Taloangi is a small stemless herb
with stout and elongated rootstock and with copious, spreading
fibers. Leaves are sessile or petiolate, linear or narrowly lanceolate,
15 to 20 centimeters long, 1 to 2.5 centimeters wide and with pointed tip. Scape is very
short, clavate. Flowers are distichous, bright yellow, with the lowest
in the raceme perfect and the upper, male. Perianth produced
above the ovary consists of filiform, hairy, very slender strips
which are 10 to 25 centimeters long and which alone, with the perianth
segments, appear above ground. Segments are 12 to 18 millimeters long, oblong-ovate,
acute, and dorsally hairy. Stamens are small, with short filaments. Fruits are oblong, about 10 millimeters in diameter. Seeds are oblong
and black with the testa deeply grooved in wavy lines.
- In open grasslands, chiefly
in Cogonales (Imperata) areas at low and medium altitudes.
- Found in Bontoc, Pangasinan, Rizal and Sorsogon provinces in
Luzon, and in Mindoro, Palawan, Biliran, Panay and Mindanao.
- Occurs in India to Java.
- Yields active compounds: flavones, glycosides, steroids, saponins, triterpenoids
and secondary metabolites.
- Tuberous root contains resin, tannin, mucilage, fat, starch, and ash with oxalate of calcium.
- Phytochemical study yielded starch, enzymes, tannins, ash; contains
curculigoside, syringic acid.
- Fresh rhizomes yield yuccagenin, a sapogenin, and alkaloid lycorin.
- Rhizome yielded a phenolic glycoside, curculigoside.
- Chloroform extract of rhizome yielded hentriacontanol, sitosterol, stigmasterol, cycloartinol, sucrose.
- Study of ethanol extract of rhizome by GC-MS analysis yielded six compounds viz.
decane 2,3,5,8-trimethyl (1), dodecane 2,6,11-trimethyl (2) hexadecane,5-butyl (3) benzoic acid, 4-ethoxy-,ethyl ester (4) docosanoic acid 1,2,3-propanetriyl ester (Tribehenin) (5) and ethyl iso allocholate (6). (see study below) (25)
- Root is aromatic, slightly bitter, mucilaginous to taste, considered demulcent, diuretic, and restorative.
According to Ayurveda, root is healing,
demulcent, aphrodisiac, appetizer, alternative, immunostimulant, hepatoprotective, antioxidant, anticancer, tonic and antidiabetic.
- According to Unani, root is carminative, tonic, aphrodisiac, antipyretic.
- Studies have suggested anticancer, antihepatotoxic, and immunomodulatory activities.
· Collect from early February to late October.
· Remove roots and rootlets, rinse, cut into pieces.
· Sun dry.
• For lumbago, weak kidney,
neurasthenia, urine retention, chronic nephritis, impotency, bed-wetting.
• Hypertension among women at late ages, chronic arthritis.
• Weakening of the knees and lumbar regions, numbness of the
4 limbs, rheumatic arthritis.
• Given with milk and sugar for gonorrhea, leucorrhea, and menstrual derangements.
• In Ayurveda, increases kapha and reduces vata and pitta; used
for treatment of piles, asthma, gonorrhea, biliousness, fatigue and blood disorders. Also considered a sexual tonic.
• In Unani, used
for bronchitis, ophthalmic, indigestion, vomiting, diarrhea, lumbago,
• In India, Pakistan
and China, tuberous roots
have been used for cancer, jaundice, asthma, wound healing. Rhizome
juice extract has been used as tonic to overcome impotence.
• In India, plant
rhizome has been used as an aphrodisiac.
Plant paste applied to skin for itchy afflictions; also applied to hemorrhoids to relieve pain and itching. Also used for gonorrhea, jaundice, vomiting.
Curculigo orchioides ethanol extract showed a definite protective effect
on bone loss in ovariectomized rats by inhibiting bone resorption and
increasing S phosphorus and calcium levels. (2)
• Antioxidant / Hepatoprotective:
Study showed the antioxidant and hepatoprotective capacity of CO in carbon tetrachloride-induced
hepatopathy in rats. (3) In a study of hepatotoxic rats, the co-administration of the methanolic extract of CO rhizomes showed a tendency to attain near normalcy in the biochemical and histopathologic parameters. • Study isolated curculignin A and curculigol screened for antihepatotoxic activity against thioacetamide and galactosomine-induced hepatotoxicity.
Ethanol extract of C orchioides showed to effective against histamine-induced
contraction and indicated a usefulness of CO in the treatment of asthma. (4)
Study showed the steam distilled extract of C orchioides has a potential
as antiseptic for the prevention and treatment of antibacterial infections. (5)
• Antimicrobial / Anti-tumor / Saponins:
Study showed antibacterial (P aeruginosa, S aureus, K pneumonia), antifungal
(Aspergillus niger and A flavus) and antitumor activities of different
fractionated extracts of CO attributed to the presence of plant glycosides, saponins. (7)
• Spermatogenic Activity:
A study of ethanolic extract in albino rats showed pronounced effect
of orientation of male towards female rates, increased anogenital sniffing
and mounting, increased spermatogenesis, findings that support the
folk use of the plant as an aphrodisiac. (8) Study of a hydroalcoholic root extract of black musli in experimental animal, Passer domesticus, showed spermatogenic enhancing properties. (34)
The plant rhizomes have been used to treat declining strength, jaundice
and asthma. The study of its methanolic extract showed significant immunostimulant
activity in an isolated purified glycoside-rich fraction, acting on
both lymphocytes and macrophages. (9) Methanol extract of CO exhibited a potential as a protective agent against cytotoxic drugs. In a study on humoral and cell mediated immunity in normal and cyclophosphamide-induced immunosuppressed mice, results showed a dose-dependent increase in humoral antibody titre and delayed-type hypersensitivity. (11)
In a study of alcohol and aqueous extracts tested with alloxan-induced diabetic rats, both produced significant hypoglycemic activity when compared with diabetic control. (10) Study of ethanolic and aqueous extracts showed antidiabetic activity in normal, glucose-loaded and alloxan-induced diabetic rats with a diabetic activity comparable to standard agent glimeperide. (23) A methanolic root extract of C. orchioides exhibited hypoglycemic activity in alloxan induced hyperglycemic rats. (32)
• Pharmacologic Properties:
Studies have observed (1) oxytocic activity of a flavone glycoside. (2) Hepatoprotective activity against rifampin-induced hepatotoxicities. (3) Ethanolic extract exhibited estrogenic activity with increase in vaginal cornification, uterine net weight and proliferative changes in the uterine endometrium.
• Aphrodisiac / Spermatogenic Effect:
Ethanolic extract of rhizome have shown improved sexual behavior in male rats with observed changes in sexual performance as: penile erection, mating performance, mount frequency and mount latency, with pronounced anabolic and spermatogenic effect.
• Effect on Hyperglycemia-Induced Oligospermia and Sexual Dysfunction:
An aqueous extract was evaluated for benefits in rats against STZ-induced hyperglycemic stress and sexual dysfunction due to hyperglycemia. Results showed amelioration in damage caused by sustained hyperglycemia vis-a-vis male sexual behavior, sperm count, penile erection index and seminal fructose content. (14)
• Curculigoside / Learning and Memory / Cognitive Benefits in Aged Rats:
Study evaluated the ameliorating effects of curculigoside from C. orchioides on learning and memory in aged rats. Results showed curculigoside can improve cognitive function in aged animals, possibly by decreasing the activity of AchE in the cerebra and inhibiting the expression of BACE1 in the hippocampus. Results suggest a potential new drug for the treatment of Alzheimer's disease. (16)
• Analgesic / Anti-Inflammatory:
An ethanol extract of rhizome showed significant dose-dependent exhibited dose-dependent anti-inflammatory and analgesic activities. Phytochemical screening yielded alkaloids, flavonoids, saponins, steroids, and tannins. (17)
• New Phenolic Glycosides / Weak Anti-HBV Activity:
Study yielded three new phenolic glycosides, curculigosides F-H from the rhizomes of C. orchioides. Compound 1 exhibited weak anti-HBV activity in vitro. (18)
• Acute Toxicity Study / Anti-Inflammatory:
A hydroalcoholic extract of rhizome and its alkaloidal and non-alkaloidal fractions were evaluated in a carrageenan-induced paw edema rat model. Results showed anti-inflammatory activity. On acute toxicity evaluation, no toxicity was noted up to 2000 mg/kg/p.o. (19)
• Antibacterial / Antioxidant / Antiproliferative:
Study evaluated the antibacterial, antioxidant, and antiproliferative activity of B. sensitivum, C. orchioides and C. dactylon. A petroleum ether extract of Curculigo orchioides showed significant antibacterial activity against pathogenic strains of bacteria. A methanolic extract showed higher phenolic and flavonoid content and significant DPPH scavenging and reducing power activity. The methanolic extract also showed strong antiproliferative activity against HepG2 (hepatocellular liver carcinoma) with IC50 of 127.12 µg/ml. (21)
• Anti-Cancer / Enhancement of Chemotherapeutic Effects:
Study evaluated the tumor reduction capacity of cyclophosphamide (CTX) in combination with C. orchioides methanolic extract using Dalton's lymphoma ascites-induced solid tumor models. Results showed the extract in combination with CTX can result in enhanced anticancer properties and also ameliorate the toxic effects of CTX. (22)
• Antimicrobial / Rhizomes: Study investigated aqueous and ethanolic extracts of C. orchioides for antimicrobial activity against Erwinia amylovora, K. pneumonia, E. coli, P. mirabilis, P. aeruginosa and Enterobacter cloacae. Among the two extracts, the ethanolic extract showed maximum antimicrobial activity against the six microorganisms. (24)
• Bioactive Compounds / Rhizomes: Study of ethanol extract of rhizome by GC-MS analysis yielded six compounds. Compound 6, ethyl iso-allocholate, has been reported to have antimicrobial, antiasthma, anti-inflammatory, anticancer, and diuretic properties. (see constituents above) (25)
• Mucilage as Suspending Agent:
Study evaluated mucilage from the roots of C. orchioides as a suspending agent, comparing it with standard suspending agents like sodium carboxymethylcellulose and Acacia. Results showed the mucilage to to be superior suspending agent than acacia indicating a potential source of a pharmaceutical adjuvant. (26)
• Silver Nanoparticles / Antibacterial:
Study reports on the comparatively rapid and inexpensive synthesis of silver nanoparticles using C. orchioides plant extract with wide application in antibacterial therapy. (27)
• Neuroprotective / Cyclophosphamide Neurotoxicity: Study evaluated the neuroprotective effect of C. orchioides in an animal mode of cyclophosphamide induced neurotoxicity. Curculigo orchioides significantly promoted restoration of catalase (p<0.005), superoxide dismutase (p<0.005), and glutathione (p<0.05) levels, together with a very significant decrease in malondialdehyde levels. Flavonoids and polyphenols content may be responsible for the neuroprotective effect. (28)
• Anti-Inflammatory / Root Tubers: Study evaluated the anti-inflammatory effect of a methanolic extract of root tubers in a carrageenan induced rat paw edema model. Results showed statistically significant anti-inflammatory activity at doses of 200 mg/kg and 499 mg/kg, Standard drug was diclofenac sodium. (29)
• Curculigoside / Ameliorative Effects on Learning and Memory: Study evaluated the ameliorative effects of curculigoside from C. orchioides on learning and memory in aged rats through step-down test and Y-maze test. Results showed curculigoside can improved cognitive function in aged animals, possibly by decreasing the activity of AchE in the cerebrum and inhibiting expression of BACE1 in the hippocampus. Results suggest a potential for the development of a drug for Alzheimer's disease. (30)
• Antipyretic / Analgesic / Rhizomes: Study evaluated a methanolic extract of rhizomes for antipyretic (yeast induced pyrexia) and analgesic (Eddy's hot plate method, acetic acid induced writhing method, and head conduction method) activity. Results showed significant antipyretic (p<0.05) and analgesic (p<0.001) activity. (31)
• Hepatoprotective / Paracetamol Toxicity / Rhizomes: Study evaluated the hepatoprotective activity of ethanolic extract of C. orchioides against paracetamol and ethanol induced hepatotoxicity in albino Wistar rats. Results showed significant hepatoprotective activity, with reduction of elevated SGOT, SGPT, ALP and total bilirubin, almost comparable to silymarin. Histopathology showed regeneration of hepatocytes. (33)
Extracts and pills in the cybermarket.