyranoside (1), (-)-lyoniresinol 3α-O-β-D-glucopyranoside (2), (+)-lyoniresinol (3), 1H-Indole-3-carboxylic acid (4), 1H-Indole-3-carboxaldehyde (5), 1H-Indole-3-acetic acid (6). (38)

• Cooling, mildly salt-tasting.
• Antiphlogistic, anticontusion, expectorant.
• Galactagogue, expectorant, carminative.

• Leaves considered emollient.
• Root is expectorant.
• Astringent; makes a good nervine tonic and stimulant.

• In Siam and Indo-China, roots considered cordial and attenuant.
- Studies have suggest antibacterial, antifungal, antioxidant, hepatoprotective, gastroprotective, anticanca, chemopreventive, anthelmintic, anti-inflammatory, anti-osteoporotic, antinociceptive properties.

Parts utilized
· Roots, bark, leaves.

- Decoction of 30-60 g of dried material used for acute and chronic hepatitis, swelling-enlargement of the liver and spleen, swelling and enlargement of the lymph nodes, gastralgia, asthma.
- Decoction of roots and leaves used for asthma; also, to aid expectoration.
- Root boiled in milk used for leucorrhea and general debility.
- Used for gastrointestinal pains.
- Leaves are high in mucilage and used as emollient fomentation in rheumatism.
- Young leaves used as an antidote for snake venom.
- In India, popularly used for its wound healing effects; tender shoots and leaves used for snake bites.
- In Malaysia, leaves used for rheumatism, neuralgia, and poison arrow wounds.
- In Thailand, decoction of whole plant used for kidney stones.
- In Goa, mucilaginous leaves used as emollient in rheumatism and neuralgia.
- Ground fresh bark is used as antiseptic.
- Decoction of leaves for pain and as blood purifier.
- In Ayurvedic medicine, it is one of 9 plants in the drug 'Sahachara,' used for rheumatic complaints.
- Plant decoction with sugar candy and cumin used for dyspepsia with acid eructations. Also used as diuretic and cure for dropsy and bilious swellings. Leaves used for snake bites, and roots used for asthma and as expectorant. Plant boiled in milk used for leucorrhea and general debility. (20)
- In Siam and Indo-China, roots used for paralysis and asthma.
- Soap: Plant is used in the manufacture of soap; the lye prepared from the ash.

Anti-Hepatic Cancer / Leaves: Study showed the aqueous leaf extract prevented hepatic DNA alterations and chromosomal damage in tumor-bearing mice. and lengthened survival. It suggests A. ilicifolius may be a potential chemoprotector against hepatic neoplasia.
Anticarcinogenic / Tumour Reducing: The study found AI extract to be effective against tumor progression and carcinogen induced skin papilloma in mice. There was reduction of tumor volume and significant delay in the onset of DMBA/Croton oil-induced skin papilloma in mice in a dose-dependent manner. (3)
Antioxidant and hepatoprotective effect of Acanthus ilicifolius: An alcoholic extract of AI inhibited the formation of oxygen derived free radicals in vitro and reduced induced hepatotoxicity in rats. The results were comparable with those obtained with curcumin. (4)
Anti-osteoporotic: Chemical constituents of Acanthus ilicifolius L. and effect on osteoblastic MC3T3E1 cells: The study yielded a new coumaric acid derivative, acancifoliuside and six other known compounds. Tested on osteoblastic cells, it concludes that A. ilicifolius may help prevent osteoporosis. (5)
Anti-Inflammatory / Free Radical Scavenging Activity: In a study to evaluate its anti-inflammatory activity, the methanolic fraction of A ilicifolius leaf extract produced significant inhibition of rat paw edema, similar to a COX and LOX inhibitor. It also produced significant inhibition of COX 1and 2 and 5-LOX activity. It also showed significant free radical scavenging activity. (6)
Antimicrobial / Leaves: Study showed the alcoholic and chloroform extract of leaves of A ilicifolius exhibited strong inhibitory action against B subtilis, S aureus, C albicans, A fumigatus and Aspergillus niger and moderate inhibitory action against P aeruginosa and P vulgaris. (7)
Antimicrobial / Leaf, Stem and Roots: Study evaluated the antimicrobial activity of ethanol, methanol, and aqueous extracts of leaf, stem, and roots of A. ilicifolius. The most active antimicrobial parts were aqueous root, ethanol stem, and methanol leaf. The ethanol extract effect was significantly higher than that produced by methanol and aqueous extracts.
Antiulcerogenic Activity: Study evaluated the antiulcerogenic activity of a water extract of Acanthus ilicifolius in different models of acute gastric ulcers in rats. Results showed pretreatment with a leaf extract (both hot water and cold water) caused a beneficial effect on NSAID-induced gastric ulcer in rats. (10)
Chemopreventive / Ehrlich Ascites Carcinoma: Study showed treatment of EAC-bearing mice with an aqueous leaf extract resulted in restoration of hematological and hepatic histological profiles and lengthening of survival of animals against the proliferation of ascites tumor in vivo. (11)
Chemopreventive Activity Against Hepatocellular Carcinoma: Study analyzed the active components of a leaf extract of A. ilicifolius. Five natural steroid compounds were compared against a synthetic drug Sorafenib and Doxorubicin on various target proteins of liver cancer. (14)
Antioxidant / Free Radical Scavenging Effect: Study confirmed the antioxidative and radical scavenging activity of an A. ilicifolius extract. (15)
Antioxidant / Cytotoxicity / Anticancer / Flowers: Flowers yielded terpenoid, phenolic compounds, and alkaloid. A methanol extract exhibited the highest antiradical efficiency against DPPH radicals and highest cytotoxicity against shrimp brine Artemia salina nauplii. Results present a potential candidate for cancer therapy. (16)
Antinociceptive: A methanolic extract of Ai leaves was tested for antinociceptive activity using acetic acid-induced writhing, formalin and hot plate testing. Results showed a significant and dose-dependent antinociceptive activity in all three models. (17)
Gastroprotective / Anti-Ulcer: Study evaluated the gastroprotective activity of a methanolic extract of A. ilicifolius using different models of gastric ulceration. In pylorus-ligated rats, the methanolic extract of leaves significantly reduced gastric volume, acidity, and peptic activity. Pretreatment significantly restored the levels of reduced glutathione (GSH) and SOD, CAT, and GPX, along with inhibition of both lipid peroxidation and myeloperoxidase activity. Results suggest the extract of leaves may possess anti-ulcer activities in addition to anti-inflammatory properties. (19)
Anti-Leishmanial / Anti-Ulcer: 2-Benzoxazolinone (BOA) isolated from the leaves showed in vitro anti-leishmanial activity against Leishmania donovani. The LC50 for BOA was 40 µg/ml and compared well with pentamidine. (20)
Anti-Diabetic / Roots: Study evaluated an ethanolic extract of roots in alloxan-induced albino Wistar rat models. Dosage of 200 and 400 mg/kg of extract significantly reduced blood glucose levels. Histopath studies showed better regeneration of ß-cells at both doses. Phytochemical analysis of roots showed the presence of flavonoids, alkaloids, terpenoids, tannins, and steroids. (21)
Hepatoprotective / Hepatitis B / Roots: Study evaluated the effect of alcohol extract on duck hepatitis B. Results showed an obvious protective effect on liver function and liver tissue. However, A. ilicifolius cannot inhibit the replication of duck hepatitis B virus. (22)
Anticarcinogen Against Hydrocortisone-Induced Genotoxicity: Study evaluated the anti-genotoxic effect of A. ilicifolius against hydrocortisone-induced genotoxicity. The extract significantly reduced the frequencies of chromosomal aberration, sister chromatid exchanges and enhancement of replication index in vitro. Results showed the Acanthus extract is highly effective in cancer prevention and quench free oxygen radicals. (23)
Diuretic Activity: Study evaluated an ethanolic extract for diuretic activity. Results showed a significant increase in urine volume (P<0.01), with increase in urine electrolyte excretion of sodium and potassium. (24)
Antiallergic / Anthelmintic / Cytotoxic / Acute Toxicity Evaluation /Aerial Parts: Study evaluated ethanolic extract of aerial parts for antiallergic, antihelmintic, and cytotoxicity activities in mice. Phytochemical screening yielded the presence of alkaloids, phenolic compounds tannins, flavonoids, glycosides, saponins, steroids, and tritrpenoids. Pretreatment with extract significantly ameliorated the TDI-induced allergic symptoms like sneezing (p<0.05), scratching (p<0.05), swelling and watery rhinorrhea. The extract caused dose dependent decrease in relative index of paralysis and death of H. contortus and P. cervi parasites. In brine shrimp lethality bioassay, the extract showed an LC50 of 44.57 µg/mL indicating promising cytotoxicity, with standard drug vincristine sulfate showing LC50 of 0.43 µg/mL. Acute toxicity testing showed no mortality in Swiss albino mice at highest dose of 3 g/kg. (27)
Antimicrobial / iNOS Inhibitory Activity of Endophytic Fungi: Study showed endophytic fungi associated with A. ilicifolius var. xiamenensis can be a potential source of novel natural active substance. Extracts of 28 isolates were found to have bioactivities against one of the following microorganisms: bacteria B. subtilis, S. aureus, and E. coli and fungi C. albicans and C. neoformans. An anti-inflammatory study of culture extracts of the isolates showed a high iNOS inhibition and low viability of cells. (28)
Thrombolytic / Anti-Inflammatory / Leaves: Comparative study eComparative study confirmed the thrombolytic and anti-inflammatory activities of methanol leaf extracts of Blumea lacera and Acanthus ilicifolium. Acanthus ilicifolius showed 38.25% clot lysis compared to 4.6% water as negative control and 69.34% streptokinase as positive control. Inhibition of protein denaturation of ME of A. ilicifolius was significant at 45.27% with acetyl salicylic acid as standard. (30)
Silver Nanoparticles / Antimicrobial: Study reports on the green biosynthesis of silver nanoparticles using an aqueous solution of A. ilicifolius as reduction material. The AgNPs showed strong antibacterial activity against selected bacteria i.e. S. aureus, B. cereus, E. coli, and P. aeruginosa. (31)
Antibacterial / Benzoate and Phenylethanoid Derivatives / Leaves: Study evaluated the antibacterial activities of column chromatography fractions of various extracts against 24 bacterial pathogens. The extracts yielded derivatives 6-hydroxy-benzoxazolinone, (Z)-4-coumaric acid 4-O-ß-D-glucopyranoside and 3,5-dimethoxy-4-hydroxymethyl benzoate. (32)
Hepatoprotective in CCl4-Induced Toxicity / Alkaloid B: Acanthus ilicifolius alkaloid A (4-hydroxy-2[3H]benzoxazolone, HBOA) is a naturally occurring compound separated from Acanthus ilicifolius. This study undertook to synthesis HBOA and two of its derivatives, specifically, 4-acetoxy-2(3H)-benzoxazolone [AcO-BOA) and 3-acetyl-4-acetoxy-2-benzoxazolone (TC-3) and evaluated its hepatoprotective potential. Results showed HBOA and its acyl derivatives were able to significantly alleviate the hepatotoxicity induced by CCl4 in mice. (33)
Anticancer / MCF-7 and PA-1 Cell Lines / Leaves and Roots: Study evaluated the anticancer activity of ethyl acetate leaf and root extracts of A. ilicifolius against MCF-7 and PA-1 cell lines. The ethyl acetate extract showed statistically significant inhibition of MCF-7 and PA-1 cell line, highest at 100 µg/mL (34)
Anthelmintic / Leaves: Study evaluated the anthelmintic activity of various extracts of Acanthus ilicifolius leaves extract against Ascaridia galli and Pheretima posthuma using parameters of time to paralysis and time to death of worms. Ethanol, aqueous and n-hexane extracts of leaves showed anthelmintic activity in a dose-dependent manner. Phytochemical screening of the extracts yielded alkaloids, flavonoids, tannins, saponins, and steroids. (35)
Chemopreventive / Azoxymethane-Induced Aberrant Crypt Foci: Study evaluated the chemopreventive effect of A. ilicifolius extract against AOM-induced colonic aberrant crypt foci (ACF) in rats. Extract treated rats with doses of 250 mg/kg and 500 mg/kg showed a decrease in ACF by 65% and 53%, respectively. There was also a significant decrease in multiplicity of ACF formations compared with control group, along with a significant decrease in lipid peroxidation MDA levels. RT-PCR showed a change in regulation of apoptosis related genes expression. Results also suggest a potential alternative approach for prevention of AOM-induced ACF in rat colon. (37)


Updated January 2020 / April 2014

IMAGE SOURCE: File:Acanthus ilicifolius 001.jpg / Lasia spinosa / Français : Vieux jardin botanique de Göttingen / 17 June 2006 / Valerie 75 / GNU Free Documentation License / Wikipedia
OTHER IMAGE SOURCE: Minor Products of Philippine Forests / Vol 1 / Philippine Mangrove Swamps / William Brown and Arthur Fisher / Plate XXXIX / Acanthus ilicifolius (Diluariu) / 1920
OTHER IMAGE SOURCE: /File:Acanthus ilicifolius Blanco1.153-original.png / Flora de Filipinas / Francisco Manuel Blanco (O.S.A.) / 1880-1883 / Public Domain / Wikimedia Commons

Additional Sources and Suggested Readings
Sea Holly / Acanthus spp.
Indian Medicinal Plant Acanthus Ilicifolius May Combat Liver Cancer / BREAKTHROUGH DIGEST MEDICAL NEWS / January 16, 2008
Tumour reducing and anticarcinogenic activity of Acanthus ilicifolius in mice / doi:10.1016/S0378-8741(01)00347-6 / B H Babu et al / Journal of Ethnopharmacology Vol 79, Issue 1, February 2002, Pages 27-33
Antioxidant and hepatoprotective effect of Acanthus ilicifolius / doi:10.1016/S0367-326X(00)00300-2 / Fitoterapia Vol 72, Issue 3, March 2001, Pages 272-277
Chemical constituents of Acanthus ilicifolius L. and effect on osteoblastic MC3T3E1 cells / Phan Van Kiem et al / Archives Of Pharmacal Research 31(7), 823-829. (2008) / DOI 10.1007/s12272-001-1232-3
Anti-inflammatory activity of Acanthus ilicifolius / K T Mani Senthil Kumar et al / Journal of Ethnopharmacology, Vol 120, Issue 1, 30 October 2008, Pages 7-12 / doi:10.1016/j.jep.2008.07.024
Antimicrobial activity of Acanthus ilicifolius(L.) / Bose S, Bose A. / Indian J Pharm Sci 2008;70: pp 821-823 / DOI: 10.4103/0250-474X.49134

A new 5,11-epoxymegastigmane glucoside from Acanthus ilicifolius / Huo C, Liang H, Tu G, Zhao Y, Lin W./ Nat Prod Res. 2008;22(10):896-900.
Screening for Antimicrobial Activity in Acanthus ilicifolius / S Ganesh, and J Janet Vennila / Archives of Applied Science Research, 2010, 2 (5):311-315
Gastric Ulcer Prevention effect of Acanthus ilicifolius leaves in Albino Rats / T. Ramanathan, P. Thirunavukkarasu, S.Panneerselvam and R.Shanmugapriya / Journal of Pharmacy Research, Vol 4, No 4 (2011)
Acanthus ilicifolius plant extract prevents DNA alterations in a transplantable Ehrlich ascites carcinoma-bearing murine model / Tridib Chakraborty, Dipak Bhuniya, Mary Chatterjee, Mosiur Rahaman, Dipak Singha, Baidya Nath Chatterjee, Subrata Datta, Ajay Rana, Kartick Samanta, Sunil Srivastawa, Sankar K Maitra, Malay Chatterjee / World J Gastroenterol 2007 December 28; 13(48): pp 6538-6548 / doi: 10.3748/wjg.v13.i48.6538
Studies on chemical constituents in herbs of Acanthus ilicifolius / Huo CH, Zhao YY, Liang H, Lin WH. / Zhongguo Zhong Yao Za Zhi. 2005 May;30(10):763-5.
Analysis of active components in Acanthus ilicifolius leaves for their potential chemoprotective activity against hepatocellular carcinoma: An in silico approach / J. Mano Bala, J. Jannet Vennila, S. Ganesh and Sachidanand Singh / Journal of Pharmacy Research 2011,4(6),1809-1812
Antioxidant and Free Radical Scavenging Effect of Acanthus ilicifolius / P. Thirunavukkarasu, T. Ramanathan, R. Shanmugapriya, G. Umamaheswari and G. Renugadevi / Research Journal of Applied Sciences, 2011; Vol 6, No 3: pp 218-222 / DOI: 10.3923/rjasci.2011.218.222
Antioxidant and Cytotoxic Activity of Acanthus ilicifolius Flower / Muhamad Firdaus, Asep Awaludin Prihanto, Rahmi Nurdani / Asian Pac J Trop Biomed. Jan 2013; 3(1): pp 17–21. / doi: 10.1016/S2221-1691(13)60017-9
/ Mohammed Amirul ISLAM, Mohammed SAIFUZZAMAN, Firoj AHMED, Mohammed Mustafizur RAHMAN, Nazneen A. SULTANA, Kamrun NAHER / Turk J. Pharm. Sci., 2012; 9(1): pp 51-60
Sorting Acanthus names / /Maintained by: Michel H. Porcher / MULTILINGUAL MULTISCRIPT PLANT NAME DATABASE / Copyright © 1995 - 2020 / A Work in Progress. School of Agriculture and Food Systems. Faculty of Land & Food Resources. The University of Melbourne. Australia.
The Gastroprotective Role of Acanthus ilicifolius - A Study to Unravel the Underlying Mechanism of Anti-Ulcer Activity / Mani Senthil Kumar KT1, Puia Z, Samanta SK, Barik R, Dutta A, Gorain B, Roy DK, Adhikari D, Karmakar S, Sen T. / Sci Pharm. 2012 September; 80(3): pp 701-717 / doi:10.3797/scipharm.1108-11 
Phytochemical and pharmacological potential of Acanthus ilicifolius / Dharya Singh and Vidhu Aeri / J Pharm Bioallied Sci. 2013 Jan-Mar; 5(1): 17–20. / doi: 10.4103/0975-7406.106557
ANTI-DIABETIC ACTIVITY OF ACANTHUS ILICIFOLIUS ROOT EXTRACT IN ALLOXAN INDUCED DIABETIC RATS / G. Venkataiah*, Mohammed Ishtiaq Ahmed, D. Sudharshan Reddy, Mary Rejeena. / IAJPR. 2013; 3(11): 9007-9012
Effect of extract of Acanthus ilicifolius L on anti-duck hepatitis B virus and protection of liver / Z. C. Xie, P.-H. Wei, X.-M. Mu, S.-Z. Wu, Y. Yang, S.-M. Xu, B. Qin / Topic: Virology and viral infections (Non-HIV), Abstract No: ISE.216
Is Acanthus ilicifolius a Potent Anticarcinogen against Hydrocortisone-Induced Genotoxicity? Study in Human Peripheral Lymphocytes Cultures / Ahmad Md. Sultan*, Sheeba, Rai Kanchan B., Ali Afsar / Advances in Life Sciences, 2012, Volume 1, Issue 1
Evaluation of Phytochemical Properties and Diuretic Activity of Ethanolic Extract of Acanthus ilicifolius linn in Wistar Rats / Mr. Deepak Kumar / Internation Journal of Advances in Pharmaceutical Research, Vol 4, Issue 8, August 2008.
Lignan glucosides from Acanthus ilicifolius / Tripetch Kanchanapoom, Mohamed Salah Kamel, Ryoji Kasai, Kazuo Yamasaki, Chayan Picheansoonthon, Yoshikazu Hiraga / Phytochemistry, 2001; 56: pp 369-372
Acanthus ilicifolius / Synonyms / The Plant List
Antiallergic, anthelmintic and cytotoxic potentials of dried aerial parts of Acanthus ilicifolius L. / Pabitra  Kumar Sardar, Shrabanti Dev, Md. Abdullah Al Bari, Susmita Paul, Mst. Sanzida Yeasmin, Asish Kumar Das, Nripendra Nath Biswas / Clinical Phytoscience, Dec 2018, 4:34
Antimicrobial and iNOS inhibitory activities of the endophytic fungi isolated from the mangrove plant Acanthus ilicifolius var. xiamenensis / Wei-Chiung Chi, Ka-Lai Pang, Weil-Ling Chen et al / Botanical Studies, 2019; 60, Article 4
Preliminary photochemical assessment and HPTLC characterization of leaves of medicinal mangrove Acanthus ilicifolius L. / S Surya, N Hari / International Journal of Pharmaceutical Science and Research, May 2017; Volume 2; Issue 3: pp 07-10
A comparative study of In-vitro Thrombolytic activity and Anti-inflammatory activity of methanolic leaves extract of Blumea lacera (Asteraceae) & Acanthus ilicifolius (Acanthaceae). / Anindya Shuvo / Phytochemical and Pharmacological Research Laboratory, Dept of Pharmacy, University of Science and Technology, Bangladesh
Characterization, Antimicrobial Activity of Silver Nanoparticles Biosynthesized by Acanthus ilicifolius / Noor Muzamil Mohamad, Siti Razila Abdul Razak, Mowaffaq Adam Ahmed, Laina Zarisa Muhd Kamal, Siti Nurfatimah Mohd. Shahpudin, Rosline Sandai, Leslie Thian Lung Than, Saad Sabbar Dahham, Yasser Tabana6 and Doblin Sandai / American Journal of Current & Applied Research in Microbiology, 2019; 1(1): pp 11-15
Antibacterial potential of benzoate and phenylethanoid derivatives isolated from Acanthus ilicifolius L. leaf extracts / S Ravikumar, M Raja, and M Gnanadesigan / Natural Product Research, 2012; 26(23): pp 2270-2273 / https://doi.org/10.1080/14786419.2011.652962
Synthesis and hepatoprotective properties of Acanthus ilicifolius alkaloid A and its derivatives / Lin Liu, Hui Fan, Ping Qi, Yan Mei, Lijuan Zhou, Liping Cai, Xing Lin, Jun Lin / Experimental and Therapeutic Medicine, 2013; pp 796-802 / https://doi.org/10.3892/etm.2013.1189
ANTICANCER ACTIVITY OF ACANTHUS ILLICIFOLIUS Linn. FROM CHETTUVA MANGROVES, KERALA, INDIA / Smitha RB, Madhusoodanan PV and Prakashkumar R / International Journals of Bioassays, 2014; 3(11): pp 3452-3455
In vitro Anthelmintic Activity of Acanthus ilicifolius Leaves Extracts on Ascaridia galli and Pheretima posthuma / Dadang Irfan Husori, Sumardi, Heron Tarigan, Selviani Gemasih, Sri Rahayu Ningsih / Journal of Applied Pharmaceutical Science, Feb 2018; 8(02): pp 164-167 / DOI: 10.7324/JAPS.2018.8224
Benzoxazinoid glucosides from Acanthus ilicifolius / Tripetch Kanchanapoom, Mohamed Salah Kamel, Ryoji Kasai, Chayan Picheansoonthon, Yoshikazu Hiraga, Kazuo Yamasaki / Phytochemistry, 2001; 58: pp 637–640
Evaluation of Chemopreventive Effects of Acanthus ilicifolius against Azoxymethane-Induced Aberrant Crypt Foci in the Rat Colon /  Amel A. Almagrami, Mohammed A. Alshawsh, Riyadh Saif-AliAbdrabuh Shwter, Sameer D. Salem, Mahmood A. Abdulla / PLOS | ONE, 2014
Study on chemical constituents of acanthus ilicifolius linn of mangrove plant from south sea China / Liu Quan, Lin Wen-Han / Journal of Harbin University of Commerce (Natural Sciences Edition), 2008-06

It is not uncommon for links on studies/sources to change. Copying and pasting the information on the search window or using the DOI (if available) will often redirect to the new link page. (Citing and Using a (DOI) Digital Object Identifier)

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