Papaya is a small, erect,, usually unbranched, fast-growing
tree growing 3 to 6 meters high. Trunk is soft and grayish, marked with large petiole-scars. Leaves are somewhat rounded in outline, 1 meter broad or less, palmately 7- or 9-lobed, each lobe pinnately incised or lobed. Petioles are stout, hollow, and about 1 meter long. Staminate inflorescence is axillary, pendulous, paniculate, and 1 to 1.5 meters long. Male flowers are in crowded clusters, straw-colored, and fragrant. Corolla tube is slender, about 2 centimeters long. Female flowers are in short, axillary spikes or racemes, the petals 7 centimeters long or less. Fruit is indehiscent, subglobose, obovoid or oblong-cylindric, 5 to 30 centimeters long, fleshy and yellowish or yellow-orange when ripe, containing numerous black seeds which are embedded in the sweet pulp.
- Found throughout the Philippines, in cultivation or semi-cultivation, in many regions.
- Thoroughly naturalized, at low and medium altitudes.
- Introduced from tropical America.
- Now pantropic.
- Contains many biologically active compounds; two important
ones are chymopapain and papain, believed to aid digestion; varying
in amount in the fruit, latex, leaves and roots.
- Phenolic compounds are higher in male trees than female.
- Leaf, fruit, stem and root yield a proteolytic enzyme, papain (papayotin), phytokinase, malic acid,
- Fresh latex yield chymopapain.
- Leaves yield carpaine (alkaloid); carposide (glucoside); saccharose,
0.85%; dextrose, 2.6%; levulose, 2.1%; citrates.
yields saccharose 0.85%, dextrose 2.6%, levulose 2.1%, mallic acid, pectin, papain, and citrates.
- Seeds yield a volatile oil.
- Study on papain reported it to be a true, soluble, digestive ferment or a mixture of ferments of vegetable origin, with a proteolytic action that is marked in acid, alkaline, and neutral solutions. It has a peculiar softening and disintegrating action on proteids, with a general proteolytic action that is of a genuine digestive ferment. It also has amylolytic action. It is considered to have greater digestive power than either pepsin or pancreatin, and can be used when pepsin is contraindicated or ineffective. Although comparable to trypsin, it does not yield leucin, tryrosin and tryptophan in appreciable quantities.
- Aerial parts polar extracts yielded phytocomponents flavonoids, tannins, alkaloids, carbohydrates and triterpenes.
(see study below) (40)
- Nutrient analysis of papaya fruit per 100 g yielded: Principle—energy 39 Kcal, carbohydrates 9.81 g, protein 0.61 g, total fat 0.14 g, cholesterol 0 mg, dietary fiber 1.80 g; Vitamins—folates 38 µg, niacin 0.338 mg, panthotenic acid 0.218 mg, pyridoxine 0.019 mg, riboflavin 0.032 mg, thiamin 0.027 mg, vitamin A 1094 IU, vitamin C 61.8 mg, vitamin E 0.73 mg, vitamin K 2.6 µg; Electrolytes—sodium 3 mg, potassium
257 mg; Minerals—calcium 24 mg, iron 0.10 mg, magnesium 10 mg, phosphorus 5 mg, zinc 0.07 mg; Phytonutrients—carotene-ß 276 µg, crypto-xanthin-ß 761 µg, lutein-zeaxanthin 75 µg. (USDA National Nutrient data base) (53)
- Study of constituents of various parts yielded: Fruits—protein, fat, fiber, carbohydrates; minerals: calcium, phosphorus, Fe, vitamin C, thiamin, riboflavin, niacin, and carotene, amino acids, citric and malic acids (green fruit); volatile compounds: linalool, benzylisothiocyanate, cis and trans 2, 6-dimethyl-3,6 epoxy-7 octen-2-ol. Juice yields n-butyric, n-hexanocic and n-octanoic acids; lipids: myristic, palmitic, stearic, linoleic, linolenic and cis-vassenic and oleic acids. Seeds yield fatty acids, crude protein, crude fiber, papaya oil; carpane, benzylisothiocyanate, benzylglucosinolate, glucotropacolin, benzylthiourea, hentriacontane, ß-sitosterol, caricin, and an enzyme myrosin. (50)
- Roots yield carposide and an enzyme, myrosine. Leaves yield alkaloids carpain, pseudocrpain and dehydrocarpaine I and II; choline, carposide, vitamin C and E. Bark yields ß-sitosterol, glucose, fructose, sucrose, galactose and xylitol. Latex yields protelytic enzymes, papain and chemopapain, glutamine cyclotransferase, chmopapains A, B, and C, peptidase A and B, and lysozymes. (50)
- Nutritive analysis of 100 g of papaya fruit (R/ripe; G/green) yielded protein 0.6 g/R, 0.7/G; fat 0.1g/R. 0.2g/G; minerals 0.5 g/R/G; fiber 0.8 g/R, 0.9 g/G; carbohydrates 7.2 g/R, 5.7 g/G; energy 32 kcal/R, 27 kcal/G; total carotene 2,740 µm/R, 0/G; beta-carotene 888 µm/R/ 0/G. (50)
- Considered antirheumatic,
- Seeds are considered antiinflammatory, anthelmintic, analgesic,
stomachic and antifungal.
- Leaves are used as tonic, stomachic and analgesic.
- Roots considered analgesic, abortifacient.
- Latex considered styptic and vermifuge. _
- Studies have shown hypotensive, hepatoprotective, nephroprotective, antisickling, anti-inflammatory, anti-dengue, wound healing, anti-cancer, anthelmintic, immunomodulatory, antidiarrheal properties.
Leaves, fruit and latex of trunk.
Edibility / Nutritional
- Fruit is a popular Filipino breakfast item. Lemon juice is often squeezed over the flesh.
- Makes an excellent ingredient for fruit salad.
- Used in making jams.
- Green fruit used in making achara (pickles).
- The unripe fruit is essential ingredient for tinola, a popular native soup.
- Leaves are sometimes used with soap or as a soap substitute for washing clothes.
Source of calcium, iron;
good source of vitamins A and B; excellent source of vitamin C.
- In the Philippines, bruised papaya leaves are used as a poultice for rheumatism.
- Decoction of the center part of the roots is used as a digestive and tonic, and used to cure dyspepsia.
- Roots are used for yaws and piles.
- In the Gold Coast, roots are used as abortifacient.
- Decoction of leaves used for asthma.
- Leaves used as heart tonic and febrifuge.
of purulent exudate and blood clots from wound and ulcer): Apply latex
(dagta) of unripe fruit or trunk on the wound or ulcer.
- Ripe fruit eaten for laxative effect. Eat ripe fruit liberally. (May cause harmless yellowing
of the skin, specially palms and soles but not the eyes.) Green fruit is also used as laxative and diuretic.
- Ripe fruit also useful for bleeding piles and dyspepsia.
- In India, milky juice from the unripe fruit used splenic and hepatic enlargement.
- Boiled cup of chopped fresh leaves and 1 cup chopped
green fruit in glasses of water used for cystitis.
- For acne, mix 3 tablespoons of mashed ripe papaya with a tablespoon
of kalamansi juice; apply the mixture to face for 30 minutes, then wash
face with warm water.
- For worm infestation, 1 cup of dried seeds, pulverized and mixed
with 1 cup of milk or water; 1 teaspoon 2 hours after supper.
- Tea decoction of dried leaves for variety of stomach troubles.
- Decoction of boiled flowers or powdered seeds promote menstruation.
- Infusion of male flowers (left insert) with honey used for
cough, hoarseness, bronchitis, laryngitis and tracheitis: a spoonful
- Poultice of roots used for centipede bites.
- Leaves used as vermifuge.
- In the West Indies, powdered seeds used as vermifuge.
- Infusion of flowers used as emmenagogue, pectoral and febrifuge.
- In India and Sri
Lanka, green papaya is used as contraceptive and abortifacient.
- In Ayurveda, used as haemostatic.
- In southern Nigeria, aqueous extract
of unripe papaya taken by sickle cell patients for its "antisickling"
- Papain used for gastric juice deficiency, dyspepsia, intestinal irritation, in doses of 1 to 5 grains. Used in solution to dissolve fibrinous membranes in croup and diphtheria. Applied to ulcers and fissures of the tongue. In pigment form prepared with borax and water, used to remove warts, corns, or other horny excrescences of the skin. Papain also used as anthelmintic; also used for warts, epithelioma and tubercles.
- In India and among the Malays, milky juice is applied to the os uteri to induce abortion.
- Latex used as styptic and vermifuge.
- Meat tenderizer: Mix the peelings of the unripe fruit or
latex with raw meat before cooking. The enzyme "papain" is
a main ingredient in commercial meat tenderizers.
- Papain is also the main ingredient of an ointment popularly
used as a topical application for cuts, rashes, stings and burns.
- Food: Eat unripe or ripe fruit.
- Cosmetics: Ripe fruit used as cosmetic; pulp used as skin soap. Juice of fruit pulp used for freckles caused by the sun.
- Young leaves of papaya are sometimes steamed and eaten like
- Seeds are edible, sharp and spicy.
· Raw papaya leaf juice: Web grapevine blogs tell of the use of raw papaya leaf
juice in patients with dengue – two leaves, cleaned, pounded and
squeezed our of a cloth for a two tablespoonfuls serving, once a day.
Reports of improvement in the decreased platelet counts –some
are rather dramatic – are attributed to the use of the papaya
leaf juice. Bioactive chemicals reported in the leaf are: carpaine,
carposide, dehydrocarpaine, flavonols, pseudocarpaine and tannins.
Other than a Nigerian folkloric use of the aqueous extract of the unripe
papaya for its "anti-sickling" effect, a search failed to show
any study on Carica papaya's effect on the platelet pathway. (Also see:
Gatas-gatas and the folk medicine grapevine
reports on use for dengue.)
· Preparation of Leaf Juice: A pilot study (Sri Lankan Family Physician, 2008, 29, 17-19)
describes the preparation of the papaya leaf extract: Crush two (2) tender, fresh papaya leaves (not too young, not too mature, using only the leafy part and discarding the stalks) and squeezing the juice by hand, and the juice drunk without dilution. (see study below) (29)
• Phytochemicals / Unripe Pulp: Phytochemical analysis of the mature unripe pulp of C papaya
yielded minerals in considerable quantities and the presence of saponins
and cardenolides that explains its astringent therapeutic uses. (2)
• Toxicity study: A study to
evaluate the toxicity of aqueous extract of unripe papaya, consumed
for its anti-sickling effect by some sickle cell patients, showed
no adverse effects or evidence of toxicity on the organ functions in
• Hypotensive: Blood pressure
depression by the fruit juice of Carica papaya (L.) in renal and DOCA-induced
hypertension in the rat: Study showed significant lowering of mean arterial
pressure, more than hydralazine. It concludes that the fruit juice of
C papaya contains antihypertensive agent/s which exhibits mainly alpha-adrenoreceptor
• Antihemolytic: Antihemolytic
action of an extract of Carica papaya bark. Possibilities of use in
glucose-6-phosphate dehydrogenase deficiencies. (5)
• Antioxidant / Antiulcer: Study of the aqueous extract on alcohol-induced acute damage and the
immediate blood oxidative stress level in rats showed that Cp may potentially
serve as a good therapeutic agent against gastric ulcer and oxidative
• Antiulcerogenic: Study on the antiulcerogenic activities of Cp extract on
aspirin-induced ulcer in rats showed reduced ulcer index, lipid peroxide
levels and alkaline phosphatase activity in rats. It suggests Cp may
exert gastroprotective effects by free radical scavenging action and
presents a therapeutic potential in the treatment of gastric diseases. (9)
• Anthelmintic / Jejunal Contraction
Modulation : Study of an ethanol extract of C papaya
seeds caused concentration-dependent inhibition of jejunal contraction
which was significantly irreversible. Benzyl isothiocyanate (BITC)is
the main bioactive compound responsible for its anthelmintic activity.
The results show that papaya seed extract and BITC are capable of weakening
the contractile capacity of isolated rabbit jejunum and concludes that
the anthelmintic efficacy level may also cause impairment of intestinal
• Antisickling Property / Leaves: Study
on the methanolic leaf extracts of Cp showed reduction of hemolysis
and protection of erythrocyte membrane stability under osmotic stress
conditions. Pretreatment with Cp leaf extract inhibited formation of
sickle cells under severe hypoxia. The results indicate the feasibility
of Cp as an attractive candidate for Sickle Cell Disease therapy. (10)
• Nephroprotective / Seeds:
Study showed the aqueous seed extract of Cp has nephroprotective
effect on carbon tetrachloride renal-injured rats, possibly mediated
through any of the phytocomponents through either an antioxidant and/or
free radical scavenging mechanism/s. (11) Study evaluated an aqueous extract of papaya seeds on CCl4-induced renal toxicity in Wistar rats. Results showed a nephroprotective effect with dose-dependent statistically significant decrease in renal function makers except potassium. (58)
• Wound Healing Property / Latex:
Study showed the papaya latex formulated in the
Carbopol gel, based on hydroxyproline content, wound contraction and
epithelialization time, to be effective in the treatment of burns and
supports its traditional use.
• Pregnancy Concerns:
A study was done to evaluate the safety of papaya
consumption in pregnancy. Ripe papaya consumption showed (1) no significant
difference in the number of implantation sites and viable fetuses in
papaya fed rats relative to control (2) no fetal or maternal toxicity
in all groups (3) No significant contractile effect on uterine smooth
muscles. However, crude papaya latex (1) induced spasmodic contraction
of the uterine muscles similar to oxytocin and prostaglandin F2a. Results
suggest, ripe papaya consumption pose no significant danger during pregnancy.
However, unripe or semi-ripe papaya that contains high concentration
of latex produces marked uterine contraction and may be unsafe during
• Male Infertility:
Study of the alkaloid extract of Cp seeds
prevented ovum fertilization, reduced sperm cell counts, sperm cell
degeneration and induced testicular cell lesion, changes that induce
reversible male infertility and a potential for a pharmaceutical male
• Leaf Extract Acute Toxicity Study: Acute toxicity study of Carica papaya leaf extract did not cause death or acute adverse effects. However hemoglobin, hematocrit, RBC, and total proteins were significantly increased suggesting dehydration. (15)
• Dried Seeds / Anthelmintic: Study evaluated air-dried papaya seeds on human intestinal parasitosis showed efficacious results without significant side effects.(16)
• Hepatoprotective: Study of Carica papaya fruit extract showed significant dose-dependent hepatoprotection in carbon tetrachloride hepatotoxic rats. (17)
• Pawpaw Wine: Wine produced from pawpaw had similar taste and characteristics with natural palm wine. It can be produced for immediate consumption or preserved by refrigeration. (18)
• Leaves / Pharmacognostic / Physiochemical / Phytochemical: Leaf showed abundant sphaeraphides and rhomboidal calcium oxalate crystals. Histochemical testing revealed the presence of alkaloids and starch.
• Anthelmintic / Latex / Poultry Nematodes: Trials concluded the latex of C. papaya (papain) has phamacotherapeutic activities against intestinal nematodes of poultry. (21)
• Acetogenins: Acetogenins have been isolated from the twigs. Acetogenins are active compounds that modulate ATP production in the mitochondria of specific cells.
• Anti-Cancer Effects: In a study that exposed 10 different types of cancers--including cervix, breast, liver, lung, and pancreas-- extract made from dried papaya leaves was reported to slow down tumor growths. While one mechanism suggested apoptosis induction as a mechanism, the extract also boosted the production of key signaling molecules called Th-1 type cytokines. Results suggest a potential therapeutic strategy that uses the immune system to fight cancers and a use for various inflammatory and autoimmune conditions. Also, the extract showed no toxicity on normal cells. (23)
• Wound Healing / Fruit: Study evaluated an aqueous extract of fruit for wound healing activity in streptozotocin-induced diabetic rats using excision and dead space wound models. Extract treated animals showed 77% reduction of wound area controlled to 59% of control. Faster epithelization was noted, with increased hydoxyproline content. Extract showed antimicrobial activity against five organisms tested. (24)
• Reversible Contraception in Male Wistar Rats: Study investigated the antifertility activity of an ethanol extract of C. papaya seeds. Study results conclude that the seed extract induces reversible male contraception in Wistar rats. The antifertility action was clearly evident on the testicular germinal epithelium of treated male rats. (25)
• Anti-tumor / Immunomodulatory: Study evaluated the effect of an aqueous-extracted CP leaf fraction on the growth of various tumor cell lines and the anti-tumor effect on human lymphocytes. Results showed significant growth inhibitory activity of the CP extract on tumor cell lines. In PBMC, IL-2 and IL-4 production was decreased, with increased cytotoxicity of activated PBMC against K562. Results showed the extract can mediate a Th1 type shift in human immune system, with a potential use for selected human diseases like cancer and allergic disorders, as well as immunoadjuvant for vaccine therapy. (26)
• Increased Platelet Count / Leaf Extract: Study showed fresh C. papaya leaf extract significantly increased the platelet and RBC counts in test groups compared to control. Identification of active constituents is paramount for its potential as medication to boost thrombopoiesis and erythropoiesis in humans and animals where those cell lineages have been compromised. (27) Open-labeled, randomized controlled trial investigated the platelet increasing property of C. papaya leaf extract in patients with thrombocytopenia associated with dengue. Results showed the leaf extract significantly increased the plate count (p<0.003) over the therapy duration. (51) An observational, prospective, uncontrolled, open label, single center study investigated the effect of papaya leaves extract capsules in acute febrile illness with thrombocytopenia in 80 patients. Results showed significant increased in platelet count (p<0.05) and maintained stability of hematocrit level. Findings suggest acceleration of platelet count increase and shortening of hospitalization time. (56)
• Acceleration of Platelet Count Increase in Dengue: Study investigated the platelet increasing property of leaf juice in patients with dengue fever. In an open-labeled randomized controlled trial of 228 patients with dengue fever (DF) and dengue hemorrhagic fever (DHF), study showed a significant increase in mean platelet count in the intervention group in both DF and DHF patients. (28)
• Salutary Effects of Leaf Extract in Dengue Fever Patients: Pilot study showed the effects of papaya leaf juice in dengue patients in elevating total WBC counts, platelet counts and recovery without hospital admission. Typically, platelet count drops in dengue after the first three days of fever, gradually increasing after the 7th day or decreasing further along with other clotting facts to develop into the dengue hemorrhagic state. In this study, the platelet count increased in all 12 patients with two doses of papaya leaf juice. (See Uses/Dengue for preparation of leaf juice) (29)
• Platelet Augmentation Activity / Leaf Aqueous Extract: Study evaluated the effect of C. papaya aqueous leaf extract in increasing platelet count in a cyclophosphamide-induced thrombocytopenic rat model. Results showed increase in platelet count and also a decrease in clotting time in rats. Vinca-alkaloids have been proven effective against anti-platelet macrophages in ITP. Saponins in Panax notoginseng have been shown to reduce platelet adhesion and aggregation, and prevent thrombosis. Papaya leaves yield phytoconstituents like saponins, tannins, cardiac glycosides and alkaloids (carpaine, pseudocarpaine, and dehydrocarpaine I and II). The study suggests the phytoconstituents can have bone marrow effects— preventing destruction or enhancing platelet production, prevented platelet destruction in the blood and increase its circulation life. (30)
• Anthelmintic / Latex: Study evaluated the anthelmintic potential of latex of Carica papaya using Pheretima posthuma as test worms. Latex of C. papaya showed significant anthelmintic activity with piperazine citrate as standard anthelmintic drug. (31)
• Hypoglycemic / Leaves: Study evaluated the hypoglycemic effect of an aqueous extract of C. papaya leaves in diabetic rats. The leaves exerted a hypoglycemic and antioxidant effect, and also improved the lipid profile in diabetic rats. (32)
• Antimicrobial / Leaves: Study evaluated various extract of dried and fresh leaves of C. papaya against bacteria and fungi of medical importance. Results showed a very significant broad spectrum of antimicrobial activity against Gram-negative and Gram-positive bacteria and fungi. Organic extracts were more effective than aqueous extracts.
• Proximate Analysis / Antioxidant / Antiproliferative: Study evaluated different parts of C papaya (ripe and unripe, leaves and seed) for proximate analysis, antioxidant and antiproliferative activities. The ripe papaya had the highest antioxidant activity (84.04%, followed by unripe papaya (81.35%), leaves (78.03%), the seeds (75.35%). Phenolic content was leaves > unripe papaya > ripe papaya > seed. Leaves had the highest ascorbic acid and ß-carotene content, while seeds had the highest vitamin E content. On cytotoxicity evaluation, the extract significant inhibited MCF-7 and MDA-MB-231 breast cancer cell lines. (34)
• Comparative Hepatoprotective Efficacy / Dried Fruits Vs Vitamin E: Carica papaya and vitamin E showed significant hepatoprotection against CCl3-iinduced hepatotoxicity, with prevention of hepatic necrosis and fatty degeneration. C. papaya showed more significant changes in ALP than vitamin E. (35)
• Co-Administration with Oral Hypoglycemic Drugs: Study evaluated the interacting effects of co-administration of C. papaya leaf extract on the hypoglycemic activity of metformin and glimepiride in an animal model. Results showed co-administration of C. papaya with glimepiride or metformin led to significant interactions which affected the hypoglycemic activities of the drugs. Carica papaya extract delayed the onset of hypoglycemic activity of glimepiride and increased the hypoglycemic activity of metformin. Further studies are needed to elucidate the pathway of mechanism of interaction. (36)
• Anti-Protozoal against Trypanosoma cruzi: Study evaluated the in vivo activity of chloroform extract of C. papaya seeds against protozoan Trypanosoma cruzi. The crude extract of seed yielded three main compounds: oleic, palmitic, and stearic acids. Results showed the fatty acids identified in the seed extracts reduced the number of parasites from both parasite stages—blood trypomastigote and amastigote (intracellular stage). (37)
• Leaves Extract Capsule Effect on Platelet Count: Study evaluated the effects of C. papaya extract capsules on dengue fever. The CPC significantly increased the platelet count, maintained the stability of the Hct, accelerated the increase in platelet count and shortened the hospitalization period. (38)
• Alcohol and Anti-Tubercular Hepatotoxicity: Study justified the use of Carica papaya leaves in the prevention of liver damage induced by alcohol and anti-tubercular drugs. (39)
• Anti-HIV 1 Activity: Study evaluated the anti-HIV 1 effect of Carica papaya aerial parts polar extracts. Methanol and aqueous extracts of aerial parts showed anti-HIV1 activity—possibly explained by the presence of phytoconstituents as flavonoids, triterpenes, alkaloids. (40)
• Caricapinoside / Anti-Sickling Activity: Study of a methanolic extract of unripe fruit of C. papaya isolated a new antisickling agent 8(2-0-β-D-4, 5-anhydroglucitoyl 1→ 2glucopyranosyl carbonyl) dibenzo [b,e] [1,4] dioxine-2-carboxylic acid, named caricapinoside. Study results suggest ingestion of aqueous extract of unripe C. papaya fruit has no adverse effects, but showed beneficial effects on cellular blood components in sickle cell patients. (41)
• Antimutagenic / Rutin: Study evaluated the antimutagenic and cytotoxic activities of an aqueous solution of C. papaya leaves extract. The extract consisted mainly of polar substances, one of which was rutin. Results showed the extract has low toxicity and an antimutagenic effect; flavonoids, such as rutin, may be involved in the action. (42)
• Antihypertensive / Root Bark: Study evaluated an ethanolic extract of C. papaya root bark powder for antihypertensive activity in renal artery occluded hypertensive male Wistar rats. Results showed a 100 mg/kg dose was comparable and equipotent to that of Captopril. The effect could be due to its action on the renin-angiotensin system. (43)
• Immunostimulant / Antioxidant: Study evaluated the antioxidant and immunostimulant effects of Carica papaya fruit aqueous extract against acrylamide induced oxidative stress and improvement of immune functions affected by free radicals liberating acrylamide in rats. The CPF aqueous extract significantly increased immune functions (IgG and IgM) while acrylamide decreased it. Results showed acrylamide-induced oxidative stress in rats can be ameliorated by administration of CPF aqueous extract. (44)
• Antidiarrheal / Fruit: Study investigated alcoholic and aqueous extracts of fruit of C. papaya for antidiarrheal activity in albino Wistar rats. Results showed dose dependent anti-diarrheal activity in castor oil induced diarrhea and magnesium sulphate induced diarrhea, comparable to standard drug Loperamide. (45)
• Effect on Thrombocyte Count in Dengue / Leaves / A Case Report: Study investigated the role of Carica papaya leaves in Dengue Fever. Toxicity study (acute, sub-acute, and chronic toxicity) on Sprague Dawley rats showed leaf juice was safe for oral consumption. In a study on a 45-year old man showed a dramatic increase in thrombocyte count from 28,000 to 1138,000 within 5 days of administration. The report was supported by another study in which the PTAFR gene, which is known to be responsible for increased platelet production and aggregation, increased 13.42-folds among patients who consumed papaya juice. Besides increasing thrombocyte count, the anti-hemolytic action of leaves could have potential therapeutic benefit. (46)
• Activity Against Dengue Fever / Leaves: Study investigated the potential of Carica papaya leaves extracts against Dengue fever in a 45 year old patient bitten by carrier mosquitoes. Extract was prepared in 25 cc of aqueous extract of leaves administered twice daily for five consecutive days. Rechecking of blood samples showed an increase in platelet count, white blood cells, and neutrophils. Results suggest potential activity against Dengue fever. (48)
• Acute and Chronic Toxicity Studies / Leaves: Study evaluated aqueous and ethanol leaf extracts of Carica papaya in Wistar rats. No deaths or signs of acute oral toxicity were recorded. Subacute and chronic toxicity observations included hypoglycemmia, hypolipidemia and hyperglycemia, associated with increased AST and BUN. The aqueous extract is hypoglycemic and hypolipidemic, while the ethanol extract showed signs of liver and kidney toxicity at high doses, confirmed by histopathological examination. The aqueous extract showed lesser toxicity than the ethanol extract. (52)
• Acute and Chronic Hepatotoxicity and Nephrotoxicity Studies / Seeds: Study evaluated the acute and chronic hepatotoxic and nephrotoxic effects of orally administered chloroform extracts of Carica papaya seeds in adult Wistar rat. Acute oral toxicity study showed the LD50 to be above 2000 mg/kg. The chloroform seed extract showed to toxicity in acute and chronic studies. There were no histopathologic changes, and liver and renal function tests were normal. (54)
• Oral Consumption of Unripe Pulp and Seed / Effect on Cerebrum and Cerebellum: Study investigated the effect of oral consumption of pulp and seeds of unripe C. papaya on cerebrum and cerebellum of rats using histological protocols. Histological results showed oral consumption of unripe pulp and seeds conferred neuronal degeneration in the cerebrum and cerebellum of treated rats. (55)
• Decreased Spermatogenesis / Seeds: Study assessed the effect of unripe papaya seeds hexane fraction extract on spermatogenesis and testosterone level of male mice. Results showed the hexane fraction of unripe seeds can decrease the mean number of spermatogonia A cells,spermatocyte of primary pachytene spermatocytes, spermatid, and sertoli cells better than the methanolic extract. Testosterone levels were not significantly decreased (p<0.05). (57)
• Anthelmintic / Intestinal Parasitosis / Seeds: Study assessed the effectiveness of air-dried seeds on human intestinal parasitosis in 60 asymptomatic Nigerian children treated with an elixir composed of air-dried seeds and honey. There was a clearance rate between 71.4 % and 100 % following CPH elixir treatment. Results suggest a potential for a cheap, natural, harmless, readily available monotherapy and preventive strategy against intestinal parasitosis. (59)
• Hepatotoxic / Seeds: Study assessed the histologic effects of hydromethanol seed extracts (HSEC) of ripe papaya on wistar rats' liver. The LD50 of HSEC is 299 mg/kg. HSEC is hepatotoxic in a time and dose-dependent manner. The hepatotoxicity is reversible. (61)
• Papaya may affect the hypoglycemic activity of antidiabetics treatment.
It may also increase the effects of warfarin (Coumadin), and increase the chances of bleeding and bruising. It may necessitate the change in coumadin dose.
• Herb-Drug Interaction / Papaya-Amiodarone: Study investigated the interference of standardized C. papaya extract on systemic exposure to amiodarone in rats. Results showed an herb-drug interaction which clearly increase drug bioavailability. (60)
- In the rural areas,
a common backyard fruit tree.
- Small and large scale commercial production.
- Perennial market produce.
- Tinctures, capsules, and seed extracts in the cybermarket.