HOME      •      SEARCH      •      EMAIL    •     ABOUT

Family Compositae
Manzanilla
Chrysanthemum indicum
WINTER ASTER; GROUND APPLE
Nue ji cao

Scientific names  Common names 
Achillea bandana Buch.-Ham. [Invalid] Dolontas (Tag.) 
Acrotis elegans Thunb. Manzanilla (Sp., Fil.) 
Bidens bardanna Wall. [Invalid] Mansanilya-a-babasit (Ilk.) 
Bidens marginata DC. Roman camomile (Engl.)
Chrysanthemum indicum L. Garden camomile (Engl.) 
Chrysanthemum japonicum Thunb. Winter aster (Engl.)
Chrysanthemum koraiense Nakai Ground apple (Engl.) 
Chrysanthemum lushanense Kitam. Mother's daisy (Engl.)
Chrysanthemum nankingense Hand.-Mazz. Whig plant (Engl.)
Chrysanthemum procumbens Lour.  
Chrysanthemum purpureum Pers.  
Chrysanthemum tripartitum Sweet  
Collaea procumbens (Rich.) Spreng  
Dendranthema indicum (L.) Des Moul.  
Dendranthema nankingense (Hand.-Mazz.) P.S.Hsu  
Matricaria indica (L.) Desr.  
Pyrethrum indicum (L.) Cass.  
Tanacetum indicum (L.) Sch.Bip.  
Some compilations list C. indicum and C. sinense as synonyms. Quisumbing's compilation lists them separately. Mansanilla is a shared common name by the two species. C. sinense is similar to C. indicum, burt usually taller.
Chrysanthemum indicum L. is an accepted name The Plant List

Other vernacular names
CHINESE: Chua hua, Hsia yeh chua hua, Ku yi, Lu bian huang, Shan ju hua, Huang ju zi, Ju hua nao, Ye ju, Ye ju hua, Nui ji cao.
HINDI: Chandramallika.
ITALIAN: Crisantemo comune.
SANSKRIT: Sevanti.
TAMIL: Civanti, Saamanthi, Sevvanthi.

Botany
Manzanilla is an erect or ascending, aromatic, somewhat hairy herb, 30 to 60 centimeters in height. Leaves are thin, pinnately lobed, ovate to oblong-ovate, and 4 to 6 centimeters long. Lobes 2 to 3 on each side, ovate or oblong-ovate, and sharply toothed. Upper surface of the leaves deep green while the under surface gray-green. Flowering heads are yellow, peduncled, corymbosely panicled, and 1.5 to 2.5 centimeters in diameter. Involucre bracts are oblong or elliptic, as large as the achenes. Receptacle is smooth or pitted, not paleaceous. Ray flowers are 1-seriate, female, ligule spreading, disc flowers numerous, perfect, limb 4- to 5-fid. Fruits are achenes, very small, cuneate-oblong, somewhat compressed and grooved.

Distribution
- Widely scattered in cultivation, esteemed for ornamental and medicinal purposes.
- Established in Benguet at 1,800 meters altitude.

- A native of China and Japan, now cultivated in most warm countries.

Constituents
- Leaves and flowers of C. japonicum yielded a volatile oil (kiku oil), 0.16%; glucoside; chrysanthemin, 7%; anthocyanin.
- The active ingredient is chrysanthemin.
- Essential oil contains chrysanthenone.
- A glucoside, chrysanthemin, an isomer of asterin, has been isolated from the flowers of the red variety.
-From the "Ruby King" variety, a glucoside has been isolated, monoglucoside of cyanidine, 7 per cent.
- Study of methanolic extract of flowers yielded flavone and flavone glycosides together with three new eudesmane-type sesquiterpenes, kikkanols A, B, and C. (see study below) (
27)
- Ethanol extract of flowers yielded seven compounds: acacetin, acacetin-7-O-(6"-O-acetyl) beta-D-glucopyranoside, linarin, apigenin-7-O-beta-D-glucopyranoside, chlorogenic acid, vanillic acid, and sucrose. (13)
- Flower oil yields 1,8-cineole, germacrene D, camphor, α-cadinol, camphene, pinocarvone, β-caryophyllene, 3-cyclohexen-1-ol, and γ-curcumene. (see study below) (22)
- GC-MS and HPLC analysis of flowers yielded 63 volatiles with an abundance of 2,6,6-trimethyl-bicyclo[3.1.1]hept-2-en-4-ol, 2-(2,4-hexadiynylidene)-1,6-dioxaspiro[4.4]non-3-ene, germacrene D, á-neoclovene, eucalyptol, á-pinene. Ten flavonoids were identified, with quercitrin, myricetin, and luteolin-7-glucoside as dominant flavonoids. (28)
- The methylene chloride fraction of C. indicum yielded major components of sudachitin, hesperetin, chrysoeriol, and acacetin. (see study below) (45)

Properties
- Considered antifungal, antiviral, anti-inflammatory, analgesic, antipyretic, bactericidal, febrifuge, vulnerary, depurative and tonic.
- Glycoside chrysanthemin considered antibacterial.
- Studies have shown antimicrobial, immunomodulatory, anti-inflammatory, anticancer, hepatoprotective, anti-diabetic, anti-dermatitis, antioxidant, acetylcholinesterase inhibitory properties.

Parts utilized
· Flowering heads.
· Entire plant also used.


Uses
Culinary / Edibility
· Seeds, flowers, leaves are edible.
· Dried flowers used in making clear yellow tea with a delicate floral aroma.

Folkloric
· Preventive for cough, flu, epidemic meningitis.
· Entire plant or flower used for whooping cough.
· For gas pains -- warm oil, add and mix the flower heads, let stand for 30 minutes and strain. Then apply the warm oily solution to abdomen.
· Used for eczema, poisonous snake bites, sprains and bruises. Also used for mammary carbuncles.
· Flowers used for hypertension.
· Emulsion of flowers used for infections of the cervix .
· Flowers are burned for use as Insect repellent.
· Tea used as a wash for sore eyes, open sores, and wounds.
· Infusion of flowering heads used as carminative.
· In Deccan, plant used in conjunction with black pepper for treatment of gonorrhea.
· Combined with bitter sweet as ointment, used for bruises, sprains, calluses.
· In China, used for migraines, hypertension, inflammation, respiratory problems. Also, flowering heads are made into tonic and sedative preparations. Infusions are used as collyrium in eye affections.
· In Malaya flowers are used for sore eyes and to promote longevity.
· The Hindus consider the plant heating and aperient; used for affections of the brain, calculus, as well as antidote to mental depression.
· In Indo-China leaves are used as depurant and prescribed for migraine. Also, flowers are used for sore eyes and inflammation of the abdomen.
· In Guam infusion of flowers are used as remedy for intermittent fevers; also, used by women as remedy for hysteria and monthly irregularities.

Studies
· Antimicrobial / Essential Oils:
Study yielded three essential oils with major constituents of 1,8-cineole, camphor, borneol and bornyl acetate. Results showed both essential oils from air-dried and processed flowers possessed significant antimicrobial effect. With higher camphor percentage, the oil of processed flowers greater bacteriostatic activity than air-dried ones. (1)
Anti-Inflammatory / Immunomodulatory:
Anti-inflammatory and immunomodulatory activities of the extracts from the inflorescence of Chrysanthemum indicum Linné: Study showed CI possesses anti-inflammatory, humoral and cellular immunomodulatory and phagocytic activity probably from its flavonoid contents. (2)
Anti-Inflammatory: Study showed C indicum extract to be an effective anti-inflammatory agent in murine phorbol ester-induced dermatitis and suggests a potential for treatment of immune-related cutaneous diseases.
Anti-Cancer:
Study of C indicum extract showed a significant apoptotic effect through a mitochondrial pathway and arrested cell cycle by regulation of cell cycle-related proteins in MHCC97H cells lines without effect on normal cells. The cancer-specific selectivity suggests the plant extract could be a potential new treatment for human cancer. (4)
Anti-Cancer / Hepatocellular Carcinoma: Study documents anti-metastatic effect through a decrease of MMP expression, simultaneous increase of TIMP expression. Results suggest CI is a potential novel medicinal plant for treatment of hepatocellular carcinoma or cancer invasion and metastasis. (6)
Anti-Cancer / Antiproliferative In Human Hepatocellular Cells: Study performed in rats with human cells showed CI extract inhibited proliferation of human hepatocellular cells in a time- and dose-dependent manner without cytotoxicity.
Flavonoids / Anti-Arthritis:
Study showed the total flavonoids of C indicum, extracted from the dried buds could induce synoviocytes apoptosis and suppress proliferation of synoviocytes in adjuvant-induced arthritis rats. (7)
Flowers / Chemical Composition:
Study of C. indicum flowers yielded 63 volatiles which included eucalyptol, a-pinene, a-neoclovene among others. Ten flavonoids were identified, including quercitrin, myricetin and luteolin-7-glucoside. It suggests C indicum flower is a good source of natural quercitrin and myricetin for the development of potential pharmaceuticals. (8)
Aldose Reductase Inhibitory Activity:
Study has shown inhibitory activity against rat lens aldose reductase and nitric oxide (NO) production in lipopolysaccharide-activated macrophages.
Anti-Inflammatory:
Study suggest the anti-inflammatory properties of CIE might results from the inhibition of inflammatory mediators, such as NO, PGE2, TNF-alpha and IL01beta, via suppression of MAPKs and NF-kappaB-dependent pathways. (9)
Flavanone Glycosides / Rat Lens Aldose Reductase Inhibition:
Study isolated two flavanone glycosides and a new phenylbutanoid glycoside from the flowers of Chrysanthemum indicum together with eight flavonoids. Both of the new flavanone glycosides showed inhibitory activity for rat lens aldose reductase. (10)
Aldose Reductase Inhibitors: Methanol extract of flowers yielded flavone and flavone glycosides, together with three new eudesmane-type sesquiterpenes, kikkanols A, B, C. (12)
Hepatoprotective / Flowers:
Study evaluated the hepatoprotective effect of a hot water extract of CI flowers in in vitro and in vivo systems using normal human hepatocytes and hepatocellular carcinoma cells against CCl4-induced hepatotoxicity. Results showed HCIF inhibited bioactivation of CCl4-induced hepatotoxicity and downregulated CYP2E1 expression in vitro and in vivo.
(14)
Topical Application Attenuates Atopic Dermatitis:
Study evaluated the effect of topically applied C. indicum in mice with atopic dermatitis-like symptoms. CIL treatment dose-dependently reduced severity of clinical symptoms of dorsal skin, ear thickness, and number of mast cells and eosinophils. Improvement with CIL-high was similar to hydrocortisone but without skin atrophy and secondary infection. Study concludes CIL may be an alternative substance for management of atopic dermatitis.   (15)
Teratogenicity Study / Safety:
Under experimental conditions, C. indicum extract did not show any significant effects in SD pregnant rats, with no apparent teratogenicity and embryotoxicity. (16)
Apoptosis in Human Hepatocellular Carcinoma:
CI extract exerted a significant apoptotic effect through a mitochondrial pathway and arrested the cell cycle by regulation of cell-cycle related proteins. A cancer-specific selectivity suggests a promising novel treatment for human cancer. (17)
Antioxidant / Prevention of Radical-Induced DNA Damage / Flowers:
Ethanol-based extract of flowers prevented free radical-induced DNA damage and did not show any cytotoxicity. Antioxidant activity was highly correlated with phenolic and flavonoid contents.
(18)
Silver Nanoparticles from C. indicum / Antibacterial:
The antimicrobial effect of synthesized AgNPs from C. indicum revealed a significant effect against K. pneumonia, E. coli, and P. aeruginosa, with no toxicity toward mouse embryo fibroblast cells. (19)
Acetylcholinesterase Inhibitors / Flowers / Alzheimer's Disease:
Ethanol extract of flowers markedly decreased AChE activity. Study yielded acaiin and acacetin-7-O-ß-D-galactopyranoside as active compounds responsible for the AChE inhibition which present as potential therapeutic agents for Alzheimer's disease. (
20)
Safety and Mutagenicity Evaluation of Flower Oil:
Acute oral toxicity evaluation of flower oil showed no mortality or clinical signs of toxicity at 2,000 mg/kg body weight per day. Levels of 15.63-500 µg C. indicum flower oil/plate did not induce mutagenicity in S. typhimurium and E. coli. Results showed the flower oil produced no bone marrow micronucleus abnormalities, mutagenicity, or chromosomal aberrations, and can be considered a functional food or medicinal ingredient. (see constituents above)    (
22)
Anti-Tyrosinasec/ Skin Whitening:
Study evaluated the ability of C. indicum extracts to inhibit in vitro tyrosinase activity and skin care effects of cosmetic formulations containing 0.5% water extracts in human volunteers. Methanol and water extracts dose dependently inhibited mushroom tyrosinase activity. Methanol extract effect was similar to kojic acid, a known tyrosinase inhibitor. Water extract also reduced melanin levels. Luteolin and acacetin-7-O-rutinoside were the major flavonoid compounds in the water extract. Results suggest the water extract has potential as a natural skin-whitening agent for functional cosmetic uses, due to its melanin-reducing efficacy. (
23)
Attenuation of Atopic Dermatitis:
Study evaluated the effect of topically applied C. indicum in mice with atopic dermatitis (AD)-like symptoms. CIL treatment dose-dependently reduced severity of clinical symptoms of dorsal skin, ear thickness, and number of mast cells and eosinophils, together with significantly reduced IgE, IgG1, IL-4, and IFN-γ levels and reduced mRNA levels of IFN-γ, IL-4, and IL-13 in dorsal skin lesion. Results suggest a potential alternative for the treatment of AD. (
24)
Linarin / Inhibition of Proliferation of A549 Cells / Lung Cancer / Flowers:
Study reported on the anti-proliferative and molecular mechanism of C. indicum on A549 human alveolar basal epithelial cells. Results showed linarin-mediated inhibition of cell proliferation is associated with suppression of Akt activation and induction of cyclin-dependent kinase inhibitory p27. Findings suggest a further evaluation and a potential for linarin for the treatment and prevention of lung cancer. (
25)
Enhancement of Osteoblast Function / Prevention of Osteoporosis:
Study evaluated the protective effects of Chrysanthemum indicum extract on response of osteoblasts to oxidative stress. Results showed CIE significantly increase cell survival, ALP activity, and calcium deposition, and decreased the production of Reactive Oxygen Species (ROS) and Tumor Necrosis Factor-α (TNF-α) in osteoblasts. The enhancement of osteoblast function by CI extract may prevent osteoporosis and inflammatory bone disease. (
26)
Aldose Reductase Inhibitors / Flowers:
A methanolic extract from flowers of C. indicum was shown to have inhibitory activity against rat lens aldose reductase. Bioassay guided separation yielded flavone and flavone glycosides and three new eudesman-type sesquiterpenes. (see constituents above) (
27)
• Anti-Inflammatory / Effect on Oxidative Stress:
Study evaluated the antioxidant impacts of C. indicum extract on oxidative stress and inflammatory responses in adjuvant-induced arthritis in rats. Treatment with extract delayed the onset of time of arthritis and decreased clinical arthritis severity score (p<0.05). Results suggest CIE alleviated oxidative stress and inflammatory responses and presents a potential for clinical treatments of rheumatoid arthritis. (29)
• Antioxidant / Prevention of DNA Damage / Flowers:
Study evaluated the antioxidant properties of flower extracts on DPPH, hydroxyl and superoxide radicals and nitrite scavenging, reducing Fe power, linoleic acid oxidation as well as free radical induced DNA damage prevention activity. The ethanol based extract prevented free radical induced DNA damage. There was no cytotoxicity on chang normal liver cell. The antioxidant activity was highly correlated with phenolic and flavonoid contents. (30)
• Biosorption / Nickel:
Study evaluated the biosorption capability of C. indicum to remove nickel ions from aqueous solution in a fixed-bed column. Results implied and affirmed the suitability of the biosorbents for nickel ion biosorption being favorable, efficient, and environment friendly. (31)
• No Antifungal Activity / Flower: Study evaluated the antifungal effect of Chrysanthemum flower decoction against Candida albicans. In this study, the flower decoction did not inhibit the growth of C. albicans. (32)
• Anxiolytic / Flowers:
Study evaluated the anxiolytic activity of ethanolic and chloroform extracts of Chrysanthemum indicum flowers using elevated plus-maze (EPM) and open field tests. The ethanolic extract showed anxiolytic activity in dosages around 250 and 500 mg/kg. (33)
• Comparative Study of Flower Phytoconstituents: Study evaluated phytocompounds from methanolic and chloroformic flower extracts of Wedelia trilobata, Achyranthes aspera and Chrysanthemum. Of the three, Chrysanthemum flowers were the richest sources of bioactive compounds. Chrysanthemum flower extract yielded cardiac glycosides, flavonoids, tannins, terpenoids, and alkaloids were present in bulk and steroids and saponins in lesser amounts. (34)
• Anti-Inflammatory Effects in RAW 264.7 Marcrophage Cell: Study evaluated the anti-inflammatory effects of C. indicum water extract in lipopolysaccharides (LPS)-induced RAW 264.7 macrophage cells. CHI extract significantly suppressed LPS-induced NO production and decreased the level of iNOS, IL-iß, COX-2 mRNA expression and downregulated PGE2 expression in a dose-dependent manner. (35)
• Insecticidal / Leaves:
Study evaluated methanol and ethyl acetate extract of leaves of C. indicum for insecticidal activity against red cotton bug, Dysdercus cingulatus. The EA solvent extract showed more insecticidal activity than the methanol extract. Mortality increased with concentration of the plant extract. (36)
• Anti-Browning Agent / Preventing of Fruit and Vegetable Discoloration: Patent was applied for a composition containing Chrysanthemum indicum extract to prevent discoloration. The extracts of C. indicum have shown good inhibitory effects on polyphenol oxidase activity to prevent the browning of fruits and vegetables. According to the invention, extracts of CI may be obtained from flowers, leaves, stems, roots, or all bodies of C. indicum, but most preferably flowers or leaves. Extracts are preferable hot water extraction or ethanol solvent extraction. (37)
• Mosquito Control / Larvicidal:
Study evaluated crude aqueous extracts of 36 plants for larvicidal properties. Leaves of Chrysanthemum indicum showed 100% mortality at 2 ml at 72 hours for Aedes mosquito genera.
(38)
• Anxiolytic / Flowers: Study investigated the anxiolytic-like effects of water extract from dried flowers of C. indicum using elevated plus-maze test in mice. Results showed anxiolytic effect which may be mediated by the GABAA and the 5-HT1A receptors. (39)
• Neuroprotective Against Cerebral Ischemia/Reperfusion Injury:Study evaluated the neuroprotective effect of C. indicum extract in a cerebral ischemia/reperfusion model in gerbils. Study suggests the C. indicum extracts protected pyramidal neurons in the hippocampal CA1 region from ischemic changes. Results suggest pretreatment can attenuate neuronal damage/death in the brain after cerebral ischemia/reperfusion via an anti-inflammatory approach. (40)
• 2,5-Diarylpyrazole Derivative / Flavonoid / Potential for Alzheimer's Disease: Study isolated four new 3,5-diarylpyrazole analogues (1-4) from a flower extract of C. indicum. All four compounds showed moderate to potent activity against Aß-aggregation with EC50s of 4.3, 15.8, 1.3 and 2.9 µM, respectively. Compound 3 showed no cytotoxicity and significant neuroprotective activity against Aß-induced cytotoxicity in SH-SY5T cell line. Results suggest a potential for the treatment of Alzheimer's disease. (41)
• Luteolin / Hypouricemic / Potential for Gout Prevention: Study evaluated a Chrysanthemum flower extract rich in luteolin for its effect of serum uric acid in Japanese men. Ingestion of the luteolin rich flower extract for 4 weeks reduced serum uric acid level. Results suggest luteolin may help prevent gout by controlling uric acid. (42)
Total Flavonoids / Potential Benefit in Rheumatoid Arthritis: Study evaluated the effect of extracts of total flavonoids of Chrysanthemum indicum on adjuvant arthritis synovial cells. Results showed dose-dependent inhibition in the proliferation of synovial cells and induction of apoptosis of synovium and synoviocytes in vivo. Study suggests potential therapeutic effect for rheumatoid arthritis. (43)
• Comparative Antioxidant Activities of Flowers: Study evaluated the antioxidant activities of aqueous extracts of 12 Chinese edible flowers in four different antioxidant models. The highest activities by TAC, ORAC, SHRC, and SSARC were seen in L. japonica, R. rugosa, and Chrysanthemum indicum. (44)
• Potential for Prostate Cancer / Suppression of STAT3 Activation: Study evaluated the potential effects of C. indicum on signal transducer and activator of transcription 3 (STAT3) signaling pathway in different tumor cells. The methylene chloride fraction of C. indicum yielded major components of sudachitin, hesperetin, chrysoeriol, and acacetin. Of these, sudachitin, chrysoeriol and acacetin exerted significant cytotoxicity and clearly suppressed constitutive STAT3 activation, and induced apoptosis. Results suggest MCI could induce apoptosis through inhibition of the JAK1/2 and STAT3 signaling pathways. (45)
• Lead Phytoremediation: Study evaluated the natural potential of Chrysanthemum indicum for clean-up of lead-contaminated soil in a pot experiment. Combinatorial treatments (sulphur and vermicompost) under lead-contaminated (10-50 mg/kg) soils showed higher remediation efficiency indicating enhanced clean-up of the soil through C. indicum. (46)


Availability
- Wild-crafted.
- Cultivated for ornamental use.

- Herbs, granules, extracts in the cybermarket. 
- Chrysanthemum tea from flowers.


Updated March 2018 / Se[tember 2016

Photo © Godofredo Stuart / StuartXchange
OTHER IMAGE SOURCE: / Chrysanthemum Indicum / Photo id: 178443 / Credit: L. R. / alterVISTA  / Click on image to see source page

Additional Sources and Suggested Readings
(1)
Chemical composition and antimicrobial activity of the essential oils of Chrysanthemum indicum / Zhu Zhu Shunying1, Yang Yang, Yu Huaidong, Ying Yue, Zou Guolin
/Journal of Ethnopharmacology, Volume 96, Issues 1-2, 4 January 2005, Pages 151-158 / doi:10.1016/j.jep.2004.08.031
(2)
Anti-inflammatory and immunomodulatory activities of the extracts from the inflorescence of Chrysanthemum indicum Linné / J Ethnopharmacol. 2005 Oct 3;101(1-3):334-7.
(3)
Dendranthema indicum - (L.)Des Moul. / Chrysanthemum / Plants For A Future

(4)
Chrysanthemum indicum extract holds promise for treating human cancer
/ Zong-fang Li et al / World Journal of Gastroenterology 2009; 15(36); 4538-4546
(5)
Anti-inflammatory activity of Chrysanthemum indicum extract in acute and chronic cutaneous inflammation / Do Yeon Lee et al / Journal of Ethnopharmacology • Volume 123, Issue 1, 4 May 2009, Pages 149-154
/ doi:10.1016/j.jep.2009.02.009
(6)
Chrysanthemum indicum ethanolic extract inhibits invasion of hepatocellular carcinoma via regulation of MMP/TIMP balance as therapeutic target / Wang Z D et al / Oncol Rep. 2010 Feb;23(2):413-21
(7)
Effect of total flavonoids of Chrysanthemum indicum on the apoptosis of synoviocytes in joint of adjuvant arthritis rats / Chen XY et al / Am J Chin Med. 2008;36(4):695-704

(8)
Analysis of chemical composition of Chrysanthemum indicum flowers by GC/MS and HPLC
/ Liang-Yu Wu, Hong-Zhou Gao et al / Journal of Medicinal Plants Research Vol. 4(5), pp. 421-426, 4 March, 2010
(9)
Chrysanthemum indicum Linné extract inhibits the inflammatory response by suppressing NF-kappaB and MAPKs activation in lipopolysaccharide-induced RAW 264.7 macrophages / Cheon MS, Yoon T et al / J Ethnopharmacol. 2009 Apr 21;122(3):473-7. Epub 2009 Feb 3.
(10)
Medicinal Flowers. VI.1) Absolute Stereostructures of Two New Flavanone Glycosides and a Phenylbutanoid Glycoside from the Flowers of Chrysanthemum indicum L.: Their Inhibitory Activities for Rat Lens Aldose Reductase / Hisashi Matsuda, Toshio Morikawa et al / Chem. Pharm. Bull. 50(7) 972—975 (2002) Vol. 50, No. 7
(11)
Chrysanthemum indicum L. / Catalogue of Life, China
(12)
Medicinal Flowers. I. Aldose Reductase Inhibitors and Three New Eudesmane-Type Sesquiterpenes, Kikkanols A, B, and C, from the Flowers of Chrysanthemum indicum L. / YOSHIKAWA M, MORIKAWA T, MURAKAMI T, TOGUCHIDA I, HARIMA S, MATSUDA H / Chem Pharm Bull, VOL.47;NO.3;PAGE.340-345(1999)
(13)
Studies on chemical constituents from flowers of Chrysanthemum indicum. / Gao MH, Li H, Zhang L, Xiao SX. / Zhong Yao Cai. 2008 May;31(5):682-4.
(14)
Hepatoprotective effect of water extract from Chrysanthemum indicum L. flower / Sang Chul Jeong, Sang Min Kim, Yong Tae Jeong and Chi Hyun Song* / Chinese Medicine 2013, 8:7 doi:10.1186/1749-8546-8-7
(15)
Topical Application of Chrysanthemum indicum L. Attenuates the Development of Atopic Dermatitis-Like Skin Lesions by Suppressing Serum IgE Levels, IFN-γ, and IL-4 in Nc/Nga Mice / Sunmin Park, Jung Bok Lee, and Suna Kang / Evidence-Based Complementary and Alternative Medicine, Volume 2012 (2012) / http://dx.doi.org/10.1155/2012/821967
(16)
Study on teratogenicity of Chrysanthemum indicum extract in SD rats / WANG Feng-yan;CHEN Rui-yi; ZHOU Yi-lin; ZHANG Zi-hong; TAN Jian-bin; YANG Mei-ling; HU Shuai-er; LI Xin / Carcinogenesis, Teratogenesis & Mutagenesis, 2012, 24(5): 386-388./ DOI: 10.3969/j.issn.1004-616x.2012.05.017
(17)
Induction of apoptosis and cell cycle arrest in human HCC MHCC97H cells with Chrysanthemum indicum extract. / Li ZF1, Wang ZD, Ji YY, Zhang S, Huang C, Li J, Xia XM. / World J Gastroenterol. 2009 Sep 28;15(36):4538-46.
(18)
ANTIOXIDANT POTENTIAL AND OXIDATIVE DNA DAMAGE PREVENTIVE ACTIVITY OF CHRYSANTHEMUM INDICUM EXTRACTS / TRISHNA DEBNATH, HAI LAN JIN, MD ABUL HASNAT, YUNSUK KIM, NADIRA BINTE SAMAD, PYO-JAM PARK andBEONG OU LIM* / Journal of Food Biochemistry, Volume 37, Issue 4, pages 440–448, August 2013 / DOI: 10.1111/j.1745-4514.2011.00644.x
(19)
Rapid green synthesis of silver nanoparticles from Chrysanthemum indicum L and its antibacterial and cytotoxic effects: an in vitro study / Selvaraj Arokiyaraj, Mariadhas Valan Arasu, Savariar Vincent, Nyayirukannaian Udaya Prakash, Seong Ho Choi, Young-Kyoon Oh, Ki Choon Choi, and Kyoung Hoon Kim / Int J Nanomedicine. 2014; 9: 379–388. / doi: 10.2147/IJN.S53546
(20)
Isolation of Acetylcholinesterase Inhibitors from the Flowers of Chrysanthemum indicum Linne / Seung-Kyoung Jeung, Hyun Jae Yim, Hye Mi Kim, Se Gye Shin, Seoung Jun Han, Jung HY Park and Il-Jun Kang / The FASEB Journal. 2007;21:lb189 /
(21)
Chrysanthemum indicum / Synonyms / The Plant List
(22)
Safety Evaluation of Chrysanthemum indicum L. Flower Oil by Assessing Acute Oral Toxicity, Micronucleus Abnormalities, and Mutagenicity / Eun-Sun Hwang, and Gun-Hee Kim / Prev Nutr Food Sci. 2013 Jun; 18(2): 111–116. / doi: 10.3746/pnf.2013.18.2.111
(23)
Dermatologic evaluation of cosmetic formulations containing Chrysanthemum indicum extract
/ Keun Taek Choi PhD, Jun Ho Kim PhD, Hyung Taek Cho MS, Soon Sung Lim PhD, Sun Soon Kwak PhD, Young Jun Kim PhD / Journal of Cosmetic Dermatology / DOI: 10.1111/jocd.12211
(24)
Topical Application of Chrysanthemum indicum L. Attenuates the Development of Atopic Dermatitis-Like Skin Lesions by Suppressing Serum IgE Levels, IFN-γ, and IL-4 in Nc/Nga Mice / Sunmin Park, Jung Bok Lee, and Suna Kang / Evidence-Based Complementary and Alternative Medicine, Volume 2012 (2012) /
http://dx.doi.org/10.1155/2012/821967
(25)
Phytochemical Linarin Enriched in the Flower of Chrysanthemum indicum Inhibits Proliferation of A549 Human Alveolar Basal Epithelial Cells Through Suppression of the Akt-Dependent Signaling Pathway /
Seo Dong-Wan, Cho Young-Rak, Kim Wooki, and Eom Seok Hyun. / Journal of Medicinal Food. December 2013, 16(12): 1086-1094 doi:10.1089/jmf.2012.2674.
(26)
Effects of Chrysanthemum indicum L. Extract on the Function of Osteoblastic MC3T3-E1 Cells under Oxidative Stress Induced by Hydrogen PeroxideJee / Yun, Jee-Hye; Hwang, Eun-Sun; Kim, Gun-Hee / Korean Journal of Food Science and Technology, Volume 44, Issue 1, 2012, pp.82-88 / DOI : 10.9721/KJFST.2012.44.1.082
(27)
Medicinal Flowers. I. Aldose Reductase Inhibitors and Three New Eudesmane-Type Sesquiterpenes, Kikkanols A, B, and C, from the Flowers of Chrysanthemum indicum L. / Masayuki YOSHIKAWA, Toshio MORIKAWA, Toshiyuki MURAKAMI, Iwao TOGUCHIDA, Shoichi HARIMA, and Hisashi MATSUDA / Chem. Pharm. Bull. 47(3) 340—345 (1999) Vol. 47, No. 3
(28)
Analysis of chemical composition of Chrysanthenum indicum flowers by GC/MS and HPLC / Liang-Yu Wu, Hong-Zhou Gao, Xun-Lei Wang, Jian-Hui Ye, Jian-Liang u and Yue-Rong Liang / Journal of Medicinal Plants Research Vol. 4(5), pp. 421-426, 4 March, 2010
(29)
The Impacts of Chrysanthemum indicum Extract on Oxidative Stress and Inflammatory Responses in Adjuvant-Induced Arthritic Rats / Mei Dong, Dongsheng Yu, Naif Abdullah Al-Dhabi, and Veeramuthu Duraipandiyan / Evidence-Based Complementary and Alternative Medicine, Vol 2017 (2017) /
https://doi.org/10.1155/2017/3285394
(30)
ANTIOXIDANT POTENTIAL AND OXIDATIVE DNA DAMAGE PREVENTIVE ACTIVITY OF  CHRYSANTHEMUM INDICUM EXTRACTS / Trishna Debnath, Hai Lan Jin, Md Abul Hasnat, Yunsuk Kim, Nadira Binte Samad, Pyo-Jam Park, Beong Ou Lim / Journal of Food Biochemistry / https://doi.org/10.1111/j.1745-4514.2011.00644.x
(31)
Continuous biosorption of nickel from aqueous solution using Chrysanthemum indicum derived biochar in a fixed-bed column / Sowmya VilvanathanS. Shanthakumar / Water Science & Technology, Volume 77, Issue 6 / DOI: 10.2166/wst.2017.289
(32)
A Study on the Antifungal Effect of Chrysanthemum Indicum Flower Decoction on an in Vitro Culture of Candida Albicans / Kristine Abul, Myrabel Artiaga, Rameses Bacolod, Swiert Basilla et al / Herdin Record #: R07-CIM-13052311354986 
(33)
ANXIOLYTIC EFFECT OF ETHANOLIC EXTRACT OF FLOWERS OF CHRYSANTHEMUM INDICUM IN ALBINO MICE / Sheela, V. Srinivasan and E. Sukumar  / INTERNATIONAL JOURNAL OF  PHARMACEUTICAL SCIENCES AND RESEARCH
(34)
Comparative Study of Phytochemical Constituents in Flower of Wedelia trilobata, Achyranthes aspera and Chrysanthemum from Durg District of Chhattisgarh, India / Nisreen Husain* and Anil Kumar / Int. J. Curr. Microbiol. App. Sci (2015) 4(4): 150-156
(35)
Anti-Inflammatory Effects of Chrysanthemum indicum Water Extract in RAW 264.7 Cell as a Whole Plant /
Kyoungah Kang / Journal of Korean Biological Nursing Science 2015;17(4):341-347 / http://dx.doi.org/10.7586/jkbns.2015.17.4.341
(36)
Insecticidal activity of chrysanthemum indicum against red cotton bug, dysdercus cingulatus fab / Gadewad M. G and Pardeshi A. B / International Journal of Recent Scientific Research, 8(12), pp. 22380-22383. / DOI: http://dx.doi.org/10.24327/ijrsr.2017.0812.1256
(37)
Composition containing chrysanthemum indicum l. extract for preventing discoloration  / Inventor: Gun Hee Kim, Min Sun Chang / US Application: US20140127369A1
(38)
Plant diversity for mosquito control: A preliminary study / Rathy MC, Sajith U and Harilal CC / International Journal of Mosquito Research 2015; 2 (1): 29-33
(39)
Anxiolytic-Like Effects of Chrysanthemum indicum Aqueous Extract in Mice: Possible Involvement of GABAA Receptors and 5-HT1A Receptors / Sa-Ik Hong, Seung-Hwan Kwon, Min-Jung Kim, Shi-Xun Ma, Je-Won Kwon, Seung-Min Choi, Soo-Im Choi, Sun-Yeou Kim, Seok-Yong Lee, and Choon-Gon Jang* / Biomol Ther (Seoul) 2012; 20(4): 413-417
(40)
Neuroprotection of Chrysanthemum indicum Linne against cerebral ischemia/reperfusion injury by anti-inflammatory effect in gerbils. / Yoo KY, Kim IH, Cho JH, Ahn JH, Park JH, Lee JC, Tae HJ, Kim DW, Kim JD, Hong S, Won MH, Kang IJ. / Neural Regen Res 2016;11:270-7 / http://www.nrronline.org/text.asp?2016/11/2/270/177735
(41)
3,5-Diarylpyrazole Derivatives Obtained by Ammonolysis of the Total Flavonoids from Chrysanthemum indicum Extract Show Potential for the Treatment of Alzheimer’s Disease / Taizong Wu, Cheng Jiang, Ling Wang, Susan L Morris-Natschket, Hui Miao, Lianguan Gu, Jun Xu, Kuo-Hsiung Lee, and Qiong Gu / J. Nat. Prod., 2015, 78 (7), pp 1593–1599 / DOI10.1021/acs.jnatprod.5b00156
(42)
Luteolin-rich chrysanthemum ower extract suppresses baseline serum uric acid in Japanese subjects with mild hyperuricemia / Marina Hirano, Shogo Takeda, Shoketsu Hitoe, and Hiroshi Shimoda* / Integrative Molecular Medicine (2017) 4(2): pp 1-5 / doi: 10.15761/IMM.1000275
(43)
Beneficial effect of total flavonoids of Chrysanthemum indicum on adjuvant arthritis by induction of apoptosis of synovial fibroblasts / Xie XF, Li J, Chen Z, Hu CM, Chen WW / Zhongguo Zhong Yao Za Zhi. 2008 Dec; 33(23): pp 2838-41
(44)
Antioxidant activities of aqueous extracts from 12 Chinese edible flowers in vitro and in vivo / Feng Wan*, Miao Miaoa*, Hui Xia, Li-Gang Yang, Shao-Kang Wang and Gui-Ju Sun / FOOD & NUTRITION RESEARCH, 2016, VOL. 61, NO. 1, 1265324 / http://dx.doi.org/10.1080/16546628.2017.1265324
(45)
Chrysanthemum indicum L. extract induces apoptosis through suppression of constitutive STAT3 activation in human prostate cancer DU145 cells. / Chulwon Kim, Moo-Chang Kim, Sung-Moo Kim, Dongwoo Nam et al / Phytother. Res., 2013 Jan; 27(1) pp 30-8. / doi: 10.1002/ptr.4689. Epub 2012 Mar 22.
(46)
Enhanced clean-up of lead-contaminated alluvial soil through Chrysanthemum indicum L. / D. Mani, C. Kumar, N. K. Patel, D. Sivakumar / Int. J. Environ. Sci. Technol. (2015) 12:1211–1222 / DOI 10.1007/s13762-013-0488-5

It is not uncommon for links on studies/sources to change. Copying and pasting the information on the search window or using the DOI (if available) will often redirect to the new link page.

HOME      •      SEARCH      •      EMAIL    •     ABOUT