Family •
Schizaeceae / Lygodiaceae
Nitong-puti
Lygodium flexuosum Swartz.
MAIDENHAIR CREEPER
Scientific names | Common names |
Hydroglossum flexuosum (L.) Willd. | Katak (Ibn.) |
Lygodium flexuosum (L.) Sw. | Nitong-puti (Tag.) |
Ophioglossum flexuosum L. | Nito-a-dadakkel (Ilk.) |
Ramondia flexuosa (L.) Mirb. | Nitu (Ibn.) |
Kakulung (Ibn.) | |
Kakulung (Ibn.) | |
Sasitang (Ilk.) | |
Nito nga purao (Ilk.) | |
Climbing fern (Engl.) | |
Maidenhair creeper (Engl.) | |
Lygodium pinnatifidum is considered a synonym by some compilations. The Missouri Botanical Garden treats it as a separate species. | |
Nito's varieties of common names is confusingly shared among four species of plants belonging to the Family Schizaeceae / Gemus Lygodium: (1) Nito, Lygodium circinnatum, nitong puti, nitoan (2) Nitong puti, Lygodium flexuosum, nito nga purao (3) Nitong-pula, Lygodium japonicum, nito, nito-a-purao (4) Nito-nitoan, Lygodium scandens, nitong parang, nito. | |
Lygodium flexuosum (L.) Sw. is an accepted name The Plant List |
Other vernacular names |
BENGALI: Miau-maka-la, Kuttijurkha, Huttigurpo. |
CHINESE: Qu zhou hai jin sha.. |
GERMAN: Bogen-kletterfarn |
INDIA: Bhutraj. |
MALAYSIA: Ribu-ribu besar, ribu-ribu gajah, akar sidin |
Properties Parts
utilized Uses • Hepatoprotective Effect: Rats treated with extracts of Lygodium flexuosum after establishment of carbon tetrachloride induced liver injury showed significant protection of the liver as evidenced by AST, ALT, LDH and MDA levels. Phytochemical study yielded saponins, triterpenes, sterols and bitter principles which could explain the possible hepatoprotective action. (1) Results suggest L. flexuosum exerts effective protection in carbon tetrachloride induced hepatic fibrosis in rats. (6) • Chemopreventive Effect / Antiproliferative/ Apoptotic: Study showed L flexuosum extract has antiproliferative and apoptotic activity in cancer cells and has inhibitory role in TNF-alpha induced NF-kappaB activation in PLC/PRF/5 cells confirming its potential as a chemopreventive agent. (2) • Antiangiogenic / Hepatoprotective: Study of antiangiogenic effect of L. flexuosum in NDEA-intoxicated Wistar rats in preventive and curative models showed the LFE reversed the hepatoxicity induced by N-nitrosodiethylamine in both experimental models. (4) • Phenolic Content / Antioxidant: In vitro antioxidant activity of different extracts of LF were evaluated in different models. Highest phenolic content was found in the methanolic extract (6.24%) with the highest antioxidant activity. (5) • Antifertility Activity: Alcoholic extract showed an antifertility effect in rats, mice, and rabbits. • Antibacterial: Rhizome extract showed more antibacterial activity compared to the petiole and leaf. The rhizome extracts were more effective against gram-positive bacteria like M. luteus and S. aureus compared to gram negative bacteria. (13) • Toxicity Testing: Various extracts in in vivo testing were found to be devoid of any toxicity in acute (5 g/kg) and subacute toxicity (1 g/kg for 30 days) evaluation in Wistar rats. (11) • Anti-Inflammatory / Antioxidant: Study of ethanolic extract in a carrageenan-induced paw edema model showed significant (p<0.001) anti-inflammatory activity. Both ethanolic and aqueous extracts showed promising antioxidant and radical scavenging activities at various concentrations. (12) • Wound Healing / Leaves: Study evaluated the protective effect of L. flexuosum against excision, incision, and dead space wound models in Wistar albino rats. Results showed accelerated wound healing. Topical application of L. flexuosum increased the percentage of wound contraction and decreased epithelization time in the excision wound model, increased the breaking strength of wounds in incision wound model, and increased hydroxyproline and the weight of dry and wet granuloma of wounds in dead space model. (17) • Anti-Histaminic / Mast Cell Stabilizing: Study evaluated ethanolic and aqueous extracts of L. flexuosum for anti-histaminic and mast cell stabilizing activity in rats sensitized by injection of horse serum and triple antigen. Both extracts showed protective activity in invitro passive mast cell degranulation and systemic anaphylaxis in mice. (18) • Antibacterial / Leaves: Study of aqueous and methanol crude leaf extracts of Lygodium flexuosum showed remarkable antibacterial effect against gram-negative bacteria only. (see constituents above) (19) • Antibacterial / Fronds: Study evaluated the antibacterial potencies of various solvent extracts against 7 multidrug resistant (MDR) bacteria. A cold-water frond extract showed best antimicrobial activity against the MDR isolates. Phytochemical analysis of the water extract yielded glycosides and carbohydrates, with absence of alkaloids, terpenoids, steroids, saponins, tannins, and flavonoids. (20) • In Vivo Wound Healing Potential / Herbal Leaf Formulation: Study of ethanol extract of leavess promoted accelerated wound healing as evidenced by increased tensile strength of wound contraction and increased hydroxyproline content. The faster wound contraction noted with topical administration was attributed to larger availability at the wound site. (21) Availability Wild-crafted. |
Updated March 2018 / October 2016
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Photos © Godofredo Stuart / StuartXchange |
OTHER IMAGE SOURCE: Lygodium flexuosum /Lowe Antique Prints of Ferns 1856 / Panteek |
Additional
Sources and Suggested Readings |
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