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Family Plumbaginaceae
Plumbago indica Linn.

Zi hua teng

Scientific names Common names
Plumbago indica Linn. Hangad-ang-babae (Tag.)
Plumbago rosea Linn. Pampasapit (Tag.)
Thela coccinea Lour. Panting-panting (Tag.)
  Indian leadwort (Engl.)
  Laurel (Engl.)
  Fire plant (Engl.)
  Rose-colored leadwort (Engl.)
  Rosy leadwort (Engl.)
  Scarlet leadwort (Engl.)
  Whorled plantain (Engl.)
Plumbago indica L. is an accepted name. The Plant List

Other vernacular names
ARABIC: Shittermul, Shitarajehmar, Shitturridge.
BENGALI: Kaing-khao, Rakt-chitrak, Raktachita, Raktachitra, Agnichita, Laichita.
CHINESE: Xie san niang, Zi hua dan.
GUJARATI: Kalochitrak, Chitro.
HINDI: Lai chitrak.
MALAYALAM: Kotuveli, Chethikiduveli.
MALAYSIA: Binasa, Chelaka merha, Cheraka merah, Setaka.
MANIPURI: Mukaklei.
PORTUGUESE: Plumbago de flor vermelha.
SANSKRIT: Rakta chitrak.
SRI LANKAN: Rath nitul.
TAMIL: Akkini.

Laurel is an erect or spreading, more or less branched, herbaceous or half-woody plant, 1.5 meters or less in height. Leaves are ovate to oblong-ovate, 8 to 13 centimeters long, smooth, slightly drooping, with entire, undulate or wavy margins, with a pointed or blunt tip and a pointed base. Spikes are 15 to 30 centimeters long. Calyx is tubular, 8 to 10 millimeters long, covered with stalked, sticky glands. Corolla is bright red, tube is slender, about 2.5 centimeters long, and the spreading limb, about 3 centimeters in diameter.

- Cultivated throughout the Philippines for ornamental purposes for its showy red flowers.
- Also occurs in Cambodia, southern China, Indonesia, Laos, Thailand, Vietnam.

- Contains plumbagin, sitosterol glucoside.
- Roots are the highest source of plumbagin, a naphthoquinone.

- Aerial parts yielded reducing sugars, alkaloids, steroids, flavonoids, and gums. (see study below) (
- Phytochemical studies of various parts yielded: Roots: quinones (plumbagin, roseanone, 6-hydroxyplumbagin, drowner, elliptical, plumbago acid lactose), phenols (flavonoids, carbolic acids), alkaloids ( α-naphthylamine), aliphatic acids (myricyl palmitate, palmitic acid), steroids (ß-sitosterol); Aerial parts: steroids (ß-sitosterol, campesterol, stigmasterol), quinones (plumbagin, 6-hydroxyplumbagin), flavonoids (plumbaginol); Flower: pigments (pelargonin, cyanidin, delphinidin, kaempferol), and carbohydrates (mono and di-galloylgucose). (17)
- Study of roots yielded a new quinone derivative-plumbagic acid lactose, two flavonol methyl ethers-azaleatin (5-O-methylquercetin), ayanin (3,7,4', tri-O-methylquercetin), two aliphatics-palmitic acid, myricyl palmitate, and one naphthoquinone-plumbagin. (

- Considered vesicant, stimulant, sialagogue, sudorific.
- Roots considered abortifacient and antifertility, stimulant, digestive, vesicant.
- Juice of the root is acridly pungent to taste, producing a severe, lancinating pain the tongue.
- Juice of the root is blistering to the skin.
- Leaves and stems are pungent in taste, but not as virulent as the root.
- Bark considered antidyspeptic.
- Phytochemical screening of leaves yielded reducing sugar, alkaloids, flavonoids, gum, steroids. (see study below)
- Studies have suggested anti-fertility, abortifacient, anti-tumor, antimicrobial, estrogenic, anti-Helicobacter, cytotoxic, macrofilaricidal, anti-influenza, anti-acne activities.

Parts used
Roots, leaves, bark.

- Poultice of bark scrapping used as poultice for headaches.
- Bark used as blistering plaster; also applied to spine for fevers; antidyspeptic.
- Juice distinctly blisters the skin.
- In India, root is used as abortifacient and antifertility medicine; root is used as irritant, introduced into the vagina and applied directly to the neck of the uterus. Juice of root used as powerful sudorific.
- Taken internally, root is poisonous and acts on the stomach as an acro-narcotic or narcotico-irritant poison. Taken internally or applied to the genital organs, it acts as an abortifacient.
- Juice of leaves and roots, alone or mixed with oil, used as application for rheumatism and paralysis, buboes, glandular swellings, and leprosy.
- Liniment made from bruised roots and mixed with oil used for treating rheumatism, paralysis, leucoderma, abscesses and scorpion stings.
- Milky juice of leaves used in ophthalmia; applied onto skin scabies, ringworm, and hemorrhoids.
- Roots also used for dyspepsia, piles, diarrhea, and to improve the appetite.
- In Ayurveda, suppresses vata and pitta.
- In Myanmar, used for leprosy and syphilis.
- In West Bengal, decoction of fresh roots used as abortifacient. (20)

- Used by the Mullu Kuruma tribe in Kerala, India as an antibacterial herb. (15)

Fetotoxic / Abortifacient:
Study evaluated a methanolic root extract of roots on rat uterus and pregnant mice. Study indicated the possible presence of utero-active compounds. Results showed pronounced fetotoxic and mild abortifacient potential, and supports its traditional use in avoiding unwanted pregnancies. (1)
Plumbagin /
Anti-Fertility: Plumbagin, a napthoquinone, has shown to have antifertility activity similar to embelin, an antifertility agent of plant origin.
Plumbagin / Isolation / Roots:
Roots are the richest source of plumbagin, a major active compound and potential biomarker. Study presents a simple method for isolation of plumbagin from roots of Plumbago rosea, through precipitation out by addition of water to an acetone extract
. (2) A reverse phase HPLC method with UV detection was developed to quantify plumbagin, the bioactive marker of the roots of P. indica and P. zeylanica. P. indica was found to contain significantly higher amounts of plumbagin than P. zeylanica. The HPLC and HPTLC methods described were simple, rapid, accurate, and sensitive. (23)

An in vivo study was done for tumor inhibitory and radiosensitizing effects of an Indian medicinal plant, Plumbago rosea on experimental mouse tumors. Results shows PE to have a weak antitumor effect, but may have a potential use in enhancing the tumor-killing effect of radiation. (3)Plumbagin / Anti-Tumor: The antitumor and radio-modifying properties of plumbagin were tested on mouse Ehrlich ascites carcinoma. Plumbagin showed inhibition of exponentially growing tumors. Its mode of anticancer activity was unclear in the study.
Plumbagin / Anti-Tumor: Plumbagin was found to have tumor growth inhibitory effects and contemplated for use in human cancer therapy.
Antimicrobial Activity in Vitro of Plumbagin Isolated from Plumbago Species: PR was shown to exhibit activity against yeast and bacteria suggesting the naphthoquinone plumbagin as a promising antimicrobial agent.
Study of five extracts of stems of PR in rats showed antifertility activity in female Wistar rats with interruption of the estrous cycle, temporary inhibition of ovulation. The acetone extract showed significant estrogenic and antiestrogenic activity. Results indicated the antifertility activity of stems of P rosea.
Toxicity Study / Roots:
Study of ethanolic root extract of PR in mice showed severe diarrhea at doses above 1250 mg / kg. While a higher dose was tolerated in fractionated administration, it was shown to have growth inhibitory effect in both sexes.
Antiovulatory / Estrogenic Activity / Antifertility: Study showed the acetone and ethanol extracts to be effective in interrupting the normal estrous cycle of rats, with prolonged diestrous cycle and consequent temporary inhibition of ovulation. Both extracts showed significant estrogenic and antiestrogenic activities. It concludes that both extracts have antifertility effects.
Study investigated the macrofilaricidal activity of P. indica in vitro against Setaria digitata, a filarial parasite of cattle. Complete inhibition of motility was observed in various concentrations. The active molecule was identified as plumbagin (5-hydroxy-2-methyl-1,4-naphthalenedione).
• Anti-Helicobacter Activity / Cytotoxicity / Roots: Study evaluated the anti-helicobacter activity and cytotoxic activity of root ethanol extract of Plumbago indica, P. auriculata, and P. zeylanica. The three plants showed dose-dependent cytotoxicity activity in HGE-17 cell lines. All plants showed significant zones of inhibition against H. pylori, with P. indica showing more activity compared to the other two plant. (15)
• Cytotoxicity / Leaves: Study evaluated leaves of Plumbago indica for possible cytotoxic effects. In brine shrimp lethality assay, the LC50 and LC90 values were found to be 4.57 µg/ml and 9.87 µg/ml for a crude methanolic extract. (16)
• Anti-Influenza Activity / Hemagglutination Inhibition:
Study evaluated the anti-influenza activity of Plumbago indica and Allium sativum extracts against Influenza A (H1N1)pdm09. Two assays were used for anti-influenza activity: simultaneous and post-treatment assays. A. sativum extracts showed only 14% reduction in hemagglutination in contrast to 100% reduction by P. indica in both simultaneous and post-treatment assay. Results suggest P. indica extracts are good candidates for anti-influenza therapy. (18)
• Anti-Acne / Roots:
Study evaluated the in vitro anti-acne activity of acetone extract of root of Plumbago indica against two acne causing bacterial, i.e., Propionibacterium acnes and Staphylococcus epidermis and yeast Malassezia furfur. The extract showed dose dependent activity against all microorganisms. Minimum inhibitory concentrations against Pa, Se, and Mf were 600, 200, and 300 µg/ml, respectively. (19)

Immunosuppressive Effect:
Study evaluated four medicinal plant species (Justicia gendarussa, Plumbago indica, Aloe vera, and Aegle marmelos) from the Kolli hills of Tamil Nadu for immunosuppressive effect. Crude methanol extracts were tested for inhibition of lymphocyte proliferation via lymphocyte proliferative assay by thymidine uptake. All the extracts exhibited inhibition of lymphocyte proliferation. J. gendarussa showed highest lymphocyte inhibition (84%). Results suggest the extracts should be further investigated for immunosuppressive components. (22)
• Anti
Study evaluated methanolic extracts of Alpinia conchigera and Plumbago indica for antidiarrheal potential against castor-oil induced diarrhea in mice using measures of latency period and diarrheal frequency by counting faeces time and number. The methanolic extracts at doses of 250 and 500 mg/kg showed antidiarrheal effect as evidenced by reduced induction time of diarrhea and total weight of faces. (24)
• Anti
Study evaluated the methanolic extract of Plumbago indica for antifungal activity using disc diffusion method. Fluconazole was used as standard. Results showed good antifungal activity with zones of inhibition ranging from 10.0-27.0 mm. Candida albicans was the most susceptible fungal strain. (25)

- Cultivated.
- Herbal biosolutions in the cybermarket.

Updated November 2019 / January 2017

Photo © Godofredo Stuart / StuartXchange
IMAGE SOURCE: Public Domain / / File:Plumbago coccinea Blanco2.298-original.png / Flora de Filipinas / 1880 - 1883 / Francisco Manuel Blanco (O.S.A) /Wikimedia Commons
OTHER IMAGE SOURCE: Public Domain / Wikimedia Commons / File:Plumbago coccinea Blanco2.298-original.png / Flora de Filipinas / 1880 - 1883 / Francisco Manuel Blanco (O.S.A) /

Additional Sources and Suggested Readings
Uterotrophic, Fetotoxic and Abortifacient Effect of Malaysian Variety of Plumbago rosea L. on Isolated Rat Uterus and Pregnant Mice / Munavvar Abdul Sattar et al / Pakistan Journ of Biological Sciences 10 (5):763-767, 2007
A simple method for isolation of plumbagin from roots of Plumbago rosea / Nayana Kapadia et al / Summary Pharmaceutical Biology 2005, Vol. 43, No. 6, Pages 551-553
In vivo tumor inhibitory and radiosensitizing effects of an Indian medicinal plant, Plumbago rosea on experimental mouse tumors
Antimicrobial Activity in Vitro of Plumbagin Isolated from Plumbago Species
Antifertility Activity of Stems of Plumbago rosea in Female Albino Rats / E. Sheeja, S.B. Joshi, D.C. Jain / Summary Pharmaceutical Biology • 2008, Vol. 46, No. 12, Pages 920-927 /
Toxic effects of crude root extract of Plumbago rosea (Rakta chitraka) on mice and rats./ Solomon FE, Sharada Ac, Devi PU / J Ethnopharmacol. 1993 Jan;38(1):79-84.
A Review of Pharmacology of Phytochemicals from Indian Medicinal Plants / Samir Malhotra MD and Amrit Pal Singh MD / The Internet Journal of Alternative Medicine. 2007 Volume 5 Number 1
Modification of Bone Marrow Sensitivity by Medicinal Plant Extracts / A Ganasoundari, S Mahmood Zare and P Uma Devi / British Journ of Radiology, 70 (1997), 599-602
Antiovulatory and estrogenic activity of Plumbago rosea leaves in female albino rats / E Sheeja, S B Joshi, D C Jain / Indian J Pharmacol. 2009 December; 41(6): 273–277. / doi: 10.4103/0253-7613.59927.

Macrofilaricidal activity of the plant Plumbago indica/rosea in vitro / Nisha Mathew*, K. P. Paily, Abidha, P. et al / Drug Development Research, Vol 56, No 1, pages 33–39, May 2002 / DOI: 10.1002/ddr.10056
Lai chitrak / Common names / Flowers of India
Plumbago rosea / Vernacular names / GLOBinMED
Pharmacognostic Studies of Aerial Part of Methanolic Extract of Plumbago indica L. / Dibyajyoti Saha* , Swati Paul / Asian J. Res. Pharm. Sci. 2012; Vol. 2: Issue 3, Pg 88-90
Plumbago rosea / Synonyms / The Plant List
Anti-Helicobacter Pylori and Cytotoxic activity of detoxified root of Plumbago auriculata, Plumbago indica and Plumbago zeylanica / Ann Shine Paul, Aneesul Islam, P. Yuvaraj / The Journal of Phytopharmacology 2013; 2 (3): 4-8
Phytochemical and pharmacological investigation of Plumbago indica L
/ Zarrin Tasnim Rafa, Md. Ashrafudoulla, Farhan Fuad, Rafiqul Islam, Mehedee Hasan, Md. Abdullah Hil Kafi, Md. Siddiqul Islam, Salma Parvin / Journal of Medicinal Plants Studies, 2016; 4(2): pp 115-118
Plumbago rosea L. – A Review on Tissue Culture and Pharmacological Research / Binoy Jose, Dhan ya B P, Silja P K, Krishn an P N, Satheeshku mar K* / Int. J. Pharm. Sci. Rev. Res., 25(1), Mar – Apr 2014, Pages: 246-256
Assessment of Anti-Influenza activity and hemagglutination inhibition of Plumbago indica and Allium sativum extracts / Rahul Dilip Chavan, Pramod Shinde, Kaustubh Girkar, Rajendra Madage, Abhay Chowhary / Pharmacognosy Research, 2016; Vol 8, No 2: pp 105-111 / DOI: 10.4103/0974-8490.172562
/ DARSHPREET KAUR, SHYAM BABOO PRASAD* / Asian Journal of Pharmaceutical and Clinical Research, Vol 9, Issue 2 (2016)
Plumbago indica / Vernacular names / GlobeInMed
Immunosuppressive effect of medicinal plants of Kolli hills on mitogen-stimulated proliferation of the human peripheral blood mononuclear cells in vitro / S Arokiyaraj, K Perinbam, P Agastian, K Balaraju / Indian Journal of Pharmacology, 2007; 39(4): pp 180-183 / DOI: 10.4103/0253-7613.36535
A reverse phase HPLC-UV and HPTLC methods for determination of plumbagin in Plumbago indica and Plumbago zeylanica / K. P. Unnikrishnan, S. Sudhakar Raja and Indira Balachandran / Indian Journal of Pharmaceutical Sciences, 2008; 70(6): pp 844-847 / DOI: 10.4103/0250-474X.49142
Study of Antidiarrheal Activity of Two Bangladesh Medicinal Plants in Castor-Oil Induced Diarrhea / Dibyajyoti Saha and Swati Paul / Reearch Journal of Pharmacy and Technology, June 2012; 5(6): pp 800-806
In vitro Screening of Antifungal Activity of Methanol Extract of Plumbago indica L. against some pathogenic species of fungi / Saha Dibyajyoti, Paul Swati / Asian Journal of Research in Pharmaceutical Science, 2012; 2(2)
Chemical Constituents of Plumbago indica roots and reactions of plumbagin: Part II / B Dinda, S K Das, A K Hajra, A Bhattacharya, K De, G Chel and B Achari / Indian Journal of Chemistry, May 1999, 38B: pp 577-582

It is not uncommon for links on studies/sources to change. Copying and pasting the information on the search window or using the DOI (if available) will often redirect to the new link page. (Citing and Using a (DOI) Digital Object Identifier)
Abuse and Plagiarism of the Compilation on Philippine Medicinal Plants Under the Guise of Fair Use

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