Salakapo is a climbing, hairy and somewhat woody vine. Leaves are oblong, 8 to 15 centimeters long, green, shining, somewhat harsh, pointed at the tip, and usually rounded at the base. Flowers are stalkless, pale-green, 5-parted, and borne on terminal, scorpioid inflorescences (cymes) about 10 centimeters or less in diameter. Calyx is 1.5 millimeters long, and hairy. Corolla is 5 millimeters long, with a limb 3.5 millimeters in diameter. Fruit is stalkless, rounded and 4 to 5 millimeters in diameter.
- In thickets and secondary forests at low and medium altitudes from the Babuyan Islands and northern Luzon to Palawan and Mindanao, in most or all islands and provinces.
- Occurs in Mauritius to Indo-China, Malaya and tropical Australia.
- Study of stems yielded three new isoprenylbenzenes, tournefoline A, B, and C (1-2), and two new 2-ethoxy-4-5-dihydroxybenzoyl compounds, 4 and 5, together with known compounds, salicylic acid and allantoin. (1)
study of stem isolated four new benzenoids, tournefolal (1), tournefolic acids A and B (2,3) and B-ethyl ester (4), together with salvianoolic acid A (5), isosalvianolic acid C (6), lithospermic acid (7), salvianolic acid F (8), and rosmarinic acid (9). (see study below) (2)
- Considered detoxicant, antioxidant, immunomodulatory, anti-inflammatory.
- In the Philippines, decoction of roots given internally after childbirth, to hasten expulsion of the placenta.
- Leaves applied as poultice on the forehead for headaches.
- In Taiwan, used as detoxicant, anti-inflammatory, and circulation promoter to remove blood stasis. (1)
- In Trinidad and Tobago, tea leaves used as carminative. Used for cuts, injuries, and swellings. (8)
- Livestock: Leaves used for destroying larvae in cattle ulcers. (•) In Trinidad and Tobago, leaves used for chiggers. (8)
• Phytochemicals / Phenolic Compounds: Study isolated three new isoprenylbenzenes, tournefolins A, B and C, with two new -dihydroxybenzoyl compounds, and known compounds, salicylic acid and allantoin.
• Anti-Lipid Peroxidative Activity / Benzenoids / Antioxidant: Study yielded four new benzenoids, tournefola, tournefolic acids A and B, and B ethyl ester, together with salvianolic acid A, isosalvionolic acid C, lithospermic acid, salvianolic acid F and rosmarinic acid from the stems of T. sarmentosa. All isolated compounds exhibited anti-LDL-peroxidative activity, more potent than probucol except for salvianolic acid F. (2)
• Neuroprotective / Polyphenolic Compounds: Study has isolated a variety of polyphenolic compounds from T. sarmentosa, most possessing antioxidative activity, including tournefolic acid B, TAB methyl ester and TAB ethyl ester. Study showed TABM / TABE blocked the activation of the caspase cascade and eliminated the accumulation of O2, thus conferring neuroprotective effects on NMDA-mediated neurotoxicity. (3)
• Hepatoprotective: Study investigated the aqueous extract effect on APAP-induced hepatotoxicity in vivo and in vitro. Pre-treatment of hepatocytes with Ts extract before and during APAP stimulation attenuated the extent of lipid peroxidation, increased cell viability and GSH level, and enhanced antioxidant enzymes. Results showed Ts can prevent APAP-induced hepatotoxicity. (5)
• Immunoregulatory: Study investigated the signaling mechanism of T. sarmentosa-medicated immunoregulation. Results suggest T. sarmentosa extract exerts dual functions on macrophages: suppressing ROS (reactive oxygen species) within cells and enhancing inflammatory responses by improving phagocytic ability and proinflammatory cytokine release. (6)
• Inhibition of ADP-Induced Platelet Aggregation / Stem: Study evaluated the effect of T. sarmentosa aqueous stem extract on adenosine diphospnate-induced platelet aggregation. Results showed the aqueous extract of stem inhibited AdP-induced platelet aggregation. Components in T. sarmentosa, including caffeic acid, rosmarinic acid, salvinolic acid played important roles in mediating adenosine diphosphate induced platelet aggregation suppression. Results demonstrate the aqueous stem extract of T. sarmentosa significantly suppressed platelet aggregation through P2Y1 and P2Y12 receptor signal pathways. The antiaggregation properties of the stem extract might help prevent cardiovascular disease. (7)
• Enhancement of Neutrophil Phagocytosis of E. coli / Caffeic Acid: Study provides evidence that T. sarmentosa can induce increased phagocytic uptake of Escherichia coli by differentiated HL-60 cells and by neutrophils. Results suggest the aqueous extract exerts effects that enhance inflammatory responses by improving phagocytic capability, inhibiting bacterial survival within cells, and increasing Mac-1 expression of neutrophils. (9)
• Tournefolic Acid B
/ Neuroprotective on NMDA-Mediated Excitotoxicity: A variety of polyphenolic antioxidative compounds, including tournefolic acid B (TAB), have been isolated from Tournefortia sarmentosa. The TAB structure related compounds have exhibited neuroprotective potency against glutamate-mediated neurotoxicity. Study reports on the evens that eliminated the accumulation of O2 and blocked activation of the caspase cascade, thereby conferring neuroprotective effects on NMDA-mediated cytotoxicity. (10)