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Family Compositae
Kasubha
Carthamus tinctorius Linn.
SAFFLOWER

Hong hua

Scientific names Common names
Calcitrapa tinctoria Roehl. Biri (Tag.)
Calcitrapa tinctoria Rohl. Kasabha (Bis.)
Carduus tinctorius Ehrh. Kasubha (Tag.)
Carduus tinctorius (L.) Falk Kasumba (Tag.)
Carthamus glaber Burm. f. Kachumba (Pamp.)
Carthamus tinctorius Linn. Lago (Tag.)
Centaurea carthamus E.H.L.Krause Parrot seed (Engl.)
  Dyer's saffron (Engl.)
  Safflower (Engl.)
  Fake saffron (Engl.)
  Bastard saffron (Engl.)
  Wild saffron (Engl.)
Carthamus tinctorius L. is an accepted name. The Plant List

Other vernacular names
ARABIC: Asfur, asfoor, Osfur, Usfar.
CHINESE: Da hong hua.
CROATIAN: Bojadisarski bodalj, Šafranika.
CZECH: Azafrán, Světlice barvířská.
DANISH: Farvetidsel, Safflor..
DUTCH: Carthamusbloem , Saffloer, Saffloer-bloem.
FINNISH: Värisaflori.
FRENCH: Carthame des teinturiers, Fleur de carthame, Graine de carthame, Safran bâtard.
GERMAN: Deutscher saflor, Färberdistel, Färbersaflor, Falscher Safran , Saflor.
GREEK: Knikos
HEBREW: Qurtami, Qurtam, Qurtema, Dardar.
HINDI: Kusum, Kusumba, Kusuma, Hubulkhurtum.
HUNGARIAN: Magyar pirosító, Pórsáfrány, Sáfrányos szeklice, Szaflór, Szeklice.
IRANIAN: Brata, Kafsha, Kafshe, Kosheh, Zafaran-golu, Kouchan gule, Kah'li, Golbar aftab, Kharkhool.
ITALIAN: Cartamo, Falso zafferano.
JAPANESE: Beni bana, Beni hana.
KOREAN: Hong hwa.
PERSIAN: Gulrang.
PORTUGUESE: Açafrão-bastardo, Cártamo, Falso-açafrão.
RUSSIAN: Saflor, Saflor krasil'nyi.
SLOVENIAN: Barvilni rumenik, Barvilni žafran, Žafranika.
SLOVAKIAN: Požlt farbiarska.
SPANISH: Alazor, Alazor bastardo, Azafrán bastardo, Cártamo.
SWEDISH: Färgtistel, Safflor.
TAMIL:Kusumba
TURKISH: Safran yalancı, Yalancı safran.
URDU:Gul rang
VIETNAMESE: Cây rum, Hồng hoa.

Gen info
Safflower is one of the oldest cultivated crops, its use dating back to ancient Egypt.

Botany
Kasubha is an erect, branched, smooth herb, 30 to 90 centimeters high. Leaves are stalkless, half-clasping, lanceolate, 5 to 10 centimeters long, 1 to 2.5 centimeters wide, but smaller toward the top, with margins minutely spiny toothed. Flowering heads are large, surrounded by a cluster of leafy bracts which gradually become the bracts of the involucre, 2.5 to 4 centimeters across. Flowers are orange-red. The achenes, often deformed, are obovoid, usually 4-ribbed and truncate at the top. Pappus is absent or scalelike.

Distribution
- Planted here and there for dyeing purposes.
Nowhere spontaneous.

- Native of Egypt.

Constituents
- Flowers yield a coloring principle, carthamin.
- Seeds contain a fixed oil, 28.7%; proteins, 14.11%; cellulose, 30.6%.

- Flowers yielded eight compounds: palmitic acid, 1-O-hexadecanolenin, trans-3-tridecene-5,7,9,11-tetrayne-1,2-diol, trans-trans-3,11-tridecadiene -5,7,9-triyne -1,2-diol, coumaric acid, daucosterol, apigenin and kaempferol.(16)
-Flower petals have yielded carthamin, safflor yellows A and B, Safflormin A and C, isocarthamin, isocarthamidin, hydroxysafflor yellow A. A water fraction yielded four compounds, viz., 6-hydroxykaempferol 3-O-glucoside (1), 6-hydroxykaempferol 7-O-glucoside (2, a new compound), kaempferol 3-O-rutinoside (3) and quercetin 3-O-glucoside (4). (20)
- Study isolated a new phenylpropanoid derivative, carthamusin A, along with two known compounds ß-daucosterol and stigmasterol. (34)

Properties
- Considered tonic, laxative, diaphoretic, abortifacient.
- Seeds and oil considered purgative and laxative.
- Flowers considered tonic and emmenagogue.

Parts used
Flowers, seeds, oil.

Uses

Culinary
- Dye from flowers used as substitute for saffron, for coloring food. Not valued as a spice.
- Oil from the seeds is a valuable and edible oil.
- In China, young shoots eaten in time of scarcity.
Folkloric
- Hot infusion of dried flowers used as a diaphoretic in jaundice, nasal catarrh and muscular rheumatism.
- Cold infusion used as a laxative and tonic in measles and scarlatina to favor efflorescence of eruptions.
- In Indochina, flowers are given for dysmenorrhea and paralysis, as tonic and emmenagogue.
- In China, plant is used as abortifacient and to expel retained placenta.
- Plant boiled in sesamum oil is used as remedy for itches.
- Medicated oil prepared from the plant used as external application for rheumatism and paralysis.
- Flowers used for hair growth.
- In Punjab, seeds used as diuretic and tonic.
- In
Thailand used as herbal tea to reduce cholesterol and prevent atherosclerosis.
- In Korea, seeds used as folk medicine to enhance bone formation or prevent osteoporosis.
Others
- Dye: Dye is impermanent; colors silk a brilliant scarlet, but is not permanent. Used in the preparation of toilet rouges. for which it is mixed with powdered talc.
- Oil: Oil from the seed used in making soap and candles; also used as lubricant and in candle-making.
- Ice cream pigment:
The addition of carthamidin (0.06 mL) in ice cream scored higher overall acceptability. (26)
- Cosmetics:
Safflower oil, rich in essential omega-6 fatty acid linoleic acid is included in skin care products and bath oils. (31)


Studies
Cardioprotective Against LPS-Induced Apoptosis:
Study showed Carthamus tinctorius possesses the ability to suppress JNK activity and inhibit LPS-induced TNF-a activation and apoptosis in H9c2 cardiomyoblast cells. CT can potentially cardioprotective against LPS-induced apoptosis. (1)
Cardioprotective / Ischemia-Reperfusion Injury: Study showed Carthamus tinctorius extract could protect myocardium damage induced by I/R injury. The mechanism of cardioprotection may be associated with inhibition of apoptosis of myocardium, upregulating protein expression of Bcl-2 gene and downregulated protein expression of Bax gene. (7)
Renoprotective:
Study showed injection of safflor significantly reduced the renal dysfunction and injury caused by I/R (ischemia/reperfusion) of the kidney, effected probably due to inhibition of cell apoptosis and caspase-3 gene expression.

Tracheloside / Anti-Estrogenic Lignan Glycoside: Tracheloside, isolated from the seeds of CT significantly decreased the activity of alkaline phosphatase, an estrogen-inducible marker enzyme, against cultured ishikawa cells, at a level of inhibition comparable to tamoxifen.
Anti-Atherosclerotic / Antioxidant / LDL-Lowering: Study showed serotonin derivatives of extract of safflower seeds attenuate atherosclerotic lesion development possibly through inhibition of oxidized LDL formation through strong antioxidative activity.
Neuroprotective: Study showed HSYA (hydroxysafflor yellow A) dose-dependently improved the neurological deficit scores and reduced the cerebral infarct area in a potency similar to the therapeutic effects of nimodipine on cerebral ischemia.
Antioxidant / Safflor Yellow: Study showed SY is an antioxidatve part of Carthamus tinctorius.
Polyphenols / Lipid Benefits: Study showed safflower polyphenols improved blood lipids by increasing the HDL-cholesterol formation and cholesterol excretion without significant uterotropic action in estrogen-deficient animals.
Flavanoids / Antioxidants: Study isolated eight flavonoids. Luteolin-acetyl-glucoside and quercetin-acetyl-glucoside showed potent antioxidative activities.
Teratogenic and Cytotoxic Effects of Safflower Extract / Coloring and Flavoring Use: Study showed that in higher doses, changes in cellular orientation and cellular degeneration were observed. also, cytotoxic assay demonstrated a concentration-dependent cytotoxic effect of the carthami flos extract. It suggests reconsideration of use as food additive.
Hypotensive Effect: Study using SY, a mixture of chalconoid compounds extracted from CT lowered the blood pressure of spontaneously hypertensive rats. Results suggest the decrease to be mediated by the renin-angiotensin system.
Breast Cancer Inhibitory Effect: The compound Zhyu-xiang, derived from extracts containing ginseng and carthamus tinctorius, was studied on treatment of MDA-MB-231 breast cancer cell and
human mammary gland cell lines. Zhu-xiang showed significant dose-dependent inhibition in cell proliferation, greater than that of commonly used cytotoxic drugs. The inhibitory effect was due to induction of apoptosis, both time- and concentration-dependent. Results suggest Zhu-xiang could be a useful anticancer compound against breast cancer.
Immunomodulatory / Antitumor Activity: Study showed the Carthamus tinctorius could promote immunity through the activation of DCs per se.
Analgesic Activity: Study showed CF oil extracted from safflower seeds is a natural local anesthetic with moderate analgesic activity mediated through influences on the serotoninergic and monoaminergic pathways. It has a potential to occupy a leading place among local anesthetics used in traditional medicine, acupuncture, and medical massage. (
4)
Quinochalcones / Anti-Inflammatory: Study isolated two new quinochalcone compounds - saffloquinoside A and saffloquinoside B - from the florets of C tinctorius. Saffloquinoside A exhibited middling anti-inflammatory activity. (5)
Bone Formation Benefits: Study in Sprague-Dawley rats showed a significant increase of osteoblast markers - osteocalcin and bone-specific alkaline phosphatase. The effect appears likely to be mediated by IGF-I at the early stages of treatment. (
6)
Antioxidant / Radical Scavenging: Study of crude extract showed antioxidant activities in various assays: DPPH scavenging, ABTS+ radical scavenging and superoxide anion radical scavenging. (
9)
Antidiabetic / Hypolipidemic: Study of a hydroalcoholic extract in diabetic male Wistar rats showed decreases in FBS, triglycerides, LDL and VLDL. Blood sugar lowering effect was comparable to glibenclamide. (10)
Antitumor: Study evaluated the antitumor activity of CT extract on dendritic cell (DC)-based vaccine in cancer treatment. Results showed a dose-dependent dramatic increase of the levels of TNF-a and IL-1ß, with more immunologic and co-stimulatory molecules expressed on the DC surface. (11)
Hepatoprotective: Study of a methanolic extract showed a hepatoprotective (antioxidant and anti-inflammatory) effect against CCl4-induced hepatotoxicity in rats as evidenced by biochemical parameters and histopathological findings. (12)
Hypolipidemic / Effects on Gene Expression: Study evaluated the hypolipidemic effect of various fractionation of crude extract. Results showed the dichlormethane extract to reduce the total cholesterol/HDL-cholesterol of hyperlipidemic rats. The results may partly be due to a decrease in the HDL-cholesterol and gene encoding enzymes of the cholesterol biosynthetic pathway. (13)
Antiulcer: Study showed an extract from Ct showed an antiulcerogenic effect, which may be due to its calcium channel blocking activity. (15)
Hair-Promoting Growth: Study examined the potential of hydroxysafflor yellow A-rich C. tinctorius extract on hair growth in vitro and in vivo. C. tinctorius floret ethanolic extract promoted the proliferation of both dermal papilla cells and HaCaT and significantly stimulated hair growth-promoting genes. It suppressed expression of transforming factor ß-1, the hair loss-related gene. Results suggest a potential for use as a hair-growth promoting agent. (17)
Anti-Inflammatory / Heme Oxygenase-1 Induction: Heme oxygenases (HO) are cytoprotective enzymes that degrade heme, generating CO, bilirubin, and ferrous iron, products with antioxidant, antiapoptotic, antithrombotic, and anti-inflammatory actions. Study evaluated methanol exhibited anti-inflammatory action , probably through induction of HO-1 expression via Nrf2 translocation and inhibition of NF-kB activity. (18)
Stimulation of Melanogenesis / Gray Hair Treatment: Study evaluated the effect of Carthamus tinctorius floret ethanolic extract on melanogenesis in murine melanoma cells. Results showed the CTE can stimulate melanogenesis at the transcriptional levels without cytotoxicity, with a potential as a gray hair treatment product. (19)
Female Reproductive Concerns: Study evaluated the possible effects of C. tinctorius on ovarian histomorphology and levels of female reproductive hormones in mice. Treatment with extracts showed detrimental effects with reduction in the number of ovarian follicles with an increase in atretic follicles, together with decrease in blood levels of FSH and estrogen. (
22)
Antidiabetic: Study evaluated the effect of C. tinctorius on fasting blood glucose and insulin levels in alloxan induced diabetic rabbits. Results showed significant hypoglycemic effect together with significantly increased insulin levels in extract treated and glibenclamide treated groups as compared to diabetic control. (
23)
• Drug Interactions with Anticoagulants and Anti-Platelet Drugs: Large amounts of safflower can slow blood clotting. Medications that slow blood clotting (anticoagulants and antiplatelet drugs) can interact with safflower and increase the risk of bruising and bleeding. (24)
• Quinochalcone C-Glycosides / HSYA / Biologic Activities / Florets: Study reports on the chemical and biologic properties of quinochalcone C-glycosides, major ingredients in the florets of C. tinctorius. The main active component of safflower yellow (SY) is HSYA (hydroxysafflor yellow A). Review presents its various biologic activities viz., anticoagulant, cardioprotective, CNS, anti-inflammatory, antioxidant, hepatoprotective, antihypertensive, and anti-tumor effects. C-glycosides have strong commercial value as cost-effective colorants used in juices, yoghurt, gelatin desserts and candies to make them more appealing. (27)
• Safety Profile in Lactation / Brain, Renal, and Hepatic Toxicity: Study evaluated the possible effects of C. tinctorius during lactation on brain, liver, kidney, and hematologic parameters of newborn mice. In histopathological studies, mild to severe injuries were observed in the kidney, liver, and brain tissues. Results suggest the use of safflower extract during lactation is toxic and advises the avoidance of its use during pregnancy and lactation. (28)
• Hepatoprotective / Hypolipidemic in Diabetic Rats / Seed Oil: Study evaluated the hepatoprotective and hypolipidemic effects of Carthamus tinctorius seed oil in alloxan-induced diabetic rats. Treatment with seed oil decreased the levels of blood glucose, TC, TGs, LDL, ALT, AST. and ALP while increasing HDL. Results suggest the use of safflower seed oil may be beneficial in preventing diabetic complications. (29)
• Acute and Subchronic Toxicity: Study evaluated the toxic and direct teratogenic potential of two dominant iranian cultivars of C. tinctorius (safflower) floret extracts (IL 111 and LRV 51 51) commonly used in food and medicinal products. No deaths or alteration of stereotype activities were observed. In cytotoxicity evaluation, results suggested no remarkable level of teratogenicity. (30)
• Effects on Placental Histomorphology and Neonate Survival / Toxicity Study: Study evaluated the effects of C. tinctorius extracts on placental histomorphology and survival of mice neonates. Results showed toxic changes in the placental structure. Advice of caution was given on consumption of the plant as alternative food or food additive. (32)
• Antithrombotic Effects: Study evaluated the effects of C. tinctorius extracts on thrombosis in rats. All test doses of CTL extracts significantly and dose-dependently prolonged thrombosis occlusion time, reduced the weight of the thrombus and increased inhibition rate (p<0.01). Studies are suggested to determine clinical potential. (33)
• Steroidal and Metabolic Effect: Study evaluated the steroidal and metabolic activity of hydroalcoholic extract of seeds of C. tinctorius in albino rats. Results showed significant (p<0.01) reduction of thymus weight together with hyperproteinemic, hypocholesterolemic and liver glycogen increasing effect with moderate increase in blood glucose level. Results suggest marked steroids and metabolic effect. The steroidal effect may be the basis for its use in nephrotic type kidney diseases, (35)
• Effect on Semen Quality and Gonadal Hormone Levels: Study evaluated the effects of C. tinctorius on spermatogenesis in a male rat model of partial infertility. Results showed a significant increase in sperm of good morphology and motility together with significant increase in count and positive effect on hormonal changes and genital organ weights. (36)
• Inhibition of Proliferation and Metastasis of MCF-7 Breast Cancer Cell: Study investigated the effects of safflower polysaccharide on the proliferation and metastasis of breast cancer cells. Results showed the polysaccharide compound significantly inhibited the proliferation of MCF-7 breast cancer cells in a dose- and time-dependent manner. The SPS induced cell apoptosis. Further study on underlying mechanisms may provide novel strategies in breast cancer therapy. (37)
• Depigmenting Effect / Seed: Study evaluated the skin depigmentation effect of extracts of three herbs viz., C. tinctorius seed, Cyperus rotundus and Schizonpeta tenuifolia. Results showed C. tinctorius seed extracts reduced tyrosinase activity and melanin formation of B16F10 melanoma cells. The underlying mechanism for its whitening activity may be the inhibition of tyrisinase, MITF, tyrosinase, TRP-1 and TRP-2 expression. Results suggest a potential as natural function ingredient with a depigmentation effect. (38)
• Antifungal / Aspergillus flavus: Study evaluated various extracts of medicinal herbs (thyme, senna, mentha, basil, safflower) on the growth of A. flavus, one of the major fungal challenges in agriculture and food industry. While all concentrations of the plant extracts significantly inhibited the fungus growth, the extracts of thyme and safflower manifested the most effective prohibition compared to benomyl with MIC of 200 and 400 µg/mL, respectively. (39)
.
Availability
Wild-crafted.
Oil, seeds, supplements in the cybermarket.

Last Update May 2015

IMAGE SOURCE / File:Illustration Carthamus tinctorius0.jpg / Original book source: Prof. Dr. Otto Wilhelm Thomé Flora von Deutschland, Österreich und der Schweiz 1885, Gera, German / Permission granted to use under GFDL by Kurt Stueber / Wikimedia Commons
OTHER IMAGE SOURCE: / File:Safflower.jpg / click on image to go to source page / Wikimedia Commons

Additional Sources and Suggested Readings
(1)
Carthamus tinctorius L. prevents LPS-induced TNFalpha signaling activation and cell apoptosis through JNK1/2-NFkappaB pathway inhibition in H9c2 cardiomyoblast cells / Tien YC, Lin JY et al /
J Ethnopharmacol. 2010 Aug 9;130(3):505-513. Epub 2010 Jun 9.
(2)
Safflower: Research Update
(a)
Effect of saffor (Carthamus tinctorius) injection on renal ischemia/reperfusion injury in rats / Zhongguo Zhong Yao Za Zhi. 2006 Nov;31(21):1814-8 / Gao F, Wu XH, Luo CL, He YF, Zhang LS, Yang
(b)
An anti-estrogenic lignan glycoside, tracheloside, from seeds of Carthamus tinctorius / Biosci Biotechnol Biochem. 2006 Nov;70(11):2783-5 / Yoo HH, Park JH, Kwon SW
(c)
Serotonin derivatives, major safflower (Carthamus tinctorius L.) seed antioxidants, inhibit low-density lipoprotein (LDL) oxidation and atherosclerosis in apolipoprotein E-deficient mice / J Agric Food Chem. 2006 Jul 12;54(14):4970-6.
(d)
Pharmacokinetics and excretion of hydroxysafflor yellow A, a potent neuroprotective agent from safflower, in rats and dogs / Planta Med. 2006 Apr;72(5):418-23 / Chu D, Liu W, Huang Z, Liu S, Fu X, Liu K.
(e)
Study on the antioxidative effect of Safflor Yellow / Zhongguo Zhong Yao Za Zhi. 2004 May;29(5):447-9 / Jin M, Li JR, Wu W.
(f)
Effects of defatted safflower seed extract and phenolic compounds in diet on plasma and liver lipid in ovariectomized rats fed high-cholesterol diets.:J Nutr Sci Vitaminol (Tokyo). 2004 Feb;50(1):32-7.Cho SH, Lee HR, Kim TH, Choi SW, Lee WJ, Choi Y
(g)
Antioxidative flavonoids from leaves of Carthamus tinctorius.:Arch Pharm Res. 2002 Jun;25(3):313-9.Lee JY, Chang EJ, Kim HJ, Park JH, Choi SW
(h)
A study on the teratogenic and cytotoxic effects of safflower extract.:J Ethnopharmacol. 2000 Dec;73(3):453-9.Nobakht M, Fattahi M, Hoormand M, Milanian I, Rahbar N, Mahmoudian M.
(i)
Hypotensive effects of safflower yellow in spontaneously hypertensive rats and influence on plasma renin activity and angiotensin II level:Yao Xue Xue Bao. 1992;27(10):785-7.Liu F, Wei Y, Yang XZ, Li FG, Hu J, Cheng RF
(j)
The inhibitory effect of a herbal formula comprising ginseng and carthamus tinctorius on breast cancer
(3)
Carthamus Tinctorius Enhances the Antitumor Activity of Dendritic Cell Vaccines via Polarization toward Th1 Cytokines and Increase of Cytotoxic T Lymphocytes / Jia-Ming Chang, Le-Mei Hung et al / eCAM, doi:10.1093/ecam/nen068
(4)
Analgesic properties of “CF” extracted from safflower (Carthamus tinctorius L.) seeds and potential for its use in medicine / A M Popova, I A Li, D I Kang / Pharmaceutical Chemistry Journal, Volume 43, Number 1 / January, 2009 / DOI 10.1007/s11094-009-0233-z
(5)
Two New Quinochalcones from the Florets of Carthamus tinctorius / Jian-Shuang Jiang et al / Org. Lett., 2010, 12 (6), pp 1196–1199 / DOI: 10.1021/ol902971w
(6)
Determination of Mineral Content in Methanolic Safflower (Carthamus tinctorius L.) Seed Extract and Its Effect on Osteoblast Markers / Young Seok Lee, Chang Won Choi et al / Int J Mol Sci. 2009 January; 10(1): 292–305. / Published online 2009 January 12 / doi: 10.3390/ijms10010292.
(7)
EFFECT OF CARTHAMUS TINCTORIUS EXTRACT ON MYOCARDIAL APOPTOSIS INDUCED BY ISCHEMIA REPERFUSION INJURY / Tsing Hua / Chinese Journal of Traditional Medical Science and Technology
(8)
Sorting Carthamus names / Maintained by: Michel H. Porcher, / MULTILINGUAL MULTISCRIPT PLANT NAME DATABASE / A Work in Progress. School of Agriculture and Food Systems. Faculty of Land & Food Resources. The University of Melbourne. Australia.
(9)
Radical Scavenging and Antioxidant Activity of Carthamus tinctorius Extracts / Rajesh Mandade, S.A. Sreenivas, Avijit Choudhury / doi:10.5530/ax.2011.3.12.
(10)
Antidiabetic effect of hydroalcoholic extract of Carthamus tinctorius L. in alloxan-induced diabetic rats /
Sedigheh Asgary et al / Journal of Research in Medical Sciences
(11)
Carthamus tinctorius Enhances the Antitumor Activity of Dendritic Cell Vaccines via Polarization toward Th1 Cytokines and Increase of Cytotoxic T Lymphocytes / Jia-Ming Chang, Le-Mei Hung, Yau-Jan Chyan, Chun-Ming Cheng, and Rey-Yuh Wu / Evidence-Based Complementary and Alternative Medicine
Volume 2011 (2011), Article ID 274858, 10 pages / doi:10.1093/ecam/nen068
(12)
Hepatoprotective Effect of C. tinctorius L. aginst Carbon-tetrachloride Induced Hepatotoxicity in Rats / Hind Salah Yar et al / Pharmacie Globale (IJCP), 2012, 9(02).
(13)
The effects of the extracts from Carthamus tinctorius L. on gene expression related to cholesterol metabolism in rats / Teerakul Arpornsuwan*, Khaimuk Changsri, Sittiruk Roytrakul and Tadsanee Punjanon / Songklanakarin J. Sci. Technol. 32 (2), 129-136, Mar. - Apr. 2010
(14)
Protective effects of dietary Safflower (Carthamus tinctorius) on experimental coccidiosis / Lee, Sunghyen
Lillehoj, Hyun et al / Journal of Poultry Science. 46:155-162. /
(15)
Antiulcer screening of Carthamus tinctorius on volume and acidity of stimulated gastric secretion in rats
/ Rajesh Mandade, SA Sreenivas, Ravi Wanare / Journal of Pharmacology and Pharmacotherapeutics, 2012, 3:185-8 / DOI: 10.4103/0976-500X.95525
(16)
Studies on chemical constituents from the flowers of Carthamus tinctorius L. / Liu Y1, Yang J, Liu Q. / Zhong Yao Cai. 2005 Apr;28(4):288-9.
(17)
Hair Growth-Promoting Effect of Carthamus tinctorius Floret Extract / Jintana Junlatat and Bungorn Sripanidkulchai* / Phytotherapy Research, 11 Dec 2013 / DOI: 10.1002/ptr.5100
(18)
Anti-inflammatory action of methanol extract of Carthamus tinctorius involves in heme oxygenase-1 induction
/
Min Soo Jun, Yu Mi Ha, Hee Sook Kim, Hwa Jin Jang, Young Min Kim, Young Soo Lee, Hye Jung Kim, Han Geuk Seo, Jae Heun Lee, Seung Ho Lee1, Ki Churl Chang∗ / Journal of Ethnopharmacology 133 (2011) 524–530
(19)
Stimulation of melanogenesis by Carthamus tinctorius floret extract in B16F10 murine melanoma cells / Jintana Juniatat, Bungom Sripandikutchai / 021-KKU / http://pharm.kku.ac.th/isan-journal/journal/volumn9-no1/003-Aesthetic/Page221.pdf
(20)
Studies on chemical components of Carthamus tinctorius petals / Li Y1, Che Q. / Yao Xue Xue Bao. 1998 Aug;33(8):626-8.
(21)
Comparative study of four safflower oils (Carthamus tinctorius) varieties grown in eastern of Morocco /
Abdessamad Ben moumen, Farid Mansouri, Lamyae Zraibi, Malika Abida Abedlghani Nabloussi, Marie-Laure Fauconnier , Mariane Sindic Ahmed El amrani,and Hana Serghini Caid / InsideFood Symposium, 9-12 April 2013
(22)
Effects of Carthamus tinctorius L. on the ovarian histomorphology and the female reproductive hormones in mice / Ali Louei Monfared∗, Amir Parviz Salati / Avicenna Journal of Phytomedicine Received: Oct 2, 2012; Accepted: Jan 13, 2013 Vol. 3, No. 2, Spring 2013, 171-177
(23)
Effect of Carthamus tinctorius (Safflower) on fasting blood glucose and insulin levels in alloxan induced diabetic rabbits / Nasreen Qazi, Rafeeq Alam Khan, Ghazala H Rizwani and Zeeshan Feroz / Pak. J. Pharm. Sci., Vol.27, No.2, March 2014, pp.377-380
(24)
Carthamus tinctorius / Synonyms / The Plant List
(25)
Safflower: Drug Interactions / WebMD
(26)
Studies on Extraction of Safflower Pigments and its Utilization in Ice Cream / Machewad GM *, Ghatge P, Chappalwar V, Jadhav B and Chappalwar A /
(27)
Chemical and Biological Properties of Quinochalcone C-Glycosides from the Florets of Carthamus tinctorius / Shijun Yue, Yuping Tang *, Shujiao Li and Jin-Ao Duan / Molecules 2013, 18, 15220-15254 / doi:10.3390/molecules181215220
(28)
Safety Pro le of Carthamus Tinctorius L. in Lactation: Brain, Renal and Hepatotoxicity / Abdolrasool Namjoo, Hamid Nasri, Abbas Talebi-Juneghani, Azar Baradaran, Mahmoud Ra eian-Kopaei / Pak J Med Sci 2013;29(1)Suppl:378-383. / doi: http://dx.doi.org/10.12669/pjms.291(Suppl).3538
(29)
Hepatoprotective and Hypolipidemic Effects of Carthamus tinctorius oil in Alloxan-induced Type 1 Diabetic Rats / Parivash Rahimi, Sedigheh Asgary, Najmeh Kabiri / J HerbMed Pharmacol. 2014; 3(2): 107-111.

(30)
Study on Acute and Subchronic Toxicity, Cytotoxicity, and In Vitro Developmental Toxicity of Safflower Extracts of IL111 and LRC5151 Cultivars / Seyed Nasser Ostad et al / Iranian Journal of Pharmaceutical Sciences, Article 11, Volume 8, Issue 1, Winter 2012, pp 343-352
(31)
Cosmeceutical Critique: Safflower Oil / Leslie S. Baumann / Dermatology News, July 2012
(32)
The effects of Carthamus tinctorius L. on placental histomorphology and sruvival of the neonates in mice /
Ali Louei Monfared, Amir Parviz Salati / Avicenna J Phytomed. 2012 Summer; 2(3): 146–152.
(33)
Anti-Thrombotic Effect of Carthamus tinctorius Linn Extracts in Rats / Sheng-hao Wu*, Cui-ping Zheng / Tropical Journal of Pharmaceutical Research October 2014; 13 (10): 1637-1642
(34)
A new Phenylpropanoid Derivative Isolated from Carthamus tinctorius L. / Xiaojia Hu, Sha Yin, Zhenru Huang, Abdelhakim Elomri and Yang Lu / Rec. Nat. Prod. 10:1 (2016) 17-21
(35)
Evaluation of Steroidal and Metabolic Effect of Tukhm-E-Qurtum (Carthamus tinctorius L. Seed) / Wasim Ahmad*, Ghufran Ahmad, Khan NA, Shamshad Ahmad / International Journal of Advances in Pharmacy Medicine and Bioallied Sciences, Volume 3, Issue 1, Page 32-36, January-April 2015.
(36)
Effects of Carthamus tinctorius on Semen Quality and Gonadal Hormone Levels in Partially Sterile Male Rats / Soghra Bahmanpour, Zahra Vojdani, Mohamad Reza Panjehshahin, Hassan Hoballah, Hamza Kassas /
Korean J Urol. 2012 Oct;53(10):705-710 / https://doi.org/10.4111/kju.2012.53.10.705
(37)
Safflower polysaccharide inhibits the proliferation and metastasis of MCF-7 breast cancer cell
/ Zhongbing Luo et al / Molecular Medicine Reports, Vol 11, Issue 6, June 2015 /  DOI: 10.3892/mmr.2015.3310

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A Study on the Depigmenting Effect of C. tinctorius Seed, Cyperus rotundus, and Schizonpeta tenuifolia Extracts / Hwang EY, Kim DH, Hwang JY, Kim HJ, Park TS, Lee IS, Son JH / Food and Agriculture Organization of the United Nations
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Evaluation of antifungal activity of aqueous extracts of some medicinal plants against Aspergillus flavus,pistachio aflatoxin producing fungus in vitro / Sahar Omidpanah et al / Drug Development and Therapeutics, 2015, Vol 6, Issue 2, pp 66-69

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