Sagilala is a low branching shrub with attractive
and variedly shaped and colored foliage. Leaves are thick and leathery,
ovate, oblong to linear, the margins entire, lobed or spirally twisted.
Young leaves are usually green, yellow or red, later changing to single
color or variegation of gold cream, white, red, maroon, purple, black
or brown. A milky sap bleeds from cut stems. Flowers are small, long, axillary, usually unisexual racemes.
- A very popular cultivated ornamental
in the Philippines.
- Probably native to the Moluccas.
- Cultivated in most tropical countries.
• Studies have yielded alkaloids, terpenes, flavonoids.
• Study of six clone cultivars of Codiaeum
variegatum showed the shoots to be rich in alkaloids (most abundant),
cardiac glycosides, saponins, tannins, cardenolides, steroids and phyllates.
• Phytochemical screening of the plant yielded saponins, reducing sugars, tannins, and gums.
• Study of extracts of leaves from two varieties of CV (spiral/CP and royal like/BP) yielded (-)-Epicatechin, p-coumaric acid, rutin hydrate and ellagic acid. (see study below) (16)
• Leaves are considered purgative,
sedative, antifungal, antiamoebic, antioxidant, and anticancerous.
• Considered emmenagogue and abortifacient.
• Studies have suggested antioxidant, antifertility, molluscicidal,immunomodulating, cytotoxic, wound healing, antimicrobial, antiamoebic, and anticonvulsant properties.
- Caution: Young leaves are reportedly used in the East Indies as vegetable, but cases of irritation have been reported. (See toxicity below)
- Freeze-dried leaf decoction taken
as tea in the Philippines (Gertrudes, 2006).
- Decoction of crushed leaves for diarrhea.
- Young leaves, with Pandanus macroieacceretia, coconut milk, and root
sap of areca catechu used for gonorrhea.
- Sap of leaves mixed with coconut milk used for syphilitic lesions.
- In Nigeria, root decoction
used for gastric ulcers. Leaves, for antibacterial and antiamoebic uses.
- In the Kagera and Coast
regions, used for the treatment of epilepsy.
- In Cameroon, leaves used for bloody diarrhea.
. In Indonesia, leaves used for the treatment of eczema.
- In Vanuatu, leaves used for amenorrhea. Chewing of 3 leaves and
swallowing the juice used as emmenagogue, to induce abortion or facilitate
- In Bangladesh, used by the Marma healers for fevers, cough, and colds. (23) In Unani practice, leaf juice is boiled with fruit oil of Olea europaea and massaged on painful areas. (25)
- In New Guinea and the Solomon Islands, used as abortifacient; leaves chewed and swallowed as contraceptive. In the North Solomons Province, the crushed root is mixed with sulfur and the mixture chewed to induced sterility. In Malaysia, a hot water extract is used to cause abortion. (27)
- In the Fijian Islands, bark decoction used to treat eczema, psoriasis, and allergies. Leaves also used to treat fish poisoning and gonorrhea. (28)
• Phytochemicals: Phytochemical screening of six clone cultivars
of Codiaeum variegatum showed bioactive constituents that included alkaloids,
anthraquinones, flavanoids, terpenes, steroid, phenol, saponins, tannins,
phlobatannin and cardenolide which suggests their use as antibacterial,
antiamoebic and antifungal. (2)
• Antiamoebic: In
a study of 55 traditional medicinal plants in Cameroon, only the leaves
extract of Codiaeum variegatum exhibited clear antiamoebic activity,
more pronounced than metronidazole. (3)
A screening of seven Euphorbiaceae species showed C variegatum to be
one of three with relevant anti-FLUAV activity from an isolated cyanoglucoside. (4)
Study showed methanol extract protected mice against picrotoxin-induced
• Immunostimulating / Spermatotoxic:
Study on 24 male albino rats with feeds supplemented by pulverized dry leaves of C variegatum showed immunostimulating and spermatotoxic effects. (6)
• Molluscicidal Activity:
Study showed the latex of Codiaeum variegatum had high molluscicidal activity against freshwater snail. (7)
• Wound Healing / Root: Study evaluated the wound healing activity of a root incorporated in a simple ointment in excision, incision, and burn wound models in rats. Results showed remarkable wound healing activity in measures of wound contracting ability, wound closure time, and tensile strength. (11)
• Antimicrobial Activity: Study evaluated the antibacterial activity of three varieties of Codiaeum variegatum against six different bacterial strains. Zones of inhibition varied with the plant varieties. The largest zone of inhibition was seen with a leaf callus extract of var. Punctatum aureum against Arthrobacter. (14)
• Cytotoxicity: Phytochemical screening yielded the presence of saponins, reducing sugars, tannins, and gums. Brine shrimp lethality bioassay indicates that the plant has cytotoxic properties. (15) In a study of 61 medicinal plants of Malaysia for cytotoxicity against HeLa cell line, Codiaenum variegatum was one of 18 plants that showed cytotoxic activity. (26)
• Antioxidant / Phenolic Content: Study evaluated in vitro antioxidant potential of two varieties of C. variegatum leaves using various assays. Extracts showed effective DPPH radical scavenging, hydrogen peroxide radical scavenging, and NO scavenging activity. Extracts yielded (-)-epicatechin, p-coumaric acid, rutin hydrate and ellagic acid. Results showed CV leaves contain high amount of phenolic compounds which may be responsible for its biologic activities in folkloric medicine. (16)
• Anti-Amoebic / Entamoeba histolytica: Study searched for active components from C. variegatum against Entamoeba histolytica and their mechanism of action. Subfractions were identified with significantly higher anti-amoebic activity. Results suggest regulation of ceramide biosynthesis pathway as a target for anti-amoebic compounds could be an alternative for drug development against E. histolytica. (17)
• Antibacterial / Fresh Leaves: Study evaluated the antibacterial activity of extract of fresh leaves against four test microorganisms, viz. E. coli, P. aeruginosa, B. subtilis and S. aureus. (19)
• Antiviral / Cytotoxicity: In a study evaluating some plants used in Malaysian indigenous medicine, C. variegatum showed activity against VSV (vesicular stomatitis viruses) and cytotoxicity using the HeLa cell line assay. (20)
• Larvicidal / Culex quinquefasciatus: Study evaluated five species of Philippine plants for larvicidal potential against Aedes aegypti and Culex quinquefasciatus. Codiaeum variegatum showed to be the third most potent larvicide against Culex quinquefasciatus. The leaves have previously shown molluscicidal properties against Oncomelania hypensis quadrasi (Garcia, 1990) which suggests an inherent pesticidal component in the leaves. (22)
• Genotoxic and Mutagenic Testing of Extract and Amoebicidal Fraction:Study evaluated the genotoxic and mutagenic potential of an aqueous extract and isolated sub-fraction. Results showed the aqueous extract of CV and the amoebicidal fraction SF9B are neither genotoxic on non-competent or metabolic competent cell lines, nor mutagenic in mouse lymphoma mutation assay and therefore can be safely used at lower doses for medicinal purpose. (24)
• Chewing on the bark and roots can cause burning
around and in the mouth. Some leaves are reported irritant. Latex have
been reported to cause eczema.
• There has been a report of occupational contact dermatitis.
• Report of Contact Dermatitis: Study reports on a case of contact eczema in a nursery gardener. Patch tests with Croton leaves were positive. Results suggest: (1) the latex produces no primary irritant reaction, (2) the latex can induce contact allergy, and (3) contact allergens are constituent of the milky sap. Sensitization experiments in guinea pigs with methanolic extract of leaves were successful. (21)