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Family Gramineae
Katigbi
Coix lacryma-jobi L.
JOB'S TEARS

Chuan gu

Scientific names Common names
Coix agrestis Lour. Abukai (Iv.)
Coix arundinacea Lam. Adlai (Bis.) 
Coix exaltata Jacq. ex Spreng. Agagai (Iv.)
Coix exaltata Jacq. Agda (Ig.) 
Coix gigantea J.Jacq. [Illegitimate] Aglai (C. Bis.) 
Coix lacryma L. [Illegitimate] Alimudias (P. Bis.) 
Coix lacryma Linn. Apagi (Ig.)
Coix lacryma-jobi Linn. Atakai (Ilk., Bon.)
Coix ouwehandii Koord. Balantakan (Pamp.) 
Coix palustris Koord. Barubaioko (Bik.)
Coix pumila Roxb. Bintikai (Bik.)  
Coix stigmatosa K.Koch & Bouché Bitogan (Bag.) 
Lithagrostis lacryma-jobi (L.) Gaertn. Daldi (Sub.) 
Sphaerium lacryma (L.) Kuntze [Illegitimate] Damdu (C. Bis.) 
  Glias (Sub.) 
  Kalabugau (Buk.) 
  Kambot (Ting.)
  Katayan (Ig.) 
  Katigbi (C. Bis.) 
  Kibaoung (If.) 
  Koldasan (Bik.)
  Kudlasan (Tag.) 
  Lamudias (P. Bis.)
  Lias (Sub.) 
  Paias (P. Bis., Bag.) 
  Pintaka (C. Bis.)
  Tidbi (S. L. Bis.) 
  Tigbi (Bik., Tag.) 
  Tigbikai (Bik.)
  TIguas (Sul,) 
  Tikaian (Bon.)
  Coix Seed (Engl.) 
  Job's tears (Engl.) 
  Pearl barley (Engl.) 
  St. Mary's tears (Engl.)
  Tear grass (Engl.)
Coix lacryma-jobi L. is an accepted name. The Plant List

Other vernacular names
ARABIC: Badrang, Dam'Ayub, Amadrayan.
CAMBODIA: Skuoy
CHINESE: Yemi ren, ye yi ren, ye yi mi, shan yi mi, Chuan gu.
FRENCH: Larmes de Job, larmilles,
GERMAN: Hiobsträne, Hiobstränengras.
INDONESIA: Jali, jali betul, jali watu. herbe a chapelets.
ITALIAN: Lacrima di Giobbe, lacrime di Gesu, erba da corone.
JAPANESE: Juzudama.
KHMER: Skuoy.
LAOS: Duay
MALAYSIA: Jelai batu, jelai pulut, menjelai.
SPANISH: Lagrimas de San Pedro, Lagrimas de Job.
THAILAND: Duai, maduai.
VIETNAM: [ys] d[ix], bo bo, c[uw][owf]m g[aj]o

Botany
Katigbi is a plant growing 1 to 2 meters high. Stem is erect, branched and stout. Leaves are 10 to 40 centimeters long, 2.5 to 4 centimeters wide, with a broad and cordate base. Spikes are 6 to 10 centimeters long, erect, and peduncled. Male spikelets are about 8 millimeters long. Fruits are capsules, enclosing the female flowers. Grains are hard, bony, white or nearly black, shining, ovoid, about 8 millimeters long.

Distribution
- Common throughout the Philippines in settled areas, at low and medium altitudes, in most or all islands and provinces.
- Native of the Old World.
- Now pantropic.



Constituents

• Adlai contains 21.27% moisture, 6.09% ash, 9.11% protein, 0.45% fat, 0.412% crude fiber, and 77.16% carbohydrates.
• The grain contains a protein, prolamin, with a high percentage of leucine, tyrosine, glutamic acid, and basic amino acids arginine, histidine, and lysine. Protein is called coicin.
• Extracts have yielded coixenolides, attributed antitumor activity.
• Study isolated 6 benzoxazinoids from the roots of CL

• Study evaluating seed phytonutrients yielded a total vitamin E content of 37.38 mg/kg, two major components were y-tocopherol and y-tocotrienol. Squalene content ranged from 31.23 to 55.00 mg/kg. Tested varieties exhibited squalene content ranging from 31.23 to 55.00 mg kg. Phytosterols content yielded campesterol 80.43, stigmasterol 131.1, and β-sitosterol 313.38. Of the six detected fatty acids, the major fatty acids were oleic (46.3%) and linoleic acids (37.4%). (19p)

Properties
• Grain starch is tonic.
• Fruit considered anti-inflammatory, antipyretic, antiseptic, antitumor, antispasmodic, hypoglycemic, hypotensive, vermifuge.
• Seeds considered to be nutritious, cooling, diuretic, demulcent, depurative, antihelmintic, antirheumatic, pectoral, tonic.
Root of plant considered an excellent anthelmintic.



Parts utilized
Roots, seeds, stems.

Uses
Edibility / Culinary
- Chief value of the plant is the edibility of the fruit. Grains are nutritious, with a higher content of protein compared to rice.
- Tea from the parched seeds.
- In Korea, yulmu cha (Job's tears tea), is a thick drink made from powdered Job's tears. In Chinese cuisine, a similar drink, Yi Ren Jiang, is made by sweeting simmered whole polished Job's tears. (36)
- A South Korean liquor, okroju, is distilled from rice and grain of Job's tears. (36)
- In Japan, aged vinegar is made from the grain. (36)
- Coffee from the roasted seeds.
- Beer and wine from fermented grains.
Folkloric
- In the Philippines, decoction of the root has been used for gonorrhea.
- Roots also used as vermifuge for children.
- Starch from the grain used as tonic and as restorative in convalescence.
- Tea from boiled seeds drunk for treatment of warts. Also used for lung abscesses, appendicitis, rheumatoid arthritis, dysuria.
- Seeds are prescribed for blenorrhagia.
- In India, roots used for menstrual disorders.
- In Liberia, juice from the stem used as drops for eye irritation due to injury.
- Decoction and tincture of seeds are emollient in catarrhal affections, in bronchitis, and inflammatory conditions of the urinary tract.
- Seeds have been used as anti-inflammatory medicine.
- In Mexico, decoction or infusion of leaves used for diabetes.
- In Japan and China, spirit from seeds used for rheumatic affections.
- In China, used for cancer treatment (30-60 gm of coix, with glutinous rice as gruel, daily, year round. Used for dysfunctions of the endocrine system. Also, used for ascites secondary to liver cirrhosis.
- In Chinese traditional medicine, considered nutritious, demulcent, cooling, pectoral, and anthelmintic. Used for spleen invigoration, diarrhea, oliguria, edema, beriberi, appendicitis and warts. Also, used as food for the dyspeptic. Coix seed has been used in the preparations used in the treatment of tumors.
- In Europe, tincture or decoction of seed use for catarrhal afflictions of the air passages.
- In Vietnam stems are used in some diabetic recipes.
- In Japan, used for warts.

Others

- Ornaments: The berries as strung as beads for rosaries and decorative for curtains, bags, trays, necklaces, etc.
- Matting: Stems used for matting.


Studies
Antitumor: Components isolated from the Chinese herbal medicine Coix lachryma-jobi showed antitumor activity attributed to the acidic fraction which was composed of four free fatty acids: palmitic, stearic, oleic and linoleic acids. (2)
Antiinflammatory / Seeds:
Results showed the methanol seed extract of seeds of CL showed antiinflammatory properties which may involved the inhibition of NO and O2 production by activated macrophages. (4)
Antiinflammatory / Roots: Study on the antiinflammatory activities of six benzoxazinoids from roots of Coix lachryma-jobi var. Ma-yuen showed the free hydroxyl group in the benzoxazinone skeleton involved in the expression of inhibitory activity. (6)
Progesterone Production Inhibition:
Study suggested decrease of progesterone production via mechanisms involving the inhibition of cAMP pathway, enzyme activities and protein expressions in rat granulosa cells. (5)
Cytotoxicity / Anti-Viral: In a study of its in vivo effects on healthy volunteers, showed the Coix seeds increase peripheral cytotoxic lymphocytes and may be effective to viral infection through enhancement of cytotoxic activity. (8)
Macrophage Biostatic Activity: Results of study of water extract of seeds suggest that some components other than the non-proteinous and defatted components in Coix lachryma seeds may contribute to activate macrophages through induction of NO for the biostatic activity. (9)
Osteoporosis Prevention: Results of study of the water extract of adlay seed suggest it may be capable of reversing the osteoporotic status in rats and may be a helpful healthy food for osteoporosis prevention. (10)
Abortifacient / Embryo toxicity: Results indicate the water extracts of adlay seeds are capable of inducing embryo toxicity and enhancing uterine contractile during pregnancy, possibly through the enhanced activities of PK-alpha, ERK1/2 and COX-2. (11)
Hypoglycemic Effect / e-sitosterol and Stationmaster: Study on STZ-induced hyperglycemia in mice, the chloroform fraction of an ethanol extract significantly reduced blood glucose as well as gluconeogenic enzyme activities. Two compounds isolated, ß-sitosterol and stigmasterol, have been reported as hypoglycemic. (14)
Hypocholesterolemic / Antioxidant: Study of polyphenol extracts on high cholesterol diet fed rats showed an effective reduction of TC, LDL cholesterol, and oxidative stress marker, MDA (malondialdehyde). There was also an increase in HDL-C and antioxidant capacity. (15)
Anticancer / Breast and Skin: Coix lacryma and Asparagus cochinchinensis showed breast and and skin anticancer activity. Coix lacryma ethanol extract yielded terpenoids, steroids, and phenolics; For Coix lacryma, the methylene chloride extract showed the most activity. (16)
Gastroprotective / Anticancer / Antiulcer: Study of extracts of bran and endosperm showed antiproliferative activity, with inhibitory effects, especially by caffeic and chlorogenic acids, on a gastric cancer cell line. Study also showed an antiulcer activity in an indomethacin-induced gastric lesion model. (17)
Anti-Obesity / Neuroendocrine Modulation: Study in high-fat diet induced obesity in rats, results showed adlay seen water extract may regulate neuroendocrine activity in the brain, causing reduction in body fat mass, body weight, serum leptin level and immune activities of NPY (neuropeptide Y) and LR (leptin receptor). Adlay presents as a potential for therapies targeting obesity. (18)
Coix Seeds / Kanglaite Injection (KLT) Preparation / Anticancer and Immunomodulating: A review on the pharmacological actions of Coix seed and its preparation Kanglaite Injection reports antitumor and immunomodulating actions. (20)
Antimutagenic Components / Cancer Chemopreventive: Study yielded six compounds exhibiting great antimutagenic activity: p-hydroxybenzaldehyde, vanillin, syringaldehyde, trans-coniferylaldehyde, sinapaldehyde, and coixol. Two exhibited potent scavenging of DPPH radicals. Among the six, trans-coniferylaldehyde may be a highly promising agent for cancer chemoprevention. (21)
Anti-Allergic / Inhibition of Chemical Mediator Release: Study evaluated the anti-allergic effects of adlay bran on rat basophilic leukemia (RBL)-2H3cells. Results showed adlay bran extract reduced the release of histamines and cytokines and suppressed production of Akt. The anti-allergic effect was through its effect on signal transduction in RBL-2H3 cells. (22)
Fructooligosaccharide / Antioxidant: Fructooligosaccharide (FOS), a prebiotic was extracted from the grain of Coix lacryma-jobi Lin. The FOS-containing extract exhibited antioxidant activity by DPPH free radical scavenging assay comparable to vitamin with a slight lipid peroxidation inhibition activity. Results suggest a potential for use as antioxidant in food and cosmetic products. (23)
Anti-Inflammatory / Seed Hull: Study evaluated the effects of adlay seed hull extracts on liposaccharide-induced inflammatory response in RAW 264.7 macrophages. Study showed anti-inflammatory effect which was attributed, in part, to eriodictyol and ceramide (2S,3S,4R)-2-[(2′R)-2′-hydroxytetracosanoyl-amino]-1,3,4-octadecanetriol, isolated for the first time from seed hull extracts. (24)
Anti-Allergic: Adlay bran extract reduced the release of histamines and cytokines and suppressed the production of Akt.--combined effects that influenced the signal transduction in RBL-2H3 cells, revealing mechanisms of the anti-allergic effects of adlay. (26)
Endochitinase / Seeds: Studies of the purification, characterization and primary structure of protein inhibitors of trypsin and -amylase from seeds of Job's Tears (Coix lacryma-jobi) were undertaken. Endochitinase activity was demonstrated. The results suggest a first characterization of a plant protein with activity as an enzyme and as an enzyme inhibitor. (27)
Anti-Tumor / Seeds: Triterpene-loaded microemulsions using Coix lacryma seed oil was evaluated for enhanced antitumor activity. The TME preparation showed markedly enhanced antitumor efficacy in a xenograft model of Lewis lung cancer after intragastric administration. Compared to cyclophosphamide, the TME showed similar antitumor activity but less general toxicity. (28)
• Melanogenesis Inhibitors / Skin Whitening / B16-F10 Melanoma Cells / Seeds: Study of seeds isolated an adenine derivative, 9-ß-D-glucopyranosyl adenine, together with nine known compounds. The compounds were assayed for melanin inhibition using B16-F10 melanoma cell line. Results showed Coix lacryma-jobi seeds have potential for use as skin whitening agent and a rich source of compounds with melanogenesis inhibitory activity. Among the isolated compounds, coixol (2) and 2-O-ß-glucopyranosyl-7-methoxy-2H-1,4-benzoxazin-3(4H)-one (8) showed potent melanogenesis activity without obvious melanocytotoxicity. (
30)
• Trolein / Induction of Cell Cycle Arrest Through P53/P21 Signaling Pathway: P53,a tumor suppressor protein, has an important role in DNA repair, cell cycle and apoptosis--key evens in cancer development. Study isolated 4 compounds (1-4), including the most potent p53-increasing compound, triolein. Triolein treatment induced P53, p21, p27, and Bax in MCF-7 cells. Data showed triolein may induce cell cycle restart involve DNA synthesis and apoptosis pathway in MCF-7 cells. (31)
• Hypouricemia / Nephroprotection / Seeds: Study of Adlay seed extract hyperuricemic rats showed showed hypouricemic and nephroprotective actions with significant reduction of Pua in a dose dependent manner, increased %FEua and Ccr to normal level and inhibited XOD activity in the liver and plasma of hyperuricemic mice. (32)
• Job's Tear Flour as Substitute to Cake Flour: Study evaluated Job's tear flow prepared by wet milling method for its potential as substitute to cake flour in butter cake. A 20% of flour obtained the highest score for Just About Right test, with only sweetness and texture attributes needing improvement. The product had a remarkable 87% consumer acceptance, with a 7.3 preference score. The addition of Job's tear flour increased fiber and protein contents of products. (33)
• Decreased Adipocyte Differentiation / Increased Glucose Uptake in 3T3-L1 Cells: Study investigated the effects of ethyl acetate fraction of an ethanol extract of Coix lacryma-jobi on glucose uptake and adipocyte differentiation in 3T3-L1 cells. The extract phosphorylated AMP-activated protein kinase in a time- and dose-dependent manner. ECLJ also cause a decrease in expression levels of adipogenesis factors in a dose dependent manner. Results suggests a possible role of AMPK in adispose differentiation. The effect on adipocyte functions could be effective in improving the symptoms of metabolic syndrome. (34)
• Liposoluble Components / Antibacterial Activities / Stem: GC-MS analysis Coix lacryma-jobi stems yielded 23 compounds, accounting for 87.12 % of total liposoluble components. Main components were fatty acids, esters, aldehydes, etc. The liposoluble components exhibited strong antibacterial activities against Staphylococcus epidermis, S. aureus, and Escherichia coli. (35)
• Larvicidal on Dengue Fever Mosquito, Aedes aegypti: In a study of 10 Indian medicinal plants for larvicidal activity against Aedes aegypti mosquito larvae, C. lacryma showed the second highest LC50 value with 92.77 ppm. (37)
• Synergism of Coix Seed Oil with Norcantharidin / Anti-Tumor: Study showed that Norcantharidin (NCTD) + Coix lacryma-jobi seed oil (CLSO) combination exhibited more potent antitumor effects in terms of cytotoxicity and apoptosis induction in human HepG2 and HepG2/ADM cells than NCTD or CLSO alone. In vivo, the combination significantly suppressed the formation of tumor in Hepal-1-hepatoma bearing mice. Results suggest the combination of NCTD+CLSO improves anti-tumor activity and regulates tumor infiltrating Tregs. (38)
• Antihypertensive / Oligopeptides: The hydrolyzed bioactive oligopeptides of adlay have been shown to be anti-hypertensive effective components. Angiotensin-1 converting enzyme (ACE) was identified as the main potential target for the antihypertensive activity of adlay oligopeptides. ALA354 was identified as a key residue of ACE inhibitors. The study provides research strategy to explore the phamacological mechanism of Traditional Chinese Medicine proteins based on in silico proteolysis and virtual screening to reveal the pharmacological action of TCM proteins and provide new lead compounds for peptides-based drug design. (39)

Availability
- Wild-crafted.
- Seeds, tinctures, dried grains in the cybermarket.

© Godofredo U. Stuart Jr., M.D.

Updated March 2018 / January 2015

Photos © Godofredo Stuart / StuartXchange

Additional Sources and Suggested Readings
(1)
Coix lacryma-jobi / Plants For A Future
(2)
Antitumor components isolated from the Chinese herbal medicine Coix lachryma-jobi / NUMATA M. et al /Planta medica / 1994, vol. 60, no4, pp. 356-359
(3)
COIX: FOOD AND MEDICINE / Subhuti Dharmananda, PhD
(4)
Inhibitory effects of methanol extract of seeds of Job's Tears (Coix lachryma-jobi L. var. ma-yuen) on nitric oxide and superoxide production in RAW 264.7 macrophages. / Seo WG, Pae HO, Chai KY, Yun YG, Kwon TH, Chung HT / Immunopharmacol Immunotoxicol. 2000 Aug;22(3):545-54.
(5)

Effects of Adlay (Coix lachryma-jobi L. var. ma-yuen Stapf.) Hull Extracts on the Secretion of Progesterone and Estradiol In Vivo and In Vitro / Hsia SM, Yeh CL, Kuo YH, Wang PS, Chiang W. / Experimental Biology and Medicine 232:1181-1194 (2007) / doi: 10.3181/0612-RM-306
(6)

Anti-Inflammatory Activity of Benzoxazinoids from Roots of Coix lachryma-jobi var. Ma-yuen
/ Hideaki Otsuka, Yuko Hirai, Tsuneatsu Nagao, Kazuo Yamasaki / J. Nat. Prod., 1988, 51 (1), pp 74–79 / DOI: 10.1021/np50055a009
(7)
Progress in pharmacodynamics and clinical studies of active components of Coix Seed (Semen Coicis) and its preparation - Kanglaite Injection (KLT) / Li Dapeng
(8)
Chinese medicine, Coix seeds increase peripheral cytotoxic T and NK cells / Yoh Hidaka, Tatsunari Kaneda et al / Biotherapy, Volume 5, Number 3 / October, 1992 / DOI 10.1007/BF02171052
(9)
Biostatic activity of Coix lacryma seed extract on Toxoplasma gondii in macrophages / Chin-Thack Soh, Sook-Hyaiig Kim et al / The Korean Journal of Parasitology, Vol. 34, No. 3, 197-206, September 1996
(10)
Evaluation of osteoporosis prevention by adlay using atissue culture model / Rong Sen Yang MD, Wenchang Chiang et al / Asia Pac J Clin Nutr 2008;17(S1):143-146
(11)
The abortifacient effects from the seeds of Coix lachryma-jobi L. var. ma-yuen Stapf. / Tzeng HP, Chiang W et al / J Toxicol Environ Health A. 2005 Sep;68(17-18):1557-65
(12)
Coix lacryma-jobi L. / Vernacular names / GLOBinMED
(13)
Sorting Coix names / Maintained by: Michel H. Porcher, / MULTILINGUAL MULTISCRIPT PLANT NAME DATABASE / Copyright © 1997 - 2000 The University of Melbourne
(14)
Chemical Composition and Effects on Carbohydrate Metabolism of Chloroform Fraction of Coix lachryma-jobi (L) Stem Extract / T.H. Phung, H.A. Nguyen, Q.C. Nguyen, T.D. Nguyen, and T.H. Nguyen / Mahidol University Journal of Pharmaceutical Science 2012; 39 (1), 19-24
(15)
Protective Effect of Polyphenols Extract of Adlay (Coix lachryma-jobi L. var. ma-yuen Stapf) on Hypercholesterolemia-Induced Oxidative Stress in Rats / Lifeng Wang, Jing Sun, Qida Yi , Xuefeng Wang and Xingrong Ju / Molecules 2012, 17, 8886-8897; doi:10.3390/molecules17088886
(16)
ACTIVITY OF LEAF EXTRACTS OF COIX LACHRYMA LINN. AND ASPARAGUS COCHINCHINENSIS LINN. AS BREAST ANTICANCER DRUGS / RESMI MUSTARICHIE, ZALINAR UDIN, JUTTI LEVITA, IDA MUSFIROH, IKAL ZULFRICAR / Medical and Health Science Journal, MHSJ, Volume 9, 2011, pp. 47-57
(17)
Gastroprotective activities of adlay (Coix lachryma-jobi L. var. ma-yuen Stapf) on the growth of the stomach cancer AGS cell line and indomethacin-induced gastric ulcers. / Chung CP, Hsia SM, Lee MY, Chen HJ, Cheng F, Chan LC, Kuo YH, Lin YL, Chiang W. / J Agric Food Chem. 2011 Jun 8;59(11):6025-33. Epub 2011 May 5.
(18)
The Water Extract of Adlay Seed (Coix lachrymajobi var. mayuen) Exhibits Anti-Obesity Effects Through Neuroendocrine Modulation / Sung Ok Kim, Su-Jin Yun, and Eunjoo H. Lee / The American Journal of Chinese Medicine, Vol. 35, No. 2, 297–308
(19)
Evaluation of phytonutrients in Adlay (Coix lacryma- jobi L.) seeds / Shiva Ram Bhandari, Suk-Keun Park, Young-Cheol Cho and Young-Sang Lee* / African Journal of Biotechnology Vol. 11(8), pp. 1872-1878, 26 January, 2012 / DOI: 10.5897/AJB11.2416
(20)
Progress in pharmacodynamics and clinical studies of active components of Coix Seed (Semen Coicis) and its preparation - Kanglaite Injection (KLT) / LI Dapeng / Zhejiang TCM University, 548 Bingwen Rd, Bingjiang District, Hangzhou, Zhejiang, 310053, China
(21)
Antimutagenic constituents of adlay (Coix lachryma-jobi L. var. ma-yuen Stapf) with potential cancer chemopreventive activity / Chen HH, Chiang W, Chang JY, Chien YL, Lee CK, Liu KJ, Cheng YT, Chen TF, Kuo YH, Kuo CC. / J Agric Food Chem. 2011 Jun 22;59(12):6444-52. doi: 10.1021/jf200539r. Epub 2011 May 17.
(22)
Inhibitory effects of adlay bran (Coix lachryma-jobi L. var. ma-yuen Stapf) on chemical mediator release and cytokine production in rat basophilic leukemia cells. / Chen HJ1, Lo YC, Chiang W. / J Ethnopharmacol. 2012 May 7;141(1):119-27. / doi: 10.1016/j.jep.2012.02.009. Epub 2012 Feb 14.
(23)
Biological activities of fructooligosaccharide (FOS)-containing Coix lachryma-jobi Linn. extract. / Journal of food science and technology, 341-346 / DOI: http://dx.doi.org/10.1007/s13197-011-0498-6
(24)
Identification of Compounds in Adlay (Coix lachryma-jobi L. var. ma-yuen Stapf) Seed Hull Extracts That Inhibit Lipopolysaccharide-Induced Inflammation in RAW 264.7 Macrophages / Din-Wen Huang, Cheng-Pei Chung, Yueh-Hsiung Kuo *, Yun-Lian Lin * and Wenchang Chiang * / J. Agric. Food Chem., 2009, 57 (22), pp 10651–10657 / DOI: 10.1021/jf9028514
(25)
COIX: FOOD AND MEDICINE / Subhuti Dharmananda, Ph.D. / Institute for Traditional Medicine, Portland, Oregon
(26)
Inhibitory effects of adlay bran (Coix lachryma-jobi L. var. ma-yuen Stapf) on chemical mediator release and cytokine production in rat basophilic leukemia cells / Hong-Jhang Chen, Yi-Chen Lo, Wenchang Chiang / Journal of Ethnopharmacology, Volume 141, Issue 1, 7 May 2012, Pages 119–127
(27)
Studies of enzyme inhibitors and endochitinase in seeds of job's tears (Coix lachryna-jobi) / Ary, Marta Baccache / Thesis, 1994
(28)
Triterpene-loaded microemulsion using Coix lacryma-jobi seed extract as oil phase for enhanced antitumor efficacy: preparation and in vivo evaluation / Ding Qu, Junjie He, Congyan Liu, Jing Zhou, Yan chen / International Journal of Nanomedicine 2014:9 109–119 / http://dx.doi.org/10.2147/IJN.S54796
(29)
Coix lacryma-jobi / Synonyms / The Plant List
(30)
Melanogenesis inhibitors from Coix lacryma-jobi seeds in B16-F10 melanoma cells / Yhiya Amen, Enos Tangke Arung, Mohamed S Afifi, Ahmed F Halim, Ahmed Ashour, Ryoji Fujimoto / Natural Product Research, Vol 31, Issue 23 (2017) / https://doi.org/10.1080/14786419.2017.1292270
(31)
Triolein from Coix Lacryma-Jobi Induces Cell Cycle Arrest through P53/P21 Signaling Pathway / Tran Thi Hien*, Do Thi Ha, Do Minh Truong, Loi Vu Duc, Trong Tuan Dao and Nguyen Thanh Hai / Biomedical and Pharmacology Journal / DOI http://dx.doi.org/10.13005/bpj/967
(32)
Hypouricemia and nephroprotection of Coix lacryma-jobi L. seed extract / Ormjai Taejarernwiriyakul, Naohiko Anzai, Promsuk Jutabha, Wantika Kruanamkam, and Suparat Chanluang* / Songklanakarin J. Sci. Technol. 37 (4), 441-447, Jul. - Aug. 2015
(33)
The Use of Job’s Tear ( Coix lacryma - jobi L) Flour to Substitute Cake Flour in Butter Cake / Marco Kutschera and Wunwisa Krasaekoopt / AU J.T. 15(4): 233-238 (Apr 2012)
(34)
Adlay Seed Extract (Coix lachryma-jobi L.) Decreased Adipocyte Differentiation and Increased Glucose Uptake in 3T3-L1 Cells / Do Thi Ha, Trinh Nam Trung, Nguyen Bich Thu, Tran Van On, Nguyen Hai Nam, Chu Van Men, Tran Thi Phuong, and Ki Hwan Bae / Journal of Medicinal Food. Vol 13, No 6 / https://doi.org/10.1089/jmf.2010.1155
(35)
Studies on Analysis of Liposoluble Components fromCoix lacryma-jobi L.Stem by GC-MS and their Antibacterial Activities / LI Rong; QIN Tao; LIANG Rong-shan;YIN Jian-hua; Huang Suo-yi / Chemical World 2015-01
(36)
Job's tears / Wikipedia
(37)
LARVICIDAL ACTIVITY OF INDIAN MEDICINAL PLANTS ON THE DENGUE FEVER MOS QUITO, AEDES AEGYPTI LINNAEUS / J Deepa, J Gokulakrishnan*, M Baranitharan, and S Dhanasekaran / International Journal of Pure and Applied Zoology, Volume 3 , Issue 2 , pp 130-136
(38)
Norcantharidin combined with Coix seed oil synergistically induces apoptosis and inhibits hepatocellular carcinoma growth by downregulating regulatory T cells accumulation
/ Dan Wang, Chendong Yang, Zhuien Wang, Yi Yang, Defang Li, Xiaojie Ding, Wenjuan Xu & Qiusheng Zheng / Scientific Reports, Vol 7, (2017) / doi:10.1038/s41598-017-09668-2
(39)
Discovery of Anti-Hypertensive Oligopeptides from Adlay Based on In Silico Proteolysis and Virtual Screening / Liansheng Qiao, Bin Li, Yankun Chen, Lingling / Int. J. Mol. Sci. 2016, 17, 2099 / doi:10.3390/ijms17122099

It is not uncommon for links on studies/sources to change. Copying and pasting the information on the search window or using the DOI (if available) will often redirect to the new link page.

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