HOME      •      SEARCH      •      EMAIL    •     ABOUT

Family Acanthaceae
Barleria prionitis Linn.

Scientific names Common names
Barleria appressa (Forssk.) Deflers Kokong-manok (Tag.)
Barleria coriacea Oberm. Kolinta (Tag.)
Barleria echinata St.-Lag. Korinta (Tag.)
Barleria hystrix Linn. Kulanta (Tag.)
Barleria prionitis Linn. Kuranta (Tag.)
Barleria quadrispinosa Stokes Common yellow nail dye plant (Engl.)
Barleria spicata Roxb. Porcupine flower (Engl.)
Prionitis hystrix (L.) Miq. Barleria (Engl.)
Barleria prionitis L. is an accepted name The Plant List

Other vernacular names
ARABIA: Shakhad.
BENGALI: Kantajinti, Peetjhanti.
HINDI: Kala bans, Katsareya, Piabansa.
INDIA: Vajradanti, Kurantaka, Koranta, Cateserina, Katsareya,Kantajati, Muti goranta, Shemulli.
MALAYSIA: Duri landak.
MALDIVES: Dat kurandu.
SPANISH: Espinosa amarilla.
SANSKRIT: Vajradanti, Kurantaka, Koranta.
SRI LANKA: Ikshura, Ikiri, Katukarandu.

Kolinta is an erect, smooth, branched shrub, growing up to 1 to 2 meters high, with slender axillary spines. Leaves are elliptic to elliptic-ovate, 6 to 12 centimeters long, narrowed, and pointed at both ends. Flowers are yellow and axillary, with the upper ones in spikes. Bracts and calyx are green, with the outer bract usually foliaceous. Corolla is about 4 centimeters long.

- In thickets and waste places, in and about towns, at low altitudes.
- Introduced.
- Also occurs in tropical Africa, Asia, and Malaya.

- Large amount of neutral and acid resin soluble in light petroleum ether.

- Leaves yield alkaloids, glycosides and tannin.
- Phytochemical analysis of leaves yielded alkaloids, flavonoids, steroids, saponins, tannin, and phenolic compounds. (See study below) (18)
- An ethanolic extract yielded a new compound, balarenone (1), along with three known compounds, pi- pataline (2), lupeol (3) and 13,14-seco-stigmasta-5,14-diene-3-α -ol (4) and three different derivatives of compound (2), 7,8-epoxypipataline (5), 8- amino-7-hydroxypipataline (6) and 7,8-dibromopipataline (7). (See study below) (20)
- Phytochemical analysis of hydromethanolic extract of whole plant yielded glycosides, saponins, flavonoids, steroids, and tannins. (Maji et al., 2011). Ethanolic extract yielded balarenone, pipataline, lupeol, prioniside A, prioniside B, and prioniside C. (Ata et al., 2007; Kosmulalage et al., 2007). Aerial parts yielded glycosides viz., barlerinoside, verbascoside, shanzhiside methyl ester, 6-O-trans-p-coumaroyl-8-O-acetylshanzhiside methyl ester, barlerin, acetylbarlerin, 7-methoxydiderroside, lupulinoside. (Taneja and Tiwari, 1975; Chen et al., 1998; Singh et al., 2005; Ata et al., 2009). (23)

- Considered diaphoretic, diuretic, expectorant, febrifuge.
- Studies have shown antimicrobial, anthelmintic, anticataract, antifertility, antioxidant, antidiabetic, anti-arthritic, anti-inflammatory, hepatoprotective, antioxidant, analgesic properties.

Parts used
Leaves, tops, roots, juice.


- In the Philippines, decoction of leaves and tops used for bathing in cases of febrile catarrh.
- Whole plant used for urinary and paralytic affections, rheumatism, jaundice, hepatic obstruction and dropsy.
- In Abyssinia, used as febrifuge.
- Paste of roots is applied to boils and glandular swellings.
- In the Konkan, dried bark is given in whooping cough; for anasarca, the juice of the fresh bark with milk.
- In catarrhal afflictions of children with fever and phlegm, two teaspoons of a mixture of the juice of leaves in honey or sugar and water, twice daily.
- For rain soaked feet, juice of the leaves applied to the feet to prevent cracking and laceration.
- Juice of leaves mixed with honey applied to bleeding gums; also used as ear drops for otitis.
- In indigenous systems of medicine in India, stem, leaves and flowers are used for fever, toothaches, inflammation, gastrointestinal disorders, whooping cough. Roots used as tonic and diuretic.
- In Thailand and India, decoction of leaves and flowers used for viral fever.
- In West Bengal used by the Santals as abortifacient: 3 gm of fresh root is crushed with about 100cc of pochai (alcohol from rice) or Mahua (alcohol from flowers of Bassia latifolia, given once daily in the early morning for 3 to 5 consecutive days in induce abortion up to 3 months pregnancy.
- In Ayurveda, known as sahachara, baana, kurantaka, kuranta, koranda, korandaka, shairiya and pita-saireyaka. (23)
- In India, flowers are used internally for the treatment of migraine, internal abscesses, edema, hemoptysis, urethral discharges, seminal disorders and to reduce obesity. Leaves used for the treatment of gastric ulcers.

Anti-Inflammatory / Anti-Arthritic:
Study of 'TAF' fraction from methanol-water extract of B prionitis exhibited significant anti-inflammatory activity against different animal test models and significant anti-arthritic activity in adjuvant-induced polyarthritis test in rats. (1)
Hepatoprotective: Study ethanol extract of aerial parts exhibited significant and concentration dependent hepatoprotective activity against carbon tetrachloride, galactosamine and paracetamol induced hepatotoxicity in rats. (2)
Anti-Diabetic: Study of the alcoholic leaf extract of Barleria prionitis showed a significant decrease of blood glucose levels and glycosylated hemoglobin. (3)
Antifertility / Reduction of Spermatogenesis: Study of isolated fractions of BP root methanolic extract in rats showed a significant reduction of sperm
atogenesis, with significant reduction of sperm motility. (4)
Antifertility / Spermatogenesis Effects: Study showed root extract to exhibit interference with spermatogenesis. The antifertility effects seem to be mediated by a disturbance in testicular somatic cells functions (Leydig and Sertoli cells) resulting in the physio-morphological events of spermatogenesis. (7)
Antinociceptive / Anti-Inflammatory Activity / Flowers: Results showed the ethanolic extract of the flower of B. prionitis possess significant anti-inflammatory and antinociceptive activity. (5)
GTS (glutathione S-transferase) and Acetylcholinesterase Inhibition: Screening of crude extracts of B prionitis showed GST inhibitory activity and AChE inhibition. GTS are considered responsible for decreasing the effectiveness of anticancer / antiparasitic agents and AChE inhibitors have potential applications in the treatment of cardiac disorders and Alzheimer's disease.(6)
Antifungal / Antimicrobial: Study of methanolic extract of bark showed more potent activity against all test oral fungi (S. cerevisiae, C. albicans strains) than the standard drug Amphotericin B. Even crude extracts showed good activity against dental caries-causing oral pathogens. (8)
Anti-Inflammatory / Roots: Various root extracts were tested for anti-inflammatory activity using carrageenan-induced rat paw edema. The aqueous extract was the most active with significant dose-dependent anti-inflammatory activity. (9)
CNS Activity / Antidepressant Effect: Study evaluated the CNS activity of a 70% ethanol extract of leaves in Swiss albino mice. Results suggested B. prionitis exhibited antidepressant activity in the tested animal models. (11)
Topical Anti-Inflammatory: Study evaluated the topical anti-inflammatory activity of different species of Barleria against croton oil induced edema in female rats. The chloroform extract of B. prionitis showed the best topical activity with 88.31 per cent inhibition of ear edema. (13)
Mast Cell Stabilization and Membrane Protection: Study evaluated the membrane stabilization and mast cell protection activity of a hydroalcoholic extract of B. prionitis whole plant. Results showed dose-dependent inhibition of hypo-saline induced erythrocyte membrane hemolysis and induced mast cell degranulation . The results validate the anti-inflammatory activity and supports its traditional usage for inflammatory disorders. (14)
Anti-Diabetic / Leaves and Roots: Study evaluated the antidiabetic activity of various parts of B. prionitis using alloxan induced hyperglycemic rats. Alcoholic and aqueous extracts of leaf and root caused significant reduction in blood glucose, an effect almost equipotent to chlorpropamide. (15)
Antibacterial / Leaves: Study evaluated various extracts of B. prionitis against S. aureus, B. subtilis, P. vulgaris, K. pneumonia, E. coli and P. aeruginosa. Results showed significant activity against all tested pathogens. (16)
Antimicrobial / Bark Extracts / Oral Diseases: Study evaluated various bark extracts for antifungal activity on two Candida albicans strains and Saccharomyces cerevisiae causing oral diseases in humans and antibacterial activity against four oral bacteria, viz., S. mutans, S. aureus, Pseudomonas sp., Bacillus sp. The methanolic extract showed more potent activity against all tested oral fungi than standard drug amphotericin B. The methanolic extract was also most effective against all four oral bacteria. (17)
Antihypertensive Activity / Leaves: Study evaluated the antihypertensive activity of a methanolic extract of leaves using DOCA salt induced antihypertensive model. Results showed significant antihypertensive effect. Phytochemical analysis yielded alkaloids, flavonoids, steroids, saponins,, tannin and phenolic compounds. (18)
Nootropic Activity / Memory Function / Leaves: Study evaluated a leaf extract for effects on cognitive dysfunction and influence on brain cholinergic system in experimental rats. Results showed the leaf extract enhances memory function possibly mediated through the brain cholinergic system. (19)
Antibacterial / Glutathione S-Transferase and AChE Inhibitory Activity: Study yielded a new compound, balarenone (1) along with three known compounds 4, 5 and 6, three derivatives of compound 2 (5,6 and 7). Compounds 1,2, and 4 exhibited antibacterial activity against B. cereus and P. aeruginosa. Compounds 1-4 showed activity against GST and AChE. (See constituents above) (20)
Immunomodulatory Activity / Aerial Parts: Study investigated in vivo and in vitro immunomodulatory activities of the iridoids fractions of B. prionitis aerial parts. Results showed potent immunostimulatory activity, stimulating both the specific and non-specific immune mechanisms. (21)
Anti-Arthritic Activity / Leaves: Study investigated the anti-arthritic potential of ethyl acetate fractions of chloroform extract of leaves of B. prionitis against formaldehyde-induced acute non- immunological and Freund's Complete Adjuvant-induced chronic immunological arthritis in rats. Results showed dose-dependent and significant inhibition of edema in both acute and chronic models. (24)
Anticataract Potential / Leaves: Study evaluated the anticataract potential of B. prionitis using Selenite and Galactose induced cataract models. Results showed oral administration of Barleria prionitis significantly delayed the onset and progression of cataract in Selenite as well as Galactose induced cataract. BP reverses cataract parameters by virtue of its antioxidant potential. (25)
Antioxidant Potential / Leaf and Stem: Study investigated the antioxidant potential of different extracts of BP leaf and stem, measured against DPPH as compared to standard ascorbic acid and BHA. Methanolic extracts of both leaf and stem should highest IC50 values of 63.41±0.32, 81.69±0.40 respectively. Antioxidant activity was attributed to phenolic contents. (26)
Gastroprotective / Anti-Ulcer / Leaves: Study evaluated the gastroprotective activity of leaf extracts using experimental in-vivo models. The chloroform extract and ethyl acetate fraction prevented gastric ulceration caused by indomethacin. Also, the EA fraction inhibited gastric secretion in pylorus ligated rats. (27)


Godofredo U. Stuart Jr., M.D.

Last Update April 2016

IMAGE SOURCE: Photo / File:Barleria prionitis.JPG / Transferred from ml.wikipedia to Commons by User:Sreejithk2000 using CommonsHelper / Sugeesh / 26 February 2012 / Creative Commons Attribution-Share Alike 3.0 Unported, 2.5 Generic, 2.0 Generic and 1.0 Generic license./ click on image to go to source page / Wikimedia Commons
OTHER IMAGE SOURCE / Modified / PD / File:Barleria spp Blanco1.214-original.png / Flora de Filipinas / Franciso Manuel Blanco (OSA), 1880-1883 / Wikimedia Commons

Additional Sources and Suggested Readings
Anti-inflammatory activity of ‘TAF’ an active fraction from the plant Barleria prionitis Linn. / B Singh, S Bani et al / Journal of Ethnopharmacology, Volume 85, Issues 2-3, April 2003, Pages 187-193 / doi:10.1016/S0378-8741(02)00358-6 |
Chemistry and hepatoprotective activity of an active fraction from Barleria prionitis Linn. in experimental animals / B Singh, B K Chandan et al / Phytotherapy Research, Volume 19 Issue 5, Pages 391 - 404 / Published Online: 16 Aug 2005
A study of the antidiabetic activity of Barleria prionitis Linn
/ Reema Dheer, Pradeep Bhatnagar / ndian Journal of Pharmacology;Apr2010, Vol. 42 Issue 2, p70
Effect of isolated fractions of Barleria prionitis root methanolic extract on reproductive function of male rats: preliminary study / Pramod Kumar Verma et al / Fitoterapia, Volume 76, Issue 5, July 2005, Pages 428-432
/ doi:10.1016/j.fitote.2005.03.007 |
EVALUATION OF FLOWER OF BARLERIA PRIONITIS FOR ANTI-INFLAMMATORY AND ANTINOCICEPTIVE ACTIVITY / Sunil K Jaiswal, Mukesh K Dubey et al / International Journal of Pharma and Bio Sciences V1(2)2010
Glutathione S-transferase- and acetylcholinesterase-inhibiting natural products from medicinally important plants / Athar Ata, Stephanie A Van Den Bosch et al / Pure Appl. Chem., Vol. 79, No. 12, pp. 2269–2276, 2007. / doi:10.1351/pac200779122269
Antifertility studies of the root extract of the Barleria prionitis Linn in male albino rats with special reference to testicular cell population dynamics / Gupta RS, Kumar P, Dixit VP, Dobhal MP / J Ethnopharmacol. 2000 May;70(2):111-7.

Potency of Barleria prionitis L. bark extracts against oral diseases causing strains of bacteria and fungi of clinical origin / Kamal Rai Aneja, Radhika Joshi, Chetan Sharma / New York Science Journal 2010;3(11)
Anti-inflammatory activity of aqueous extract fractions of Barleria prionitis L. roots / Khadse C. D. and Kakde R. B. / Asian Journal of Plant Science and Research, 2011, 1 (2):63-68
Some abortifacient plants used bythe tribal people of West Bengal / S Mitra and Sobhan Kr Mukherjee / Natural Product Radiance, Vol. 8(2), 2009, pp.167-171
Central Nervous System Activity of Barleria prionitis Linn. on the Locomotor Activity of Swiss Albino Mice using Actophotometer / Amites Gangopadhyay et al / International Journal of Pharma and Biological Archives 2012; 3(2):403-405
Barleria prionitis / Vernacular names / GLOBinMED
Topical anti-inflammatory studies on Barleria prionitis and B. cristata. / Maninder Karan*, Kawal Preet & Karan Vasisht / J Pharm Biomed Sci., 2013 June; 31(31): 1164-1169.
Mast Cell Stabilization and Membrane Protection Activity of Barleria prionitis L. / A.K. Maji, S. Bhadra, S. Mahapatra, P. Banerji, D. Banerjee / Pharmacognosy Journal / DOI: 10.5530/pj.2011.24.13
Antidiabetic activity of Barleria prionitis Linn. / M. Geetha*, A.K. Wahi / JOURNAL OF NATURAL REMEDIES, Vol. 64, 1/1 (2001) 64 - 66
SCREENING OF IN-VITRO ANTIBACTERIAL ASSAY OF BARLERIA PRIONITIS LINN. / Chetan B. Chavan*, Ulka V. Shinde, Maheshwar Hogade, Somnath Bhinge / Journal of Herbal Medicine and Toxicology 4 (2) 197-200 (2010) ISSN : 0973-4643
Potency of Barleria prionitis L. bark extracts against oral diseases causing strains of bacteria and fungi of clinical origin / Kamal Rai Aneja, Radhika Joshi, Chetan Sharma / New York Science Journal 2010;3(11)
Investigation of Antihypertensive activity of Leaves of Barleria Prionitis in Doca Salt Induced Hypertensive Rats / Bhavna H. Marya*, S. B. Bothara / Int. J. Pharm. Sci. Rev. Res., 18(2), Jan – Feb 2013; no 03, 17-19
Screening ethanolic extract of barleria Prionitis for nootropic activity in rats / Bagewadi, Suhasini .S. / Dissertation / 2011
Glutathione S-Transferase, Acetylcholinesterase Inhibitory and Antibacterial Activities of Chemical Constituents of Barleria prionitis / Kalhari S. Kosmulalage, Shamsulhaq Zahid, Chibuike C. Udenigwe, Sarfraz Akhtar, Athar Ata, and Radhika Samarasekera / Z. Naturforsch. 2007, 62b, 580 – 586
In vitro and in vivo immunomodulatory activities of iridoids fraction from Barleria prionitis Linn / B.V. Ghule P.G. Yeole / Journal of Ethnopharmacology, 2012 | 141 | 1 | 424-431
Barleria prionitis L. / Synonyms / The Plant List
Barleria prionitis Linn.: A Review of its Traditional Uses, Phytochemistry, Pharmacology and Toxicity / D. Banerjee, A.K. Maji, S. Mahapatra and P. Banerji / Research Journal of Phytochemistry, 6: 31-41.
Anti-arthritic activity of Barleria prionitis Linn. leaves in acute and chronic models in Sprague Dawley rats / Manjusha Choudhary, Vipin Kumar, , Pankaj Kumar Gupta, Surender Singh / Bulletin of Faculty of Pharmacy, Cairo University, Volume 52, Issue 2, December 2014, Pages 199–209 / doi:10.1016/j.bfopcu.2014.07.002
ANTICATARACT POTENTIAL OF BARLERIA PRIONITIS: IN VIVO STUDY / Mohammed Atif, Shaik Abdul Rahman, Mohammed Ibrahim Ahmed, Syed Baquer Mahmood, Mohammed Azharuddin / International Journal of Pharmacy and Pharmaceutical Studies, Vol 7, Issue 2, 2015
Evaluation of Antioxidant Potential of Barleria prionitis Leaf and Stem / Piush Sharma, Ganesh N. Sharma, B. Shrivastava, Hemant R. Jadhav / AMERICAN JOURNAL OF PHYTOMEDICINE AND CLINICAL THERAPEUTICS, Vol 2, No 10 (2014)
Gastroprotective potential of chloroform leaves extract of Barleria prionitis Linn.: From traditional use to scientific approach / Manjusha Choudhary, Vipin Kumar*, Surender Singh / Advances in Chemistry and Biochemistry Sciences, Volume 1 | Issue 1 | Pages 01-11

It is not uncommon for links on studies/sources to change. Copying and pasting the information on the search window or using the DOI (if available) will often redirect to the new link page.

HOME      •      SEARCH      •      EMAIL    •     ABOUT