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Family Passifloraceae
Passiflora edulis Sims.

Ji dan guo

Scientific names Common names
Passiflora cuneifolia Cav. Miraflor (Ilk.)
Passiflora diaden Vell. Granadilla (Tag.)
Passiflora edulis Sims. Grenadine (Engl.)
Passiflora edulis f. albida Vanderpl. & S.L.Edwards Pasyonaria (Tag.)
Passiflora edulis f. flavicarpa O.Deg. Pasyonario (Tag.)
Passiflora edulis var. pomifera (M.Roem.) Mast. Pasyonaryo (Tag.)
Passiflora edulis var. rubricaulis (J.Jacq.) Mast. Passion flower fruit (Engl.)
Passiflora fragrans Regel ex Mast. Passion fruit (Engl.)
Passiflora incarnata Ker Gawl.  
Passiflora iodocarpa Barb. Rodr.  
Passiflora middletoniana J. Paxton  
Passiflora pallidifora Bertol.  
Passiflora perfecta J.R.Duncan & V.C.Davies  
Passiflora picroderma Barb.Rodr.  
Passiflora pomifera M. Roem.  
Passiflora rubricaulis J.Jacq.  
Passiflora vernicosa Barb.Rodr.  
Passiflora verrucifera Lindl.  
Granadilla is a shared common name for three varieties of Passiflora: Passiflora quadrangularis, Passiflora incarnata, and Passiflora edulis.
Passiflora edulis Sims is an accepted species. KEW: Plants of the World Online

Other vernacular names
CHINESE: Xi fan lian, Xi guo fan lian, Yan shi liu, Ji dan duo.
DANISH: Granatblomst, Passionsfrugt.
DUTCH: Eetbare passiebloem, Paarse-passievrucht, Passiebloem, Passievrucht, Passie vrucht.
ENGLISH: Couzou (Guyana, Surinam), Passion fruit.
FINNISH: Kärsimyshedelmä, Passiohedelmä.
FRENCH: Couzou, Fruit de la passion, Grenadille pourpre, Maracaju pourpre, Passiflore comestible.
GERMAN: Granadilla, Passionsfrucht, Purpurgranadilla, Purpur-Granadille.
HUNGARIAN: Golgotavirág gyümölcse.
ITALIAN: Granadiglia, Frutto della passione, Passiflora commestibile.
JAPANESE: Kudamonotokeiso.
MALAY: Buah susu, Konyal (orange-skinned), Markisa (purple-skinned).
POLISH: Meczennica jadalna.
PORTUGUESE: Flor-da-paixão, Granadilho, Maracuj (Brazil), Maracujá, Maracujá-mirim, Maracujá-peroba, Maracujá-pequeno, Maracujá-roxo, Maracujá-suspiro.
SPANISH: Ceibey (Cuba), Couzou (West Indies), Curuba (Colombia), Fruta de la pasión, Maracuja Parcha (Puerto Rico, Venezuela), Parchita (Venezuela), Parchita maracuyá.
SWEDISH: Passionsfrukt.
THAI: Lin mang kon, Ling mang kon, Saowarot.

Gen info
- Passiflora edulis belongs to the Passifloraceae family, with about 500 species distributed in warm temperatures and tropical regions.
- Granadilla is a shared common name for three varieties of Passiflora: Passiflora quadrangularis, Passiflora incarnata, and Passiflora edulis. - The "passion" plant name derives from the early Spanish times when the floral parts symbolized aspects of the Crucifixion: the five stamens signifying the wounds; the petals and sepals, the apostles; the corona inside the petals, the crown of thorns; and the three pistil stiles, the nails of the cross, and
the tendrils on the vines representing the whip that lashed Christ.
- In 2017, global passion fruit production was estimated at 1.5 million tons. Brazil is the largest producer at 690,444 tons in 2020.

• Pasyonaryo is a sturdy climbing vine with angular stems. Leaves are ovate, deeply 3-lobed, green, with many serrate edges, up to 13 centimeters broad. Fruits are edible, globular-oblong, dull purplish, with a hard rind, up to 6 centimeters in diameter.

• Passiflora edulis is a herbaceous vines, woody at base, ca. 6 m long. Stem slender-striate, glabrous. Leaves 6-13 × 8-13 cm, membranous, base cuneate or cordate, deeply 3-lobed, middle lobe ovate, lateral lobes ovate-oblong, margin glandular-serrate, with 1 or 2 small cup-shaped glands near base of sinuses, glabrous. Inflorescence a reduced cyme, central flower not developed, one lateral branch converted to a tendril,flower opposite tendril; bracts green, broadly ovate or rhombic, 1-1.2 cm, margin irregularly serrulate. Pedicel 4-4.5 cm, biglandular at apex. Flowers 4-7 cm in diam.; hypanthium 0.8-1 × 1-1.2 cm. Sepals green outside, light green or white inside, 2.5-4 × ca. 1.5 cm, awn 2-4 mm. Petals 2.5-3 cm × ca. 8 mm. Corona in 4 or 5 series; outer 2 series ligulate with filiform distal half, 2-2.5 cm, base light green, middle purple, apex white; inner 2 or 3 series filiform, 1-3 mm, green and purple; operculum recurved, 1-1.2 mm, margin entire or irregularly lacerate apically; disk ca. 4 mm high, membranous; androgynophore 1-1.2 cm tall; trochlea (ring-shaped enlargement on androgynophore) just above disk. Filaments 5-6 mm, flat, coherent at base; anthers light yellow-green, oblong, 5-6 mm. Ovary obovoid, ca. 8 mm, glabrous to pubescent; styles flat; stigma reniform. Fruit purple at maturity, ovoid, 3-4 cm in diam., glabrous. Seeds many, ovoid, 5-6 mm. (Flora of China)

- Introduced.
- In the Philippines, cultivated in gardens in towns and cities.

- Native to Argentina, Brazil, Paraguay.

- Phytochemical screening of leaf and callus yielded alkaloids, saponins, tannins, and triterpenes from ethanol and chloroform extracts. (See study below) (5)
- Study of methanolic and aqueous extracts revealed a predominance of triterpenoid steroids and saponins. The methanolic extract also showed tannins and flavonoids. (See study below) (7)
- Flavonoids, mainly C-glycosylflavones, are the major constituents of leaves and pulp.  (9)
- Phytochemical analysis of various extracts of leaves yielded saponins, steroids, cardiac glycosides, amino acids, terpenoids, alkaloids, flavonoids, phenolic compounds, reducing sugars, and tannins. A methanolic extract yielded 5 bioactive compounds, viz., dodecanoic acid,10-methyl-,methyl ester (C14H28O2 ), E,E,Z-1,3,12-Nonadecatriene-5,14-diol (C19H3402), 9,12,15-Octadecatrienoic acid,2,3- dihydroxypropyl ester (Z,Z,Z) (C21H36O4 ), S.Hexadecenoic acid,9-octadecenyl ester (Z,Z)  (C34H64O2 ) and Docosanoc acid,1,2,3 propanetriyl ester (C69H134O6) respectively. (11) 
- Nutritive analysis of fresh fruit per 100 g yield 97 Kcal, 23.38 g. carbohydrates, 2.20 g. protein, 0.70 g total fat, 0 mg cholesterol, 10.40 g dietary fiber. Vitamin contents yielded 14 µg folates, 1.50 mg niacin, 0.10 mg pyridoxine, 0.130 mg riboflavin, 0 mg thiamine, 1274 IU vitamin A, 30 mg vitamin C, 0.02 µg vitamin E, 0.7 mg vitamin K. Electrolytes yielded 0 mg sodium, 348 mg potassium. Minerals analysis yielded 12 mg calcium, 0.086 mg copper, 1.60 mg iron, 29 mg magnesium, 68 mg phosphorus, 0.6 µg selenium, and 0.10 mg zinc. Phytonutrient analysis yielded 743 µg carotene-B, 41 µg crypto-xanthine-B, and 0 µg lycopene. (19)
- In a study for phenolic content, a methanol extract of P. edulis yielded 2.37 ± 0.11 g GAE/100 g. Antioxidant activity of the leaf was 653.5 ± 6.1 µg/mL. Antioxidant activity of stem was 429.6 ± 3.6 µg/mL. (31)
- Phytochemical analysis of ethanolic and aqueous extracts of leaves and fruits yielded tannins, flavonoids, and cardiotonic glycosides. (see study below) (34)
- Nutrient analysis of seeds (g/100 g on dry basis) yielded protein 13.99, lipids 32.65, carbohydrates 51.87, ash 1.49, dietary fiber 48.18; mineral content (mg/100g): sodium 241.7, magnesium 138.3, potassium 352.5, calcium 173.1, phosphorus 115.3, iron 6.2, copper 1.4, zinc 5.6.   (47)

- Studies have shown antibacterial, anxiolytic, anti-inflammatory and lipid-benefit activities.
- Studies have suggested the fruit rind has a higher nutrient content than the pulp. (9)
- Studies have suggested antioxidant, anti-inflammatory, antiproliferative, anxiolytic, hypnotic, antibacterial, analgesic, anticonvulsant, anti-sickling, melanogenesis inhibitry, antihypertensive, neuropharmacological, anti-aging properties.

Parts used
Leaves, fruits, flowers.


- An edible fruit, sour, the pulp eaten raw with seeds.
- In Brazil, the fruit is widely cultivated and used in the food industry as concentrates and processed juices.
- Used for making juices, jellies, and ice cream.
- No reported medicinal use in the Philippines.
- Elsewhere, used for hypertension.
- In Brazil, leaves extracts long used as treatment for anxiety and insomnia. Flower decoction used to treat asthma, bronchitis, and whooping cough. () Cataplasm made from leaves used as healing agent for skin infections and inflammations. (41)
- In American countries, leaves used for anxiety and nervousness. (11)
- In China, South America, India and other countries, used as tonic, digestive, sedative, diuretic, antidiarrheal, insecticidal. Used for treatment of cough, constipation, insomnia, diarrhea, dysmenorrhea, infant colic, joint pain, dysentery, etc.
- Rituals:
Juice reportedly used in Brazilian jurema rituals.

Anxiolytic Activities / Flavonoid Contents / Comparative Effects:
Study compared the anxiolytic activities and flavonoid compositions of species of P. edulis with purple fruit and yellow fruit. Ethanolic extracts of P. edulis flavicarpa displayed anxiolytic activities while P. edulis edulis exhibited sedative effect. Study yielded six major flavonoid compounds from the leaves of PE 'flavicarpa': lucenin-2, vicenin-2, isoorientin, isovitexin, luteolin-6-C-chinovoside, and luteolin-6-C-fucoside. Results suggest flavicarpa is extremely different from edulis and should be distinguished. (3)
Anxiolytic Activities: Study of hydroalcoholic extracts of P alata and P. edulis leaves using the elevated plus-maze test showed anxiolytic activity. (4)
Phytochemicals / Antibacterial: Study evaluated the phytochemical and antibacterial activity of leaf and callus of P. edulis Sims using various extracts. A chloroform extract of leaf and callus showed the maximum solubility and antimicrobial activity. (5)
Increased HDL Cholesterol Levels / Industrial Waste Potential: Study evaluated the biochemical profile of male Wistar rats treated with extract of rind of Passiflora edulis. Results showed increase in HDL cholesterol levels. The passion fruit rinds are discarded by fruit processing plants and its waste has a potential as source of new functional product. (6)
Anti-Inflammatory / Antibacterial / Leaves: A methanolic extract exhibited significant antibacterial activity against S. aureus. The extracts were devoid of antifungal activity. A methanolic extract exhibited significant anti-inflammatory activity in Wistar rats using carrageenan-induced left hind paw edema method. (7)
Angiotensin-Converting Enzyme Inhibitory Activity: Study evaluated the ACE-inhibitory effect of several extracts from species of P. edulis and P. crispus. Considerable angiotensin-converting enzyme inhibitory activity was found for Passiflora edulis ethanolic extracts of fruit juice and leaves but not for Petroselinum crispum leaves. (8)
Antioxidant / Isoorientin / Fruit Rind: Study showed a higher amount of isoorientin in healthy rinds. Studies allied to assays of radical scavenging activity suggest the potential of P. edulis rinds as a natural source of flavonoids or as a possible functional food. (9)
Lipid and Oxidative Stress Benefits: Study showed P. edulis juice in experimental conditions showed beneficial effects on lipid profile and improved lipid peroxidation in Wistar rats. (10)
Antimicrobial: Study evaluated the antimicrobial activities of the leaf extracts against Escherichia coli, Bacillus subtilis, Staphylococcus aureus, Pseudomonas aeruginosa, Salmonella typhi, Klebsiella pneumoniae. A methanol extract exhibited the best antimicrobial activity against the bacteria. (11)
Human Spermicidal Effect / Fruit Extract: Study evaluated the spermicidal activity of Passiflora edulis extract on human spermatozoa. Results showed decreased motility and viability. Extract showed no cytotoxic effects on proliferation of MDBK and VERO cells. (12)
Diabetes Benefits / Decreased Insulin Resistance / Peel Flour Supplementation: P. edulis fruit peel flour have showed positive action in adjuvant blood glucose control. Study showed supplementation decreased insulin resistance in type 2 diabetic patients, suggesting a potential for adjuvant therapy in blood glucose control. (13)
Sedative / Anticonvulsant / Dried Leaves: P. edulis extract showed sedative activity in mice, significantly increasing total sleep time induced by diazepam. The extract also showed anticonvulsant activity protecting mice against strychnine-induced seizures and antagonized NMDA-induced turning behavior in mice. (14)
Toxicity Studies / Effect on Hematological Parameters / Safety: Study evaluated the toxicological effects of aqueous leaf extract in Wistar albino rats in acute and subacute toxicity studies. Results showed no effect of hematological parameters, renal and hepatic markers. Acute toxicity study showed the extract to be safe up to 2000 mg/kg. Subacute study showed no effects on bone marrow function, with no hepatotoxic or nephrotoxic effects. (15)
Anti-Anxiety: Study in rats showed that, similar to diazepam, P. edulis and P. alata induced anxiolytic-like effects in rats, with no disruption in the memory process. P. edulis required lower active doses of aqueous extracts than P. alata in inducing anxiolytic-like effects. (16)
Antioxidant / Leaves: Study evaluated an ethanol extract of P. edulis leaves for antioxidant activity using a DPPH quenching assay and reducing power test models. The leaf extract showed potential antioxidant in both assay models. Phytochemical analysis yielded saponins, tannin and phenolic compounds, flavonoids, steroids, oils and fats, and terpenoids. (17) Study evaluated the leaf extracts of P. alata and P. edulis for antioxidant activities in in vitro and ex vivo assays. Both extracts showed antioxidant properties, the activities significantly correlating with polyphenol contents. Both extracts attenuated ex vivo iron-induced cell death. (18) Study evaluated the in vitro and in vivo antioxidant potential of aqueous extract of P. edulis leaves. The leaf extract yielded vitexin, isovitexin, and isoorientin. Animals treated with the tea extract showed a 45% reduction on DOS activities in the liver and brain. Tea intake also promoted colonic bacterial growth. Results suggest a potential for enhancement of antioxidants and protection against oxidative stress. (29)
High Fiber Diet Effect on Metabolic Profile: Study evaluated the effect of high-fiber diet albedo of passion fruit on metabolic and biochemical profile in alloxan induced diabetic rats. Results showed a statistically significant decrease in plasma glucose, suggesting a potential hypoglycemic effect and an ability to reduce triglycerides and VLDL-cholesterol levels, with a principal reduction of insulin and leptin. (20)
Analgesic / Leaves: Study evaluated leaf extracts of P. edulis for analgesic activity by tail immersion method in Swiss albino mice. The n-butanol extract showed better analgesic activity when compared to the other extracts and the standard drug, aspirin. (21)
Hypoglycemic / Leaves: Study investigated P. edulis for hypoglycemic effects in Wistar albino rats. Results showed significant hypoglycemic activity which may be attributed to the presence of phenols and flavonoids. (22)
Piceatannol / Seeds / Melanogenesis Inhibition / Promotion of Collagen Synthesis: Study evaluated the effect of passion fruit o melanin inhibition and collagen synthesis on cultured human melanoma and fibroblast cells. Fruit seeds yielded piceatannol (3,4,3′,5′-tetrahydroxy-trans-stilbene), a major component shown to be responsible for the effects on melanogenesis and collagen synthesis.       (23)
Antihypertensive Effect / Leaves and Fruit Juice: Study showed the ethanolic extract of leaves and fruit juice of P. edulis were effective in decreasing the arterial blood pressure in hypertensive rats, with oral acute toxicity. (24)
In Vitro Anti-Sickling Potential Effect: Study
evaluated the in vitro antisickling potential of aqueous extracts of leaf and fruit extracts of P. edulis. Results showed activities with linear increase in inhibitory and reversal activities as concentration of the aqueous extract increased. The leaf extract was more active in inhibitory and reversal activities compared to the fruit juice. (25)
Neuropharmacological Effects / Pericarp: Study evaluated the central effects of various extracts and fraction of P. edulis flavicarpa in mice. Results showed an anxiolytic-like effect. The AE showed a sedative effect, potentiating the hypnotic effects of ethyl ether. The extracts and fractions showed a predominance of C-glycosylflavonoids, identified as isoorientin, vicenin-2-spinosin, and 6,8-ci-C-glycosylchrysin. (26)
• Inhibition of Protein Glycation / Diabetic Benefits / Leaves: Study evaluated the effects of ethanolic extract of Passiflora edulis leaves on blood glucose, protein glycation, NADPH oxidase activity and macrophage phagocytic capacity after Candida exposure in alloxan-induced diabetic rats. Extract treated diabetic animals showed lower fructosamine concentrations. Results showed the leaf extract prevented an increase in serum protein glycation and helped maintain diabetic rat macrophage ROS production at levels similar to non-diabetic animals. (28)
• Drug Interactions: P. edulis have moderate interactions with CNS depressants. It may cause drowsiness and sleepiness with sedatives such as pentobarbital (Nembutal), phenobarbital (Luminal), secobarbital (Seconal), clonazepam (Klonipin), lorazepam (Ativan), zolpidem (Ambien), among others. (30)
• Hypnotic-Sedative / Toxicity Study: Study evaluated the hypnotic-sedative effects and toxicity aqueous extract of P. edulis in rats and mice and in healthy volunteers. Results showed a non-specific central nervous system depressant effect. Study also showed hepatobiliary and pancreatic toxicity. (32)
• Cytotoxicity / Potential Anticancer : Study evaluated the cytotoxicity of 17 methanol extracts from 11 Cameroonian medicinal plants against the sensitive leukemia CCRF-CEM cells. Passiflora edulis was one of five plants that showed good cytotoxicity against CCRF-CEM leukemia cells and its resistant subline CEM/ADR5000 cells. The selectivity to the two cells lines suggest a potential for the development of novel anticancer drugs to fight leukemia. (33)
• Antiproliferative / Antioxidant / Leaves and Fruit Juice: Study investigated the antioxidant and antiproliferative activity of ethanolic and aqueous extracts from leaves and fruits of P. edulis. An ethanolic extract from leaves showed best antioxidant activity (EC50=0.096 mg/ml) in DPPH assay and the juice (EC50=0.022 mg/ml) on Hydroxyl free radical scavenging assay. All extracts showed greater than 98% inhibition of hemolysis induced by H2O2. The aqueous extract from leaves showed highest cytotoxicity against SW480 and SW620. (see constituents above) (34)
• Anti-Inflammatory / Leaves: Study evaluated the mechanism of anti-inflammatory effect of aqueous lyophilized extract from leaves of P. edulis var. flavicarpa in a mouse model of pleurisy induced by carrageenanan (Cg). bradykinin, histamine or substance P. Results showed anti-inflammatory effect that be due to the inhibition of pro-inflammatory cytokines (TNF-α, IL-1ß), enzyme (myeloperoxidase) and mediators (bradykinin, histamine, substance P, nitric oxide) release and/or action. (35)
• Isoorientin / Flavonoids / Fruit Pulp: Quantification study of passion fruit pulp (P. edulis Sims f. flavicarpa) yielded 16.226 ± 0.050 mg L-1 of isoorientin and 158.037 ± 0.062 mg L-1 of total flavonoid. Levels suggest P. edulis may be comparable to other flavonoid food sources like orange juice and sugarcane juice. (36)
• Cytotoxic / Apoptotic / Leaves and Juice: Study evaluated the effect of leaf and juice extracts of P. edulis var. flavicarpa on viability, cytotoxicity, and induction of apoptosis in an in-vitro model of liver cancer (HepG2 cell). Phytochemical analysis showed the leaf extract to have higher polyphenolic content, whereas the juice had more polysaccharide content. The juice extract effected a significant decrease in viability while the leaf extract caused a significant increase in cytotoxicity. Both extracts significantly increased propapoptotic activity. (37)
• Mutagenic Effects: Study evaluated the toxic, aneugenic, and clastogenic effect of P. edulis tincture on the initial development and mitotic index of meristematic onion root cells using Allium cepa test system. The tincture showed great mutagenic potential, and was responsible for inducing damage to the cell cycle. Author advises further testing for validation of its use in humans. (38)
• Effect on Bladder Wound Healing / Leaves: Study evaluated the effects of hydroalcoholic extract of Passiflora edulis leaves in the healing of urinary bladder in Wistar rats from histological measure. The use of P. edulis leaves extract resulted in less acute inflammation, greater fibroblastic proliferation, collagenous formation, and capillary neo-formation on rats' bladder wound healing. (39)
• Review / Antihypertensive / Anxiolytic / Rind / Leaves: Significantly decreased systolic diastolic blood pressure of spontaneously hypertensive rats were observed after 1 to 7 hours of oral administration of methanol extract of P. edulis rind (10 mg/kg or 50 mg/kg)evaluated the hypoglycemic property of P. edulis leaf extract. Rind extract content of GABA (y-amino butyric acid) was 2.4 mg/g dry weight. It has been reported the oral GABA significantly lowered BP in spontaneously hypertensive rats but not in normotensive rats. Study of spray-dried powder of leaves by elevated plus-maze test in Swiss rats showed anxiolytic effect at low doses. (40)
• Effect on Open Wounds / Morphologic and Histologic Study: Study evaluated the healing effect of a hydroalcoholic extract of leaves ins open wounds of adult Wistar rats. While the application of P. edulis extract did not accelerate the healing process of open wounds in rats, there was an increase in the number of fibroblasts on the 7th day and greater collagen deposition on the 15th P.O. day. (41)
• Flavonoid Extraction: Study reports on a simple, rapid, and environmentally friendly extraction method for flavonoid. In the study, the optimized conditions for flavonoid extraction for P. edulis is maceration with 75% ethanol. (42)
• Anti-Aging / Comparative Antihyaluronidase Activity / Peel and Seeds: Study compared the antioxidant activity and anti-hyaluronidase activities of peels and seeds of P. edulis. Results showed percentage reduction of ABTS of seed and peel was 15.58 and 27.68, respectively at 50 µg/ml. Hyaluronidase inhibition of seed and peel was 70.96 and 61.68%, with anti-hyaluronidase activity IC50s of 122.70 and 67.35, respectively. Results suggest anti-aging potential for seeds and peels. (44)
• Acne Vulgaris Treatment / Fruit / Pilot Study: The fruit is known have high linoleic acid and piceatannol content with reported antibacterial, anti-inflammatory, and antioxidant activities. Study evaluated the efficacy of topical use of P. edulis var. edulis seeds extract on acne vulgaris. Results showed significant reductions in noninflammatory (80.9%), inflammatory (71.1%), and total (73%) lesion count after 8 weeks of cream application (p<0.001). Most subjects (77.8%) noticed significant improvement in their acne vulgaris and expressed good satisfaction rate. (45)
• Effect on Metabolic Profile of Diabetic Rats: Study evaluated the effects of passion fruit on biochemical profile of offspring from diabetic rats induced by streptozotocin. Treatment showed significant reduction of total cholesterol, triglyceride, and LDL-cholesterol and increased HDL-cholesterol. Results showed passion fruit juice improved lipid profiles, and may have beneficial effects in the prevention and treatment of dyslipidemias and hyperglycemia. (46)
• Seeds / Safety Studies and Potential: Passion fruit seeds are eaten raw with the pulp. Many human and animal studies on seeds extracts have not reported serious side effects or adverse events. In a human study, 11 healthy adults consumed a beverage containing 27.3 g of seed extract (100 mg of piceatannol) daily for four weeks. There were no reported adverse effects, no changes in hematological and biochemical parameters. Another skin-patch study of cream formulation of seed extract showed no signs or symptoms of irritation. Studies suggest safety and potential for use in food and cosmetic applications. (47)
• Effect on Striae Distensae (Stretch Marks) / Fruit Seed Cream: Striae distensae (stretch marks) is a skin disorder that can be cause of cosmetic concern and psychological effects. Fruit seeds contain piceatannol, ascorbic acid, flavonoids, resveratrol, hydroalcohols and sterols, which play a role in repair of striae distensae through ant-inflammatory mechanisms, fibroblast proliferation, collagen production, and increased cross-linking between collagen fibers and moisturizers. Study evaluated the effect of 6% purple fruit seed extract cream on striae distensae. Results showed improved appearance of striae distensae without side effects and with good level of satisfaction. (48)
• Effect on Glycemic Management of Diabetes / Review: Study evaluated the effects of different parts of P. edulis on glycemic control of individuals with diabetes mellitus, based on studies and reviews, three of which were randomized controlled trials, two were experimental studies, using various pharmaceutical forms i.e., flour from peel and albedo, seed extract and ethanolic extract from leaves of P. edulis. Most studies showed lowering of fasting blood glucose and glycated hemoglobin. Study suggests that passion fruit parts such as seeds, leaves, and peel contain substances that can help in the glycemic control of diabetic patients. (49)


Updated August 2023 / Dec 2018 / Dec 2017 / Jun 2015
October 2013

Photos ©Godofredo Stuart / StuartXchange

Additional Sources and Suggested Readings
Sorting Passiflora names
/ Maintained by: Michel H. Porcher / MULTILINGUAL MULTISCRIPT PLANT NAME DATABASE / A Work in Progress. School of Agriculture and Food Systems. Faculty of Land & Food Resources. The University of Melbourne. Australia / Copyright © 1997 - 2000 The University of Melbourne.
Passiflora edulis Sims (accepted name) / Chinese names / Catalogue of Life, China
Comparative studies on anxiolytic activities and flavonoid compositions of Passiflora edulis 'edulis' and Passiflora edulis 'flavicarpa'. / Li H, Zhou P, Yang Q, Shen Y, Deng J, Li L, Zhao D. / J Ethnopharmacol. 2011 Feb 16;133(3):1085-90. doi: 10.1016/j.jep.2010.11.039. Epub 2010 Nov 24.
Comparative pharmacological study of hydroethanol extracts of Passiflora alata and Passiflora edulis leaves / Petry RD, Reginatto F, de-Paris F, Gosmann G, Salgueiro JB, Quevedo J, Kapczinski F, Ortega GG, Schenkel EP. / Phytother Res. 2001 Mar;15(2):162-4.
Preliminary Phytochemical and Anti-Bacterial Studies on Passiflora edulis / Johnson, M*, Maridass, M and Irudayaraj V / Ethnobotanical Leaflets 12: 425-432. 2008.
Yellow passion fruit rind (Passiflora edulis): an industrial waste or an adjuvant in the maintenance of glycemia and prevention of dyslipidemia? / Sandra Maria Barbalho*, Maricelma da Silva Soares de Souza, Júlio César de Paula e Silva, Claudemir Gregório Mendes, Gabriela Aparecida de Oliveira, Tainara Costa and Flávia M. V. Farinazzi-Machado / Journal of Diabetes Research & Clinical Metabolism / DOI : http://dx.doi.org/10.7243/2050-0866-1-5
Leaves of Passiflora edulis sims : Phytochemical, Anti-inflammatory and Anti-microbial activities / Sapna Shrikumar*, T.K. Ravi. / Pharmainfo.net
Angiotensin-Converting Enzyme Inhibitory Activity of Passiflora edulis f. flavicarpa and Petroselinum crispum (Mill) Fuss / Rodrigo A. Restrepo, Nelsy Loango, Mónica V. Moncada and Patricia Landazuri* / British Journal of Pharmaceutical Research, 3(4): 776-785, 2013
Analysis of passion fruit rinds (Passiflora edulis): isoorientin quantification by HPTLC and evaluation of antioxidant (radical scavenging) capacity / Maria Luiza Zeraik; Janete H. Yariwake, *Jean-Noël Wauters, Monique Tits; Luc Angenot / Quím. Nova vol.35 no.3 São Paulo 2012
Effects of Passiflora edulis (Yellow Passion) on Serum Lipids and Oxidative Stress Status of Wistar Rats /
Maricelma da Silva Soares de Souza, Sandra Maria Barbalho, De ́bora Cristina Damasceno, Marilza Vieira Cunha Rudge, Kleber Eduardo de Campos, Ana Carolina Goyos Madi, Bruno Ribeiro Coelho, Rodrigo Cesar Oliveira, Rodrigo Cartaxo de Melo, and Vińıcius Castrequini Donda / JOURNAL OF MEDICINAL FOOD J Med Food 15 (1) 2012, 78–82 / DOI: 10.1089/jmf.2011.0056
Phytochemical Analysis and Antimicrobial Activity of Passiflora Edulis of Kodaikanal Region of Tamilnadu / KadarKanaan / American Journal of Agricultural Sciences, Vol.2 No.2 2011
Human Spermicidal Activity of Passiflora edulis Extract / Angela M. Alvarez-Gómez, Wálter Cardona-Maya, Jorge Forero, Angela P. Cadavid / Journal of Reproduction & Contraception, 2010 Jun.; 21(2):95-100
Effect of the yellow passion fruit peel flour (Passiflora edulis f. flavicarpa deg.) in insulin sensitivity in type 2 diabetes mellitus patients / Maria do Socoro Ramos de Queiroz*, Daniele Idalino Janebro, Maria Auxiliadora Lins da Cunha, Josimar dos Santos Medeiros, Armando UO Sabaa-Srur, Margareth de Fatima FM Diniz and Silvana Cristina dos Santos / Nutrition Journal, 2012; 11:89 / doi:10.1186/1475-2891-11-89
Rigobert Espoir Ayissi Mbomo, SilvereVincent Rakotonirina, Alice Rakotonirina / Afr. J. Trad. CAM (2004) 1: 63 - 71
Effect of Aqueous Extract of Passiflora edulis on Biochemical and Hematological Parameters of Wistar Albino Rats / K. Devaki, U. Beulah, G. Akila, and V. K. Gopalakrishnan / Toxicol Int. 2012 Jan-Apr; 19(1): 63–67. / doi: 10.4103/0971-6580.94508
The aqueous extracts of Passiflora alata and Passiflora edulis reduce anxiety-related behaviors without affecting memory process in rats. / Barbosa PR1, Valvassori SS, Bordignon CL Jr, Kappel VD, Martins MR, Gavioli EC, Quevedo J, Reginatto FH. / J Med Food. 2008 Jun;11(2):282-8. doi: 10.1089/jmf.2007.722.
Antioxidant Activity of Passiflora edulis Sims Leaves / M. Sunitha and K. Devaki* / Indian J Pharm Sci., May-Jun 2009; 71(3): pp 310–311. / doi: 10.4103/0250-474X.56038
Antioxidant and antiglycation properties of Passiflora alata and Passiflora edulis extracts / Martina Rudnicki, Marcos Roberto de Oliveira, Tiago V. Pereira, Flavio Reginatto, Felipe Dal-Pizzol / Food Chemistry,: 3.26; 01/2007; 100(2):719-724 / DOI: 10.1016/j.foodchem.2005.10.043
Nutritive Value per 100 g, Passion Fruit, Fresh / USDA National Nutrient Data Base
THE INTAKE OF FIBER MESOCARP PASSIONFRUIT (PASSIFLORA EDULIS) LOWERS LEVELS OF TRIGLYCERIDE AND CHOLESTEROL DECREASING PRINCIPALLY INSULIN AND LEPTIN / E.M. Corrêa, L. Medina, J. Barros-Monteiro, N.O. Valle, R. Sales, A. Magalães, F.C.A. Souza, T.B. Carvalho, J.R. Lemos, E.F. Lira, E.S. Lima, D.M.L. Galeno, L. Morales, C. Ortiz, R.P. Carvalho / The Journal of Aging Research & Clinical Practice
Phytochemical Investigation and Evaluation of Analgesic Activity of Passiflora edulis Linn Leaves Available in South Eastern Odisha / Lingaraj Nayak, Sangram Keshari Panda* / International Journal of Pharmaceutical & Biological Archives 2012; 3(4):897-899
Hypoglycemic Activity of Passiflora edulis Sims Leaf Extract in Wistar Albino Rats / Velliyur Kanniappan Gopalakrishnan et al / IRJP 2011, 2(9). 170-172
Extract of Passion Fruit (Passiflora edulis) Seed Containing High Amounts of Piceatannol Inhibits Melanogenesis and Promotes Collagen Synthesis / Yuko Matsui, Kenkichi Sugiyama, Masanori Kamei, Toshio Takahashi, Tamio Suzuki, Yohtaro Katagata, and Tatsuhiko Ito / J. Agric. Food Chem., 2010, 58 (20), pp 11112–11118 / DOI: 10.1021/jf102650d
Antihypertensive effect and lethal dose 50 of Passiflora edulis leaves (maracuya) fruit juice and ethanolic extract in rats / ROJAS, Juan et al. / An. Fac. med. [online]. 2006, vol.67, n.3, pp. 206-213.
In Vitro Antisickling Activities of Yellow Passion Fruit (Passiflora edulis F. Flavicarpa Deg) / Amujoyegbe O.O.*, Agbedahunsi J. M., Akinpelu B.A., Amujoyegbe B.J., Idu M., Oyedapo O.O. / Photon Journal
Neuropharmacological activity of the pericarp of Passiflora edulis flavicarpa degener: putative involvement of C-glycosylflavonoids. / Ligia Moreiras Sena, Silvana Maria Zucolotto, Flávio Henrique Reginatto, Eloir Paulo Schenkel, Thereza Christina Monteiro De Lima / Exp. Biol. Med. (Maywood), 2009 Aug 2;234(8):967-75.

Passiflora edulis Sims / Synonyms / KEW: Plants of the World Online
Ethanolc extract of Passiflora edulis Sims leaves inhibits protein glycation and restores the oxidative burst in diabetic rat macrophages after Candida albicans exposure / Carolina Fernandes Ribas Martins, Bruno Cesar Correa Salles, Fernanda Borges de Aruj Paula et al / Brazilian Journal of Pharmaceutical Sciences, Vol 51, No 4, Oct-Dec 2015
Antioxidant activity of aqueous extract of passion fruit (Passiflora edulis) leaves: In vitro and in vivo study / Juliana Kellyda Silva, Cinthia Baú BetimCazarin, Talita C.Colomeu, Ângela GiovanaBatista, Laura M.M.Meletti, Jonas Augusto RizzatoPaschoal, StanislauBogusz JúniordMayra FontesFurlan, Felix Guillermo Reyes Reyes, FábioAugusto, Mário Roberto Maróstica Júnior, Ricardode Lima Zollner / Food Research International, Volume 53, Issue 2, October 2013, Pages 882-890
Interactions / WebMD
Assessment of Total Phenolic, Antioxidant, and Antibacterial Activities of Passiflora Species / Shiamala Devi Ramaiya, Japar Sidik Bulang, Muta Harah Zakaria / The Scientific World Journal
Volume 2014 (2014) / http://dx.doi.org/10.1155/2014/167309
Assessment of the hypnotic/sedative effects and toxicity of Passiflora edulis aqueous extract in rodents and humans / E Maluf, HMT Barros, ML Frochtengarten, R Benti, JR Leite / Phytotherapy Research, Dec 1991 / DOI: 10.1002/ptr.2650050607
Cytotoxicity of methanol extracts of Annona muricataPassiflora edulis and nine other Cameroonian medicinal plants towards multi-factorial drug-resistant cancer cell lines / Victor Kuete, Joachim K. Dzotam, Igor K. VoukengAimé G. Fankam and Thomas Efferth / SpringerPlus 2016; 5:1666 / https://doi.org/10.1186/s40064-016-3361-4
Antioxidant and antiproliferative activity of ethanolic and aqueous extracts from leaves and fruits juice Passiflora edulis / Johanny Aguillón Osma; María Elena Maldonado; Nelsy Loango Chamorro; Sandra Sulay Arango Varela; Patricia Landázuri / Perspect Nut Hum,  Vol 15, No1, Medellín Jan./June 2013
Evidence of anti-inflammatory effects of Passiflora edulis in an inflammation model  [2007] / Montanher, A.B., Zucolotto, S.M., Schenkel, E.P., Fröde, T.S. / AGRIS
Quantification of isoorientin and total flavonoids in Passiflora edulis fruit pulp by HPLC-UV/DAD / M. L. Zeraik, J. H. Yariwake / Microchemical Journal, 2010; 96: pp 86–91
Cytotoxic and apoptotic activity of extracts from leaves and juice of passiflora edulis / Aguillón J, Arango S S, Uribe D F, Loango N / Journal of Liver Research, Disorders & Therapy, 2018; 4(2): pp 67-71 /
eISSN: 2471-1381
Evaluation of the mutagenic effects of Passiflora edulis Sims (maracujá) tincture on the Allium cepa test system / MSc. Schirley Ap. Costalonga, PhD. Maria do Carmo Pimentel Batitucci / Revista Cubana de Plantas Medicinales, 2014; 19(1): pp 329-337
Effect of Passiflora edulis (passion fruit) extract on rats' bladder wound healing: morphological study / Goncalves Filho A, Torres O J, Campos A C et al / Acta cirurgica brasileira, 2006;  21 Suppl 2: pp 1-8
Alternative Herbal Medicine for Hypertension and Anxiety: Passiflora sp.-A short review / Sabyasachi Chatterjee, Kaniz Wahida Sultana, Anindita Roy, Indrani Chandra / Research & Reviews: Research Journal of Biology
Extract from Passiflora edulis on the healing of open wounds in rats: morphometric and histological study / Garros Ide C, Campos A C, Tambara E M, Tenorio S B, Torres O J et al / Acta Cirurgica Brasileira, Jan 2006; 21(Suppl3): pp 55-65 / DOI: 10.1590/S0102-86502006000900009 
Applying design of experiments (DOE) to flavonoid extraction from Passiflora alata and P. edulis / Peky Noriega, Débora de Freitas Mafud, Bruna de Souza, Marta Soares-Scott, Diogo Pineda Rivelli, Silvia Berlanga de Moraes Barros, Elfriede Marianne Bacchi / Rev. bras. farmacogn., 2012; Vool 22, No 5: pp 1119-1129 / http://www.producao.usp.br/handle/BDPI/39008
Passiflora edulis: An Insight Into Current Researches on Phytochemistry and Pharmacology / Xirui He, Fei Luan, Yan Yang, Ze Wang, Yongsheng Li et al / Frontiers in Pharmacology, 2020; 11 / PMID: 32508631 /
DOI: 10.3389/fphar.2020.00617
A Comparative Study of Peel and Seed Extract of Passion Fruit (Passiflora edulis) as Antihyaluronidase / Darwis Dariwis, I Nyoman Ehrich Lister, Edy Fachrial / American Scientific Research Journal for Engineering, Technology, and Sciences, 2019; 52(1) 
Passion fruit purple variant (Passiflora edulis Sims var. edulis) seeds extract 10% cream in acne vulgaris treatment: an open-label pilot study /  Nani K Dewi MD, Imam B Putra MD PhD, Nelva K Jusuf MD PhD / International Journal of Dermatology,  2020; 59(12): pp 1506-1512 / DOI: 10.1111/ijd.15178
Effects of Passiflora edulis on the Metabolic Profile of Diabetic Wistar Rat Offspring / Sandra M Barbalho, Debora C Damasceno, Ana Paula Machada Spada, Claudemir Gregorio Mendez et al / Journal of Medicinal Food, 2011; 14(12): pp 1490-1495 / DOI: 10.1089/jmf.2010.0318
Constituent Characteristics and Functional Properties of Passion Fruit Seed Extract / Shinpei Kawakami, Makoto Morinaga, Sakuka Tsukamoto-Sen, Sadao Mori, Yuko Matsui, Toshihiro Kawama / :Life, 2022; 21(1) / DOI: 10.3390/life23010038
Effect of Purple Passion Fruit Extract Cream (Passiflora edulis Sims var. Edulis) 6% against Striae Distensae / Chyntia Giska Aryunisari, Imam Budii Putra, Nelva K Jusuf / Open Access Macedonian Journal of Medical Sciences, 2021; 9(B) / DOI: 10.3889/oamjms.2021.6424
Effects of Passion Fruit (Passiflora edulis) on the Glycemic Management of Diabetes Mellitus / Renata Cristina Machado Mendes, Mariana Pimentel Gomes Souza, Maria Yasmin Paz Teixeira Martins, Dayanna Magalhaes dos Reis / Research, Society and Development, 2023; 11(5) / DOI: 10.33448/rsd-v11i5.28296

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