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Family Apocynaceae
Rauvolfia serpentina (L.) Benth. ex Kurz
She gen mu

Scientific names Common names
Ophioxylon album Gaertn. Serpentina (Tag.)
Ophioxylon obversum Miq. Java devil pepper (Engl.)
Ophioxylon salutiferum Salisb. Rauwolfia (Engl.)
Ophioxylon serpentinum L. Rauvolfia (Engl.)
Ophioxylon trifoliatum Gaertn. Serpent wood (Engl.)
Rauvolfia obversa (Miq.) Baill. Snakeroot (Engl.)
Rauvolfia serpentina (L.) Kurz  
Rauvolfia trifoliata (Gaertn.) Baill.  
Serpentina is a common name shared by Andrographis paniculata (Sinta) and Rauvolfia serpentina (Snakeroot).
Rauvolfia serpentina (L.) Benth. ex Kurz is an accepted name. The Plant List

Other vernacular names
ASSAMESE: Arachoritita.
BENGALI: Chandra.
BURMESE: Bongmaiza.
CHINESE: She gen mu, Yin du luo fu mu, Yin du she gen mu, Yin du she mu.
FRENCH: Arbre aux serpents.
GERMAN: Indische Schlangenwurzel, Rauwolfie, Schlangenholz.
HINDI: Candrabhaga, Chandrabhaga, Chota chand, Sarpagandha , Sarpgandha.
JAPANESE: Indo shaboku, Indo shaboku.
KANNADA: Sarpangandha, Sarpagandhi, Patalagandhi, Sarpgandha, Sarpgandha.
MALAY: Akar tikus, Pule pandak (Java), Pulai pandak (Indonesia).
ORIYA: Patalagarur.
SANSKRIT: Chandrika, Chundrika, Patalguruda, Sarpagandha.
TAMIL: Chevanamalpodi.
TELUGU: Patalaguni, Patalagaruda, Sarpagandha.

Additional info
- There are more than 100 species in the Rauwolfia genus.
- R. serpentina has been use in India's folk medicine for centuries. It was brought to notice in Western medicine in a milestone paper in 1949 by Indian physician Rustom Jal Vakil as an antihypertensive. By 1949, more than 90% of Indian physicians were using Rauwolfia in the treatment of hypertension. It fell out of popularity when adverse effects, including depression and cancer, became associated with it. (13)

Serpentina i is a small evergreen erect shrub with whorled branches and milky sap. Leaves are opposite, entire, oblong-elliptic, up to 30 centimeters long. Flowers are white, clustered in axillary cymes, with slender corolla tube and 5 spreading lobes. Fruit is a small drupe, shiny, black or purple.

- Introduced to the Philippines.
- Indigenous to India and tropical Asia.
- Reported in the Himalayas, Assam, Java, and the Malaya peninsula.

- Yields bioactive constituents: yohimbine, reserpine, ajmaline, deserpidine, rescinnamine, serpentinine.
- Roots have yielded two alkaloids (1% of the dried root),
a lot of resin and starch.
- Study yielded phytosterols, oleic acid, and unsaturated alcohols, and five alkaloids classified in two groups: three in the ajmaline group, white crystalline, weak bases, ajmaline, ajmaliine, and ajmalicine; and two in the serpentine group, yellow crystalline stronger bases, serpentine and serpentinine.
- The principal active constituent is the alkaloid reserpine.
- Rauwolfia yields alcohols, sugars and glycosides, fatty acids, flavonoids, phytosterols, oleoresins, steroids, tannins and alkaloids. The most important of the alkaloids are indole alkaloids, more than 50 of which have been isolated in the plant. (13)
- All parts of the plant, including stems and leaves, contain indole alkaloids. Identified indole alkaloids include ajmalidine, ajmaline, ajmalinine, ajmalicine, aricine, canescine, coryanthine, deserpidine, isoajmaline, isoserine, isoserpiline, lankanescine, neoajmaline, papaverine, raubasine, raucaffricine, rauhimbine, rauwolfinine, recanescine, rescinnamine, reserpiline, reserpine, reserpinine, sarpagine, serpentine, serpentinine, thebaine, yohimbine, and yohimbinine. (Panwar GS, Guru SK. Alkaloid profiling and estimation of reserpine in Rauwolfia serpentina plant by TLC, HP-TLC and HPLC. Asian J Plant Sci. 2011;10(8):393–400) (Woodson RE, Youngken HW, Schlittler E, Schneider JE. Rauwolfia: Botany, Pharmacognosy, Chemistry and Pharmacology. Boston, MA: Little, Brown and Company; 1957. pp. 32–33) (13)
- Methanolic root extract yielded alkaloids, carbohydrates, flavonoids, glycosides, cardiac glycosides, phlobatannins, resins, saponins, steroids, tannins, and triterpenoids, while quantitatively the extract was rich in total phenols. (see study below) (15)

- Bitter, cool.
- Considered hypotensive, neuroleptic, sympatholytic.
- Febrifuge, antitussive, diuretic.
- In Siddha medicine, considered antihypertensive, styptic, nervine-tonic and abortifacient.

Parts used


- No reported folkloric medicinal use in the Philippines.
- A medicinal plant of antiquity. Used for millenia inn India. Used to counter the effects of poisoned arrow. Ghandi reported used it as a tranquilizer.
- Used as febrifuge, as stimulant to uterine contractions, for insomnia and insanity.
- Used for high blood pressure.
- For millenia, used as antidote to stings and bites of insects and poisonous reptiles.
- Used in Ayurveda, Unani and folk medicine systems for reducing blood pressure, for its CNS depressant effect, and as hypnotic.
- Ingredient to an Ayurvedic herbal mixture once used in the treatment of schizophrenia.
- In India, referred to as the "insanity herb," used to treat mental disorders, i.e., anxiety, paranoia, nervousness.
- In Siddha medicine, root power given with equal amounts of Triphala powder twice daily is used for hypertension and associated headache and giddiness. Root powder given for amenorrhea, oligomenorrhea and dysmenorrhea-like abnormalities. For snake bites and scorpion bites, root powder mixed with Piper cubeba and salt applied externally to the bite as well as taken internally. For hysteria in women and epilepsy, root powder is mixed with equal amounts of powder of Nardostachys jatamanji.
- Wood: Used for woodcarving and lathe work.

Pharmacologic Activities:
Studies on the root have shown: (1) Action on the vasomotor center, with generalized vasodilation and lowering of blood pressure. (2) Depressant action on the nervous system (3) Sedative action on the gastric mucosa (4) Stimulation of the bronchial musculature.
Hypotensive: Study showed R. serpentina proved capable of lowering both systolic and diastolic blood pressure. (3)
Mechanisms of Hypotensive Action of Reserpine: Studies on the alkaloid reports: (1) the marked hypotensive effect was in part due to depression of CNS mechanisms. It was less marked in decerebrate animals. (2) Effect was, in part, a result of a direct inhibitory effect on the musculature of the blood vessels. (3) There was a fall i cardiac output of the isolated heart. (4) Subsequent studies have suggested the effect mediated solely via central nervous mechanisms. (4)
Strictosidine Synthase: STR1 from R. serpentina is of primary importance for the biosynthetic pathway of the indole alkaloid ajmaline. STR1 catalyzes a Pictet-Spengler-type reaction and represents a novel six-bladed ß-propeller fold in plant proteins. Mutagenesis experiments demonstrate the essential role of Glu-309 in catalysis. (5)
Psychoactive: Considered a theoretical psychoactive due to the yohimbane-type alkaloids (corynanthine, isorauhimbine, and yohimbine.
Side Effects / Depression: Crude and purified derivatives are considered free of serious toxic reactions. Mild side effects are frequent, consisting of nasal stuffiness, fatigue, weight gain, decreased initiative, drowsiness, nightmares, and diarrhea. Symptoms can be relieved by reducing the dosage without sacrificing its hypotensive effect. In large doses, depression occurs with significant frequency. (6)
Hypolipidemic: Study showed root powder of R. serpentina has hypotriglyceridemic and hypocholesterolemic effects with no detectable side effects on liver and cardiac functions. (7)
Serpasil / Cardiovascular and Respiratory Effects: Serpasil, a crystalline alkaloid obtained from Rauwolfia serpentina, produced a gradual persistent blood pressure and respiratory depression when administered intravenously to barbitalized dogs. No significant blood pressure drop occurred in five unanesthetized dogs with serpasil administration. Serpasil produces a central inhibition of the sympathetic nervous system, possibly through specific hypothalamic depression. (9)
Antibacterial: Study evaluated the antibacterial effect of RS aqueous and ethanol extracts, with Norfloxacin as control drug. Results showed the ethanol extract exhibited greater antibacterial activity than the aqueous extract against Staphylococcus aureus. (10) Study evaluated the antibacterial effect of four important medicinal plants i.e., Rauvolfia serpentina, Tagetes erecta, Brassica nigra, and Ocimum tenuiflorum. R. serpentina showed excellent antibacterial activity against tested bacterial organisms as compared to Norfloxacin, and greater activity than other plant leaves extract. (20)
Corrosion Inhibition: Study evaluated an alkaloid extract of R. serpentina as corrosion inhibitor for mild steel in 1 M HCl and H2SO4. Results showed inhibition of corrosion in both acids through absorption process and formation of a protective layer over the mild steel surface. (11)
• Reserpine / Rauwolfia in Hypertension: Reserpine is the most widely studied alkaloid in R. serpentina. It was first isolated and used in 1950. Based on literature review, Rauwolfia appears to be a safe and effective treatment for hypertension. Alseroxylon extract or pure reserpine, an equivalent dose of pure Rauwolfia alkaloids, can also be used for hypertension treatment. Review discusses dosages for Rauwolfia, extracts, root, and tinctures. (see constituents above) (13)
• Rauvolfia serpentina as Inhibitor of Aldose Reductase: In the Himalayan mountain range, extracts of R. serpentina has been known to be effective in alleviating diabetes and its complications. Study sought to prospect for novel plant-derived inhibitors from R. serpentina. Study identified 3 structurally distinct PDMs (plant derived molecules) as best candidates: indobine, indobininer, and 19(S),20(R)-dihydroperaksine-17,21-al. Results report on 2-plant derived indole alkaloids and their 16 structural analogs as potential ARIs. (14)
• Antiatherogenic / Cardioprotective / Hypoglycemic / Roots: Study evaluated the phytochemistry and effect of methanolic root extract of Rauwolfia serpentina on alloxan-induced diabetic mice, The MREt improved the glycemic, antiatherogenic, coronary risk, and cardioprotective indices in alloxan-induced diabetic mice. (15)
• Antimicrobial / Roots: Study investigated the antimicrobial activity of solvents and aqueous extracts of R. serpentina roots against various bacteria and fungi.. The methanol extract showed highest antimicrobial activity against multidrug resistant S. aureus at 100 mg/ml concentration, while S. aureus was the most susceptible bacterium to all extracts. K. pneumonia was resistant against solvent and aqueous extracts. (16)
• Antifungal / Roots: Study evaluated the antifungal activity of aqueous extracts of whole plant, roots, and stems of Rauvolfia serpentina against pathogenic fungi i.e., Alternaria alternata, Aspergillus flavus, and Mucor rouxii. The aqueous extract of root showed significant higher antifungal activity against Alternaria alternata and Aspergillus flavus than other extracts. (19)
• Mosquito Larvicidal / Aedes aegypti / Fruits: Study evaluated the larvicidal activities of Rauvolfia serpentina fruits against 3rd instar larvae of Aedes aegypti. Highest larvicidal mortality was seen in an ethanol extract at concentration of 200 ppm after 48 hours of treatment. Results suggest potential as indigenous mosquito control agent and alternative to conventional chemical mosquito larvicides. (21)
• Role in Stroke Induced Experimental Dementia: Study evaluated the role of R. serpentina in stroke induced experimental dementia. Global cerebral ischemia induced dementia by occlusion of both common carotid arteries. Administration of RS significantly attenuated induced cerebral alterations and showed neuroprotective effect against oxidative stress, infarct size, and learning and memory impairment. The neuroprotective effect suggests a potential role as prophylactic drug in stroke induced experimental dementia. The effect was attributed to phenolic acid, flavanoids, and tannins. (22)

- Wildcrafted.
- Pills, liquid supplements, and powder extracts in the cybermarket.

Updated April 2018 / July 2014

IMAGE SOURCE: Flower / File:Rauwolfia serpentina(Flower).jpg / Pieria / 30 June 2007/ Wikipedia
IMAGE SOURCE: Rauvolfia serpentina, Apocyanaceae, Snakeroot, flowers. Botanical Garden KIT, Karlsruhe, Germany. / File:Rauvolfia serpentina 002.JPG / H. Zell / 5 July 2009 / GNU Free Documentation License / Wikimedia Commons
IMAGE SOURCE: Snakeroot, Fruits. Botanical Garden KIT, Karlsruhe, Germany. /File:Rauvolfia serpentina 003.JPG / H. Zell / 5 July 2009 / GNU Free Documentation License / Wikimedia Commons

Additional Sources and Suggested Readings
Rauvolfia serpentina / Wikipedia
A CLINICAL TRIAL OF RAUWOLFIA SERPENTINA IN ESSENTIAL HYPERTENSION / RUSTOM JAL VAKIL/ Cardiological Department, King Edward Memorial Hospital, Bombay, India / Jan 1949
Rauvolfia serpentina or Snake Root - Natural remedy for Hypertension / Siddha – Natural Medicine & Treatment
Mechanism of Hypotensive Action of Reserpine, an Alkaloid of Rauwolfia serpentina / E. G. MCQUEEN, A. E. DOYLE & F. H. SMIRK / Nature 174, 1015 (27 November 1954); doi:10.1038/1741015b0
The Structure of Rauvolfia serpentina Strictosidine Synthase Is a Novel Six-Bladed ß-Propeller Fold in Plant Proteins / Xueyan Maa, Santosh Panjikarb, Juergen Koepke, Elke Loris and Joachim Stöckigt / The Plant Cell 18:907-920 (2006)
DEPRESSION AND ANXIETY OCCURRING DURING RAUWOLFIA THERAPY / John C. Muller, M.D.; William W. Pryor, M.D.; James E. Gibbons, M.D.; Edward S. Orgain, M.D. / JAMA. 1955;159(9):836-839. doi: 10.1001/jama.1955.02960260006002
Hypolipidaemic Activity of Rauwolfia serpentina Benth / Shamim A. Qureshi and Shamsa K. Udani / Pakistan Journal of Nutrition 8 (7): 1103-1106, 2009
Sorting Rauvolfia names / MULTILINGUAL MULTISCRIPT PLANT NAME DATABASE / Porcher Michel H. et al. 1995 - 2020
STUDY ON THE ANTIBACTERIAL EFFECT OF RAUWOLFIA SERPENTINA ON STAPHYLOCOCCUS AUREUS / Vishal kumar deshwal* and Kavita vig / International Journal of Pharmaceutical Invention
Studies on the Inhibition of Mild Steel Corrosion by Rauvolfia serpentina in Acid Media / Bothi Raja, P.; Sethuraman, M. G. / Journal of Materials Engineering and Performance, Volume 19, Issue 5, pp.761-766
Rauvolfia serpentina / Synonyms / The Plant List
Rauwolfia in the Treatment of Hypertension / Douglas Lobay, BSc, ND, Naturopathic Physician / Integr Med (Encinitas), 2015 June; 14(3): pp 40-46
Prospecting for Novel Plant-Derived Molecules of Rauvolfia serpentina as Inhibitors of Aldose Reductase, a Potent Drug Target for Diabetes and Its Complications / Shivalika Pathania, Vinay Randhawa, and Ganesh Bagler / PLOS/one 2013; 8(4) e61327 /  doi:  10.1371/journal.pone.0061327
Methanolic Root Extract of Rauwolfia serpentina Benth Improves the Glycemic, Antiatherogenic, and Cardioprotective Indices in Alloxan-Induced Diabetic Mice / Muhammad Bilal Azmi and Shamin A Qureshi / Advances in Pharmacological Sciences, Volume 2012 (2012) / http://dx.doi.org/10.1155/2012/376429
In-vitro Antimicrobial Activity of Roots of Rauwolfia serpentina L. Benth Kurz / Aniel K. OWK, Mutyala N. LAGUDU* / Not Sci Biol, 2016, 8(3):312-316. / DOI: 10.15835/nsb.8.3.9831
Isolation and Extraction of flavonoid from the leaves of Rauwolfia serpentina and evaluation of DPPH-scavenging antioxidant potential / Jaya Gupta*  and Amit Gupta / Oriental Journal of Chemistry, An International Research Journal of Pure and Aplied Chemistry, Vol 31, Special Issue / DOI http://dx.doi.org/10.13005/ojc/31.Special-Issue1.28
Snake Root and Medical misinterpretations / Nature and Science
EVALUATION OF IN VITRO ANTIFUNGAL POTENTIAL OF RAUVOLFIA SERPENTINA (L). BENTH. EX KURZ. AGAINST PHYTOPATHOGENIC FUNGI / Neetu Thakur, Kritika Jagota, Bansuli Shama & Niketa Sareen / I.J.S.N. (International Journal of Science and Nature), VOL.6 (2) 2015: 165-168
Comparative Study on the Antibacterial Activity o f Four Medicinal Plants Leaves of Different Ages / Md. Mamun Or Rashid, Mohammad Ruhul Amin, Mohammed Mehadi Hassan Chowdhury, Md. Arifur Rahman, Md. Shamim / International Journal of Pharmaceutical Science Invention, Vol 3, Issue 3; March 2014: pp 26-32
Larvicidal activity of Rauvolfia serpentina L. fruits against Aedes aegypti Mosquito larvae / Nayak J.B. and Mohan B. / International Research Journal of Biological Sciences, December 2015; Vol. 4(12): pp 54-56
Role of R auwolfia serpentina in stroke induced experimental dementia / Neema Kanyal * / Indian J. Pharm. Biol. Res. 2016; 4(1): pp 19-30

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