Mala-anis is an erect, much branched, smooth, herbaceous,
or half-woody plant 25 to 80 centimeters in height. Leaves are opposite and whorled, lanceolate to elliptic
or oblanceolate, 0.5 to 2 centimeters long, pointed at both ends and narrowed
below the short stalk, and toothed in the margins. Flowers are white, small, very numerous, and in pairs;
their stalks slender, and 1 centimeter long or less. Sepals are 4 or 5, imbricate,
corolla rotate, 4-fid, the throat bearded, lobes subequal, white
stamens 4, subequal. Capsules are ovoid or rounded, 2 to 3 millimeters in diameter.
- Ubiquitous weed throughout
the Philippines in settled areas at low to medium altitudes along roadsides,
sides of ditches, and other more or less shaded and moist places.
- Native or tropical America.
- Now pantropic.
• When chewed, bitter at first, later sweet.
• Sweet and has cooling nature.
• Considered antipyretic, diuretic, analgesic, antiinflammatory, antifungal, antibacterial,
• Considered by some as aphrodisiac.
• Studies have shown antiviral, antimalarial, antidiabetic, anticancer, anti-inflammatory, antioxidant properties.
• Contains a trace of an alkaloid, an insoluble bitter principle, and much salicilic acid.
• Study yielded diterpenoids, flavonoids, tannins, alkaloids, triterpenes, hexaconasol, b-sitosterol, ketone, dulcitone and amellin.
• Triterpene and mannitol isolated from the roots; dulcitol from
• Phytochemical studies revealed acacetin, amellin, amyrin, apigenin, benzoxazin, benzoxalinone, betulinic acid, daucosterol, dulcidion . . among others. Also isolated were a flavone glycoside and a diterpene.
• Studies have yielded amellin, scoparic acid A, B, and C, scopadulic acid A & B, scopadulin, scoparinol, friedelin and glutinol. (29)
• Studies revealed the presence of flavonoids, steroids, quinone, starch, cellulose, terpenoids, phenols, carbohydrates, fixed oil and fat, and saponins in varying solvents. (33)
· Whole plant.
· Collected from April to June.
· Wash, cut into pieces, dry under the sun.
· In the Philippines, roots, leaves, and tops used as infusion for gastralgia, diarrhea, and dysentery.
· Root decoction used for fevers.
· Decoction of leaves and tops used for intestinal affections.
· Decoction of dried material used for cold and fever, enteritis,
diarrhea, beriberi, edema, difficulty in urination.
· For miliaria, rub the squeezed juice from fresh plant.
· For headaches associated with fevers, leaf or whole plant macerated in water is drunk copiously when cooled.
· Used as a children's remedy for coughs and diuretic.
· In Liberia decoction taken for gravel and kidney complaints.
· Decoction applied as fomentation on bruises and contusions.
· In Brazil decoction used for bronchitis and broncho-pulmonary afflictions.
· In the Antiles, plant used as emollient; decoction used as enema and for local baths.
· Decoction used for diarrhea, colic, and indigestion.
· Roots used as diuretic.
· In Costa Rica decoction of leaves used as stomachic; infusion used as emmenagogue.
· In India, China
and Southeast Asia, used for pain, fever,
dysentery, diarrhea, cough, bronchitis, hypertension, piles and insect
· In Vietnam, used
for snakebites and antidote for cassava intoxication. Also, for pimples,
impetigo, ulcers and eczema.
· In Taiwan, used
·Murong tribe in Bangladesh used the plant in the treatment of malaria.
· In Sierra Leone, used
for remittent fevers and gonorrhea. For the latter, a cold infusion, sweet and mucilaginous, is drunk repeatedly.
· In Nigeria, plant used in the management of sickle cell anemia.
· In Nicaragua, plant used for malaria.
· In India, used
for gonorrhea, to induce labor, and diabetes.
· In India, leaves ground to a paste applied topically for wound healing.
· In China, used
· In Burma and
India, herb infusion used
as mouthwash for infected gums.
· In Nepal, leaves used for stomach ache and venereal diseases. (41)
· In Brazilian folk medicine, used for bronchitis, gastric disorders, hemorrhoids, insect bites, skin wounds.
· Ritual: In Trinidad's
santowah ceremony, sweetbroom is used to sprinkle holy water.
• Antioxidant / Free Radical Scavenging: Free Radical
Scavenging Activity of Scoparia dulcis Extract: Study showed
strong antioxidant activity corresponding to the reduction of hydroxyl radical generation, a possible rationale for the weeds observed therapeutic effects. (3) Study of methanol and aqueous extracts of Scoparia dulcis showed significant free radical scavenging activity by DPPH, Nitric Oxide and Superoxide ion models. (39)
• Antioxidant / Anti-Diabetic: Study showed significant decrease in TBARS and hyperperoxides formation in the brain of rats suggesting a role in protection against lipid peroxidation induced membrane damage. Results suggest, in addition to its antidiabetic effect, SD possess antioxidant potential. (5)
• Antihyperglycemic / Polyol Pathway: Effect of an
aqueous extract of Scoparia dulcis on blood glucose, plasma insulin
and some polyol pathway enzymes in experimental rat diabetes:
Study showed SD was effective in attenuating hyperglycemia in rats,
possibly due to the decreased influx of glucose into the polyol pathway with increased activities of antioxidant enzymes and plasma insulin and decreased activity of sorbitol dehydrogenase. (4)
• Anti-Diabetic: Study showed the aqueous extract of Scoparia dulcis exhibited antihyperglycemic effect by attenuating biochemical alterations in streptozotocin-induced diabetic rats.
• Cytoprotective / Insulin-Secretagogue Activity: Study showed significant decrease in blood glucose with significantly increased plasma insulin level with use of aqueous extract of S dulcis in STZ-induced diabetic rats. Other results showed its insulin secretagogue activity and protection against STZ-mediated cytotoxicity. The glucose lowering effect was associated with potentiation of insulin release from the pancreatic islets. (10)
• Anti-Ulcer: Study showed water extracts of S dulcis showed dose-dependent inhibition of indomethacin-induced gastric damage in rats validating its use in traditional medicine as an antacid and anti-ulcer agent.
• Antioxidant: Protective role of Scoparia dulcis plant extract on
brain antioxidant status and lipid peroxidation in STZ diabetic male
Wistar rats. Study showed levels of peroxidation markers in the brain were significantly a role in protection against lipidperoxidation-induced membrane damage.
• Antibacterial / Antifungal:
Study of isolated fractions showed significant antimicrobial and antifungal activity against all tested organisms – S typhii, S aureus, E coli, B subtilis, P aeruginosa, P vulgaris and fungal strains (C albicans, A niger and F oxysporum). (6) An ethanolic extract and cream based formulation exhibited significant antimicrobial activity against gram-positive organisms (S. aureus and E. coli) and antifungal (C. albicans and A. niger) organisms. (23) Study showed a methanol extract displayed better MIC compared to aqueous extract against gram-positive and gram-negative bacteria and fungus. (30)
• Antitumor / Scopadulcic Acid B: Scopadulcic acid B (SDB), a tetracyclic diterpenoid
isolated from S dulcis, inhibited the effects of a tumor promoter, inhibited phospholipid synthesis and suppressed the promoting effect of TPA on skin tumor formation. Its potency is stronger than other natural anti-tumor promoting terpenoids. (7)
Effect of Scoparia dulcis (Sweet Broomweed)
in Streptozotocin Diabetic Rats: Study showed antidiabetic
and antihyperlipidemic activity in normal and experimental diabetic
• NGF Activity: Acetylated Flavonoid Glycosides Potentiating NGF Action
from Scoparia dulcis: Three new acetylated flavonoid glycosides
were isolated, two of which showed enhancing activity of nerve growth
factor-mediated neurite outgrowth. (9)
• Cytotoxicity: Study isolated four new diterpenes. Crude extracts and pure diterpenes suggested cytotoxicty.
• Scoporic Acid A / Beta-glucoronidase Inhibitor: Study isolated three labdane-type diterpene acids: scoparic acid A, B and C. Scoporic acid A was found to be a potent beta-glucoronidase inhibitor. (8)
• Hepatoprotective / Antioxidant: Study isolated showed the hydroalcoholic extract of S dulcis exhibits significant hepatoprotective activity against carbon tetrachloride-induced liver damage in rats, an activity attributed to free radical scavenging activity. (13) Study investigated the antioxidant and hepatoprotective activity of aqueous extracts of S. dulcis against N-nitrosodiethylamine (DEN) induced liver cirrhosis in experimental rats. Results showed hepatoprotective activity significant (p<0.01) decrease in enzyme markers and increase antioxidant enzymes, with significant reduction in LPO levels in extract treated animals. (36)
• Anti-Trypanosomal Immunosuppression / Immunological Boosting: Previous findings suggest T. brucei is immunosuppressive. Study showed Scoparia dulcis provides a measure of immunological boost during experimental T. brucei infection in rabbits.
• Sympathomimetic Effects / Catecholamines: Study yielded both noradrenaline and adrenaline in the plant extract. The catecholamines may be responsible for the hypertensive and inotropic effects after parenteral administration of S dulcis extracts. (15)
• Anti-Urolithiasis: Study investigating the inhibition of calcium oxalate, calcium phosphate and calcium carbonate mineralization by five medicinal plants – A aspera, P leschenaultii, S amplexicaulis, Scoparia dulcis and A lanata – showed that increased intake of the fruit juices and seed extracts of the test plants would be helpful in urinary stone prophylaxis. The sequestering of the insoluble calcium salts by the fruit juices may be due to single or mixed ligand chelation by the hydroxyl acids present in them. (16) Study evaluated the on the effect of ethanolic leaf extract of Scoparia dulcis on the urolithiatic and control kidney marker enzymes on urolithiasis induced by ethylene glycol. Results showed decrease in the levels of marker enzymes suggesting the capability of S. dulcis in counteracting the toxic effect of ethylene glycol. (40)
• Anti-Inflammatory / Analgesic: Study results indicate that the extract of S dulcis possess analgesic effects probably related to its antiinflammatory activity, effects probably attributable to the presence of glutinol and flavonoids. (17)
• Pro Blood Clotting Activity: Study investigated the effect of a decoction of S. dulcis on blood clotting time in rats. Results showed significant reduction in clotting time. The proclotting activity was faster than vitamin K. (19)
• Anti-Malarial / Scopadulcic acid A: Phytochemical screening yielded pharmacologically active compounds scopadulcic acid A (SDA) and scopadulcic acid B (SDB), and semisynthetif analogues. SDB has shown antiviral activity against Herpes simplex virus 1 and antitumor activity against various human cancer cell lines, and potent inhibitory activity against gastric proton pumps. Pure SDA was tested and found to have in vitro activity against P. falcifarum. (20)
• Anti-Diabetic / Antioxidant: Study on in vivo hypoglycemic activity of methanol extract of Scoparia dulcis on streptozotocin induced diabetic model showed significant effect on blood glucose simlar to that of glibenclamide. The extract showed promising results on both DPPH and ferric ion reducing capacity. The antioxidant activity is directly correlated to the antidiabetic potential of the drug. (22)
• Antilithiatic / Antibacterial: Chloroform and ethanol extracts of stems and leaves showed maximum resistance against Staphylococcus aureus while ethanol and aqueous extracts showed maximum resistance against Klebsiella pneumonia. The plant extract showed in vitro antilithiatic activity for kidney stones with great great potential to dissolve calcium oxalate crystals. (24)
• Antiurolithiatic / Combination with Aerva lanata: Study evaluated the potential of Scoparia dulcis and Aerva lanata in the management of urine volume in ethylene glycol induced urolithiatic male albino rats. Administration of SD and AL gradually increased urine volume. Results indicated that the fruit part of Scoparia dulcis in combination with A. lanata showed higher antiurolithiatic activity than others. (25)
• Neuroprotective / Cytoprotective: Study evaluated the protective effect of various extracts of S. dulcis against neuroinflammation and erythrocyte hemolysis. Results showed significant neuroprotective effect on both brain neuronal cells and neurotransmitter enzyme as acetylcholinesterase. Cytoprotective effect was evidenced by prevention of rat erythrocytes hemolysis between 56% and 83% at 300 µg/ml. The protective effects may be attributed to its antioxidant components as flavonidic polyphenols. (26)
• Antidiabetic / Antioxidant / Anti-Inflammatory: Review article discusses the antidiabetic activities as well as its antioxidant and anti-inflammatory properties of Scoparia dulcis. The primary mechanisms of antidiabetic activity are through a-glucosidase inhibition, curbing of PPAR-y and increased secretion of insulin. (27)
• Analgesic / Whole Herb: Study evaluated two medicinal plants, Ficus racemosa and Scoparia dulcis for central analgesic activity using hot plate and peripheral pharmacologic action using acetic acid induced writhing test in mice. Results showed the whole herb of S. dulcis demonstrated both central and peripheral analgesic activities. (28)
• Antisickling / LD50 / Leaves: Study evaluated the antisickling activity of plant leaves on sodium metabisulphite-induced sickling of HbSS red blood cells obtained from sickle cell patients who were not in crises. Results showed antisickling activity with significant (p<0.05) percentage sickling inhibition by the aqueous methanol extract compared to crude extracts. LD50 in mice was above 8000 mg/kg body weight when administered orally. Toxicological evaluation at 250 and 500 mg/kg showed mild congestion in virtually all target organs. (31)
• Anti-Anaemic: A major feature of trypanosome infection is anemia. Study evaluated the effect of Scoparia dulcis on Trypanosoma brucei induced anemia in a rabbit model. Although no significant (p>0.05) changes were observed in the RBC indices, the severity of the anemia was significantly less pronounced (p<0.05) in treated infected rabbits. The mechanism/s of its anti-anaemic activity still need to be established. (32)
• Flavone Cirsitakaoside / Clastogenicity: Study evaluated the mutagenic effect of flavone cirsitakaoside isolated from Scoparia dulcis and tested in vitro by using human peripheral blood cultures. The compound was found to be mutagenic at highest concentration (15 µg/ml). The proliferative index was significantly reduced in all cultures treated with flavone, although the mitotic index was not reduced. (34)
• Antibacterial / Immuno-Stimulatory: Study showed a methanol extract of plant demonstrated antibacterial activity against Haemophilus influenzae and Klebsiella pneumonia. The extract showed good immunostimulatory effect with a significant increase (p<0.05) in white blood cell proliferation. The extract was non toxic with an LD50 of 3807 mg/kbw. (35)
• Immunomodulatory Triterpenoids / Glutinone: Study investigated the immunomodulatory potential of five compounds isolated from S. dulcis by inhibition of oxidative burst. Among the five compounds isolated, compound 1, glutinone showed anti-inflammatory potential with potent inhibition of intracellular reactive oxygen species (ROS), with moderate inhibition of production of proinflammatory cytokines TNF-a dn IL-1ß. (36)
• Anti-Anxiety: Study investigated the anti-anxiety activity of crude hydroalcoholic extract of S. dulcis by various behavioural models: Open-field test, Elevated plus-maze, Elevated Zero-maze, Social Interaction, and Novely induced suppressed feeling latency tests. Phytochemical analysis yielded phenols and flavonoids. Results showed dose dependent anxiolytic activity of Scoparia dulcis. (37)
• Anti-Diarrheal: Study investigated the antidiarrheal potential of a Scoparia dulcis decoction in a castor oil-induced diarrheal rat model. Results showed significant (p<0.05) and dose-dependent antidiarrheal effect. The effect was mediated via inhibition of intestinal transit due to impairment of intestinal peristalsis. Results suggest potential use for symptomatic relief of non-specific acute diarrhea. (38)
Powders, extracts in the cybermarket.