Kuliak-daga is a shrub or a small tree growing up to 2 to 5 meters. Branches are somewhat hairy and armed with sharp, slender axillary spines 5 to 10 millimeters in length. Leaves are ovate to elliptic-ovate, 1 to 2.5 centimeters long, short-petioled, and pointed at both ends. Flowers are greenish-yellow or nearly white, about 6 millimeters long, borne singly in the axils of the leaves. Fruit is red, fleshy, ovoid, about 7 millimeters long.
- Found in dry thickets
at low altitudes in Pangasinan, Zambales, Bulacan, Rizal, Camarines, and Sorsogon Provinces in Luzon.
- Also occurs in Burma to Malaya.
- Sometimes used as hedge plant.
Leaves and bark.
• Phytochemical study showed
the roots to predominantly consist of triterpenes, alkaloids, anthraquinones,
steroids, organic acid, phenols and carbohydrates.
• Study of essential oils from CH showed the main components to be 1,2-benzenedicarboxylic acid bis(2-methylpropyl) ester(36.08%),bis(2-ethylhexyl) phthalate(13.82%),n-hexadecanoic acid(8.32%),(Z,Z,Z)-9,12,15octadecatrien-1-ol(9.61%) among others. (1)
• Study of CH stems yielded ten compounds: syringaresinol, scoparone, scopoletin, 3'-methoxy-4'-hydroxy-trans-cinnamaldehyde, sinapic aldehyde, syringic acid, mannitol, vanillic acid 4-O-beta-D-glucopyranoside, beta-daucosterol and beta-sitosterol. (see study below) (3)
• Study of stem extract isolated 20 compounds:
syringaresinol (1), quercetin(2), scoparone(3), scopoletin(4), fraxidin(5), sinapic aldehyde(6), 3-methoxy-4-hydroxy-trans-cinnamaldehyde (7), coniferyl alcohol (8), p-hydroxybenzoic acid (9), vanillic acid (10), syringic acid (11), syringaldehyde (12), di-isobutyl phthalate (13), vanillic acid 4-O-β-D-glucopyranoside(14), 3-(1-C-β-D-glucopyranosyl)-2,6-dihydroxy-5-methoxybenzoic acid (15), mannitol (16), β-daucosterol (17), β-sitosterol (18), nonadecanoic acid (19), dibutyl phthalate (20). (see study below) (8)
· In Java, confections are made from the acid fruit.
· In the Philippines, boiled leaves and bark used to hasten menstruation.
· In Malaya, plant is used for wounds and fevers.
· In Indo-China, bark and young twigs used for dysentery.
· Decoction also used after childbirth.
• In Indonesia, used to soothe inflammed eyes. In Malaysia, used to heal wounds and promote recovery from childbirth. (7)
Vietnam bark and young stems used to treat dysentery. (7)
• In China, leaves are mashed and
used externally for snakebites and plaster from mashed leaves used for
• Boiled fruits used to treat foot wounds.
• Anti-Bacterial: Study
isolated compounds found for the first time, Carulignan, lupeol, b-sitosterol,
among many others. The chloroform fraction showed anti-bacterial activities.
• Phytochemicals / Antibacterial: Study
of the chemical composition of the roots of C horridum yielded triterpene, alkaloid, anthraquinone, steroid, organic acid, phenol, carbohydrates among others. The chloroform fraction was shown to have antibacterial properties. (2)
• Constituents / Antimicrobial: Study of CH stems yielded ten compounds: syringaresinol, scoparone, scopoletin, 3'-methoxy-4'-hydroxy-trans-cinnamaldehyde, sinapic aldehyde, syringic acid, mannitol, vanillic acid 4-O-beta-D-glucopyranoside, beta-daucosterol and beta-sitosterol. Siringic acid had the highest activity against Bacillus subtilis; syringaresinol showed good activity against E coli, B subtilis and S aureus. (3)
• Phenolics / Antioxidant: Study
of leaves showed the polyphenol content of 0.4879%. Results show the leaves had strong antioxidant activity, with an IC50 value of 0.35mg/mL. (5)
• Antibacterial / Stems: Bioassay-guided isolated studies of stem extract isolated 20 compounds. Compound 1 showed high inhibitory activity against Escherichia coli, Bacillus subtilis and Staphylococcus aureus. Compounds 3 and 7 had medium activity against these bacteria. No compounds showed activity against Aspergillus niger. (8)