Kuisia is a small, erect, glabrous and branching
shrub, growing to 1.5 meters high. Leaves are glossy green, opposite,
up to 3 centimeters long, petioled, ovate, with a rounded tip. Flowers are in
clusters, fragrant, bright yellow, up to 1.5 centimeters across, in clusters
of 4 to 6 at the stem tips.
Popularly cultivated in towns and
- Makes a good hedge plant.
- Flowers year-round.
- Native to Mexico.
• No reported folkloric medicinal
use in the Philippines.
• In Latin American
traditional medicine, used for asthma and allergies.
• In Mexican traditional
medicine, used as a sedative and tranquilizer for mental disorders and nervous excitement.
• Homeopathic Proving:
Statistical analysis showed no significant
differences, certain symptoms were observed, i.e., relaxing, sedative,
anxiolytic and anti-allergic. Results confirmed toxicological and clinical
effects of Galphimia glauca compared to placebo, but not enough to satisfy
the ICCH criteria for distinguishing between specific and unspecific
Bronchoconstriction inhibition / Asthma:
The ethylacetate fraction of the aerial
parts significantly and selectively inhibited the bronchoconstriction
induced by leukotrine D4 (LTD4). (2)
• Anxiolytic / Galphimine B: Study
has yielded an active principle, galphimine B (GB, a nor-seco-triterpene).
Aqueous extract of Gg showed anxiolytic effectiveness, similar to that
produced by lorazepam, but with regards side effects, Gg showed a higher
tolerability than lorazepam. (3)
• Anxiolytic / Galphimine B: Study evaluated the anxiolytic effects of galphimine B, A and E. Results showed the GRF (galphamine-rich fraction) had activity similar to the most active pure glaphamines (1 and 2), and the main determining factor for anxiolytic activity was the presence of free hydroxyl groups at C4,6,and 7 and the double bond A ring. (7)
• Anxiolytic / Friedelanes: Studies have isolated the anxiolytic and sedative principle consisting of a mixture of norsecofriedelanes, named the galphimine series. (6)
• Hay Fever / Pollinosis: Study
comparing Galphimia glauca to placebo in the treatment of pollinosis
showed a significant superiority of Gg over placebo, with effects comparable
to those of conventional antihistamines but with no side effects. (4)
• Toxicological / Cytotoxic: Study
of extracts have yielded different triterpenes: galphimines. Galphimine
B possess anxiolytic activity and selectively inhibits dischargers of
dopaminergic neurons in rats. This study saw no deaths, no histopath
changes; behavioral parameters showed a diminution of spontaneous activity.
All the extracts inhibited colon cancer cell line growth with no genotoxic
• Phytochemicals / Weak Anti-Protozoal Activity: Study
isolated four new terpenoids with the known sterols and flavonol quercetin. Quercetin was the only isolate that showed any antiprotozoal activity, and weak at that. (6)
• Generalized Anxiety Disorder / Clinical Trial / Comparison with Lorazepam: Study of G. glauca herbal medicinal product, standardized in 0.175 mg of glaphimine-B and administered for 15 weeks to patients with generalized anxiety disorder, showed greater anxiolytic effectiveness compared with lorazepam, with a high percentage of therapeutic tolerability and safety. (9)
• Re-Analysis of Homeopathic Use for Hay Fever: An earlier meta-analysis reached a positive conclusion regarding use of GC for hay fever. This findings from this reanalysis seem to suggest efficacy, however, important caveats prevent any firm conclusions and casts doubts on the reliability of conclusion of the published meta-analysis. (12)
• Anti-Inflammatory / Leaves: In a bio-guided isolation of anti-inflammatory compounds from extracts of leaves of G. glauca, the hexane extract showed to have the strongest anti-inflammatory activity. (13)
Pellets, extracts and supplements in the cybermarket.