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Family Solanaceae
Pantug-pantugan
Physalis minima Linn.
TINKLING BELL GRASS
K'u chi

Scientific names  Common names 
Nicandra indica Roem. & Schult.            Unresolved Amansit (Ilk.)
Physalis angulata var. villosa  Bonati Amanti-ti-ugsa (Bon.)
Physalis micrantha Link. Itlog-gagamba (Tag.)
Physalis minima Linn.. Lapak-lapak (Sul.)
Physalis parviflora R. Br.. Pantug-pantugan (Tag.)
  Takla (Sub.)
  Tultullaki (Ilk.)
  Unti (Tag.)
  Unti-untihan (Tag.)
  Ground cherry (Engl.)
  Pygmy groundcherry (Engl.)
  Sunberry (Engl.)
  Tinkling bell grass (Engl.)
  Wild cape gooseberry (Engl.)
Physalis minima L. is an accepted name The Plant List
Unti-untian shares a confusing phonetic similarity with Kama-kamatisan, Solanum nigrum (onti, konti, kunti).

Other vernacular names
BENGALI: Bantepariya.
CHINESE: Xiao suan jiang, K'u chi.
HINDI: Rasbhari, Ban tipariya, Chirpati.
FRENCH: Coqueret à petit fruit, Coqueret médicinal.
GUJARATI: Popti.
KANNADA: Gadde hannu.
MALAY: Letup, Letup-letup, Rumput meranti.
MALAYALAM: Nottinota.
MARATHI: Chirboti, Nanvachivel, Ran-popti.
TAMIL: Kupanti.
TELUGU: Kupanti.

Taxon confusion
Physalis, a genus of the family Solanaceae consists of about 100 species. Among these, Physalis minima has been confused with P. angulata (putokan). Some compilations list them as synonyms, others list them as separate species. In Bangladesh, the two have long been misidentified. A critical examination separates them as species. (See below: sources)

Botany
Pantug-pantugan is an erect, branched, hairy annual herb, growing 0.5 to 0.8 meter high. The branches are terete and often tinged with purple, the ultimate ones slightly angular. Leaves are ovate, 6 to 12 centimeters long, 4.5 to 7 centimeters wide, with pointed tip, rounded or slightly heart-shaped base, nearly entire or with faintly undulately lobed margins. Flowers are solitary, axillary, about 8 millimeters long. Corolla is pale yellow, with 5 large, purple spots at the base inside. Fruit is round, fleshy and edible, about 1 centimeter in diameter. Calyx is inflated, accrescent, and ovoid, about 3 centimeters long, 2 centimeters in diameter, green, with 5 prominent and alternating slender and purplish ribs.

Distribution
- Found from the Babuyan Islands and northern Luzon to Mindanao and Palawan.
- Often common in open, waste places at low altitudes, ascending up to 1,600 meters.
- Pantropic weed.

Constituents
- Phytochemical studies yield alkaloids, anthraquinones, flavonoids, cardiac glycosides, phenols, quinones, reducing sugars, saponins, steroids, starch, tannin and terpenoids from the stem, leaf, and unripe fruit.
- Ethanolic extract of leaves yielded major compounds, viz. acetamide, 2,2,2- trifluoro-N-methyl- (7.2%), 2-cyclopenten-1-one, 2- methyl- (3.83%), phytol (17.88%), n-Hexadecanoic acid (29.81%), octadecanoic acid (5.04%), oleic acid (3.55%), 9,12-octadecadienoic acid (Z,Z)- (12.47%), hexaethylene glycol monododecyl ether (5.6%) and 9,12,15-octadecatrienoic acid, (Z,Z,Z) (14.63%). Ethanolic extract of roots yielded n- Hexadecanoic acid (4.06%), 2-[2-[2-[2-[2-[2-[2-(2- Hydroxyethoxy)ethoxy]ethoxy]ethoxy] ethoxy]ethoxy]eth oxy]ethanol (1.43%), O-Methyl-DL-serine,N- dimethylaminomethylene-,ethyl ester (63.20%) and Ethyl dl-(1-naphthyl)glycolate (4.94%). (18)
- Fruits yielded major compounds, viz. acetamide, 2,2,2-trifluoro-N-methyl- (3.90%), 4H-pyran-4-one, 2,3-dihydro-3,5-dihydroxy-6- methyl-(8.40%), 5-hydroxymethylfurfural (14.07%), (Z)- 3-phenyl-2-propenoic acid (3.33%), n-hexadecanoic acid (28.98%), octadecanoic acid (3.35%), octadec-9-enoic acid (9.15%), 9,12-octadecadienoic acid (Z,Z)- (16.09%), 2-Isopropoxyethyl propionate (9.28%) and 9,12,15- octadecatrienoic acid, (Z,Z,Z)- (3.47%). (18)
- Study for bioactive compounds in leaves yielded heneicosanoic acid (25.22), bicyclo [4.1.0] hepta-2, 4-dien (27.41), octadecanoic acid (CAS), stearic acid (31.19) and octadeca-9, 12-dienoic acid (32.02). Phenolic compounds profile yielded ellagic acid (4.13 min), catechol (3.59 min), gallic acid (4.12 min) and catechin (7.41 min).
(19)

Properties
- Bitter tasting, cooling in effect.
- Fruit is alterative, diuretic, aperient.
- Plant is considered appetizer, antipyretic, anti-inflammatory, antitussive, diuretic, laxative, expectorant, purgative, and tonic.

Parts utilized
Roots, leaves, fruits.

Uses
Nutritional
- Fruit is edible, with a taste of a sweet cherry tomato.
Folkloric
- In Java, root is used as vermifuge.
- Root extract used for fever.
- Poultice of leaves, smeared with oiled and heated, applied to ulcers.
- Decoction of leaves with Plantago major used for gonorrhea; also, diuretic.
- Fruit used as alterative, diuretic and aperient; used in dropsy, urinary diseases, and gout.
Used for colds and fever, swelling pain of the throat, bronchitis.
- Fruit used for gout; also used to infuse vigor and offset premature decay.
- In Konkan, plant paste made with rice water used to restore flaccid breasts.
- Poultice of fruits used for headaches and intestinal pains.
- In the Punjab, used for gonorrhea.
- Malays used a poultice for headaches and intestinal pains
- Pounded fresh material may be used as poultice or decoction of the same may be used as wash for eczema infection.
- Juice of leaves, mixed with mustard oil and water, used for earaches.

- In India, used for dysuria, ascites, ulcers, cough, bronchitis, pruritus and erysipelas. Used as a tonic, diuretic and purgative; as a remedy for spleen disorders. Also used for diabetes.

Studies
Antifertility: Study of extract of P minima on female albino rats exhibited variations in ovarian and uterine weights and significant histopathologic changes in the histoarchitecture of the female reproductive system. (1)
Antimicrobial: Antimicrobial activity of Rauvolfia tetraphylla and Physalis minima leaf and callus extracts: Leaf and callus extracts of R. tetraphylla and P. minima inhibited bacterial and fungal growth.   (2)
Phytochemicals / Withaphysalin D: Study yielded Withaphysalin D, a new withphysalin. (3)
Anti-Inflammatory / Analgesic: Study of the whole plant of Physalis minima on rats showed marked anti-inflammatory and analgesic activities. The antipyretic activity was insignificant. Results showed PM as a potential candidate as an antiinflammatory and analgesic agent. (4)
Cytotoxic / Anti-Cancer / Human Lung Adenocarcinoma Cell Line: In the study, the chloroform extract of Physalis minima exhibited remarkable cytotoxic activities on human lung adenocarcinoma cell line in time- and dose-dependent manners. Its apoptotic effect suggests potential for development as an anticancer drug. (5)
Cytotoxic / Anti-Cancer / Withaphysalin: Study yielded a novel withanolide, withaphysalin P with six other new withaphysalins 1-7 and three known withaphysalins 8-10. Some compounds showed moderate cytotoxic activity against two human cancer cell lines – colorectal-carcinoma and non-small cell lung cancer. (6)
Hypoglycemic / Alpha-Glucosidase Inhibition: Physalis minima extract showed in-vitro inhibitory activity of intestinal alpha glucosidase enzyme maltase with decrease intestinal absorption of monosaccharides through inhibition of disaccharide hydrolysis. (7)
Apoptotic Effects / Anti-Breast Cancer: A chloroform extract of Physalis minima produced significant inhibition against human T-47D breast carcinoma cells. It induced apoptotic cell death via p53-, caspase-3-, and c-myc-dependent pathways. (8)
Antibacterial Potential: Study showed a methanol and chloroform extracts of P. minima exhibited potent inhibitory activity against all the bacterial strains tested. Polar compounds in the crude extract were responsible for the antimicrobial action. (10)
Antibacterial: Study showed leaf and stem extracts to have moderate antibacterial activity when evaluated against Bacillus cereus, B. subtilis, Citrobacter sp., Enterobacter aerogenes, E. coli, K. pneumonia, P. aeruginosa, P. fluorescens and S. aureus. Overall antibacterial assay showed the ethanolic extract to be more effective than other solvents. (12)
Anti-Lipid Peroxidation: Study evaluated the free radical scavenging activity of ethanolic extracts of Piper trioicum and Physalis minima, with goat liver as the lipid source. Results showed suppression of lipid peroxidation. In the study, P. trioicum extract showed more activity than Physalis minima. (11)
Diuretic Activity / Leaves: Study evaluated the diuretic effect of petroleum ether extract of P. minima in albino rats. Results showed significant increase in urine volume, with increased excretion of potassium and sodium. The effect was similar to furosemide. (15)
Antioxidant / Stems and Leaves: Study evaluated the in vitro antioxidant activity of crude extracts of stems and leaves of P. minima by DPPH and reducing power assay. The methanolic extract of leaf showed higher activity to others extracts of stem and leaves. The entire tested sample showed lower scavenging activity than standard ascorbic acid. (16)
Free Radical Scavenging Activity / Leaves : Study screened an ethanolic extract for in vitro antioxidant activity by various radical scavenging assays. Results showed marked concentration dependent antioxidant activity and may be attributed to the presence of bioflavonoids in the leaf. (17)
• Antidiabetic / Toxicity Study: Study evaluated the hypoglycemic effects of P. minima extracts in alloxan-induced diabetic rats. Chronic administration of flower and leaf extract showed a fall in fasting blood sugar of rats. Toxicity study showed the medium lethal dose (LD50) f the extract is higher than 1 g/kg body weight. (20)
• Hypoglycemic Effect: Study evaluated the effect of methanolic extract of Physalis minima on blood glucose level and sperm quality in normoglycemic mice. Results showed a significant dose dependent decrease (p<0.05) in blood glucose of treatment groups, without affecting sperm quality in male mice. (21)
• Anti-Inflammatory Effect on Gastric Tissue: Study investigated the effect of a methanolic extract of P. minima in gastric inflammation and gastric ulcer formation in rats. The methanol extract of Pm exhibited anti-inflammatory action due to its effect in inhibiting phospholipase A2 expression in gastric tissue. The gastric ulcer formation as side effect of the MEMP was lower compared to aspirin. (22)
• Antidiabetic / Toxicity Study /Leaves: Study evaluated Physalis minima leaves for in vitro a-amylase, a-glucosidase inhibitory activities and glucose uptake by yeast cells in alloxan-induced diabetic rats. Results showed a dose-dependent percent inhibition by the extract against α-amylase (16%-84%), α-glucosidase (18%-76%), and glucose uptake by yeast cells (16%-78%). Toxicity study showed a medium lethal dose (LD50) of the extracts is higher than 1 g/kg body weight. (23)
• Anti-Ulcer Activity: Study evaluated the anti-ulcer effect of different extracts of Physalis minima in NSAIDs induced ulcer model in albino rats. Extract dose at 200 and 400 mg/kg produced significant inhibition of gastric ulcers induced by NSAIDs. (24)

Availability
Wild-crafted. 

Godofredo U. Stuart Jr., M.D.

Last Update January 2017

Photos © Godofredo Stuart / StuartXchange
SOURCES

Additional Sources and Suggested Readings
(1)
Antifertility Effects of the Petroleum Ether Extract of Physalis Minima on Female Albino Rats
Pharmaceutical Biology / 1999, Vol. 37, No. 4, Pages 269-272
(2)
Antimicrobial activity of Rauvolfia tetraphylla and Physalis minima leaf and callus extracts
African Journal of Biotechnology Vol. 5 (10), pp. 946-950, 16 May 2006

(3)
Withaphysalin D, A New Withaphysalin from Physalis minima Linn. Var. Indica / Mahendra Sahai and Isaac Kirson / J. Nat. Prod., 1984, 47 (3), pp 527–529 / DOI: 10.1021/np50033a022
(4)
Anti-inflammatory, analgesic and antipyretic activities of Physalis minima Linn / Murad Ali Khan et al / Journal of Enzyme Inhibition and Medicinal Chemistry, Volume 24, Issue 3 June 2009 , pages 632 - 637
/ DOI: 10.1080/14756360802321120
(5)
Cytotoxic Activities of Physalis minima L. Chloroform Extract on Human Lung Adenocarcinoma NCI-H23 Cell Lines by Induction of Apoptosis / Ooi Kheng Leong et al / Oxford Journals Medicine Evidence-based Compl. and Alt. MedicineeCAM Advance Access10.1093/ecam/nep057
(6)
Cytotoxic Withaphysalins from Physalis minima / Lei Ma et al / Helvetica Chimica Acta • Volume 90 Issue 7, Pages 1406 - 1419 / 10.1002/hlca.200790143 DOI

(7)
Alpha-Glucosidase Inhibitory and Hypoglycemic Activities of Physalis Minima Extract / Sathis Kumar, Raju S N et al / Pharmacognosy Journal, Dec 2009, Vol 1, Issue 4, Pp 273-278.
(8)
Apoptotic effects of Physalis minima L. chloroform extract in human breast carcinoma T-47D cells mediated by c-myc-, p53-, and caspase-3-dependent pathways / Ooi K L, Tengku Muhammad et al / Integr Cancer Ther. 2010 Mar;9(1):73-83. Epub 2010 Feb 11.
(9)
PHYSALIS ANGULATA L. (SOLANACEAE)-A NEW ANGIOSPERMIC RECORD FOR BANGLADESH / Nahid Sultana, M A Hassan et al / Bangladesh J. Bot. 37(2):195-198, 2008 (December) - Short communication
(10)
Study on the Antibacterial Potential of Physalis Minima Linn / T. Patel, K. Shah, K. Jiwan, and Neeta Shrivastava / Indian J Pharm Sci. 2011 Jan-Feb; 73(1): 111–115. / doi: 10.4103/0250-474X.89770
(11)
ANTI LIPID PEROXIDATION ACTIVITY OF PIPER TRIOICUM ROXB. AND PHYSALIS MINIMA L. EXTRACTS / Sathis Kumar Dinakaran et al / Pak. J. Pharm. Sci., Vol.24, No.3, July 2011, pp.411-413
(12)
Preliminary phytochemical and anti-bacterial studies on Physalis minima Linn. / Nathiya M and D. Dorcus / INT J CURR SCI 2012, 24-30
(13)
Physalis minima L. / Synonyms / The Plant List
(14)
Sorting Physalis names / /Maintained by: Michel H. Porcher / MULTILINGUAL MULTISCRIPT PLANT NAME DATABASE / Copyright © 1995 - 2020 The University of Melbourne.
(15)
Diuretic activity of methanolic extract of Physalis minima leaves / *Jyothibasu Tammu, K.Venkata Ramana, Sreenu Thalla, Ch Narasimha raju Bh / Der Pharmacia Lettre, 2012, 4 (6):1832-1834
(16)
Evaluation of Antioxidant Activity of Physalis Minima / SHWETA SINGH* and POONAM PRAKASH / Chemical Science Transactions 2014, 3(3), 1179-1185 / DOI:10.7598/cst2014.800
(17)
Free radical scavenging activity of Physalis minima Linn. leaf extract (PMLE)
/ C. Karpagasundari and S. Kulothungan / Journal of Medicinal Plants Studies 2014; 2(4): 59-64
(18)
Preliminary Phytochemical Screening and GC- MS Analysis of Ethanol Extract of Physalis Minima L. (Solanaceae) / Norhanizan Usaizan, Nur Ashikin Psyquay Abdullah, Siti Hajar Ahmad and Ghizan Saleh / Journal of Advanced Agricultural Technologies Vol. 1, No. 2, December 2014
(19)
Analysis of bioactive compounds in Physalis minima leaves using GC MS, HPLC, UV-VIS and FTIR techniques / C. Karpagasundari and S. Kulothungan / Journal of Pharmacognosy and Phytochemistry 2014; 3(4): 196-201
(20)
Evaluation of antidiabetic activity of medicinal plant extracts used by tribal communities in rural areas of Warangal district, Andhra Pradesh, India / Esampally Sucharitha, Mamidala Estari* / Biology and Medicine, 5: 20–25, 2013
(21)
Physalis minima Linn Methanolic Extract Reduces Blood Glucose Level without Compromising Sperm Quality in Normoglycaemic Mice / Dzulsuhaimi Daud*, Siti Fatimah Elias, Fatimah Sarah Mohamad Hassan, Mohammad Noor Jalil, Alene Tawang / Journal of Applied Pharmaceutical Science Vol. 6 (06), pp. 008-011, June, 2016 / DOI: 10.7324/JAPS.2016.60602
(22)
Effect of methanolic extract of Physalis minima on gastric inflammation and gastric ulcers formation / Umi Kalsum, Mulyohadi Ali, M. Aris Widodo, Handono Kalim / J Exp Integr Med 2013; 3(4):331-335

(23)
IN VITRO ANTIDIABETIC ACTIVITY OF Physalis minima METHANOL LEAVES EXTRACT C.
/ Karpagasundari and S. Kulothungan / International Journal of Research in Plant Science 2015; 5(4): 37-40
(24)
ANTI-ULCER ACTIVITY OF PHYSALIS MINIMA PLANT EXTRACT IN ALBINO RATS / T. Joshi Anand*, R. Ratna Manjula, SK. Liakhat Ali, M. Hindu Sai and V. Padmaja / International Journal of Pharmaceutical Sciences and Research


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